Decreased interleukin-2 responses to fusobacterium nucleatum and porphyromonas gingivalis in generalized aggressive periodontitis

Journal of Periodontology

Volumn 80, Issue 5, 2009, Pages 800-807

  Borch, Tanja Skuldbøl ^a,b   Løbner, Morten ^b   Bendtzen, Klaus ^b   Holmstrup, Palle ^a,c   Nielsen, Claus Henrik ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Rigshospitalet   (Denmark)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

Aggressive periodontitis; CD4 positive T lymphocytes; Cytokines; Interleukin 2; T cell proliferation

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; TETANUS TOXOID;

ADOLESCENT; ADULT; ARTICLE; BIOSYNTHESIS; CASE CONTROL STUDY; CELL CULTURE; FEMALE; FUSOBACTERIUM NUCLEATUM; HELPER CELL; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MALE; METABOLISM; MICROBIOLOGY; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; PREVOTELLA INTERMEDIA; SMOKING;

ADOLESCENT; ADULT; AGGRESSIVE PERIODONTITIS; CASE-CONTROL STUDIES; CELLS, CULTURED; CYTOKINES; FEMALE; FUSOBACTERIUM NUCLEATUM; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MALE; PORPHYROMONAS GINGIVALIS; PREVOTELLA INTERMEDIA; SMOKING; T-LYMPHOCYTES, HELPER-INDUCER; TETANUS TOXOID; YOUNG ADULT;

EID: 66649124944     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2009.080513     Document Type: Article

References (38)

