Coregulated expression of loline alkaloid-biosynthesis genes in Neotyphodium uncinatum cultures

Fungal Genetics and Biology

Volumn 46, Issue 8, 2009, Pages 517-530

  Zhang, Dong Xiu ^a   Stromberg, Arnold J ^a   Spiering, Martin J ^a   Schardl, Christopher L ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Gene cluster; Gene expression; Grass endophytes; Loline alkaloids; Neotyphodium uncinatum

Indexed keywords

ALKALOID; FUNGAL PROTEIN; LAEA LIKE PROTEIN; LOLINE; LOLINE ALKALOID; PROTEIN C2H2; PROTEIN LOLA2; PROTEIN LOLC2; PROTEIN LOLD2; PROTEIN LOLE2; PROTEIN LOLF2; PROTEIN LOLO2; PROTEIN LOLP1; PROTEIN LOLT2; PROTEIN LOLU2; PROTEIN METE; PROTEIN PLOLA2UIDA; PROTEIN PLOLC2UIDA; PROTEIN PROC; PROTEIN TUBB; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; FUNGAL GENE; FUNGAL GENOME; FUNGUS; FUNGUS CULTURE; GENE CLUSTER; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE LOCUS; GENETIC TRANSCRIPTION; NEOTYPHODIUM UNCINATUM; NONHUMAN; NUCLEOTIDE SEQUENCE; POSITION EFFECT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN SYNTHESIS;

ALKALOIDS; BINDING SITES; BIOSYNTHETIC PATHWAYS; DNA, FUNGAL; FUNGAL PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, FUNGAL; NEOTYPHODIUM; POACEAE; REGULATORY ELEMENTS, TRANSCRIPTIONAL;

EPICHLOE; HEXAPODA; LOLA; MAMMALIA; NEOTYPHODIUM; NEOTYPHODIUM UNCINATUM; POACEAE; POOIDEAE;

EID: 66649109106     PISSN: 10871845     EISSN: 10960937     Source Type: Journal    
DOI: 10.1016/j.fgb.2009.03.010     Document Type: Article

References (27)

