Expression of survivin and its spliced variants in bladder tumors as a potential prognostic marker

Urology Journal

Volumn 6, Issue 2, 2009, Pages 101-108

  Nouraee, Nazila ^a   Mowla, Seyed Javad ^a   Ozhand, Ardalan ^b   Parvin, Mahmoud ^b   Ziaee, Seyed Amir Mohsen ^b   Hatefi, Nasim ^a,b  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Apoptosis; Bladder neoplasms; Reverse transcriptase polymerase chain reaction; Survivin protein

Indexed keywords

BIRC5 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; TUMOR MARKER;

ADULT; AGED; ARTICLE; BLADDER TUMOR; CANCER STAGING; COHORT ANALYSIS; CYSTECTOMY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MALE; METABOLISM; METHODOLOGY; MIDDLE AGED; MORTALITY; PATHOLOGY; PROGNOSIS; RETROSPECTIVE STUDY; RISK ASSESSMENT; RNA SPLICING; SENSITIVITY AND SPECIFICITY; SURVIVAL; TISSUE CULTURE TECHNIQUE; TRANSITIONAL CELL CARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, TRANSITIONAL CELL; COHORT STUDIES; CYSTECTOMY; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RNA SPLICING; SENSITIVITY AND SPECIFICITY; SURVIVAL ANALYSIS; TISSUE CULTURE TECHNIQUES; TUMOR MARKERS, BIOLOGICAL; URINARY BLADDER NEOPLASMS;

EID: 66549103849     PISSN: 17351308     EISSN: 1735546X     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Spruck CH, 3rd, Ohneseit PF, Gonzalez-Zulueta M, et al. Two molecular pathways to transitional cell carcinoma of the bladder. Cancer Res. 1994;54:784-8.
2. Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science. 1995;267:1456-62.
3. Lowe SW, Lin AW. Apoptosis in cancer. Carcinogenesis. 2000;21:485-95.
4. Rossi D, Gaidano G. Messengers of cell death: apoptotic signaling in health and disease. Haematologica. 2003;88:212-8.
5. Salvesen GS, Duckett CS. IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol. 2002;3:401-10.
6. Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science. 1998;281:1322-6.
7. O'Driscoll L, Linehan R, Clynes M. Survivin: role in normal cells and in pathological conditions. Curr Cancer Drug Targets. 2003;3:131-52.
8. Mahotka C, Wenzel M, Springer E, Gabbert HE, Gerharz CD. Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties. Cancer Res. 1999;59:6097-102.
9. Caldas H, Honsey LE, Altura RA. Survivin 2alpha: a novel Survivin splice variant expressed in human malignancies. Mol Cancer. 2005;4:11.
10. Span PN, Tjan-Heijnen VC, Manders P, van Tienoven D, Lehr J, Sweep FC. High survivin predicts a poor response to endocrine therapy, but a good response to chemotherapy in advanced breast cancer. Breast Cancer Res Treat. 2006;98:223-30.
11. Mowla SJ, Emadi Baygi M, Ziaee SAM, Atlasi Y, Nikpoor P. Evaluation of sensitivity and specificity of urine survivin as a new molecular marker in diagnosis of bladder tumors. Iran J Biotechnol. 2005;3:163-9.
12. Nikpoor P, Mowla SJ, Movahedin M, Ziaee SA, Tiraihi T. CatSper gene expression in postnatal development of mouse testis and in subfertile men with deficient sperm motility. Hum Reprod. 2004;19:124-8.
13. National Center for Biotechnology Information [Home page on the internet]. Blast Human Sequences [cited April 1, 2009]. Available from: http://www.ncbi.nlm.nih.gov/genome/seq/BlastGen/BlastGen.cgi?taxid=9606
14. Sambrook J, Russel DW. Molecular cloning a laboratory manual. 3rd ed. New York: Cold Spring Harbor Laboratory Press; 2001.
15. Babaei E, Mowla SJ, Shariat Torbaghan S, Emadi Bayegi M. Detection of survivin gene expression in formalin-fixed paraffin-embedded tissues of human osteosarcoma: its potential usefulness in diagnosis and prognosis of bone tumors. Iran Biomed J. 2006;10:39-45.
16. Vegran F, Boidot R, Oudin C, Defrain C, Rebucci M, Lizard-Nacol S. Association of p53 gene alterations with the expression of antiapoptotic survivin splice variants in breast cancer. Oncogene. 2007;26:290-7.
17. McCabe ML, Dlamini Z. The molecular mechanisms of oesophageal cancer. Int Immunopharmacol. 2005;5:1113-30.
18. Shen M, Rothman N, Berndt SI, et al. Polymorphisms in folate metabolic genes and lung cancer risk in Xuan Wei, China. Lung Cancer. 2005;49:299-309.
19. Mowla SD, Emadi Baygi M, Ziaee SA, Nikpoor P. Evaluating expression and potential diagnostic and prognostic values of survivin in bladder tumors: a preliminary report. Urol J. 2005;2:141-7.
20. Meng H, Lu C, Mabuchi H, Tanigawa N. Prognostic significance and different properties of survivin splicing variants in gastric cancer. Cancer Lett. 2004;216:147-55.