An atom economic synthesis and antitubercular evaluation of novel spiro-cyclohexanones

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 13, 2009, Pages 3461-3465

  Ranjith Kumar, Raju ^a   Perumal, Subbu ^a   Manju, S C ^a   Bhatt, Pritesh ^b   Yogeeswari, Perumal ^b   Sriram, Dharmarajan ^b  

^a MADURAI KAMARAJ UNIVERSITY   (India)

^b BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

1,3 Dipolar cycloaddition; Antimycobacterial activity; Atom economy; Azomethine ylide; Spirocyclohexanone

Indexed keywords

1,3 THIAZOLANE 4 CARBOXYLIC ACID; 2,6 BIS(METHYLIDENE)CYCLOHEXANONE DERIVATIVE; 4 (2,4 DICHLOROPHENYL) 5 PHENYLPYRROLO(SPIRO[2.2'']ACENAPHTHEN 1'' ONE)SPIRO[3.2'] 6' (2,4 DICHLOROPHENYLMETHYLIDENE)CYCLOHEXANONE; ACENAPHTHENEQUINONE; ALPHA AMINO ACID; AZOMETHINE YLIDE; CYCLOHEXANONE DERIVATIVE; ETHAMBUTOL; PHENYLGLYCINE; PROLINE; PYRAZINAMIDE; SARCOSINE; SPIRO[5.2'']ACENAPHTHEN 1'' ONESPIRO[6.2'] 6' (2,4 DICHLOROPHENYLMETHYLIDENE)CYCLOHEXANONE 7 (2,4 DICHLOROPHENYL)TETRAHYDRO 1H PYRROLO[1,2 C][1,3]THIAZOLE; SPIROCYCLOHEXANONE DERIVATIVE; UNCLASSIFIED DRUG;

AGAR DILUTION; ANTIBACTERIAL ACTIVITY; ARTICLE; CYCLOADDITION; DRUG STRUCTURE; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; STEREOCHEMISTRY;

ANTITUBERCULAR AGENTS; CRYSTALLOGRAPHY, X-RAY; CYCLOHEXANONES; MOLECULAR CONFORMATION; MYCOBACTERIUM TUBERCULOSIS; SPIRO COMPOUNDS; STEREOISOMERISM;

MYCOBACTERIUM TUBERCULOSIS;

EID: 66349116680     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.05.018     Document Type: Article

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18. 3) 206.8, 203.3, 142.1, 139.4, 137.8, 137.5, 136.8, 135.6, 132.4, 131.8, 130.3, 129.7, 128.7, 128.2, 128.1, 128.0, 127.9, 126.8, 125.2, 125.1, 120.2, 80.0, 65.4, 58.3, 49.6, 34.8, 30.9, 28.0, 20.2.
19. 3) 205.0, 204.4, 141.5, 141.3, 138.4, 137.8, 137.7, 137.1, 135.5, 131.8, 131.7, 130.6, 130.4, 129.8, 128.6, 128.3, 128.2, 128.1, 127.6, 127.4, 126.8, 125.1, 124.3, 121.6, 77.1, 66.1, 65.9, 61.6, 30.4, 28.1, 20.2.
20. 3) 205.2, 199.5, 137.7, 136.6, 135.5, 134.5, 134.4, 134.2, 133.3, 132.4, 132.3, 131.7, 131.4, 130.8, 130.5, 129.4, 129.2, 129.1, 127.9, 127.3, 126.4, 125.8, 125.6, 121.0, 77.4, 70.5, 68.7, 48.6, 45.2, 32.7, 31.2, 27.8, 19.3.
21. 3) 207.2, 202.6, 141.0, 138.2, 138.0, 137.4, 135.2, 134.8, 133.4, 130.5, 130.3, 129.7, 129.3, 128.2, 128.1, 128.0, 127.9, 126.8, 124.9, 122.2, 119.8, 83.2, 70.8, 65.9, 58.2, 48.4, 33.6, 30.0, 27.3, 25.5, 21.3.
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