Modulation of the antifungal activity of new medicinal plant extracts active on candida glabrata by the major transporters and regulators of the pleiotropic drug-resistance network in saccharomyces cerevisiae

Microbial Drug Resistance

Volumn 15, Issue 1, 2009, Pages 11-17

  Kolaczkowski, Marcin ^a   Kolaczkowska, Anna ^b   Stermitz, Frank R ^c  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

^b WROCLAW UNIVERSITY OF ENVIRONMENTAL AND LIFE SCIENCES   (Poland)

^c Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ARTEMISIA ANNUA EXTRACT; ARTEMISININ; DALEA FORMOSA EXTRACT; HYDRASTIS CANADENSIS EXTRACT; KETOCONAZOLE; MAHONIA FORTUNEI EXTRACT; PINUS EDULIS EXTRACT; PLANT EXTRACT; PROTEIN PDR1P; PROTEIN PDR3P; PROTEIN PDR5P; PROTEIN SNQ2P; PROTEIN YOR1P; UNCLASSIFIED DRUG; ZANTHOXYLUM ZANTHOXYULOIDES EXTRACT;

ANTIFUNGAL ACTIVITY; ARTEMISIA ANNUA; ARTICLE; CANDIDA GLABRATA; DALEA FORMOSA; HERB; HYDRASTIS; MAHONIA; MEDICINAL PLANT; NONHUMAN; PINE; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; ZANTHOXYLUM;

ANTIFUNGAL AGENTS; ARTEMISININS; ATP-BINDING CASSETTE TRANSPORTERS; AZOLES; CANDIDA GLABRATA; CARRIER PROTEINS; DRUG RESISTANCE, FUNGAL; GENOTYPE; INDICATORS AND REAGENTS; KETOCONAZOLE; MICROBIAL SENSITIVITY TESTS; P-GLYCOPROTEINS; PLANT EXTRACTS; PLANTS, MEDICINAL; SACCHAROMYCES CEREVISIAE;

ARTEMISIA ANNUA; CANDIDA ALBICANS; CANDIDA GLABRATA; DALEA FORMOSA; SACCHAROMYCES CEREVISIAE;

EID: 66749127894     PISSN: 10766294     EISSN: None     Source Type: Journal    
DOI: 10.1089/mdr.2009.0854     Document Type: Article

References (39)

