The neuroprotective and anti-inflammatory effects of diltiazem in spinal cord ischaemia - Reperfusion injury

Journal of International Medical Research

Volumn 37, Issue 2, 2009, Pages 520-533

  Fansa, Iyad ^a   Altug, M E ^a   Melek, I ^a   Ucar, E ^a   Kontas, T ^a   Akcora, B ^a   Atik, E ^a   Duman, T ^a  

^a MUSTAFA KEMAL UNIVERSITY   (Turkey)

Author keywords

Animal model; Diltiazem; Free radicals; Inflammatory cytokines; Spinal cord ischaemia

Indexed keywords

DILTIAZEM; GLUTATHIONE; INTERLEUKIN 10; INTERLEUKIN 6; MALONALDEHYDE; NITRIC OXIDE; SODIUM CHLORIDE; ANTIINFLAMMATORY AGENT; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; AORTA OCCLUSION; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; HINDLIMB; HISTOPATHOLOGY; LEG MOVEMENT; MALE; MOTOR PERFORMANCE; NERVE FUNCTION; NEUROLOGIC EXAMINATION; NEUROPROTECTION; NONHUMAN; PROTEIN BLOOD LEVEL; RABBIT; REPERFUSION INJURY; SPINAL CORD; SPINAL CORD INJURY; SPINAL CORD ISCHEMIA; ANIMAL; BLOOD; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; DILTIAZEM; GLUTATHIONE; INTERLEUKIN-10; INTERLEUKIN-6; MALE; MALONDIALDEHYDE; NEUROPROTECTIVE AGENTS; NITRIC OXIDE; RABBITS; REPERFUSION INJURY; SPINAL CORD ISCHEMIA;

EID: 66649095947     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323000903700228     Document Type: Article

References (55)

