메뉴 건너뛰기




Volumn 15, Issue 5, 2009, Pages

Peroxisome proliferator-activated receptor - Gamma and retinoid X receptor-alpha expression in pancreatic ductal adenocarcinoma: Association with clinicopathological parameters, tumor proliferative capacity, and patients' survival

Author keywords

Clinicopathological parameters; Immunohistochemistry; Pancreatic adenocarcinoma; Patients' survival; PPAR gamma; RXR alpha

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOID X RECEPTOR ALPHA;

EID: 66649131659     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (25)

References (47)
  • 3
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Nuclear control of metabolism
    • Desvergne B, Wahli W: Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev, 1999; 20: 649-688 (Pubitemid 30650602)
    • (1999) Endocrine Reviews , vol.20 , Issue.5 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 4
    • 32644460092 scopus 로고    scopus 로고
    • From molecular action to physiological outputs: Peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions
    • DOI 10.1016/j.plipres.2005.12.002, PII S0163782705000603
    • Feige JN, Gelman L, Michalik L et al: From: molecular action to physiological outputs: Peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. Prog Lipid Res, 2006; 45: 120-159 (Pubitemid 43248732)
    • (2006) Progress in Lipid Research , vol.45 , Issue.2 , pp. 120-159
    • Feige, J.N.1    Gelman, L.2    Michalik, L.3    Desvergne, B.4    Wahli, W.5
  • 5
    • 20444497357 scopus 로고    scopus 로고
    • Receptor-independent actions of PPAR thiazolidinedione agonists: Is a mitochondrial function the key?
    • Feinstein DL, Spangolo A, Akar C et al: Receptor-independent actions of PPAR thiazolidinedione agonists: Is a mitochondrial function the key? Biochem Pharmacol, 2005; 70: 177-188
    • (2005) Biochem Pharmacol , vol.70 , pp. 177-188
    • Feinstein, D.L.1    Spangolo, A.2    Akar, C.3
  • 6
    • 33751533155 scopus 로고    scopus 로고
    • LXIII Retinoid X Receptors
    • International Union of Pharmacology
    • Germain P, Chambon P, Eichele G et al: International Union of Pharmacology. LXIII Retinoid X Receptors. Pharmacol Rev, 2006; 58: 760-772
    • (2006) Pharmacol Rev , vol.58 , pp. 760-772
    • Germain, P.1    Chambon, P.2    Eichele, G.3
  • 8
    • 0030047806 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-α, -β and -γ in the adult rat
    • Braissant O, Foufelle F, Scotto C et al: Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-α, -β and -γ in the adult rat. Endocrinology, 1996; 137: 354-366
    • (1996) Endocrinology , vol.137 , pp. 354-366
    • Braissant, O.1    Foufelle, F.2    Scotto, C.3
  • 10
    • 0041668076 scopus 로고    scopus 로고
    • Rapid increase in the use of oral Antidiabetic drugs in the United States, 1990-2001
    • Wysowski DK, Armstrong G, Governale L: Rapid increase in the use of oral Antidiabetic drugs in the United States, 1990-2001. Diabetes Care, 2003; 26: 1852-1855
    • (2003) Diabetes Care , vol.26 , pp. 1852-1855
    • Wysowski, D.K.1    Armstrong, G.2    Governale, L.3
  • 11
    • 4344568552 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma ligands as cell-cycle modulators
    • DOI 10.1016/j.ctrv.2004.04.004, PII S0305737204000799
    • Theocharis S, Margeli A, Vielh P, Kouraklis G: Peroxisome proliferator- activated receptor-gamma ligands as cell-cycle modulators. Cancer Treat Rev, 2004; 30: 545-554 (Pubitemid 39157854)
    • (2004) Cancer Treatment Reviews , vol.30 , Issue.6 , pp. 545-554
    • Theocharis, S.1    Margeli, A.2    Vielh, P.3    Kouraklis, G.4
  • 12
    • 35248833161 scopus 로고    scopus 로고
    • Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) ligands as investigational modulators of angiogenesis
    • Giaginis C, Margeli A, Theocharis S: Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) ligands as investigational modulators of angiogenesis. Expert Opin Investig Drug, 2007; 16: 1561-1572
    • (2007) Expert Opin Investig Drug , vol.16 , pp. 1561-1572
    • Giaginis, C.1    Margeli, A.2    Theocharis, S.3
  • 13
    • 44049084020 scopus 로고    scopus 로고
    • Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) ligands: Potential pharmacological agents for targeting the angiogenesis signaling cascade in cancer
    • Giaginis C, Tsantili-Kakoulidou A, Theocharis S: Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) ligands: potential pharmacological agents for targeting the angiogenesis signaling cascade in cancer. PPAR Res, 2008; 2008: 431763
    • (2008) PPAR Res , vol.2008 , pp. 431763
    • Giaginis, C.1    Tsantili-Kakoulidou, A.2    Theocharis, S.3
  • 15
    • 0032985541 scopus 로고    scopus 로고
    • Pancreatic cancer: A report of treatment and survival trends for 100,313 patients diagnosed from 1985-1995, using National Cancer Database
    • Sener DB, Jessup JM, Colacchio T: Pancreatic cancer: a report of treatment and survival trends for 100,313 patients diagnosed from 1985-1995, using National Cancer Database. J Am Coll Surg, 1999; 189: 1-7
    • (1999) J Am Coll Surg , vol.189 , pp. 1-7
    • Sener, D.B.1    Jessup, J.M.2    Colacchio, T.3
  • 16
    • 35348864295 scopus 로고    scopus 로고
    • Pancreatic cancer: Pathogenesis, prevention and treatment
    • DOI 10.1016/j.taap.2006.11.007, PII S0041008X06004212
    • Sarkar FH, Banerjee S, Li Y: Pancreatic cancer: pathogenesis, prevention and treatment. Toxicol Appl Pharmacol, 2007; 224: 326-336 (Pubitemid 47575667)
    • (2007) Toxicology and Applied Pharmacology , vol.224 , Issue.3 , pp. 326-336
    • Sarkar, F.H.1    Banerjee, S.2    Li, Y.3
  • 17
    • 0036135985 scopus 로고    scopus 로고
    • Growth inhibition and differentiation of pancreatic cancer cell lines by PPARgamma ligand troglitazone
    • DOI 10.1097/00006676-200201000-00001
    • Kawa S, Nikaido T, Unno H et al: Growth inhibition and differentiation of pancreatic cell lines by PPAR-gamma ligand troglitazone. Pancreas, 2002; 24: 1-7 (Pubitemid 34019653)
    • (2002) Pancreas , vol.24 , Issue.1 , pp. 1-7
    • Kawa, S.1    Nikaido, T.2    Unno, H.3    Usuda, N.4    Nakayama, K.5    Kiyosawa, K.6
  • 18
    • 33645717060 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-γ decreases pancreatic cancer cell invasion through modulation of the plasminogen activator system
    • Sawai H, Liu J, Reber HA et al: Activation of peroxisome proliferator-activated receptor-γ decreases pancreatic cancer cell invasion through modulation of the plasminogen activator system. Mol Cancer Res, 2006; 4: 159-167
    • (2006) Mol Cancer Res , vol.4 , pp. 159-167
    • Sawai, H.1    Liu, J.2    Reber, H.A.3
  • 20
    • 4344703257 scopus 로고    scopus 로고
    • Suppression of human pancreatic cancer cell proliferation by AGN194204, an RXR-selective retinoid
    • DOI 10.1093/carcin/bgh122
    • Balasubramanian S, Chandraratna RAS, Eckert R: Suppression of human pancreatic cancer cell proliferation by AGN194204, an RXR-selective retinoid. Carcinogenesis, 2004; 25: 1377-1385 (Pubitemid 39162704)
    • (2004) Carcinogenesis , vol.25 , Issue.8 , pp. 1377-1385
    • Balasubramanian, S.1    Chandraratna, R.A.S.2    Eckert, R.L.3
  • 21
    • 0028882623 scopus 로고
    • Retinoids: Effects on growth, differentiation, and nuclear receptor expression in human pancreatic carcinoma cell lines
