The reduction of large von Willebrand factor multimers in plasma in essential thrombocythaemia is related to the platelet count

British Journal of Haematology

Volumn 93, Issue 4, 1996, Pages 962-965

  Van Genderen, Perry J J ^a   Budde, Ulrich ^b   Michiels, Jan J ^a   Van Strik, Roel ^c   Van Vliet, Huub H D M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Asklepios Klinik Harburg   (Germany)

^c ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

aspirin; bleeding; myeloproliferative disorders; platelets; von Willebrand factor

Indexed keywords

ACETYLSALICYLIC ACID; HYDROXYUREA; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR; VON WILLEBRAND FACTOR MULTIMER;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; THROMBOCYTE COUNT; THROMBOCYTHEMIA; THROMBOCYTOSIS;

EID: 0029951483     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1996.d01-1729.x     Document Type: Article

References (13)

1. Barbui, T., Buelli, M., Cortelazzo, S., Viero, P. & De Gaetano, G. (1987) Aspirin and the risk of bleeding in patients with thrombocythemia. American Journal of Medicine, 83, 265-268.
2. Bellucci, S., Janvier, M., Tobelem, G., Flandrin, G., Charpak, Y., Berger, R. & Boiron, M. (1986) Essential thrombocythemias: clinical, evolutionary and biological data. Cancer, 58, 2440-2447.
3. Budde, U., Schafer, G., Muller, N., Eyk, H., Dent, J., Ruggeri, Z. & Zimmerman, T. (1984) Acquired von Willebrand's disease in the myeloproliferative syndrome. Blood, 64, 981-985.
4. Budde, U., Scharf, R.E., Franke, P., Hartmann-Budde, K., Dent, J. & Ruggeri, Z.M. (1993) Elevated platelet count as a cause of abnormal von Willebrand factor multimer distribution. Blood, 82, 1749-1757.
5. Casonato, A., Fabris, F., Boscaro, M. & Girolami, A. (1987) Increased factor VIII/VWF levels in patients with reduced platelet number. Blut, 54, 281-288.
6. Fabris, F., Casonato, A., Del Ben, M.G., De Marco, L. & Girolami, A. (1986) Abnormalities of von Willebrand factor in myeloproliferative disease: a relationship with bleeding diathesis. British Journal of Haematology, 63, 75-83.
7. Fenaux, P., Simon, M., Caulier, M.T., Lai, J.L., Goudemand, J. & Bauters, F. (1990) Clinical course of essential thrombocythemia in 147 cases. Cancer, 66, 549-556.
8. Schafer, A.I. (1991) Essential thrombocythemia. Progress in Thrombosis and Hemostasis, 10, 69-96.
9. Tartaglia, A.P., Goldberg, J.D., Berk, P.D. & Wasserman, L.R. (1986) Adverse effects of antiaggregating platelet therapy in the treatment of polycythemia vera. Seminars in Hematology, 23, 172-176.
10. van Genderen, P.J.J. & Michiels, J.J. (1993) Primary thrombocythemia: diagnosis, clinical manifestations and management. Annals of Hematology, 67, 57-62.
11. van Genderen, P.J.J. & Michiels, J.J. (1994a) Erythromelalgic, thrombotic and haemorrhagic manifestations of thrombocythaemia. Presse Médicale, 23, 73-77.
12. van Genderen, P.J.J., Michiels, J.J., van der Poel-van de Luytgaarde, S.C.P.A.M. & van Vliet, H.H.D.M. (1994b) Acquired von Willebrand disease as a cause of recurrent mucocutaneons bleeding in primary thrombocythemia: relationship with platelet count. Annals of Hematology, 69, 81-84.
13. van Genderen, P.J.J., Vink, T., Michiels, J.J., van 't Veer, M.B., Sixma, J.J. & van Vliet, H.H.D.M. (1994c) Acquired von Willebrand disease caused by an autoantibody selectively inhibiting the binding of von Willebrand factor to collagen. Blood, 84, 3378-3384.