1. Genco RJ, Slots J. Host responses in periodontal diseases. J Dent Res 1984;63:441-451.
2. Meng H, Xu L, Li Q, Han J, Zhao Y. Determinants of host susceptibility in aggressive periodontitis. Peri-odontol 2000 2007;43:133-159.
3. Gemmell E, Yamazaki K, Seymour GJ. Destructive periodontitis lesions are determined by the nature of the lymphocytic response. Crit Rev Oral Biol Med 2002;13:17-34.
4. Ivanyi L, Lehner T. Stimulation of lymphocyte transformation by bacterial antigens in patients with periodontal disease. Arch Oral Biol 1970;15:1089-1096.
5. Baker JJ, Wright WE, Chan SP, Oppenheim JJ. Longitudinal effects of clinical therapy and the edentulous state on the transformation of lymphocytes from patients with severe periodontitis. Clin Exp Immunol 1978; 34:199-205.
6. Ivanyi L, Wilton JM, Lehner T. Cell-mediated immunity in periodontal disease; cytotoxicity, migration inhibition and lymphocyte transformation studies. Immunology 1972;22:141-145.
7. Ivanyi L, Challacombe SJ, Lehner T. The specificity of serum factors in lymphocyte transformation in periodontal disease. Clin Exp Immunol 1973;14:491-500.
8. Ivanyi L, Lehner T. Stimulation of human lymphocytes by B-cell mitogens. Clin Exp Immunol 1974; 18:347-356.
9. Ivanyi L, Topic B, Lydyard PM. The role of TG Iymphocytes in cell-mediated immunity in patients with periodontal disease. Clin Exp Immunol 1981;46:633-639.
10. Ivanyi L, Newman HN, Marsh PD. T cell proliferative responses to molecular fractions of periodontopathic bacteria. Clin Exp Immunol 1991;83:108-111.
11. Church H, Dolby AE. The relationship between the dose of dentogingival plaque and the in vitro lympho-proliferative response in subjects with periodontal disease. J Oral Pathol 1978;7:318-325.
12. Donaldson SL, Ranney RR, Burmeister JA, Tew JG. Blastogenic responses by Iymphocytes from periodontally healthy populations induced by periodontitis-as-sociated bacteria. J Periodontol 1982;53:743-751.
13. Engel D, Monzingo S, Rabinovitch P, Clagett J, Stone R. Mitogen-induced hyperproliferation response of peripheral blood mononuclear cells from patients with severe generalized periodontitis: Lack of correlation with proportions of T cells and T-cell subsets. Clin Immunol Immunopathol 1984;30:374-386.
14. Lang NP, Smith FN. Lymphocyte blastogenesis to plaque antigens in human periodontal disease. I. Populations of varying severity of disease. J Periodontal Res 1977;12:298-309.
15. Mosmann TR, Coffman RL. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-173.
16. Gaffen SL, Hajishengallis G. A new inflammatory cy-tokine on the block: Re-thinking periodontal disease and the Thl/Th2 paradigm in the context of Th17 cells and IL-17. J Dent Res 2008;87:817-828.
17. Harrington LE, Hatton RD, Mangan PR, et al. Interleu-kin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005;6:1123-1132.
18. McFarlane CG, Reynolds JJ, Meikle MC. The release of interleukin-1 beta, tumor necrosis factor-alpha and interferon-gamma by cultured peripheral blood mono-nuclear cells from patients with periodontitis. J Periodontal Res 1990;25:207-214.
19. Takahashi K, Ohyama H, Kitanaka M, et al. Heterogeneity of host immunological risk factors in patients with aggressive periodontitis. J Periodontol 2001;72:425-437.
20. Sigusch B, Klinger U, Glockmann E, Simon HU. Early-onset and adult periodontitis associated with abnormal cytokine production by activated T Iymphocytes. J Periodontol 1998;69:1098-1104.
21. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1-6.
22. Syed SA, Loesche WJ. Survival of human dental plaque flora in various transport media. Appl Microbiol 1972;24:638-644.
23. Hunt DE, Jones JV, Dowell VR Jr. Selective medium for the isolation of Bacteroides gingivalis. J Clin Microbiol 1986;23:441-445.
24. Singletary MM, Crawford JJ, Simpson DM. Dark-field microscopic monitoring of subgingival bacteria during periodontal therapy. J Periodontol 1982;53:671-681.
25. Lyons AB, Parish CR. Determination of Iymphocyte division by flow cytometry. J Immunol Methods 1994; 171:131-137.
26. Hedegaard CJ, Krakauer M, Bendtzen K, Sorensen PS, Sellebjerg F, Nielsen CH. The effect of beta-interferon therapy on myelin basic protein-elicited CD4+ T cell proliferation and cytokine production in multiple sclerosis. Clin Immunol 2008; 129:80-89.
27. Granucci F, Vizzardelli C, Pavelka N, et al. Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nat Immunol 2001;2:882-888.
28. Malek TR. The biology of interleukin-2. Annu Rev Immunol 2008;26:453-479.
29. Malek TR, Bayer AL. Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol 2004;4:665-674.
30. Williams MA, Tyznik AJ, Bevan MJ. Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells. Nature 2006;441: 890-893.
31. Waldmann TA, Dubois S, Tagaya Y. Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: Implications for immunotherapy. Immunity 2001; 14: 105-110.
32. Armitage RJ, Macduff BM, Eisenman J, Paxton R, Grabstein KH. IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. J Immunol 1995; 154:483-490.
33. Colic M, Vasilijic S, Gazivoda D, Vucevic D, Marjanovic M, Lukic A. Interleukin-17 plays a role in exacerbation of inflammation within chronic periapical lesions. Eur J Oral Sci 2007;115:315-320.
34. Johnson RB, Wood N, Serio FG. Interleukin-11 and IL-17 and the pathogenesis of periodontal disease. J Periodontol 2004;75:37-43.
35. Vernal R, Dutzan N, Chaparro A, Puente J, Antonieta VM, Gamonal J. Levels of interleukin-17 in gingival crevicular fluid and in supernatants of cellular cultures of gingival tissue from patients with chronic periodontitis. J Clin Periodontol 2005;32:383-389.
36. Oda T, Yoshie H, Yamazaki K. Porphyromonas gingivalis antigen preferentially stimulates T cells to express IL-17 but not receptor activator of NF-kappaB ligand in vitro. Oral Microbiol Immunol 2003;18:30-36.
37. Sato K, Suematsu A, Okamoto K, et al. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med 2006;203:2673-2682.
38. Yu JJ, Ruddy MJ, Wong GC, et al. An essential role for IL-17 in preventing pathogen-initiated bone destruction: Recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals. Blood 2007; 109:3794-3802.