    • Rosewicz S, Stier U, Brembeck F et al: Retinoids: effects on growth, differentiation, and nuclear receptor expression in human pancreatic carcinoma cell lines. Gastroenterology, 1995; 109: 1646-1660
    • (1995) Gastroenterology , vol.109 , pp. 1646-1660
    • Rosewicz, S.1    Stier, U.2    Brembeck, F.3
  • 23
    • 43049122454 scopus 로고    scopus 로고
    • Clinical significance of tumor-associated antigen RCAS1 expression in human pancreatic ductal adenocarcinoma
    • Giaginis C, Davides D, Zarros A et al: Clinical significance of tumor-associated antigen RCAS1 expression in human pancreatic ductal adenocarcinoma. Dig Dis Sci, 2008; 53(6): 1728-1734
    • (2008) Dig Dis Sci , vol.53 , Issue.6 , pp. 1728-1734
    • Giaginis, C.1    Davides, D.2    Zarros, A.3
  • 24
    • 34547843591 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator-activated receptor-gamma in colon cancer: Correlation with histopathological parameters, cell cycle-related molecules, and patients' survival
    • DOI 10.1007/s10620-007-9794-4
    • Theocharis S, Giaginis C, Parasi A et al: Expression of Peroxisome Proliferator-Activated Receptor-gamma in colon cancer: correlation with histopathological parameters, cell cycle related molecules and patients' survival. Dig Dis Sci, 2007; 52: 2305-2311 (Pubitemid 47246534)
    • (2007) Digestive Diseases and Sciences , vol.52 , Issue.9 , pp. 2305-2311
    • Theocharis, S.1    Giaginis, C.2    Parasi, A.3    Margeli, A.4    Kakisis, J.5    Agapitos, E.6    Kouraklis, G.7
  • 25
    • 0036247888 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator activated receptor-gamma in non-small cell lung carcinoma: Correlation with histological type and grade
    • DOI 10.1016/S0169-5002(02)00013-2, PII S0169500202000132
    • Theocharis S, Kanelli H, Politi E et al: Expression of peroxisome proliferator activated receptor-gamma in non-small cell lung carcinoma: correlation with histological type and grade. Lung Cancer, 2002; 36: 49-55 (Pubitemid 34497122)
    • (2002) Lung Cancer , vol.36 , Issue.3 , pp. 249-255
    • Theocharis, S.1    Kanelli, H.2    Politi, E.3    Margeli, A.4    Karkandaris, C.5    Philippides, T.6    Koutselinis, A.7
  • 26
    • 13644251609 scopus 로고    scopus 로고
    • COX and PPAR: Possible interactions in pancreatic cancer
    • DOI 10.1097/00006676-200411000-00002
    • Eible G, Reber HA, Hines OJ, Go VLW: COX and PPAR: Possible interactions in pancreatic cancer. Pancreas, 2004; 29: 247-253 (Pubitemid 40228269)
    • (2004) Pancreas , vol.29 , Issue.4 , pp. 247-253
    • Eibl, G.1    Reber, H.A.2    Hines, O.J.3    Go, V.L.W.4
  • 28
    • 0033999211 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptor-gamma (PPAR-gamma) mediates the action of gamma linolenic acid in breast cancer cells
    • DOI 10.1054/plef.1999.0131
    • Jiang WG, Redfern A, Bryce RP, Mansel RE: Peroxisome proliferator activated receptor-gamma (PPAR-gamma) mediates the action of gamma linolenic acid in breast cancer cells. Prostaglandins Leukot Essent Fatty Acids, 2000; 62: 119-127 (Pubitemid 30216391)
    • (2000) Prostaglandins Leukotrienes and Essential Fatty Acids , vol.62 , Issue.2 , pp. 119-127
    • Jiang, W.G.1    Redfern, A.2    Bryce, R.P.3    Mansel, R.E.4
  • 29
    • 0033780029 scopus 로고    scopus 로고
    • Modulation of retinoid signaling through NGF-induced nuclear export of NGFI-B
    • Katagiri Y, Takeda K, Yu ZX et al: Modulation of retinoid signaling through NGF-induced nuclear export of NGFI-B. Nat Cell Biol, 2000; 2: 435-440
    • (2000) Nat Cell Biol , vol.2 , pp. 435-440
    • Katagiri, Y.1    Takeda, K.2    Yu, Z.X.3
  • 31
    • 0034652462 scopus 로고    scopus 로고
