3-Deazaadenosine prevents smooth muscle cell proliferation and neointima formation by interfering with ras signaling

Circulation Research

Volumn 104, Issue 10, 2009, Pages 1192-1200

  Sedding, Daniel G ^a   Tröbs, Monique ^a   Reich, Fabian ^a   Walker, Gerhard ^a   Fink, Ludger ^a   Haberbosch, Werner ^b   Rau, Wigbert ^a   Tillmanns, Harald ^a   Preissner, Klaus T ^a   Bohle, Rainer M ^a   Langheinrich, Alexander C ^a,c  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b Suhl Central Hospital   (Germany)

^c MAYO GRADUATE SCHOOL   (United States)

Author keywords

Neointima formation; Restenosis; Signal transduction; Smooth muscle cells; Vascular smooth muscle cell proliferation

Indexed keywords

3 DEAZAADENOSINE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; P21 ACTIVATED KINASE; PROPIDIUM IODIDE; PROTEIN KINASE B; PROTEIN S ISOPRENYLCYSTEINE O METHYLTRANSFERASE; RAS PROTEIN; RETINOBLASTOMA PROTEIN; TRYPAN BLUE; 3-DEAZAADENOSINE; ADENOSYLHOMOCYSTEINASE; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN P21; TUBERCIDIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTERY DILATATION; ARTICLE; C57BL 6 MOUSE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CORONARY ARTERY; DIET; DOSE RESPONSE; ENZYME ACTIVITY; FEMORAL ARTERY; FLUORESCENCE ACTIVATED CELL SORTER; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTIMA; MALE; MEMBRANE TRANSPORT; METHYLATION; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; STAINING; VASCULAR SMOOTH MUSCLE; ANGIOGENESIS; ANIMAL; C57BL MOUSE; CELL CYCLE; CELL MOTION; CORONARY BLOOD VESSEL; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PHYSIOLOGY;

ADENOSYLHOMOCYSTEINASE; ANIMALS; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; CORONARY VESSELS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALE; METHYLATION; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 3; MONOMERIC GTP-BINDING PROTEINS; MUSCLE, SMOOTH, VASCULAR; NEOVASCULARIZATION, PHYSIOLOGIC; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS P21(RAS); SIGNAL TRANSDUCTION; TUBERCIDIN;

EID: 66949121780     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.194357     Document Type: Article

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