Investigation of residues Lys112, Glu136, His138, Gly247, Tyr248, and Asp249 in the active site of yeast cystathionine β-synthase

Biochemistry and Cell Biology

Volumn 87, Issue 3, 2009, Pages 531-540

  Lodha, Pratik H ^a   Shadnia, Hooman ^a   Woodhouse, Colleen M ^a   Wright, James S ^a   Aitken, Susan M ^a  

^a CARLETON UNIVERSITY   (Canada)

Author keywords

Cystathionine; Homocysteine; Homocystinuria; Pyridoxal 5 phosphate; Transsulfuration

Indexed keywords

ACTIVE SITE; CATALYTIC CORE; CYSTATHIONINE; HOMOCYSTEINE; HOMOCYSTINURIA; IN-SILICO; L-SERINE; POLAR RESIDUES; REPLACEMENT REACTIONS; SITE DIRECTED MUTAGENESIS; SYNTHASE; TRANSSULFURATION;

AMINO ACIDS; CONTEXT SENSITIVE GRAMMARS; ELECTRIC CIRCUIT BREAKERS; ENZYMES; SUBSTITUTION REACTIONS; YEAST;

BINDING SITES;

ASPARTIC ACID; CYSTATHIONINE; CYSTATHIONINE BETA SYNTHASE; GLUTAMINE; GLYCINE; HISTIDINE; HOMOCYSTEINE; LYSINE; PYRIDOXAL 5 PHOSPHATE; SERINE; TYROSINE;

ARTICLE; CATALYSIS; COMPUTER MODEL; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENE CONSTRUCT; GENE MUTATION; GENETIC ASSOCIATION; HOMOCYSTINURIA; MATHEMATICAL ANALYSIS; MOLECULAR DOCKING; NONHUMAN; PREDICTION; SITE DIRECTED MUTAGENESIS; YEAST;

AMINO ACIDS; CATALYTIC DOMAIN; CYSTATHIONINE BETA-SYNTHASE; HUMANS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; SACCHAROMYCES CEREVISIAE;

EID: 66349116162     PISSN: 08298211     EISSN: 12086002     Source Type: Journal    
DOI: 10.1139/O09-003     Document Type: Article

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