Unfractionated heparin and new heparin analogues from ascidians (chordate-tunicate) ameliorate colitis in rats

Journal of Biological Chemistry

Volumn 284, Issue 17, 2009, Pages 11267-11278

  Belmiro, Celso L R ^a   Castelo Branco, Morgana T L ^a   Melim, Leandra M C ^a   Schanaider, Alberto ^a   Elia, Celeste ^a   Madi, Kalil ^a   Pavão, Mauro S G ^a   de Souza, Heitor S P ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-INFLAMMATORY EFFECTS; CELLULAR LEVELS; DERMATAN SULFATE; EPITHELIAL CELLS; KINASE ACTIVATION; MOLECULAR LEVELS; THERAPEUTIC USE; UNFRACTIONATED HEPARINS;

CELL DEATH; CHEMICAL ACTIVATION; PATHOLOGY; RATS;

POLYSACCHARIDES;

BIOLOGICAL PRODUCT; DERMATAN SULFATE; GLYCOSAMINOGLYCAN; HEPARIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; STYELA PLICATA EXTRACT; TRANSFORMING GROWTH FACTOR BETA; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN; COLLAGEN; DRUG DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; ASCIDIACEA; COLITIS; COLON; CONTROLLED STUDY; DRUG DETERMINATION; DRUG ISOLATION; ENZYME ACTIVATION; FIBROSIS; HISTOPATHOLOGY; LYMPHOCYTE; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; RAT; STYELA PLICATA; WISTAR RAT; ANIMAL; BIOLOGICAL MODEL; BLEEDING; CHORDATA; MALE; METABOLISM; PATHOLOGY;

ASCIDIA; ASCIDIACEA; INVERTEBRATA; MAMMALIA; RATTUS; STYELA PLICATA;

ANIMALS; APOPTOSIS; CHORDATA; COLITIS; COLLAGEN; COLON; FIBROSIS; HEMORRHAGE; HEPARIN; LYMPHOCYTES; MACROPHAGES; MALE; MODELS, BIOLOGICAL; RATS; RATS, WISTAR;

EID: 66449104935     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M807211200     Document Type: Article

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