Synthesis and evaluation of 4-bromo-1-(3-[18F]fluoropropyl)-2- nitroimidazole with a low energy LUMO orbital designed as brain hypoxia-targeting imaging agent

Biological and Pharmaceutical Bulletin

Volumn 25, Issue 5, 2002, Pages 616-621

  Yamamoto, Fumihiko ^a   Aoki, Mizuho ^c   Furusawa, Yoshiya ^c   Ando, Koichi ^c   Kuwabara, Yasuo ^b   Masuda, Kouji ^b   Sasaki, Shigeki ^a   Maeda, Minoru ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

Biodistribution; Brain tissue; Fluorine 18; Nitroimidazole; Tumor

Indexed keywords

3 METHYLCHOLANTHRENE; 4 BROMO 1 (3 FLUOROPROPYL) 2 NITROIMIDAZOLE; ARGININE DERIVATIVE; FLUORIDE ION; FLUORINE 18; HYDRALAZINE; NITROIMIDAZOLE DERIVATIVE; RADIOSENSITIZING AGENT; TOLUENESULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; 1 FLUORO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; 4-BROMO-1-(3-FLUOROPROPYL)-2-NITROIMIDAZOLE; DIAGNOSTIC AGENT; DRUG DERIVATIVE; FLUORINE; LIPID; MISONIDAZOLE; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; CALCULATION; CELL FRACTIONATION; CONTROLLED STUDY; ENERGY; FIBROSARCOMA; HYPOXIC CELL; IN VITRO STUDY; LIPOPHILICITY; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; RADIOCHEMISTRY; RADIOSENSITIZATION; SYNTHESIS; TISSUE DISTRIBUTION; TUMOR LOCALIZATION; ANIMAL; BIOTRANSFORMATION; C3H MOUSE; CHEMISTRY; CHO CELL; COMPARATIVE STUDY; ELECTRON; EXPERIMENTAL NEOPLASM; HAMSTER; PHYSICAL CHEMISTRY; RAT; SCINTISCANNING; WISTAR RAT;

ANIMALS; BIOTRANSFORMATION; CHEMISTRY, PHYSICAL; CHO CELLS; CRICETINAE; ELECTRONS; FLUORINE RADIOISOTOPES; HYPOXIA, BRAIN; LIPIDS; MICE; MICE, INBRED C3H; MISONIDAZOLE; NEOPLASMS, EXPERIMENTAL; NITROIMIDAZOLES; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

EID: 0036579822     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.25.616     Document Type: Article

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