Characterization of biopartitioning micellar chromatography system using monolithic column by linear solvation energy relationship and application to predict blood-brain barrier penetration

Journal of Chromatography A

Volumn 1216, Issue 27, 2009, Pages 5190-5198

  Lu, Rong ^a   Sun, Jin ^a   Wang, Yongjun ^a   Li, Haiyan ^a   Liu, Jianfang ^a   Fang, Liang ^a   He, Zhonggui ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Biopartitioning micellar chromatography; Blood brain barrier; Linear solvation energy relationship; Monolithic column

Indexed keywords

BIOLOGICAL PROCESS; BIOMEMBRANE; BIOPARTITIONING MICELLAR CHROMATOGRAPHIES; BIOPARTITIONING MICELLAR CHROMATOGRAPHY; BLOOD-BRAIN BARRIER; DRUG PENETRATION; HIGH-FLOW RATE; HIGH-THROUGHPUT; HIGH-THROUGHPUT ANALYSIS; LINEAR SOLVATION ENERGY RELATIONSHIP; LINEAR SOLVATION ENERGY RELATIONSHIPS; MOLAR REFRACTIONS; MONOLITHIC COLUMN; MONOLITHIC COLUMNS; ORAL ABSORPTION; PREDICTIVE CAPABILITIES; TRANSDERMAL; TRANSPORT PROCESS;

BLOOD; BRAIN; CHROMATOGRAPHIC ANALYSIS; HYSTERESIS MOTORS; PRINCIPAL COMPONENT ANALYSIS; SOLVATION;

COLUMN CHROMATOGRAPHY;

ACETYLSALICYLIC ACID; ALPRAZOLAM; AMINOPHENAZONE; AMITRIPTYLINE; AMOBARBITAL; ATENOLOL; ATROPINE; BENZENE; CAFFEINE; CARBAMAZEPINE; CHLORPROMAZINE; CLONIDINE; DIAZEPAM; ETHYLBENZENE; HALOPERIDOL; IBUPROFEN; IMIPRAMINE; MIANSERIN; MIDAZOLAM; OXAZEPAM; PARACETAMOL; PENTOBARBITAL; PHENAZONE; PHENYLBUTAZONE; PHENYTOIN; PHYSOSTIGMINE; PROPRANOLOL; SALICYLIC ACID; UNINDEXED DRUG; XYLENE;

ARTICLE; BIOPARTITIONING MICELLAR CHROMATOGRAPHY; BLOOD BRAIN BARRIER; CHROMATOGRAPHY; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG PENETRATION; DRUG TRANSPORT; FLOW RATE; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; SOLVATION;

BLOOD-BRAIN BARRIER; CHROMATOGRAPHY, LIQUID; MICELLES; MODELS, BIOLOGICAL; ORGANIC CHEMICALS; PERMEABILITY; SOLVENTS;

EID: 66249113910     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2009.05.007     Document Type: Article

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