Gating on the outside

Journal of General Physiology

Volumn 133, Issue 6, 2009, Pages 549-553

  Harris, Andrew L ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; GAP JUNCTION PROTEIN;

BINDING SITE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DISULFIDE BOND; MOLECULAR DOCKING; NOTE; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; CONNEXINS; GAP JUNCTIONS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA;

EID: 66749150483     PISSN: 00221295     EISSN: 15407748     Source Type: Journal    
DOI: 10.1085/jgp.200910256     Document Type: Note

References (31)

1. Beahm, D.L., A. Oshima, G.M. Gaietta, G.M. Hand, A.E. Smock, S.N. Zucker, M.M. Toloue, A. Chandrasekhar, B.J. Nicholson, and G.E. Sosinsky. 2006. Mutation of a conserved threonine in the third transmembrane helix of alpha- and beta-connexins creates a dominant-negative closed gap junction channel. J. Biol. Chem. 281:7994-8009. (Pubitemid 43847417)
2. Bukauskas, F.F., Q. Shao, A. Bukauskiene, M.V.L. Bennett, D.W. Laird, and V.K. Verselis. 2001. Gating properties of gap junction channels assembled from connexin43 and connexin43 fused with green fluorescent protein. Biophys. J. 81:137-152. (Pubitemid 32605958)
3. Cruciani, V., and S.O. Mikalsen. 2006. The vertebrate connexin family. Cell. Mol. Life Sci. 63:1125-1140. (Pubitemid 43939000)
4. Ebihara, L., and E. Steiner. 1993. Properties of a nonjunctional current expressed from a rat connexin46 cDNA in Xenopus oocytes. J. Gen. Physiol. 102:59-74. (Pubitemid 23210593)
5. Ebihara, L., X. Liu, and J.D. Pal. 2003. Effect of external magnesium and calcium on human connexin46 hemichannels. Biophys. J. 84:277-286. (Pubitemid 36026396)
6. Fleishman, S.J., V.M. Unger, M. Yeager, and N. Ben-Tal. 2004. A C-alpha model for the transmembrane alpha helices of gap junction intercellular channels. Mol. Cell. 15:879-888. (Pubitemid 39277985)
7. Foote, C.I., L. Zhou, X. Zhu, and B.J. Nicholson. 1998. The pattern of disulfide linkages in the extracellular loop regions of connexin32 suggests a model for the docking interface of gap junctions. J. Cell Biol. 140:1187-1197. (Pubitemid 28128878)
8. Harris, A.L., D.C. Spray, and M.V.L. Bennett. 1981. Kinetic properties of a voltage-dependent junctional conductance. J. Gen. Physiol. 77:95-117. (Pubitemid 11179579)
9. Hülser, D.F., M.L. Rutz, R. Eckert, and O. Traub. 2001. Functional rescue of defective mutant connexons by pairing with wild-type connexons. Pflugers Arch. 441:521-528. (Pubitemid 32128148)
10. Kronengold, J., E.B. Trexler, F.F. Bukauskas, T.A. Bargiello, and V.K. Verselis. 2003. Single-channel SCAM identified pore-lining residues in the first extracellular loop and first transmembrane domains of Cx46 hemichannels. J. Gen. Physiol. 122:389-405. (Pubitemid 37254724)
11. Maeda, S., S. Nakagawa, M. Suga, E. Yamashita, A. Oshima, Y. Fujiyoshi, and T. Tsukihara. 2009. Structure of the connexin 26 gap junction channel at 3.5 A resolution. Nature. 458:597-602.
12. Oh, S., Y. Ri, M.V.L. Bennett, E.B. Trexler, V.K. Verselis, and T.A. Bargiello. 1997. Changes in permeability caused by connexin32 mutations underlie X-linked Charcot-Marie-Tooth disease. Neuron. 19:927-938. (Pubitemid 27471396)
13. Oh, S., C.K. Abrams, V.K. Verselis, and T.A. Bargiello. 2000. Stoichiometry of transjunctional voltage-gating polarity reversal by a negative charge substitution in the amino terminus of a connexin32 chimera. J. Gen. Physiol. 116:13-31. (Pubitemid 30458360)