1. Belofsky, G., R. Carreno, K. Lewis, A. Ball, G. Casadei, and G.P. Tegos. 2006. Metabolites of the "Smoke Tree" Dalea spinosa, potentiate antibiotic activity against multidrug-resistant Staphylococcus aureus. J. Nat. Prod. 69:261-264.
2. Belofsky, G., D. Percivill, K. Lewis, G.P. Tegos, and J. Ekart. 2004. Phenolic metabolites of Dalea versicolor that enhance activity against model pathogenic bacteria. J. Nat. Prod. 67:481-484.
3. Birdsall, T.C., and G.S. Kelly. 1997. Berberine: therapeutic potential of an alkaloid found in several medicinal plants. Alt. Med. Rev. 2:94-103.
4. Carter, J.L. 1997. Trees and Shrubs of New Mexico. Johnson Books, Boulder, CO.
5. Chukwuka, K.S., and F.T. Agulanna. 2005. Laboratory assay of the active ingredients in Zanthoxylum zanthoxyloides (Lam) Zepern and Timler and its remedy in dental problems. Int. J. Biomed. Health. Sci. 1:37-40.
6. Cuenca-Estrella, M., W. Lee-Yang, M.A. Ciblak, B.A. Arthington-Skaggs, E. Mellado, D.W. Warnock, and J.L. Rodriguez-Tudela. 2002. Comparative evaluation of NCCLS M27-A and EUCAST broth microdilution procedures for antifungal susceptibility testing of Candida species. Anti-microb. Agents Chemother. 46:3644-3647.
7. Delaveau, T., A. Delahodde, E. Carvajal, J. Subik, and C. Jacq. 1994. PDR3, a new yeast regulatory gene, is homologous to PDR1 and controls the multidrug resistance phenomenon. Mol. Gen. Genet. 244:501-511.
8. DeRisi J., H.B. van den Hazel, P. Marc, E. Balzi, P. Brown, C. Jacq, and A. Goffeau. 2000. Genome microarray analysis of transcriptional activation in multidrug resistance yeast mutants. FEBS Lett. 470:156-160.
9. Ellis, M.2 2002. Invasive fungal infections: evolving challenges for diagnosis and therapeutics. Mol. Immunol. 38:947-957.
10. Fidel, P.L., Jr., J.A. Vazquez, and J.D. Sobel. 1999. Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans. Clin. Microbiol. Rev. 12:80-96.
11. Hallstrom, T.C., L. Lambert, S. Schorling, E. Balzi, A. Goffeau, and W.S. Moye-Rowley. 2001. Coordinate control of sphingolipid biosynthesis and multidrug resistance in Saccharomyces cerevisiae. J. Biol. Chem. 276:23674-23680.
12. Ji, X., Y. Li, H. Liu, Y. Yan, and J. Li. 2000. Determination of the alkaloid content in different parts of some Mahonia plants by HPCE. Pharm. Acta Helv. 74:387-391.
13. Kolaczkowska, A., M. Kolaczkowski, A. Delahodde, and A. Goffeau. 2002. Functional dissection of Pdr1p, a regulator of multidrug resistance in Saccharomyces cerevisiae. Mol. Genet. Genomics 267:96-106.
14. Kolaczkowska, A., M. Kolaczkowski, A. Goffeau, and W.S. Moye-Rowley. 2008. Compensatory activation of the multidrug transporters Pdr5p, Snq2p, and Yor1p by Pdr1p in Saccharomyces cerevisiae. FEBS Lett. 582:977-983.
15. Kolaczkowski, M., A. Cybularz-Kolaczkowska, J. Luc-zyń ski, S. Witek, and A. Goffeau. 1998. In vivo characterization of the drug resistance profile of the major ABC transporters and other components of the yeast pleiotropic drug resistance network. Microb. Drug Resist. 4:143-158.
16. Kolaczkowski, M., A. Kolaczkowska, B. Gaigg, R. Schneiter, and W.S. Moye-Rowley. 2004. Differential regulation of ceramide synthase components LAC1 and LAG1 in Saccharomyces cerevisiae. Eukaryot. Cell 3:880-892.
17. Kolaczkowski, M., K. Michalak, and N.R. Motohashi. 2003. Phenothiazines as potent modulators of yeast multi-drug resistance. Int. J. Antimicrob. Agents 22:279-283.
18. Liu, K.C.-S., S.-L. Yang, M.F. Roberts, B.C. Elford, and J.D. Phillipson. 1992. Antimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures. Plant Cell Rep. 11:637-640.
19. Miyazaki, H., Y. Miyazaki, A. Geber, T. Parkinson, C. Hitchcock, D.J. Falconer, D.J. Ward, K. Marsden, and J.E. Bennett. 1998. Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, PDH1, in Candida glabrata. Antimicrob. Agents Che-mother. 42:1695-1701.
20. Mueller, M.S., I.B. Karhagomba, H.M. Hirt, and E. We-makor. 2000. The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects. J. Ethnopharmacol. 73:487-493.
