Novel poly(HEMA-co-METAC)/alginate semi-interpenetrating hydrogels for biomedical applications: Synthesis and characterization

Journal of Biomedical Materials Research - Part A

Volumn 90, Issue 1, 2009, Pages 292-302

  La Gatta, Annalisa ^a   Schiraldi, Chiara ^a   Esposito, Annaclaudia ^b   D'Agostino, Antonella ^a   De Rosa, Alfredo ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b Department of Clinic Public and Preventive Medicine   (Italy)

Author keywords

Biocompatibility; Hydrogels; pHEMA; Semi interpenetrating polymers; Swelling

Indexed keywords

2-HYDROXYETHYLMETHACRYLATE; AMMONIUM CHLORIDE; AQUEOUS SOLUTIONS; BIOLOGICAL CHARACTERIZATION; BIOLOGICAL RESPONSE; BIOMEDICAL APPLICATIONS; BIOMEDICAL FIELDS; BIOMEDICAL USE; CELL ATTACHMENTS; EFFECT OF IONIC STRENGTH; HUMAN FIBROBLAST; HYDROGEL SURFACES; HYDROXYETHYLMETHACRYLATE; INTERPENETRATING HYDROGELS; ISO 10993; PH VALUE; PHEMA; POLYSACCHARIDE CONTENTS; PRESENCE OF WATER; PROTEIN ABSORPTION; SEMI-INTERPENETRATING POLYMERS; SEMI-IPN; SWELLING BEHAVIOR; SWELLING DEGREE; SWELLING STUDIES; SYNTHESIS AND CHARACTERIZATION; WATER UPTAKE;

ADHESION; ALGINATE; AMMONIUM COMPOUNDS; BIOCOMPATIBILITY; CELL ADHESION; CELL CULTURE; CHLORINE COMPOUNDS; IONIC STRENGTH; IONIZATION OF LIQUIDS; PH EFFECTS; POLYSACCHARIDES; SWELLING; SYNTHESIS (CHEMICAL); WATER CONTENT;

HYDROGELS;

BIOMATERIAL; COPOLYMER; POLY(HYDROXYETHYL METHACRYLATE CO 2 METHACRYLOXYETHYLTRIMETHYLAMMONIUM CHLORIDE); POLYELECTROLYTE; POLYSACCHARIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CELL ADHESION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; HYDROGEL; IONIC STRENGTH; MOUSE; NONHUMAN; PH; POLYMERIZATION; SURFACE PROPERTY; SYNTHESIS; WATER TRANSPORT;

3T3 CELLS; ADSORPTION; ALGINATES; ANIMALS; BIOCOMPATIBLE MATERIALS; CELL ADHESION; CELL PROLIFERATION; FIBROBLASTS; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; HYDROGEL; MATERIALS TESTING; METHACRYLATES; MICE; POLYMERS; STRESS, MECHANICAL;

EID: 66849132438     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32094     Document Type: Article

References (39)