14. Oh, S., S. Rivkin, Q. Tang, V.K. Verselis, and T.A. Bargiello. 2004. Determinants of gating polarity of a connexin 32 hemichannel. Biophys. J. 87:912-928. (Pubitemid 39095073)
15. Oh, S., V.K. Verselis, and T.A. Bargiello. 2008. Charges dispersed over the permeation pathway determine the charge selectivity and conductance of a Cx32 chimeric hemichannel. J. Physiol. 586:2445-2461.
16. Oshima, A., K. Tani, Y. Hiroaki, Y. Fujiyoshi, and G.E. Sosinsky. 2007. Three-dimensional structure of a human connexin26 gap junction channel reveals a plug in the vestibule. Proc. Natl. Acad. Sci. USA. 104:10034-10039. (Pubitemid 47175258)
17. Pantano, S., F. Zonta, and F. Mammano. 2008. A fully atomistic model of the Cx32 connexon. PLoS One. 3:e2614.
18. Pfahnl, A., and G. Dahl. 1999. Gating of Cx46 gap junction hemichannels by calcium and voltage. Pflugers Arch. 437:345-353. (Pubitemid 29071932)
19. Puljung, M.C., V.M. Berthoud, E.C. Beyer, and D.A. Hanck. 2004. Polyvalent cations constitute the voltage gating particle in human connexin37 hemichannels. J. Gen. Physiol. 124:587-603. (Pubitemid 39506292)
20. Purnick, P.E.M., D.C. Benjamin, V.K. Verselis, T.A. Bargiello, and T.L. Dowd. 2000a. Structure of the amino terminus of a gap junction protein. Arch. Biochem. Biophys. 381:181-190. (Pubitemid 32260304)
21. Purnick, P.E.M., S.H. Oh, C.K. Abrams, V.K. Verselis, and T.A. Bargiello. 2000b. Reversal of the gating polarity of gap junctions by negative charge substitutions in the N-terminus of connexin 32. Biophys. J. 79:2403-2415.
22. Skerrett, I.M., J. Aronowitz, J.H. Shin, G. Cymes, E. Kasperek, F.L. Cao, and B.J. Nicholson. 2002. Identification of amino acid residues lining the pore of a gap junction channel. J. Cell Biol. 159:349-359. (Pubitemid 35283403)
23. Spray, D.C., A.L. Harris, and M.V.L. Bennett. 1981. Equilibrium properties of a voltage-dependent junctional conductance. J. Gen. Physiol. 77:77-93. (Pubitemid 11179578)
24. Srinivas, M., J. Kronengold, F.F. Bukauskas, T.A. Bargiello, and V.K. Verselis. 2005. Correlative studies of gating in Cx46 and Cx50 hemichannels and gap junction channels. Biophys. J. 88:1725-1739. (Pubitemid 40976189)
25. Tang, Q., T.L. Dowd, V.K. Verselis, and T.A. Bargiello. 2009. Conformational changes in a pore-forming region underlie voltage- dependent "loop gating" of an unapposed connexin hemichannel. J. Gen. Physiol. 133:555-570.
26. Trexler, E.B., M.V.L. Bennett, T.A. Bargiello, and V.K. Verselis. 1996. Voltage gating and permeation in a gap junction hemichannel. Proc. Natl. Acad. Sci. USA. 93:5836-5841. (Pubitemid 26190764)
27. Trexler, E.B., F.F. Bukauskas, J. Kronengold, T.A. Bargiello, and V.K. Verselis. 2000. The first extracellular loop domain is a major determinant of charge selectivity in connexin46 channels. Biophys. J. 79:3036-3051.
28. Verselis, V.K., and M. Srinivas. 2008. Divalent cations regulate connexin hemichannels by modulating intrinsic voltage-dependent gating. J. Gen. Physiol. 132:315-327.
29. Verselis, V.K., C.S. Ginter, and T.A. Bargiello. 1994. Opposite voltage gating polarities of two closely related connexins. Nature. 368:348-351. (Pubitemid 24104271)
30. Verselis, V.K., M.P. Trelles, C. Rubinos, T.A. Bargiello, and M. Srinivas. 2009. Loop gating of connexin hemichannels involves movement of pore-lining residues in the first extracellular loop domain. J. Biol. Chem. 284:4484-4493.
31. Zhou, X.W., A. Pfahnl, R. Werner, A. Hudder, A. Llanes, A. Luebke, and G. Dahl. 1997. Identification of a pore lining segment in gap junction hemichannels. Biophys. J. 72:1946-1953. (Pubitemid 27184424)