Regulation of expression and activity of rat intestinal multidrug resistance-associated protein 2 by cholestatic estrogens

Drug Metabolism and Disposition

Volumn 37, Issue 6, 2009, Pages 1277-1285

  Arias, Agostina ^a   Villanueva, Silvina S M ^a   Ruiz, María L ^a   Luquita, Marcelo G ^a   Veggi, Luis M ^a   Pellegrino, José M ^a   Vore, Mary ^b   Catania, Viviana A ^a   Mottino, Aldo D ^a  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DINITROPHENYL S GLUTATHIONE; ESTRADIOL 17 GLUCURONIDE; ETHINYLESTRADIOL; GLUTATHIONE DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN 2; PROBENECID; SPIRONOLACTONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; BILE FLOW; CHOLESTASIS; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; IMMUNOFLUORESCENCE MICROSCOPY; INTESTINE CELL; JEJUNUM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SMALL INTESTINE ABSORPTION; WESTERN BLOTTING; XENOBIOTIC METABOLISM;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL MARKERS; BIOLOGICAL TRANSPORT, ACTIVE; BODY WEIGHT; CHOLESTASIS; DOWN-REGULATION; ESTRADIOL; ESTROGENS; GENE EXPRESSION; INTESTINES; MALE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; RATS; RATS, WISTAR;

RATTUS;

EID: 66649110565     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.025643     Document Type: Article

References (41)