1. Peppas NA, Bures P, Leobandung W, Ichikawa H. Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm 2000;50:27-46. (Pubitemid 30326687)
2. Hennink WE, van Nostrum CF. Novel crosslinking methods to design hydrogels. Adv Drug Deliv Rev 2002;54:13-36. (Pubitemid 34075312)
3. Patrickios CS, Georgiou TK. Covalent amphiphilic polymer networks. Curr Opin Colloid Interface Sci 2003;8:76-85. (Pubitemid 36755215)
4. Ju HK, Kim SY, Lee YM. pH/temperature-responsive behaviors of semi-IPN and comb-type graft hydrogels composed of alginate and poly(N- isopropylacrylamide). Polymer 2001;42: 6851-6857. (Pubitemid 32441154)
5. Lou X, Munro S, Wang S. Drug release characteristics of phase separation pHEMA sponge materials. Biomaterials 2004;25:5071-5080. (Pubitemid 38520837)
6. Rosso F, Barbarisi A, Barbarisi M, Petillo O, Margarucci S, Calarco A, Peluso G. New polyelectrolyte hydrogels for biomedical applications. Mater Sci Eng C 2003;23:371-376. (Pubitemid 36211429)
7. Hsiue GH, Guu JA, Cheng CC. Poly(2-hydroxyethyl methacrylate) film as a drug delivery system for pilocarpine. Biomaterials 2001;22:1763-1769.
8. Wichterle O, Lim D. Hydrophilic gels in biological use. Nature 1960;185:117-118.
9. Schneider GB, English A, Abraham M, Zaharias R, Stanford C, Keller J. The effect of hydrogel charge density on cell attachment. Biomaterials 2004;25:3023-3028. (Pubitemid 38210194)
10. Santin M, Huang SJ, Iannace S, Ambrosio L, Nicolais L, Peluso G. Synthesis and characterization of a new interpenetrated poly(2- hydroxyethylmethacrylate)-gelatin composite polymer. Biomaterials 1996;17:1459-1467. (Pubitemid 26254174)
11. De Rosa M, Cartenì M, Petillo O, Calarco A, Margarucci S, Rosso F, De Rosa A, Farina E, Grippo P, Peluso G. Cationic polyelectrolyte hydrogel fosters fibroblast spreading, proliferation, and extracellular matrix production: Implication for tissue engineering. J Cell Physiol 2004;198:133-143. (Pubitemid 38120974)
12. Schiraldi C, D'Agostino A, Oliva A, Flamma F, De Rosa A, Apicella A, Aversa R, De Rosa M. Development of hybrid materials based on hydroxylethylmethacrylate as supports for improving cell adhesion and proliferation. Biomaterials 2004;25:3645-3653. (Pubitemid 38327053)
13. Peluso G, Petillo O, Anderson JM, Ambrosio L, Nicolais L, Melone MAB, Eschbach FO, Huang SJ. The differential effects of poly(2-hydroxyethyl methacrylate) and poly(2-hydroxyethyl methacrylate)/poly(caprolactone) polymers on cell proliferation and collagen synthesis by human lung fibroblasts. J Biomed Mater Res 1997;34:327-336. (Pubitemid 27097802)
14. Rihova B. Immunocompatibility and biocompatibility of cell delivery systems. Adv Drug Deliv Rev 2000;42:65-80.
15. Cicerchia Perez L, Faris B, LaPointe G, Beldecal J, Leibowitz H, Franzblau C. Use of collagen-hydroxyethylmethacrylate hydrogels for cell growth. Proc Natl Acad Sci USA 1980;77:2064-2068. (Pubitemid 10089599)
16. Jeyanthi R, Panduranga Kao K. In vivo biocompatibility of collagen-poly(hydroxyethyl methacrylate) hydrogels. Biomaterials 1990;11:238-243.
17. Hoffman AS. Hydrogels for biomedical applications. Adv Drug Deliv Rev 2002;43:3-12. (Pubitemid 34081178)
18. Chen S, Liu M, Jin S, Chen Y. Synthesis and swelling properties of pH-sensitive hydrogels based on chitosan and poly (methacrylic acid) semi-interpenetrating polymer network. J Appl Polym Sci 2005;98:1720-1726. (Pubitemid 41634464)
19. Lee JW, Kim SY, Kim SS, Lee YM, Lee KH, Kim SJ. Synthesis and characteristics of interpenetrating polymer network hydrogel composed of chitosan and poly(acrylic acid). J Appl Polym Sci 1999;73:113-120.
20. Bajpai AK, Bajpai J, Shukla S. Water sorption through a semi-interpenetrating polymer network (IPN) with hydrophilic and hydrophobic chains. React Funct Polym 2001;50:9-21. (Pubitemid 33711070)