1. Cambria RP, Davison JK, Zannetti S, et al: Clinical experience with epidural cooling for spinal cord protection during thoracic and thoracoabdominal aneurysm repair. J Vasc Surg 1997; 25: 241-243.
2. Gharagozloo F, Larson J, Dausmann MJ, et al: Spinal cord protection during surgical procedures on the descending thoracic and thoracoabdominal aorta: review of current techniques. Chest 1996; 109: 799-809.
3. Stys PK: White matter injury mechanisms. Curr Mol Med 2004; 4: 113-130.
4. 2+ channel activation of ryanodine receptors. Neuron 2003; 40: 53-63.
5. Dirnagl U, Iadecola C, Moskowitz MA: Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 1999; 22: 391-397.
6. Chavko M, Kalincakova K, Kluchova D, et al: Blood flow and electrolytes in spinal cord ischemia. Exp Neurol 1991; 112: 299-303.
7. Rhee RY, Gloviczki P, Cambria RA, et al: The effects of nimodipine on ischemic injury of the spinal cord during thoracic aortic cross-clamping. Int Angiol 1996; 15: 153-161.
8. Danielisová V, Chavko M: Comparative effects of the N-methyl-D-aspartate antagonist MK-801 and the calcium channel blocker KB-2796 on neurologic and metabolic recovery after spinal cord ischemia. Exp Neurol 1998; 149: 203-208.
9. Johnson SH, Kraimer JM, Graeber GM: Effects of flunarizine on neurological recovery and spinal cord blood flow in experimental spinal cord ischemia in rabbits. Stroke 1993; 24: 1547-1553.
10. de Mol B, Hamerlijnck R, Janssen T, et al: Infrarenal aortic occlusion in the rabbit to assess the effect of flunarizine in the prevention of ischemic spinal cord injury. Thorac Cardiovasc Surg 1991; 39: 36-39.
11. Schittek A, Bennink GB, Cooley DA, et al: Spinal cord protection with intravenous nimodipine. A functional and morphologic evaluation. J Thorac Cardiovasc Surg 1992; 104: 1100-1105.
12. Burns LH, Jin Z, Bowersox SS: The neuroprotective effects of intrathecol administration of the selective N-type calcium channel blocker ziconotide in a rat model of spinal ischemia. J Vasc Surg 1999; 30: 334-343.
13. Kroner A, Seitelberger R, Schirnhofer J, et al: Diltiazem during reperfusion preserves high energy phosphates by protection of mitochondrial integrity. Eur J Cardiothorac Surg 2002; 21: 224-231.
14. Takeo S, Tanonaka K, Iwai T, et al: Preservation of mitochondrial function during ischemia as a possible mechanism for cardioprotection of diltiazem against ischemia/reperfusion injury. Biochem Pharmacol 2004; 67: 565-574.
15. Czarnowska E, Karwatowska-Prokopczuk E, kurzydlowski K: Ultrastructural study of calcium shift in ischemic/reperfused rat heart under treatment with dimethylthiourea, diltiazem and amiloride. Basic Res Cardiol 1998; 93: 269-275.
16. Janero DR, Burghardt B, Lopez R: Protection of cardiac membrane phospholipid against oxidative injury by calcium antagonists. Biochem Pharmacol 1988; 37: 4197-4203.
17. Koller PT, Bergmann SR: Reduction of lipid peroxidation in reperfused isolated rabbit hearts by diltiazem. Circ Res 1989; 65: 838-846.
18. Herzog WR, Vogel RA, Schlossberg ML, et al: Short-term low dose intracoronary diltiazem administered at the onset of reperfusion reduces myocardiol infarct size. Int J Cardiol 1997; 59; 21-27.
19. Isozaki H, Fujii K, Nomura E, et al: Calcium concentration in hepatocytes during liver ischaemia-reperfusion injury and the effects of diltiazem and citrate on prefused rat liver. Eur J Gastroenterol Hepatol 2000; 12: 291-297.
20. Fansa I, Gol M, Nisanoglu V, et al: Does diltiazem inhibit the inflammatory response in cardiopulmonary bypass? Med Sci Monit 2003; 9: PI30-PI36.
21. Dubey L, Hesong Z: Anti-inflammatory action of diltiazem in patients with unstable angina. Postgrad Med J 2006; 82: 594-597.
22. Institute of Laboratory Animal Resources, Commission on life Sciences, National Research Council: Guide for the Care and Use of Laboratory Animals. Washington: National Academy Press, 1996.
23. Houssiau FA, Bukasa K, Sindic CJ, et al: Elevated levels of the 26K human hybridoma growth factor (interleukin 6) in cerebrospinal fluid of patients with acute infection of the central nervous system. Clin Exp Immunol 1988; 71: 320-323.
24. Blay JY, Burdin N, Rousset F, et al: Serum interleukin-10 in non-Hodgkin's lymphoma: a prognostic factor. Blood 1993; 82: 2169-2174.
25. Doumas BT, Bayse DD, Carter RJ, et al: A candidate reference method for determination of total protein in serum. I Development and validation. Clin Chem 1981; 27: 1642-1650.
26. Tarlov IM: Acute spinal cord compression paralysis. J Neurosurg 1972; 36: 10-20.
27. Cassada DC, Tibble CG, Long SM, et al: Adenosine A2A agonist reduces paralysis after spinal cord ischemia: correlation with A2A receptor expression on motor neurons. Ann Thorac Surg 2002; 74: 846-849.
