Radiosensitization and anti-tumour effects of cytosine deaminase and thymidine kinase fusion suicide gene in human adenoid cystic carcinoma cells

Journal of International Medical Research

Volumn 37, Issue 2, 2009, Pages 479-490

  Huang, S Y ^a,b   Zhang, Dong Sheng ^b   Han, J Q ^b   Zhang, N ^b   Zhang, S Z ^b   Mu, W L ^b   Wei, F C ^b  

^a TONGJI UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

5 Fluorocytosine; Adenoid cystic carcinoma; Ganciclovir; Radiosensitization; Suicide gene

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOSINE DEAMINASE THYMIDINE KINASE FUSION PROTEIN; FLUCYTOSINE; GANCICLOVIR; UNCLASSIFIED DRUG; CYTOSINE DEAMINASE; MESSENGER RNA; THYMIDINE KINASE;

ADENOID CYSTIC CARCINOMA; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL DAMAGE; CELL REGENERATION; CELL SURVIVAL; COLONY FORMATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EXPOSURE; GENE TRANSFER; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IRRADIATION; LIPOSOMAL GENE DELIVERY SYSTEM; RADIOSENSITIVITY; RADIOSENSITIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUICIDE GENE THERAPY; WESTERN BLOTTING; CELL DEATH; DRUG EFFECT; DRUG SCREENING; GENE EXPRESSION REGULATION; GENE FUSION; GENETICS; METABOLISM; PATHOLOGY; RADIATION DOSE; RADIATION EXPOSURE; SUICIDE TRANSGENE; TUMOR CELL LINE; X RAY;

ARTIFICIAL GENE FUSION; BLOTTING, WESTERN; CARCINOMA, ADENOID CYSTIC; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; CYTOSINE DEAMINASE; DRUG SCREENING ASSAYS, ANTITUMOR; FLUCYTOSINE; GANCICLOVIR; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TRANSGENIC, SUICIDE; HUMANS; RADIATION TOLERANCE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THYMIDINE KINASE; X-RAYS;

EID: 66649130588     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323000903700224     Document Type: Article

References (36)