21. Nakamoto, K., S. Sadamori, and T. Hamada. 1990. Effects of crude drugs and berberine hydrochloride on the activities of fungi. J. Prosthet. Dent. 64:691-694.
22. National Committee for Clinical Laboratory Standards. 2000. Approved standard: M7-A5. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aer-obically, fifth edition. NCCLS, Wayne, PA.
23. Ngono Ngane, A., L. Biyiti, P.H. Amvam Zollo, and P. Bouchet. 2000. Evaluation of antifungal activity of extracts of two Cameroonian Rutaceae: Zanthoxylum leprieurii Guill. et Perr. and Zanthoxylum xanthoxyloides Waterm. J. Ethno-pharmacol. 70:335-342.
24. Nourani, A., D. Papajova, A. Delahodde, C. Jacq, and J. Subik. 1997. Clustered amino acid substitutions in the yeast transcription regulator Pdr3p increase pleiotropic drug resistance and identify a new central regulatory domain. Mol. Gen. Genet. 256:397-405.
25. Phillipson, J.D., C.W. Wright, G.C. Kirby, and D.C. War-hurst. 1995. Phytochemistry of some plants used in tradi- tional medicine for the treatment of protozoal disease. In K. Hostettman, A. Marston, M. Maillard, and M. Hamburger (eds.), Phytochemistry of plants used in traditional medicine. Clarendon Press, Oxford, pp. 95-135.
26. Ruhnke, M. 2006. Epidemiology of Candida albicans infections and role of non-Candida-albicans yeasts. Curr. Drug Targets 7:495-504.
27. Sanglard, D., F. Ischer, D. Calabrese, M. de Michell, and J. Bille. 1998. Multiple resistance mechanisms to azole antifun-gals in yeast clinical isolates. Drug Resist. Updates 1:255-265.
28. Sanglard, D., F. Ischer, D. Calabrese, P.A. Majcherczyk, and J. Bille. 1999. The ATP binding cassette transporter gene CgCDR1 from Candida glabrata is involved in the resistance of clinical isolates to azole antifungal agents. Antimicrob. Agents Chemother. 43:2753-2765.
29. Sanglard, D., F. Ischer, M. Monod, and J. Bille. 1997. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 143:405-416.
30. Sanguinetti, M., B. Posteraro, B. Fiori, S. Ranno, R. Torelli, and G. Fadda. 2005. Mechanisms of azole resistance in clinical isolates of Candida glabrata collected during a hospital survey of antifungal resistance. Antimicrob. Agents Chemother. 49:668-679.
31. Seneviratne, C.J., R.W.K. Wong, and L.P. Samaranayake. 2007. Potent anti-microbial activity of traditional Chinese medicine herbs against Candida species. Mycoses 51:30-34.
32. Spelman, K., J.A. Duke, and M.J. Bogenschutz-Godwin. 2006. The synergy principle at work with plants, pathogens, insects, herbivores and humans. In L.J. Cseke, A. Kir-akosyan, P.B. Kaufman, S.L. Warber, J.A. Duke, and H.L. Brielmann (eds.), Natural Products from Plants. Taylor & Francis, Boca Raton, pp. 475-502.
33. Stermitz, F.R., T.D. Beeson, P.J. Mueller, J.F. Hsiang, and K. Lewis. 2001. Staphylococcus aureus MDR efflux pump inhibitors from a Berberis and a Mahonia (sensu strictu) species. Biochem. Syst. Ecol. 29:793-798.
34. Stermitz, F.R., P. Lorenz, J.N. Tawara, L.A. Zenewicz, and K. Lewis. 2000. Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5′-methoxyhydnocarpin, a multidrug pump inhibitor. Proc. Natl. Acad. Sci. USA 97: 1433-1437.
35. Stermitz, F.R., L.N. Scriven, G. Tegos, and K. Lewis. 2002. Two flavonols from Artemisia annua which potentiate the activity of berberine and norfloxacin against a resistant strain of Staphylococcus aureus. Planta Med. 68:1140-1141.
36. Stermitz, F.R., J.N. Tawara, M. Boeckl, M. Pomeroy, T.A. Foderaro, and F.G. Todd. 1994. Piperidine alkaloid content of Picea (spruce) and Pinus (pine). Phytochemistry 35:451-453.
37. Torelli, R., B. Posteraro, S. Ferrari, M. La Sorda, G. Fadda, D. Sanglard, and M. Sanguinetti. 2008. The ATP-binding cassette transporter-encoding gene CgSNQ2 is contributing to the CgPDR1-dependent azole resistance of Candida glab-rata. Mol. Microbiol. 68:186-201.
38. Wenzel, R.P. 1995. Nosocomial candidemia: risk factors and attributable mortality. Clin. Infect. Dis. 20:1531-1534.
39. White, T.C., S. Holleman, F. Dy, L.F. Mirels, and D.A. Stevens. 2002. Resistance mechanisms in clinical isolates of Candida albicans. Antimicrob. Agents Chemother. 46:1704- 1713.