Naringin suppresses osteoclast formation and enhances bone mass in mice

Journal of Health Science

Volumn 55, Issue 3, 2009, Pages 463-467

  Hirata, Michiko ^a   Matsumoto, Chiho ^a   Takita, Morichika ^a   Miyaura, Chisato ^a   Inada, Masaki ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

Bone mass; Citrus flavonoid; Naringin; Osteoclast

Indexed keywords

AURANTIIN; INTERLEUKIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MARROW CELL; BONE MASS; BONE TURNOVER; CANCELLOUS BONE; CELL DIFFERENTIATION; CELL SIZE; COCULTURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; IN VITRO STUDY; IN VIVO STUDY; METAPHYSIS; MOUSE; NEWBORN; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS;

CITRUS; MUS;

EID: 66749136863     PISSN: 13449702     EISSN: 13475207     Source Type: Journal    
DOI: 10.1248/jhs.55.463     Document Type: Article

References (16)

1. Wong, B. R., Rho, J., Arron, J., Robinson, E., Orlinick, J., Chao, M., Kalachikov, S., Cayani, E., Bartlett, F. S., III, Frankel, W. N., Lee, S. Y. and Choi, Y. (1997) TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J. Biol. Chem., 272, 25190-25194. (Pubitemid 27415705)
2. Lacey, D. L., Timms, E., Tan, H. L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., Hsu, H., Sullivan, J., Hawkins, N., Davy, E., Capparelli, C., Eli, A., Qian, Y. X., Kaufman, S., Sarosi, I., Shalhoub, V., Senaldi, G., Guo, J., Delaney, J. and Boyle, W. J. (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell, 93, 165-176. (Pubitemid 28180851)
3. Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., Tsuda, E., Morinaga, T., Higashio, K., Udagawa, N., Takahashi, N. and Suda, T. (1998) Osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc. Natl. Acad. Sci. U.S.A., 95, 3597-3602. (Pubitemid 28173173)
4. Chen, D., Zhao, M. and Mundy, G. R. (2004) Bone morphogenetic proteins. Growth Factors, 22, 233-241. (Pubitemid 40136452)
5. Swiader, K. E. and Zarawska, E. (1996) Flavonoids of rare Artemesia species and their antifungal properties. Fitoterapia, 67, 77-78. (Pubitemid 26104673)
6. Sifton, D. W. (2000) Zocor. N. Physicians' Desk Reference (Sifton, D. W., Ed.), Medical Economics Company, Montvale, NJ, U.S.A., pp. 1917-1920.
7. Chen, Y. M., Ho, S. C. and Woo, J. L. (2006) Greater fruit and vegetable intake is associated with increased bone mass among postmenopausal Chinese women. Br. J. Nutr., 96, 745-751. (Pubitemid 46470199)
8. Wu, J. B., Fong, Y. C., Tsai, H. Y., Chen, Y. F., Tsuzuki, M. and Tang, C. H. (2008) Naringin-induced bone morphogenetic protein-2 expression via PI3K, Akt, c-Fos/c-Jun and AP-1 pathway in osteoblasts. Eur. J. Pharmacol., 588, 333-341.
9. Wong, R. W. and Rabie, A. B. (2006) Effect of naringin on bone cells. J. Orthop. Res., 24, 2045-2050. (Pubitemid 44717966)
10. Mundy, G., Garrett, R. and Harris, S. (1999) Stimulation of bone formation in vitro and in rodents by statins. Science, 286, 1946-1949. (Pubitemid 129515901)
11. Mandadi, K., Ramirez, M., Jayaprakasha, G. K., Faraji, B., Lihono, M., Deyhim, F. and Patil, B. S. (2008) Citrus bioactive compounds improve bone quality and plasma antioxidant activity in orchidectomized rats. Phytomedicine, in press [Epub ahead of print].
12. Miyaura, C., Inada,M., Matsumoto, C., Ohshiba, T., Uozumi, N., Shimizu, T. and Ito, A. (2003) An essential role of cytosolic phospholipase A2α in prostaglandin E2-mediated bone resorption associated with Inflammation. J. Exp. Med., 197, 1303-1310. (Pubitemid 36617777)
13. Nakashima, T. and Takayanagi, H. (2008) The dynamic interplay between osteoclasts and the immune system. Arch. Biochem. Biophys., 473, 166-171.
14. Deyhim, F., Garica, K., Lopez, E., Gonzalez, J., Ino, S., Garcia, M. and Patil, B. S. (2006) Citrus juice modulates bone strength in male senescent rat model of osteoporosis. Nutrition, 22, 559-563.
15. Chiba, H., Uehara, M., Wu, J., Wang, X., Masuyama, R., Suzuki, K., Kanazawa, K. and Ishimi, Y. (2003) Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice. J. Nutr., 133, 1892-1897. (Pubitemid 36666531)
16. Sugiura, M., Nakamura, M., Ogawa, K., Ikoma, Y., Ando, F. and Yano, M. (2008) Bone mineral density in post-menopausal female subjects is associated with serum antioxidant carotenoids. Osteoporos. Int., 19, 211-219.