28. Caparelli DJ, Cattaneo SM 2nd, Bethea BT, et al: Pharmacological preconditioning ameliorates neurological injury in a model of spinal cord ischemia. Ann Thorac Surg 2002; 74: 838-844.
29. Matsushita K, Wu Y, Qiu J, et al: Fas receptor and neuronal cell death after spinal cord ischemia. J Neurosci 2000; 20: 6879-6887.
30. Marsala M, Sorkin LS, Yaksh TL: Transient spinal ischemia in rat: extracellular amino acid release, and concurrent histopathological damage. J Cereb Blood Flow Metab 1994; 14: 604-614.
31. 2+ exchanger after traumatic or hypoxic/ischemic injury to spinal cord white matter. Spine J 2002; 2: 35-40.
32. Hirose K, Okajima K, Taoka Y, et al: Activated protein C reduces the ischemia/reperfusion-induced spinal cord injury in rats by inhibiting neutrophil activation. Ann Surg 2000; 232: 272-280.
33. Toumpoulis IK, Papakostas JC, Matsagas MI, et al: Superiority of early relative to late ischemic preconditioning in spinal cord protection after descending thoracic aortic occlusion. J Thorac Cardiovasc Surg 2004; 128: 724-730.
34. Roseborough G, Gao D, Chen L, c The mitochondrial K-ATP channel opener, diazoxide, prevents ischemia-reperfusion injury in the rabbit spinal cord. Am J Pathol 2006; 168: 1443-1451.
35. Jalc P, Marsala J, Jalcova H: Postischemic reperfusion causes a massive calcium overload in the myelinated spinal cord fibers. Mol Chem Neuropathol 1995; 25: 143-153.
36. Savas S, Delibas N, Savas C, et al: Pentoxifylline reduces biochemical markers of ischemia- reperfusion induced spinal cord injury in rabbits. Spinal Cord 2002; 40: 224-229.
37. Cassada DC, Gangemi JJ, Rieger JM, et al: Systemic adenosine A2A agonist ameliorates ischemic reperfusion injury in the rabbit spinal cord. Ann Thorac Surg 2001; 72: 1245-1250.
38. Lee CJ, Kim KW, Lee HM, et al: The effect of thalidomide on spinal cord ischemia/reperfusion injury in a rabbit model. Spinal Cord 2007; 45: 149-157.
39. Kawanishi Y, Okada K, Tanaka H, et al: The adverse effect of back-bleeding from lumbar arteries on spinal cord pathophysiology in a rabbit model. J Thorac Cardiovasc Surg 2007; 133: 1553-1558.
40. 2+ channel blocker, prevents neurologic injury after spinal cord ischemia in rabbits. J Thorac Cardiovasc Surg 2005; 129: 364-371.
41. Shi E, Jiang X, kazui T, et al: Controlled low-pressure perfusion at the beginning of reperfusion attenuates neurologic injury after spinal cord ischemia. J Thorac Cardiovasc Surg 2007; 133: 942-948.
42. Suzuki K, Kazui T, Terada H, et al: Experimental study on the protective effects of edaravone against ischemic spinal cord injury. J Thorac Cardiovasc Surg 2005; 130: 1586-1592.
43. Tsuruta S, Matsumoto M, Fukuda S, et al: The effects of cyclosporin A and insulin on ischemic spinal cord injury in rabbits. Anesth Analg 2006; 102: 1722-1727.
44. de Haan P, Kalkman CJ, Ubags LH, et al: A comparison of the sensitivity of epidural and myogenic transcranial motor-evoked responses in the detection of acute spinal cord ischemia in the rabbit. Anesth Analg 1996; 83: 1022-1027.
45. Boyle EM Jr, Pohlman TH, Cornejo CJ, et al: Endothelial cell injury in cardiovascular surgery: ischemia-reperfusion. Ann Thorac Surg 1996; 62: 1868-1875.
46. Siesjo BK, Hu B, Kristian T: Is the cell death pathway triggered by the mitochondrion or the endoplasmic reticulum? J Cereb Blood Flow Metab 1999; 19: 19-26.
47. Lewen A, Matz P, Chan PH: Free radical pathways in CNS injury. J Neurotrauma 2000; 17: 871-890.
48. Mauney MC, Blackbourne LH, Langenburg SE, et al: Prevention of spinal cord injury after repair of the thoracic or thoracoabdominal aorta. Ann Thorac Surg 1995; 59: 245-252.
49. Oren S, Gossman E, Frochlich ED: Effects of calcium entry blockers on distribution of blood volume. Am J Hypertens 1996; 9: 628-632.
50. Kulick DL, McIntosh N, Campese VM, et al: Central and renal hemodynamic effects and hormonal response to diltiazem in severe congestive heart failure. Am J Cardiol 1987; 59: 1138-1143.
51. Elkayam U, Weber L, Torkan B, et al: Comparison of hemodynamic responses to nifedipine and nitroprusside in severe chronic congestive heart failure. Am J Cardiol 1984; 53: 1321-1325.
52. Crenesse D, Tornieri K, Laurens M, et al: Diltiazem reduces apoptosis in rat hepatocytes subjected to warm hypoxia-reoxygenation. Pharmacoogy 2002; 65: 87-95.
53. Chin S, Ikeda M, Ozaki M, et al: Protective effect of diltiazem on hepatic ischemia-reperfusion injury in rats by improving liver tissue blood flow. Transplant Proc 2005; 37: 4556-4559.
54. Reece TB, Kern JA, Tribble CG, et al: The role of pharmacology in spinal cord protection during thoracic aortic reconstruction. Semin Thorac Cardiovasc Surg 2003; 15: 365-377.
55. Wan S, LeClerc JL, Vincent JL: Cytokine responses from cardiac transplantation. Ann Thora Surg 1997; 63: 269-276.