Synthesis of α-carboranyl-α-acyloxy-amides as potential BNCT agents

Tetrahedron Letters

Volumn 50, Issue 30, 2009, Pages 4314-4317

  Jonnalagadda, Subash C ^a   Cruz, Jonathan S ^a   Connell, Ryan J ^b   Scott, Patricia M ^b   Mereddy, Venkatram R ^b  

^a ROWAN UNIVERSITY   (United States)

^b UNIVERSITY OF MINNESOTA DULUTH   (United States)

Author keywords

Boron neutron capture therapy; Carboranes; Isonitriles; Low density lipoprotein; Multicomponent reactions

Indexed keywords

AMIDE; ANTINEOPLASTIC AGENT; CARBORANE DERIVATIVE; CYTOTOXIC AGENT; LOW DENSITY LIPOPROTEIN RECEPTOR;

ARTICLE; BRAIN TUMOR; CANCER CELL CULTURE; CELL VIABILITY; CHEMICAL REACTION; DRUG CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; NEUTRON CAPTURE THERAPY;

EID: 66449131273     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.05.026     Document Type: Article

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27. oC in DMEM containing 10% fetal bovine serum and 1% primocin. Cells were plated in 96-well plates at 2000 cells per well and were allowed to adhere for 18 h. Cells were then treated with each compound (50 μM) or with 0.3% DMSO alone for 18 h. The MTS tetrazolium salt assay was used for determining the number of remaining viable cells after exposure to compounds. Twenty microliters of MTS were added to 100-μl culture medium in each well. After incubation at 37 °C for three hours, absorbance at 490 nm was measured using an ELISA plate reader. MTS is converted to a formazan dye by the enzyme dehydrogenase found in the active cells. The quantity of formazan product measured by absorbance at 490 nm is directly proportional to the number of living cells in culture. Percent survival represents the ratio of viable cells remaining in compound-treated cells to viable cells remaining in DMSO-treated cells. As mentioned earlier, all the compounds that were tested under these conditions proved to be non-toxic at 50 μM.