1. Back DJ and Orme ML (1990) Pharmacokinetic drug interactions with oral contraceptives. Clin Pharmacokinet 18:472-484. (Pubitemid 20183889)
2. Cao J, Huang L, Liu Y, Hoffman T, Stieger B, Meier PJ, and Vore M (2001) Differential regulation of hepatic bile salt and organic anion transporters in pregnant and postpartum rats and the role of prolactin. Hepatology 33:140-147. (Pubitemid 32016896)
3. Cao J, Stieger B, Meier PJ, and Vore M (2002) Expression of rat hepatic multidrug resistance-associated proteins and organic anion transporters in pregnancy. Am J Physiol Gastrointest Liver Physiol 283:G757-G766.
4. Catania VA, Luquita MG, Sánchez Pozzi EJ, and Mottino AD (2000) Quantitative and qualitative gender-related differences in jejunal glutathione S-transferase in the rat effect of testosterone administration. Life Sci 68:467-474. (Pubitemid 32011898)
5. Crocenzi FA, Mottino AD, Cao J, Veggi LM, Pozzi EJ, Vore M, Coleman R, and Roma MG (2003) Estradiol-17beta-D-glucuronide induces endocytic internalization of Bsep in rats. Am J Physiol Gastrointest Liver Physiol 285:G449-G459. (Pubitemid 36875218)
6. Crocenzi FA, Pellegrino JM, Catania VA, Luquita MG, Roma MG, Mottino AD, and Pozzi EJ (2006) Galactosamine prevents ethinylestradiol-induced cholestasis. Drug Metab Dispos 34:993-997. (Pubitemid 43763756)
7. Crocenzi FA, Sánchez Pozzi EJ, Pellegrino JM, Favre CO, Rodríguez Garay EA, Mottino AD, Coleman R, and Roma MG (2001) Beneficial effects of silymarin on estrogen-induced cholestasis in the rat: a study in vivo and in isolated hepatocyte couplets. Hepatology 34:329-339. (Pubitemid 32702346)
8. Dietrich CG, de Waart DR, Ottenhoff R, Schoots IG, and Elferink RP (2001) Increased bioavailability of the food-derived carcinogen 2-amino-1-methyl-6- phenylimidazo[4,5- b]pyridine in MRP2-deficient rats. Mol Pharmacol 59:974-980. (Pubitemid 32381575)
9. Dietrich CG, Geier A, Salein N, Lammert F, Roeb E, Oude Elferink RP, Matern S, and Gartung C (2004) Consequences of bile duct obstruction on intestinal expression and function of multidrug resistance-associated protein 2. Gastroenterology 126:1044-1053. (Pubitemid 38451176)
10. Elias E and Mills CO (2007) Coordinated defence and the liver. Clin Med 7:180-184. (Pubitemid 46713730)
11. Ghanem CI, Gómez PC, Arana MC, Perassolo M, Delli Carpini G, Luquita MG, Veggi LM, Catania VA, Bengochea LA, and Mottino AD (2006) Induction of rat intestinal P-glycoprotein by spironolactone and its effect on absorption of orally administered digoxin. J Pharmacol Exp Ther 318:1146-1152. (Pubitemid 44268320)
12. Institute of Laboratory Animal Resources (1996) Guide for the Care and Use of Laboratory Animals, 7th ed, Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, Washington, DC.
13. Iyanagi T (2007) Molecular mechanism of phase I and phase II drug-metabolizing enzymes: implications for detoxification. Int Rev Cytol 260:35-112. (Pubitemid 46670211)
14. Johnson BM, Zhang P, Schuetz JD, and Brouwer KL (2006) Characterization of transport protein expression in multidrug resistance-associated protein (Mrp) 2-deficient rats. Drug Metab Dispos 34:556-562.
15. Keppler D (1999) Export pumps for glutathione S-conjugates. Free Radic Biol Med 27:985-991. (Pubitemid 29507471)
16. Kessler M, Acuto O, Storelli C, Murer H, Müller M, and Semenza G (1978) A modified procedure for the rapid preparation of efficiently transporting vesicles from small intestinal brush border membranes: their use in investigating some properties of D-glucose and choline transport systems. Biochim Biophys Acta 506:136-154. (Pubitemid 8237850)
17. Krishnamurthy P and Schuetz JD (2006) Role of ABCG2/BCRP in biology and medicine. Annu Rev Pharmacol Toxicol 46:381-410. (Pubitemid 43271195)
18. Lee JM, Trauner M, Soroka CJ, Stieger B, Meier PJ, and Boyer JL (2000) Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology 118:163-172. (Pubitemid 30020384)
19. Lindell M, Lang M, and Lennernäs H (2003) Expression of genes encoding for drug metabolising cytochrome P450 enzymes and P-glycoprotein in the rat small intestine; comparison to the liver. Eur J Drug Metab Pharmacokinet 28:41-48. (Pubitemid 36505825)
20. Meyers M, Slikker W, Pascoe G, and Vore M (1980) Characterization of cholestasis induced by estradiol-17 beta-D-glucuronide in the rat. J Pharmacol Exp Ther 214:87-93. (Pubitemid 10032387)
