Facile synthesis of active antitubercular, cytotoxic and antibacterial agents: A Michael addition approach

European Journal of Medicinal Chemistry

Volumn 40, Issue 11, 2005, Pages 1143-1148

  Chande, Madhukar S ^a   Verma, Ranjit S ^a   Barve, Pravin A ^a   Khanwelkar, Rahul R ^a   Vaidya, R B ^a   Ajaikumar, K B ^b  

^a INSTITUTE OF SCIENCE   (India)

^b Amla Cancer Research Center   (India)

Author keywords

Antibacterial; Antitubercular; Cytotoxic; Dieckmann condensation; Isoxazolone; Michael addition; Oxindole; Thorpe Ziegler cyclization

Indexed keywords

2 AZA 3,4 BENZ 7 CYANO 2 ETHYL 8 IMINO 1 OXOSPIRO[5.4]DECANE; 3 [3 (2 METHOXYCARBONYLETHYL) 1 ETHYL 2 OXO 2,3 DIHYDRO 1H INDOL 3 YL]PROPIONIC ACID; 3 [4 (2 CYANOETHYL) 5 OXO 3 PHENYL 4,5 DIHYDROISOXAZOL 4 YL]PROPIONITRILE; 3 AZA 1,8 DIOXO 7 METHOXYCARBONYL 2 OXA 4 PHENYLSPIRO[4.5]DEC 3 ENE; ANTIINFECTIVE AGENT; CYTOTOXIC AGENT; ISOXAZOLE DERIVATIVE; OXINDOLE; SPIRO COMPOUND; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG ACTIVITY; DRUG SYNTHESIS; MICHAEL ADDITION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; POLYMERIZATION;

ALKYLATION; ANDROSTENOLS; ANIMALS; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; ANTITUBERCULAR AGENTS; CELL SURVIVAL; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; INDOLES; MICE; MICROBIAL SENSITIVITY TESTS; SPIRO COMPOUNDS; TUMOR CELLS, CULTURED;

EID: 26844449924     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.06.004     Document Type: Article

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