21. La Gatta A, De Rosa A, Laurienzo P, Malinconico M, De Rosa M, Schiraldi C. A novel injectable poly(ε-caprolactone)/calcium sulfate system for bone regeneration: synthesis and characterization. Macromol Biosci 2005;5:1108-1117. (Pubitemid 41735591)
22. Slater TF, Sawyer B, Strauli U. Studies on succinate-tetrazolium reductase systems. III. Points of coupling of four different tetrazolium salts. Biochim Biophys Acta 1963;77:383-393.
23. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano I, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC. Measurement of protein using bicinchoninic acid. Anal Biochem 1985;150:76-85. (Pubitemid 16258399)
24. Mazzarella N, Femiano F, Gombos F, De Rosa A, Giuliano M. Matrix metalloproteinase gene expression in oral lichen planus: Erosive vs. reticular forms. J Eur Acad Dermatol Venereol 2006;20:953-957. (Pubitemid 44241383)
25. Kim SJ, Lee CK, Lee YM, Kim IY, Kim SI. Electrical/pH-sensitive swelling behaviour of polyelectrolyte hydrogels prepared with hyaluronic acid-poly(vinyl alcohol) interpenetrating polymer networks. React Funct Polym 2003;55:291-298.
26. Khare AR, Peppas NA. Swelling/deswelling of anionic copolymer gels. Biomaterials 1995;16:559-567.
27. Davis PA, Huang SJ, Nicolais L, Ambrosio L. Modified pHEMA hydrogels. In: Szycher M, editor. High Performance Biomaterials. Lancaster, Pennsylvania, USA: Technonic; 1991. p 343-368.
28. Ratner BD, Hoffman AS. Synthetic hydrogels for biomedical applications. In: Andrade J, editor. Hydrogels for medical and related applications, ACS symposium Ser. 3.1, Washington, DC: American Chemistry Society; 1976. p 1-36.
29. am Ende MT, Hariharan D, Peppas NA. Factors influencing drug and protein transport and release from ionic hydrogels. React Polym 1995;25:127-137.
30. Elliott JE, Macdonald M, Nie J, Bowman CN. Structure and swelling of poly(acrylic acid) hydrogels: Effect of pH; ionic strength, and dilution on the crosslinked polymer structure. Polymer 2004;45:1503-1510. (Pubitemid 38175353)
31. Budtova T. Swelling behaviour of a polyelectrolyte network under load. Polymer 1997;38:5947-5952. (Pubitemid 127410684)
32. Ben Jar PY, Shan Wu Y. Effect of counter-ions on swelling and shrinkage of polyacrylamide-based ionic gels. Polymer 1997;38:2557-2560. (Pubitemid 127422237)
33. Markland P, Zhang Y, Amidon GL, Yang VC. A pH- and ionic strength-responsive polypeptide hydrogel: Synthesis, characterization, and preliminary protein release studies. J Biomed Mater Res 1999;47:595-602. (Pubitemid 29468565)
34. Kim SJ, Yoon SG, Lee KB, Park YD, Kim SI. Electrical sensitive behavior of a polyelectrolyte complex composed of chitosan/hyaluronic acid. Solid State Ionics 2003;164:199-204.
35. LeRoux MA, Guilak F, Setton LA. Compressive and shear properties of alginate gel: Effects of sodium ions and alginate concentration. J Biomed Mater Res 1999;47:46-53. (Pubitemid 29344968)
36. Wang X, Spencer HG. Calcium alginate gels: Formation and stability in the presence of an inert electrolyte. Polymer 1998;13:2759-2764. (Pubitemid 128396442)
37. Cardenas A, Arguelles-Monal W, Goycoolea FM, Higuera-Ciapara I, Peniche C. Diffusion through membranes of the polyelectrolyte complex of chitosan and alginate. Macromol Biosci 2003;3:535-539. (Pubitemid 37309677)
38. Young C-D, Wu J-R, Tsou T-L. High-strength, ultra-thin and fiber-reinforced pHEMA artificial skin. Biomaterials 1998;19: 1745-1752.
39. Horbett TA, Schway MB. Correlations between mouse 3T3 spreading and serum fibronectin absorption on glass and hydroxyethylmethacrylate-ethylmethacrylate co-polymers. J Biomed Mater Res 1988;22:763-793. (Pubitemid 18194493)