Noninvasive assessment of tumor hypoxia with 99mTc labeled metronidazole

Pharmaceutical Research

Volumn 16, Issue 5, 1999, Pages 743-750

  Yang, David J ^a   Ilgan, Seyfettin ^a   Higuchi, Tetsuya ^a   Zareneyrizi, Fereshteh ^a   Oh, Chang Sok ^a   Liu, Chun Wei ^a   Kim, Edmund E ^a   Podoloff, Donald A ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

99mTc; Imaging; Metronidazole; Radiosensitizer; Tumor hypoxia

Indexed keywords

1 (3 DIMETHYLAMINOPROPYL) 3 ETHYLCARBODIIMIDE; 1 FLUORO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL F 18; CHELATING AGENT; IODOMISONIDAZOLE I 131; METRONIDAZOLE; N,N' ETHYLENEDICYSTEINE TC 99M; RADIOPHARMACEUTICAL AGENT; SUCCINIMIDE DERIVATIVE; TECHNETIUM 99M; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST TUMOR; CONTROLLED STUDY; DRUG CONJUGATION; FEMALE; GAMMA SCINTIGRAPHY; HYPOXIA; IMAGING SYSTEM; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION; WHOLE BODY AUTORADIOGRAPHY;

ANIMALS; AUTORADIOGRAPHY; CELL HYPOXIA; CYSTEINE; FEMALE; FLUORINE RADIOISOTOPES; IODINE RADIOISOTOPES; MAMMARY NEOPLASMS, EXPERIMENTAL; METRONIDAZOLE; MICROELECTRODES; MISONIDAZOLE; NEOVASCULARIZATION, PATHOLOGIC; ORGANOTECHNETIUM COMPOUNDS; OXYGEN; RADIATION-SENSITIZING AGENTS; RADIONUCLIDE IMAGING; RATS; RATS, INBRED F344; TISSUE DISTRIBUTION;

EID: 0032909824     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018836911013     Document Type: Article

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