1. Soares EC, Carreiro Filho FP, Costa FW, et al: Adenoid cystic carcinoma of the tongue: case report and literature review. Med Oral Patol Oral Cir Bucal 2008; 13: E475-E478.
2. Billroth T: Beobachtungen über geschwülste der speicheldrüsen. Virchows Arch (Pathol Anat Physiol) 1859; 17: 357-375 [in German].
3. Sigal R, Monnet O, de Baere T, et al: Adenoid cystic carcinoma of the head and neck: evaluation with MR imaging and clinical-pathologic correlation in 27 patients. Radiology 1992; 184: 95-101.
4. Avery CM, Moody AB, McKinna FE, et al: Combined treatment of adenoid cystic carcinoma of the salivary glands. Int J Oral Maxillofac Surg 2000; 29: 277-279.
5. Cohen AN, Damrose EJ, Huang RY, et al: Adenoid cystic carcinoma of the submandibular gland: a 35-year review. Otolaryngol Head Neck Surg 2004; 131: 994-1000.
6. Dodd RL, Slevin NJ: Salivary gland adenoid cystic carcinoma: a review of chemotherapy and molecular therapies. Oral Oncol 2006; 42: 759-769.
7. Fogar P, Navaglia F, Basso D, et al: Suicide gene therapy with the yeast fusion gene cytosine deaminase/uracil phosphoribosyltransferase is not enough for pancreatic cancer. Pancreas 2007; 35: 224-231.
8. Negroni L, Samson M, Guigonis JM, et al: Treatment of colon cancer using the cytosine deaminase/5-fluorcytosine suicide system induces apoptosis, modulation of the proteome, and Hsp90β phosphorylation. Mol Cancer Ther 2007; 6: 2747-2756
9. Tomicic MT, Thust R, Kaina B: Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: critical role of DNA breaks, Bcl-2 decline and caspae-9 activation. Oncogene 2002; 21: 2141-2153.
10. Luo C, Mori J, Goshima F, et al: Replication-competent, oncolytic herpes simplex virus type 1 mutants induce a bystander effect following ganciclovir treatment. J Gene Med 2007; 9: 875-883.
11. Tang Y, Li J, Zhao S, et al: Killing effect of the herpes simplex virus thymidine kinase/ganciclovir enzymes/prodrug system on human nasopharyngeal carcinoma cells. J Int Med Res 2007; 35: 433-441.
12. Van Dillen IJ, Mulder NH, Sluiter WJ, et al: Consequences of chemoresistance for the herpes simplex virus thymidine kinase/ ganciclovir-induced bystander effect in a human small cell lung cancer cell line model. Anticancer Res 2005; 25: 255-261.
13. Miletic H, Fischer Y, Litwak S, et al: Bystander killing of malignant glioma by bone marrow-derived tumor-infiltrating progenitor cells expressing a suicide gene. Mol Ther 2007; 15 1373-1381.
14. Xu B, Liu ZZ, Zhu GY, et al: Efficacy of recombinant adenovirus-mediated double suicide gene therapy in human keloid fibroblasts. Clin Exp Dematol 2008; 33: 322-328.
15. Ichikawa T, Tamiya T, Adachi Y, et al: In vivo efficacy and toxicity of 5-fluorocytosine/cytosine deaminase gene therapy for malignant gliomas mediated by adenovirus. Cancer Gene Ther 2000; 7: 74-82.
16. Sun C, He R, Zhang Z, et al: Biological characters of adenoid cystic carcinoma cells transduced with HSV- tk gene. Hua Xi Kou Qiang Yi Xue Za Zhi 1999; 17: 304-306 [in Chinese].
17. Zhang Z, Lin J, Chu J, et al: Activation of caspase-3 noninvolved in the bystander effect of the herpes simplex virus thymidine kinase gene/ganciclovir (HSV-tk/GCV) system. J Biomed Opt 2008; 13: 031209.
18. Sun C, He R, Zhang Z: The effects of suicide gene theraphy system on adenoid systic carcinoma of salivary gland in athymic mice. Zhonghua Kou Qiang Yi Xue Za Zhi 2000; 35: 34-37 [in Chinese].
19. McBride WH, Dougherty GJ: Radiotherapy for genes that cause cancer. Nat Med 1995; 1: 1215-1217.
20. Spiro RH, Huvos AG: Stage means more than grade in adenoid cystic carinoma. Am J Surg 1992; 164: 623-628.
21. Chen AM, Bucci MK, Weinberg V, et al: Adenoid cystic carcinoma of the head and neck treated by surgery with or without postoerative radiation theraphy: prognostic features of recurrence. Int J Radial Oncol Biol Phys 2006; 66: 152-159.
22. Haddad A, Enepekides DJ, Manolidis S, et al: Adenoid cystic carcinoma of the head and neck: a clinicopathology study of 37 cases. J Otolaryngol 1995; 24: 201-205.
23. Kreitner KF, Zapf S, Collo D, et al: The value of radiation theraphy in the management of adenoid-cystic carcinoma of the head and neck. Strahienther Onkol 1988; 164: 451-456 9in German].
24. Brusco CE, Shewach DS, Lawrence TS: Fluorodeoxyuridine-induced radiodensitazation and inhibition of DNA double stand break repair in human colon cancer cells. Int J Radiat Oncol Biol Phys 1990; 19: 1411-1417.
25. Miller EM, Kinsella TJ: Radiosensitization by fluorodeoxyuridine: effects of thymidylate synthase inhibition and cell synchronization. Cancer Res 1992; 52: 1687-1694.
26. Boucher PD, Im MM, Freytag SO, et al: A novel mechanism of synergistic cytotoxicity with 5-fluorocytosine and ganciclover in double suicide gene theraphy. Cancer Res 2006; 66: 3230-3237.
27. Lawrence TS, Davis MA, Maybaum J, et al: The effect of single versus double-strand substitution on halogenated pyrimidine-induced radiosensitization and DNA strand breakage in human tumor cells. Radiat Res 1990; 123: 192-198.
28. Yu T, Xiong Z, Chen S, et al: The use of models in "target" theory to evaluate the survival curves of human ovarian carcinoma cell line exposure to adriamycin combined with ultrasound. Ultrason Sonochem 2005; 12: 345-348.
29. Kieback DG, Fischer DC, Engehausen DG, et al: Intraperitoneal adenovirous-mediated suicide gene theraphy in combination with either topotecn or paditaxel in nude mice with human ovarian cancer. Cancer Gene Ther 2002; 9: 478-481.
30. Faneca H, Faustino A, Pedroso de Lima MC: Synergistic antitumoral effect of vinblastine and HSV-TK/GCV gene theraphy mediated by albumin-associated cationic liposomes. J Control Release 2008; 126: 175-184.
31. Smalley SR, Kimler BF, Evans RG: 5-Fluorouracil modulation of radiosensitivity in cultured human carcinoma cells. Int J Radiat Oncol Biol Phys 1991; 20: 207-211.
32. Lee YJ, Lee H, Borrelli MJ: Gene transfer into human prostate adenocarcinoma cells with an adenoviral vector: hyperthermia enhances a double suicide gene expression, cytotoxicity and radiotoxicity. Cancer Gene Ther 2002; 9: 267-274.
33. von der Maase H: Experimental studies on interactions of radiation and cancer chemotherapeutic drugs in normal tissue and a solid tumour. Radiother Oncol 1986; 7: 47-68.
34. Kim JH, Kim SH, Kolozsvary A, et al: Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents. Int J Radiat Oncol Biol Phys 1995; 33: 861-868.
35. Wu DH, Liu L, Chen LH: Antitumor effects and radiosensitization of cytosine deaminase and thymidine kinase fusion suicide gene on colorectal carcinoma cells. World J Gastroenterol 2005; 11: 3051-3055.
36. Bertin S, Neves S, Gavelli A, et al: Cellular and molecular events associated with the antitumor response induced by the cytosine deaminase/ 5-fluorocytosine suicide gene theraphy system in a rat liver metastasis model. Cancer Gene Ther 2007; 14: 858-866.