Structure of the complex of a mitotic kinesin with its calcium binding regulator

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 20, 2009, Pages 8175-8179

  Vinogradova, Maia V ^a   Malanina, Galina G ^a   Reddy, Anireddy S N ^b   Fletterick, Robert J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Calmodulin; EF hand; Motor; Regulation

Indexed keywords

ADENOSINE DIPHOSPHATE; BINDING PROTEIN; KINESIN; KINESIN LIKE CALMODULIN BINDING PROTEIN; KINESIN LIKE CALMODULIN BINDING PROTEIN INTERACTING CALCIUM BINDING PROTEIN; MOLECULAR MOTOR; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; CALCIUM BINDING; CRYSTAL STRUCTURE; ENZYME STRUCTURE; MITOSIS; MOLECULAR INTERACTION; MOLECULAR MIMICRY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; STEREOSPECIFICITY;

ARABIDOPSIS PROTEINS; CALCIUM-BINDING PROTEINS; CALMODULIN-BINDING PROTEINS; CRYSTALLOGRAPHY, X-RAY; KINESIN; MICROTUBULE-ASSOCIATED PROTEINS; MITOSIS; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 66349123278     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0811131106     Document Type: Article

References (34)

1. Schliwa M, Woehlke G (2003) Molecular motors. Nature 422:759-765.
2. Vale RD (2003) The molecular motor toolbox for Intracellular transport, Cell 112:467480,
3. Kull FJ, Sablin EP, Lau R, Fletterick RJ, Vale RD (1996) Crystal structure of the kinesin motor domain reveals a structural similarity to myosin, Nature 380:550-555,
4. Sablin EP, Kull FJ, Cooke R, Vale RD, Fletterick RJ (1996) Crystal structure of the motor domain of the kinesin-related motor ncd, Nature 380:555-559,
5. Vale RD, Milligan RA (2000) The way things move: Looking under the hood of molecular motor proteins, Science 288:88-95,
6. Sablin EP, et al, (1998) Direction determination In the minus-end-directed kinesin motor ncd, Nature 395:813-816,
7. Rice S, etal, (1999) A structural change In the kinesin motor protein that drives motility, Nature 402:778-784,
8. Kozielski F, etal, (1997) The crystal structure of dimeric kinesin and Implications for microtubule-dependent motility, Cell 91:985-994,
9. Sindelar CV, et al, (2002) Two conformations In the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy, Nat Struct Biol 9:844-848,
10. Turner J, etal. (2001) Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker, J Biol Chem 276:25496-25502,
11. Verhey KJ, etal, (1998) Light chain-dependent regulation of kinesin's Interaction with microtubules, J Cell Biol 143:1053-1066,
12. Blasius TL, Cal D, Jih GT, Toret CP, Verhey KJ (2007) Two binding partners cooperate to activate the molecular motor Kinesin-1, J Cell Biol 176:11-17,
13. Hackney DD, Stock MF (2000) Kinesin's IAK tall domain Inhibits Initial microtubulestimulated ADP release. Nat Cell Bioi 2:257-260.
14. Lee JR, et al. (2004) An Intramolecular Interaction between the FHA domain and a colled coll negatively regulates the kinesin motor KIF1A. EMBO J 23:1506-1515,
15. Bathe F, etal, (2005) The complex Interplay between the neck and hinge domains In kinesin-1 dimerization and motor activity, Mol Biol Cell 16:3529-3537,
16. Espeut J, et al, (2008) Phosphorylation relieves autoInhibition of the kinetochore motor Cenp-E, Mol Cell 29:637-643,
17. Dietrich KA, et al, (2008) The kinesin-1 motor protein Is regulated by a direct Interaction of Its head and tall, Proc Natl Acad Sci USA 105:8938-8943,
18. 2+-dependent regulation of klneslnmediated mitochondrial motility, Cell 136:163-174,
19. Reddy AS, Safadi F, Narasimhulu SB, Golovkin M, Hu X (1996) A novel plant calmodulinbinding protein with a kinesin heavy chain motor domain, J Biol Chem 271:7052-7060,
20. Vos JW, Safadi F, Reddy ASN, Hepler PK (2000) The kinesin-like calmodulin binding protein Is differentially Involved In cell division, Plant Cell 12:979-990,
21. Kao YL, Deavours BE, Phelps KK, Walker RA, Reddy AS (2000) Bundling of microtubules by motor and tall domains of a kinesin-like calmodulin-binding protein from Arabldopsis'. Regulation by Ca(2+)/calmodulin, Biochem Biophys Res Commun 267:201-207,
22. Deavours BE, Reddy AS, Walker RA (1998) Ca2-/calmodulin regulation of the Arabldopsis kinesin-like calmodulin-binding protein, Cell Motil Cytoskeleton 40:408-416,
23. Reddy VS, Day IS, Thomas T, Reddy AS (2004) KIC, a novel Ca2+ binding protein with one EF-hand motif, Interacts with a microtubule motor protein and regulates trichome morphogenesis, Plant Cell 16:185-200,
24. Narasimhulu SB, Reddy AS (1998) Characterization of microtubule binding domains In the Arao/dops/s kinesin-like calmodulin binding protein, Plant Cell 10:957-965,
25. Vinogradova MV, Reddy VS, Reddy AS, Sablin EP, Fletterick RJ (2004) Crystal structure of kinesin regulated by Ca(2+)-calmodulin, J Biol Chem 279:23504-23509,
26. Vinogradova MV, Malanina GG, Reddy VS, Reddy AS, Fletterick RJ (2008) Structural dynamics of the microtubule binding and regulatory elements In the kinesin-like calmodulin binding protein, J Struct Biol 163:76-83,
27. Gifford JL, Walsh MP, Vogel HJ (2007) Structures and metal-ion-binding properties of the Ca2+-binding helix-loop-helix EF-hand motifs, Biochem J 405:199-221,
28. Vinogradova MV, et al, (2005) Ca(2-)-regulated structural changes In troponin, Proc Natl Acad Sci USA 102:5038-5043,
29. MénétreyJ, etal, (2008) The post-rigor structure of myosin Viand Implications for the recovery stroke, EMBO J 27:244-252,
30. Clapperton J, et al, (2002) Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: Studies of the kinase activation mechanism, Biochemistry 41:14669-14679,
31. Kawasaki H, NakayamaS, KretsingerRH (1998) Classification and evolution of EF-hand proteins, BioMetals 11:277-295,
32. Sablin EP, Fletterick RJ (2004) Coordination between motor domains In processive kinesins, J Biol Chem 279:15707-15710,
33. Kikkawa M, etal, (2001) Switch-based mechanism of kinesin motors, Nature 411:439445.
34. Hirose K, Akimaru E, Akiba T, Endow SA Amos LA (2006) Large conformational changes In a kinesin motor catalyzed by Interaction with microtubules. Mol Cell 23:913-923.