    • Induction of differentiation and apoptosis by ligands of peroxisome proliferator-activated receptor gamma in non-small cell lung cancer
    • Chang TH, Szabo E: Induction of differentiation and apoptosis by ligands of peroxisome proliferator-activated receptor gamma in non small cell lung cancer. Cancer Res, 2000; 60: 1129-1138 (Pubitemid 30129556)
    • (2000) Cancer Research , vol.60 , Issue.4 , pp. 1129-1138
    • Chang, T.-H.1    Szabo, E.2
  • 34
    • 0036934710 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ ligand inhibits cell growth and invasion of human pancreatic cancer cells
    • Hashimoto K, Ethridge RT, Evers BM: Peroxisome proliferator-activated receptor γ ligand inhibits cell growth and invasion of human pancreatic cancer cells. Int J Gastrointest Cancer, 2002; 32: 7-22 (Pubitemid 36323098)
    • (2002) International Journal of Gastrointestinal Cancer , vol.32 , Issue.1 , pp. 7-22
    • Hashimoto, K.1    Ethridge, R.T.2    Evers, B.M.3
  • 35
    • 1442304433 scopus 로고    scopus 로고
    • 2-Induced Apoptosis in the Human Pancreatic Cancer Cell Line MIA PaCa-2
    • DOI 10.1097/00006676-200403000-00006
    • Hashimoto K, Farrow BJ, Evers BM: Activation and role of MAP kinases in 15d-PGJ2-induced apoptosis in the human pancreatic cancer cell line MIA PaCa-2. Pancreas, 2004; 28: 153-159 (Pubitemid 38269775)
    • (2004) Pancreas , vol.28 , Issue.2 , pp. 153-159
    • Hashimoto, K.1    Farrow, B.J.2    Evers, B.M.3
  • 36
    • 0034306992 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor γ by troglitazone inhibits cell growth through the increases of p27Kip1 in human pancreatic carcinoma cells
    • Motamura W, Okumura T, Takahashi N et al: Activation of peroxisome proliferator-activated receptor γ by troglitazone inhibits cell growth through the increases of p27Kip1 in human pancreatic carcinoma cells. Cancer Res, 2000; 60: 5558-5564
    • (2000) Cancer Res , vol.60 , pp. 5558-5564
    • Motamura, W.1    Okumura, T.2    Takahashi, N.3
  • 38
    • 34548403010 scopus 로고    scopus 로고
    • Prognostic Significance of Vitamin D Receptor and Retinoid X Receptor Expression in Renal Cell Carcinoma
    • DOI 10.1016/j.juro.2007.05.119, PII S0022534707013900
    • Obara W, Konda R, Akasaka S et al: Prognostic significance of vitamin D receptor and retinoid X receptor expression in renal cell carcinoma. J Urol, 2007; 178: 1497-1503 (Pubitemid 47368384)
    • (2007) Journal of Urology , vol.178 , Issue.4 , pp. 1497-1503
    • Obara, W.1    Konda, R.2    Akasaka, S.3    Nakamura, S.4    Sugawara, A.5    Fujioka, T.6
  • 39
    • 33744962679 scopus 로고    scopus 로고
    • 9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway
    • DOI 10.1074/jbc.M601593200
    • Singh RR, Gururaj AE, Vadlamudi RK, Kumar R: 9-cis-retinoic acid upregulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway. J Biol Chem, 2006; 281: 15394-15404 (Pubitemid 43855131)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.22 , pp. 15394-15404
    • Singh, R.R.1    Gururaj, A.E.2    Vadlamudi, R.K.3    Kumar, R.4
  • 40
    • 0035990286 scopus 로고    scopus 로고
    • The expression of retinoic acid receptors and the effects in vitro by retinoids in human pancreatic cancer cell lines
    • Albrechtsson E, Ohlsson B, Axelson J: The expression of retinoic acid receptors and the effects in vitro by retinoids in human pancreatic cancer cell lines. Pancreas, 2002; 25: 49-56
    • (2002) Pancreas , vol.25 , pp. 49-56
    • Albrechtsson, E.1    Ohlsson, B.2    Axelson, J.3
  • 41
    • 9644295744 scopus 로고    scopus 로고
    • Synergistic effect of a retinoid X receptor-selective ligand bexarotene (LGD1069, Targretin) and paclitaxel (Taxol) in mammary carcinoma