21. Miguet JP, Vuitton D, Thebault-Lucas A, Joanne C, and Dhumeaux D (1980) Spironolactone and enzyme induction in patients with alcoholic cirrhosis. Gastroenterology 78:996-1000. (Pubitemid 10120916)
22. Mottino AD, Cao J, Veggi LM, Crocenzi F, Roma MG, and Vore M (2002) Altered localization and activity of canalicular Mrp2 in estradiol-17beta-D- glucuronide-induced cholestasis. Hepatology 35:1409-1419. (Pubitemid 34966895)
23. Mottino AD, Hoffman T, Jennes L, Cao J, and Vore M (2001) Expression of multidrug resistance-associated protein 2 in small intestine from pregnant and postpartum rats. Am J Physiol Gastrointest Liver Physiol 280:G1261-G1273. (Pubitemid 32552430)
24. Mottino AD, Hoffman T, Jennes L, and Vore M (2000) Expression and localization of multidrug resistant protein mrp2 in rat small intestine. J Pharmacol Exp Ther 293:717-723. (Pubitemid 30417835)
25. Reyes H and Simon FR (1993) Intrahepatic cholestasis of pregnancy: an estrogen-related disease. Semin Liver Dis 13:289-301. (Pubitemid 23294215)
26. Rost D, Mahner S, Sugiyama Y, and Stremmel W (2002) Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine. Am J Physiol Gastrointest Liver Physiol 282:G720-G726. (Pubitemid 34651651)
27. Ruiz ML, Villanueva SS, Luquita MG, Ikushiro S, Mottino AD, and Catania VA (2007) Beneficial effect of spironolactone administration on ethynylestradiol-induced cholestasis in the rat: involvement of up-regulation of multidrug resistance-associated protein 2. Drug Metab Dispos 35:2060-2066. (Pubitemid 350005196)
28. Ruiz ML, Villanueva SS, Luquita MG, Sánchez-Pozzi EJ, Crocenzi FA, Pellegrino JM, Ochoa JE, Vore M, Mottino AD, and Catania VA (2005) Mechanisms involved in spironolactone-induced choleresis in the rat: role of multidrug resistance-associated protein 2. Biochem Pharmacol 69:531-539. (Pubitemid 40094512)
29. Ruiz ML, Villanueva SS, Luquita MG, Vore M, Mottino AD, and Catania VA (2006) Ethy- nylestradiol increases expression and activity of rat liver MRP3. Drug Metab Dispos 34:1030-1034. (Pubitemid 43763761)
30. Shenfield GM (1993) Oral contraceptives. Are drug interactions of clinical significance? Drug Saf 9:21-37.
31. Stieger B, Fattinger K, Madon J, Kullak-Ublick GA, and Meier PJ (2000) Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver. Gastroenterology 118:422-430. (Pubitemid 30067515)
32. Suzuki M, Suzuki H, Sugimoto Y, and Sugiyama Y (2003) ABCG2 transports sulfated conjugates of steroids and xenobiotics. J Biol Chem 278:22644-22649. (Pubitemid 36830322)
33. Tanaka Y, Slitt AL, Leazer TM, Maher JM, and Klaassen CD (2005) Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice. Biochem Biophys Res Commun 326:181-187.
34. Trauner M, Arrese M, Soroka CJ, Ananthanarayanan M, Koeppel TA, Schlosser SF, Suchy FJ, Keppler D, and Boyer JL (1997) The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology 113:255-264. (Pubitemid 27281782)
35. Trauner M, Meier PJ, and Boyer JL (1999) Molecular regulation of hepatocellular transport systems in cholestasis. J Hepatol 31:165-178. (Pubitemid 29287625)
36. van Herwaarden AE, Jonker JW, Wagenaar E, Brinkhuis RF, Schellens JH, Beijnen JH, and Schinkel AH (2003) The breast cancer resistance protein (Bcrp1/Abcg2) restricts exposure to the dietary carcinogen 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine. Cancer Res 63:6447-6452. (Pubitemid 37255195)
37. Villanueva SS, Ruiz ML, Ghanem CI, Luquita MG, Catania VA, and Mottino AD (2008) Hepatic synthesis and urinary elimination of acetaminophen glucuronide are exacerbated in bile duct-ligated rats. Drug Metab Dispos 36:475-480.
38. Vore M (1987) Estrogen cholestasis: membranes, metabolites, or receptors? Gastroenterology 93:643-649.
39. Vore M, Hadd H, and Slikker W Jr (1983) Ethynylestradiol-17 beta D-ring glucuronide conjugates are potent cholestatic agents in the rat. Life Sci 32:2989-2993.
40. Vore M, Liu Y, and Huang L (1997) Cholestatic properties and hepatic transport of steroid glucuronides. Drug Metab Rev 29:183-203. (Pubitemid 27293609)
41. Yokooji T, Murakami T, Yumoto R, Nagai J, and Takano M (2007) Site-specific bidirectional efflux of 2,4-dinitrophenyl-S-glutathione, a substrate of multidrug resistance-associated proteins, in rat intestine and Caco-2 cells. J Pharm Pharmacol 59:513-520. (Pubitemid 47051124)