In Vitro Uptake of a New Cholesteryl Carborane Ester Compound by Human Glioma Cell Lines

Journal of Pharmaceutical Sciences

Volumn 93, Issue 1, 2004, Pages 13-19

  Peacock, Gina ^a   Sidwell, Richard ^b   Pan, Guangliang ^b   Øie, Svein ^b   Lu, D Robert ^a,c  

^a SHENANDOAH UNIVERSITY   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c TEMPLE UNIVERSITY   (United States)

Author keywords

Boron; Cellular uptake and retaining; Cholesteryl conjugate; Lipoprotein; Liposomes; Tumor

Indexed keywords

BORON; CARBORANE DERIVATIVE; CHOLESTEROL ESTER; CHOLESTERYL 1,12 DICARBADODECABORANE CARBOXYLATE; CHOLESTERYL CARBORANE ESTER; LIPOPROTEIN; LIPOSOME; UNCLASSIFIED DRUG;

ARTICLE; BRAIN NERVE CELL; CANCER CELL CULTURE; CHOLESTEROL TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG FORMULATION; DRUG STRUCTURE; DRUG UPTAKE; EVALUATION; GLIOBLASTOMA; GLIOMA CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; TIME;

EID: 0346494442     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10452     Document Type: Article

References (15)

1. Leibel SA. 1998. Primary and metastatic brain tumors in adults. In: Leibel SA, Phillips TL, editors. Textbook of radiation oncology. Philadelphia, PA: WB Saunders Company, pp 293-323.
2. Maletinska L, Blakely EA, Bjornstad KA, Deen DF, Knoff JJ, Forte TM. 2000. Human glioblastoma cell lines: Levels of low-density lipoprotein receptor and low-density lipoprotein receptor-related protein. Cancer Res 60:2300-2303.
3. Ho YK, Smith RG, Brown MS, Goldstien JL. 1978. Low-density lipoprotein (LDL) receptor activity in acute myelogenous leukemia cells. Blood 52:1099-1114.
4. Laster BH, Kahl SB, Popenoe EA, Pate DW, Fairchild RG. 1991. Biological efficacy of boronated low-density lipoprotein for boron neutron capture therapy as measured in cell culture. Cancer Res 51: 4588-4593.
5. Firestone RA. 1994. Low-density lipoprotein as a vehicle for targeting antitumor compounds to cancer cells. Bioconjug Chem 5:105-113.
6. Vitols S, Gahrton G, Peterson C. 1984. Significance of the low-density lipoprotein receptor pathway for the in vitro accumulation of AD-32 incorporated into LDL in normal and leukemic white blood cells. Cancer Treat Rep 68:515-520.
7. Vitols S, Angelin B, Ericsson S, Gahrton G, Juliusson G, Masquelier M, Paul C, Peterson C, Rudling M, Soderberg-Reid K, Tidefelt U. 1990. Uptake of low density lipoproteins by human leukemic cells in vivo: Relation to plasma lipoprotein levels and possible relevance for selective chemotherapy. Proc Natl Acad Sci USA 87:2598-2602.
8. Vitols S, Peterson C, Larsson O, Holm P, Aberg B. 1987. Elevated uptake of low-density lipoproteins by human lung cancer tissue in vivo. Cancer Res 47: 4105-4108.
9. Rudling MJ, Angelin B, Peterson CO, Collins VP. 1990. Low-density lipoprotein receptor activity in human intracranial tumors and its relation to the cholesterol requirement. Cancer Res 50:483-487.
10. Rudling MJ, Collins VP, Peterson CO. 1983. Delivery of aclacinomycin A to human glioma cells in vitro by the low-density lipoprotein pathway. Cancer Res 43:4600-4605.
11. Gutman RL, Peacock G, Lu DR. 2000. Targeted drug delivery for brain cancer treatment. J Control Release 65:31-41.
12. Shelly K, Feakes DA, Hawthorne MF, Schmidt PG, Krisch TA, Bauer WF. 1992. Model studies directed toward the boron neutron-capture therapy of cancer: Boron delivery to murine tumors with liposomes. Proc Natl Acad Sci USA 89:9039-9043.
13. Hawthorne MF, Shelly K. 1997. Liposomes as drug delivery vehicles for boron agents. J Neurooncol 33: 53-58.
14. Ji B, Peacock G, Lu DR. 2002. Synthesis of cholesterol-carborane conjugate for targeted drug delivery. Bioorg Med Chem Lett 12:2455-2458.
15. Peacock G, Ji B, Wang CK, Lu DR. 2003. Cell culture studies of a carborane cholesteryl ester with conventional and PEG liposomes. Drug Deliv 10:29-34.