    • DOI 10.1007/s10549-004-1426-5
    • Yen W-C, Prudente RY, Lamph WW: Synergistic effect of a retinoid X receptor-selective ligand bexarotene (LGD1069, Targretin) and paclitaxel (Taxol) in mammary carcinoma. Breast Cancer Res Treat, 2004; 88: 141-148 (Pubitemid 39575571)
    • (2004) Breast Cancer Research and Treatment , vol.88 , Issue.2 , pp. 141-148
    • Yen, W.-C.1    Prudente, R.Y.2    Lamph, W.W.3
  • 43
    • 33847325833 scopus 로고    scopus 로고
    • The retinoid X receptor-selective ligand, LGD1069, inhibits tumor-induced angiogenesis via suppression of VEGF in human non-small cell lung cancer
    • DOI 10.1016/j.canlet.2006.06.012, PII S0304383506004204
    • Fu J, Ding Y, Huang D et al: The retinoid X receptor-selective ligand, LGD1069, inhibits tumor-induced angiogenesis via suppression of VEGF in human non-small cell lung cancer. Cancer Lett, 2007; 248: 153-163 (Pubitemid 46319348)
    • (2007) Cancer Letters , vol.248 , Issue.1 , pp. 153-163
    • Fu, J.1    Ding, Y.2    Huang, D.3    Li, H.4    Chen, X.5
  • 44
    • 0043163884 scopus 로고    scopus 로고
    • Thiazolidinediones inhibit growth of gastrointestinal, biliary, and pancreatic adenocarcinoma cells through activation of the peroxisome proliferator-activated receptor γ/retinoid X receptor α pathway
    • DOI 10.1016/S0014-4827(03)00263-5
    • Tsujie M, Nakamori S, Okami J et al: Thiazolidinediones inhibit growth of gastrointestinal, biliary, and pancreatic adenocarcinoma cells through activation of the peroxisome proliferator-activated receptor γ/retinoid X receptor α pathway. Exp Cell Res, 2003; 289: 143-151 (Pubitemid 36993844)
    • (2003) Experimental Cell Research , vol.289 , Issue.1 , pp. 143-151
    • Tsujie, M.1    Nakamori, S.2    Okami, J.3    Hayashi, N.4    Hiraoka, N.5    Nagano, H.6    Dono, K.7    Umeshita, K.8    Sakon, M.9    Monden, M.10
  • 45
    • 0037083972 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma reduces the growth rate of pancreatic cancer cells through the reduction of cyclin D1
    • DOI 10.1016/S0024-3205(01)01524-7, PII S0024320501015247
    • Toyota M, Miyazaki Y, Kitamura S et al: Peroxisome proliferator-activated receptor gamma reduces the growth rate of pancreatic cancer cells through the reduction of cyclin D1. Life Sci, 2002; 70: 1565-1575 (Pubitemid 34164550)
    • (2002) Life Sciences , vol.70 , Issue.13 , pp. 1565-1575
    • Toyota, M.1    Miyazaki, Y.2    Kitamura, S.3    Nagasawa, Y.4    Kiyohara, T.5    Shinomura, Y.6    Matsuzawa, Y.7
  • 46
    • 35548999307 scopus 로고    scopus 로고
    • Synergistic effects of RXR alpha and PPAR gamma ligands to inhibit growth in human colon cancer cells - Phosphorylated RXR alpha is a critical target for colon cancer management
    • DOI 10.1136/gut.2007.129858
    • Yamazaki K, Shimizu M, Okuno M et al: Synergistic effects of RXR alpha and PPAR gamma ligands to inhibit growth in human colon cancer cells-phosphorylated RXR alpha is a critical target for colon cancer management. Gut, 2007; 56: 1557-1563 (Pubitemid 350033194)
    • (2007) Gut , vol.56 , Issue.11 , pp. 1557-1563
    • Yamazaki, K.1    Shimizu, M.2    Okuno, M.3    Matsushima-Nishiwaki, R.4    Kanemura, N.5    Araki, H.6    Tsurumi, H.7    Kojima, S.8    Weinstein, I.B.9    Moriwaki, H.10
  • 47
    • 33745103705 scopus 로고    scopus 로고
    • In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer
    • Saidi SA, Holland CM, Charnock-Jones DS, Smith SK:In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer. Mol Cancer, 2006; 5: 13
    • (2006) Mol Cancer , vol.5 , pp. 13
    • Saidi, S.A.1    Holland, C.M.2    Charnock-Jones, D.S.3    Smith, S.K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.