1. Al-Samarrai T.H., and Schmid J. A simple method for extraction of fungal genomic DNA. Letters in Applied Microbiology 30 (2000) 53-56
2. Anonymous, 2007. PRISM ABI 7900 Sequence Detection System User Guide. Applied Biosystems, Foster City, California.
3. Arévalo-Rodríguez M., Calderón I.L., and Holmberg S. Mutations that cause threonine sensitivity identify catalytic and regulatory regions of the aspartate kinase of Saccharomyces cerevisiae. Yeast 15 (1999) 1331-1345
4. Blankenship J.D., Houseknecht J.B., Pal S., Bush L.P., Grossman R.B., and Schardl C.L. Biosynthetic precursors of fungal pyrrolizidines, the loline alkaloids. Chembiochem 6 (2005) 1016-1022
5. Blankenship J.D., Spiering M.J., Wilkinson H.H., Fannin F.F., Bush L.P., and Schardl C.L. Production of loline alkaloids by the grass endophyte, Neotyphodium uncinatum, in defined media. Phytochemistry 58 (2001) 395-401
6. Bok J.W., and Keller N.P. LaeA, a regulator of secondary metabolism in Aspergillus spp. Eukaryotic Cell 3 (2004) 527-535
7. Carroll A.M., Sweigard J., and Valent B. Improved vectors for selecting resistance to hygromycin. Fungal Genetics Newsletter 41 (1994) 20-21
8. Faulkner J.R., Hussaini S.R., Blankenship J.D., Pal S., Branan B.M., Grossman R.B., and Schardl C.L. On the sequence of bond formation in loline alkaloid biosynthesis. Chembiochem 7 (2006) 1078-1088
9. Hellman A., and Chess A. Gene body-specific methylation on the active X chromosome. Science 315 (2007) 1141-1143
10. Jefferson A.R. Assaying chimeric genes in plants: the GUS gene fusion system. Plant Molecular Biology Reporter 5 (1987) 387-405
11. Kato N., Brooks W., and Calvo A.M. The expression of sterigmatocystin and penicillin genes in Aspergillus nidulans is controlled by veA, a gene required for sexual development. Eukaryotic Cell 2 (2003) 1178-1186
12. Kutil B.L., Greenwald C., Liu G., Spiering M.J., Schardl C.L., and Wilkinson H.H. Comparison of loline alkaloid gene clusters across fungal endophytes: predicting the co-regulatory sequence motifs and the evolutionary history. Fungal Genetics and Biology 44 (2007) 1002-1010
13. Moon C.D., Miles C.O., Jarlfors U., and Schardl C.L. The evolutionary origins of three new Neotyphodium endophyte species from grasses indigenous to the Southern Hemisphere. Mycologia 94 (2002) 694-711
14. Orejas M., Espeso E.A., Tilburn J., Sarkar S., Arst H.N., and Penalva M.A. Activation of the Aspergillus PacC transcription factor in response to alkaline ambient pH requires proteolysis of the carboxy-terminal moiety. Genes & Development 9 (1995) 1622-1632
15. Papadopoulou K.K., Kavroulakis N., Tourn M., and Aggelou I. Use of beta-glucuronidase activity to quantify the growth of Fusarium oxysporum f. sp. radicis-lycopersici during infection of tomato. Journal of Phytopathology 153 (2005) 325-332
16. Perrin R.M., Fedorova N.D., Bok J.W., Cramer R.A., Wortman J.R., Kim H.S., Nierman W.C., and Keller N.P. Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA. PLoS Pathogens 3 (2007) 508-517
17. Roberts I., Oliver R., Punt P., and Van den Hondel C. Expression of the Escherichia coli beta-glucuronidase gene in industrial and phytophathogenic filamentous fungi. Current Genetics 15 (1989) 177-180
18. Roze L.V., Arthur A.E., Hong S.Y., Chanda A., and Linz J.E. The initiation and pattern of spread of histone H4 acetylation parallel the order of transcriptional activation of genes in the aflatoxin cluster. Molecular Microbiology 66 (2007) 713-726
19. Schardl C.L., Grossman R.B., Nagabhyru P., Faulkner J.R., and Mallik U.P. Loline alkaloids: currencies of mutualism. Phytochemistry 68 (2007) 980-996
20. Spiering M.J., Faulkner J.R., Zhang D.-X., Machado C., Grossman R.B., and Schardl C.L. Role of the LolP cytochrome P450 monooxygenase in loline alkaloid biosynthesis. Fungal Genetics and Biology 45 (2008) 1307-1314
21. Spiering M.J., Moon C.D., Wilkinson H.H., and Schardl C.L. Gene clusters for insecticidal loline alkaloids in the grass-endophytic fungus Neotyphodium uncinatum. Genetics 169 (2005) 1403-1414
22. Spiering M.J., Wilkinson H.H., Blankenship J.D., and Schardl C.L. Expressed sequence tags and genes associated with loline alkaloid expression by the fungal endophyte Neotyphodium uncinatum. Fungal Genetics and Biology 36 (2002) 242-254
23. Suzuki M.M., and Bird A. DNA methylation landscapes: provocative insights from epigenomics. Nature Reviews Genetics 9 (2008) 465-476
24. Tilburn J., Sarkar S., Widdick D.A., Espeso E.A., Orejas M., Mungroo J., Penalva M.A., and Arst H.N. The Aspergillus PacC zinc-finger transcription factor mediates regulation of both acid-expressed and alkaline-expressed genes by ambient pH. EMBO Journal 14 (1995) 779-790
25. Tripathi G., Wiltshire C., Macaskill S., Tournu H., Budge S., and Brown A.J.P. Gcn4 co-ordinates morphogenetic and metabolic responses to amino acid starvation in Candida albicans. EMBO Journal 21 (2002) 5448-5456
26. Ullu E., Djikeng A., Shi H., and Tschudi C. RNA interference: advances and questions. Philosophical Transactions the Royal Society B 357 (2002) 65-70
27. Vakoc C.R., Mandat S.A., Olenchock B.A., and Blobel G.A. Histone H3 lysine 9 methylation and HP1 gamma are associated with transcription elongation through mammalian chromatin. Molecular Cell 19 (2005) 381-391