High-strength, ultra-thin and fiber-reinforced pHEMA artificial skin

Biomaterials

Volumn 19, Issue 19, 1998, Pages 1745-1752

  Young, Chung Daw ^a   Wu, Jing Ran ^a   Tsou, Tai Li ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Fiber reinforced; Poly(2 hydroxyethyl methacrylate); Tensile strength; Water evaporation rate; Water transmission rate; Yielding

Indexed keywords

ELASTIC MODULI; EVAPORATION; FIBER REINFORCED PLASTICS; INITIATORS (CHEMICAL); KNIT FABRICS; POLYACRYLATES; POLYMERIC MEMBRANES; POLYMERIZATION; SKIN; SWELLING; TENSILE STRENGTH; YIELD STRESS;

POLYHYDROXYETHYL METHACRYLATE; WATER TRANSMISSION RATE;

ARTIFICIAL ORGANS;

MONOMER; POLYMACON; WATER;

ARTICLE; ARTIFICIAL SKIN; EVAPORATION; MEMBRANE; POLYMERIZATION; PRIORITY JOURNAL; STRENGTH; TENSILE STRENGTH; ULTRAVIOLET RADIATION; YOUNG MODULUS;

BIOCOMPATIBLE MATERIALS; BIOMECHANICS; HYDROGELS; MEMBRANES, ARTIFICIAL; POLYHYDROXYETHYL METHACRYLATE; SKIN, ARTIFICIAL;

EID: 0032190708     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(98)00083-0     Document Type: Article

References (26)

1. [1] Nikolaos AP. Hydrogels in medicine and pharmacy. Boca Raton, FL: CRC Press, 1986.
2. [2] Young CD, Wu JN, Tsou TL. Fabrication and characteristics of strength-proved polyHEMA artificial skin. J Membr Sci, 1998; in press.
3. [3] Lou JH, Fleisher F, Amidon GL. Release of phenylpropanolamine from dynamically swelling poly-(hydroxyethyl methacrylate-co-methacrylic acid) hydrogels. In: Gebelein CG, Cheng TC, Yang VC, editors. Cosmetic and pharmaceutical applications of polymers. New York: Plenum, 1990:201-8.
4. [4] Rao JK, Ramesh DV, Rao KP. Implantable controlled delivery systems for proteins based on collagen-pHEMA hydrogels. Biomaterials 1994;15:383-9.
5. [5] Davis PA, Huang SJ, Nicolais L, Ambrosio L. Modified pHEMA hydrogels. In: Szycher M, editor. High performance biomaterials. Lancaster: Technomic, 1991:343-67.
6. [6] Friends GD, Künzler JF, Ozark RM. High-strength hydrogels based on N-vinyl pyrrolidinone and 4-t-butyl-2-hydroxycyclo-hexylmethacrylate. J Biomed Mater Res 1992;26:59-67.
7. [7] Chirila TV, Yu DY, Chen YC, Grawford GJ. Enhancement of mechanical strength of poly(2-hydroxyethyl methacrylate) sponges. J Biomed Mater Res 1995;29:1029-32.
8. [8] Kickhöfen B, Wokalek H, Scheel D and Ruh H. Chemical and physical properties of a hydrogel wound dressing. Biomaterials 1986;7:67-71.
9. [9] Davis TP, Huglin MB. Some mechanical properties of poly(2-hydroxyethyl methacrylate) gels swollen in water/1,4-dioxane mixture. Makromol Chem Rapid Commun 1988;9:39-43.
10. [10] Carfagna C, Migliaresi C, Nicolais L, Sacerdoti A. Physical characterization of poly(2-hydroxyethylmethacrylate) gels: effect of the diluent content on the mechanical and transport properties. In: Chiellini E, Giusti P, editors. Polymers in medicine. New York: Plenum, 1983:311-20.
11. [11] Rego JM, Huglin MB. Influence of composition on properties of hydrogels of 2-hydroxyethyl methacrylate with a sulphobetaine comonomer. Polym J 1991;23:1425-34.
12. [12] Janáček J. Mechanical behavior of hydroxyalkyl methacrylate polymers and copolymers. J Macromol Sci 1973;C9:1-47.
13. [13] Chirila TV, Vijayasekaran S, Horne R, Chen YC, Delton PD, Constable IJ, Crawford GJ. Interpenetration polymer network (IPN) as a permanent joint between the elements of a new type of artificial cornea. J Biomed Mater Res 1994;28:745-53.
14. [14] Santin M, Huang SJ, Iannace S, Ambrosio L, Nicolais L, Peluso G. Synthesis and characterization of a new interpenetrated poly(2-hydroxyethylmethacrylate)-gelation composite polymer. Biomaterials 1996;17:1459-67.
15. 2. Intern J Polymeric Mater 1972;1:187-201.
16. [16] Acierno D, Nicolais L, Vojta V, Janàček J. Viscoelastic behavior of glass-bead filled crosslinked polymers in the dry and swollen states. J Polym Sci: Polym Phy Ed 1975;13:703-14.
17. [17] Nicolais L, Mashelkar RA. The strength of polymeric composites containing spherical fillers. J Appl Polym Sci 1976;20:561-3.
18. [18] Nicolais L, Acierno D, Janáček J. Ultimate behavior of dry and water-swollen polymer network/glass bead composites. Polym Eng Sci 1975;15:35-9.
19. [19] Husain MT, Akhtar M, Akhtar N. Report on evaluation of hydron film as burn wound dressing. Burns 1983;9; 330-4.
20. [20] Nathan P, Robb EC, Law EJ, MacMillan BG. A clinical study of antimicrobial agents delivered to burn wounds from a drug-loaded synthetic dressing. J Trauma 1982;22:1015-18.
21. [21] Migliaresi C, Carfagna C, Nicolais L. Laminates of poly(2-hydroxyethyl methacrylate) and polybutadiene as potential burn covering. Biomaterials 1980;1:205-8.
22. [22] Warren RJ, Snelling CF. Clinical evaluation of the Hydron burn dressing. Plast Reconstruc Surg 1980; 66:361-8.
23. [23] Eckstein EC, Pinchuk L, Van De Mark MR. A responsive hydrogel as a means of preventing calcification in urological protheses. In: Hoffman AS, Ratner BD, Horbett TA, editors. Polymers as biomaterials. New York: Plenum, 1984:323-32.
24. [24] Smetana Jr K, Šulc J, Krčová Z, Pitrová Š. Intraocular biocompatibility of hydroxyethyl methacrylate and methacrylic acid copolymer/partially hydrolyzed poly(2-hydroxyethyl methacrylate). J Biomed Mater Res 1987;21:1247-53.
25. [25] Chirila TV. Melanized poly(HEMA) hydrogels: basic research and potential use. J Biomater Appl 1993;8:107-45.
26. [26] American Society for Testing and materials (ASTM), Method D-638-91: Standard test method for tensile properties of plastics, In: 1992 Annual Book of ASTM Standards, vol. 08.01. Philadelphia, PA, USA: American Society for Testing and Materials, 1992;52-64.