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Volumn 13, Issue 4, 1999, Pages 443-452

Review article: Anthranoid laxatives and their potential carcinogenic effects

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRANOID LAXATIVE; ANTHRAQUINONE; LAXATIVE; UNCLASSIFIED DRUG;

EID: 0032891538     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.1999.00468.x     Document Type: Review
Times cited : (154)

References (107)
  • 1
    • 0027486881 scopus 로고
    • The senna drug and its chemistry
    • Franz G. The senna drug and its chemistry. Pharmacol 1993; 47(Suppl. 1): 2-6.
    • (1993) Pharmacol , vol.47 , Issue.SUPPL. 1 , pp. 2-6
    • Franz, G.1
  • 2
    • 0018854928 scopus 로고
    • A review of the genetic effects of naturally occurring flavonoids, anthraquinones and related compounds
    • Brown JP. A review of the genetic effects of naturally occurring flavonoids, anthraquinones and related compounds. Mutation Res 1980; 75: 243-77.
    • (1980) Mutation Res , vol.75 , pp. 243-277
    • Brown, J.P.1
  • 3
    • 0017190047 scopus 로고
    • Anthraquinone derivatives in vegetable laxatives
    • Van Os FHL. Anthraquinone derivatives in vegetable laxatives. Pharmacol 1976; 14(Suppl. 1): 7-17.
    • (1976) Pharmacol , vol.14 , Issue.SUPPL. 1 , pp. 7-17
    • Van Os, F.H.L.1
  • 4
    • 0027372488 scopus 로고
    • Metabolism and pharmacokinetics of anthranoids
    • De Witte P. Metabolism and pharmacokinetics of anthranoids. Pharmacol 1993; 47(Suppl. 1): 86-97.
    • (1993) Pharmacol , vol.47 , Issue.SUPPL. 1 , pp. 86-97
    • De Witte, P.1
  • 5
    • 0023855586 scopus 로고
    • Metabolism of sennosides - An overview
    • Lemli J. Metabolism of sennosides - An overview. Pharmacol 1988; 36(Suppl. 1): 126-8.
    • (1988) Pharmacol , vol.36 , Issue.SUPPL. 1 , pp. 126-128
    • Lemli, J.1
  • 6
    • 0019822014 scopus 로고
    • The metabolism of sennosides A and B by the intestinal microflora: In vitro and in vivo studies on the rat and the mouse
    • Dreessen M, Eyssen H, Lemli J. The metabolism of sennosides A and B by the intestinal microflora: In vitro and in vivo studies on the rat and the mouse. J Pharm Pharmacol 1981; 33: 679-81.
    • (1981) J Pharm Pharmacol , vol.33 , pp. 679-681
    • Dreessen, M.1    Eyssen, H.2    Lemli, J.3
  • 7
    • 0025667979 scopus 로고
    • The metabolism of anthranoid laxatives
    • De Witte P, Lemli L. The metabolism of anthranoid laxatives. Hepatogastroenterol 1990; 37: 601-5.
    • (1990) Hepatogastroenterol , vol.37 , pp. 601-605
    • De Witte, P.1    Lemli, L.2
  • 8
    • 0021895367 scopus 로고
    • 2 synthesis and water and electrolyte secretion by senna anthraquinones is inhibited by indomethacin
    • 2 synthesis and water and electrolyte secretion by senna anthraquinones is inhibited by indomethacin. J Pharm Pharmacol 1985; 37: 248-51.
    • (1985) J Pharm Pharmacol , vol.37 , pp. 248-251
    • Beubler, E.1    Kollar, G.2
  • 9
    • 0018886065 scopus 로고
    • Metabolism of sennosides and rhein in the rat
    • Lemli J, Lemmens L. Metabolism of sennosides and rhein in the rat. Pharmacol 1980: 20(Suppl. 1): 50-7.
    • (1980) Pharmacol , vol.20 , Issue.SUPPL. 1 , pp. 50-57
    • Lemli, J.1    Lemmens, L.2
  • 10
    • 0017090854 scopus 로고
    • Pharmacokinetics and metabolism of anthraquinone laxatives
    • Breimer DD, Baars AJ. Pharmacokinetics and metabolism of anthraquinone laxatives. Pharmacol 1976; 14(Suppl. 1): 30-47.
    • (1976) Pharmacol , vol.14 , Issue.SUPPL. 1 , pp. 30-47
    • Breimer, D.D.1    Baars, A.J.2
  • 11
    • 0018266173 scopus 로고
    • Laxatives: An update on mechanism of action
    • Gaginella TS, Bass P. Laxatives: An update on mechanism of action. Life Sci 1978; 23: 1001-10.
    • (1978) Life Sci , vol.23 , pp. 1001-1010
    • Gaginella, T.S.1    Bass, P.2
  • 12
    • 0021887934 scopus 로고
    • Comparative physiological disposition of some anthraquinone glycosides and aglycones
    • Moreau JP, Moreau S, Skinner S. Comparative physiological disposition of some anthraquinone glycosides and aglycones. Biopharm Drug Disp 1985; 6: 325-34.
    • (1985) Biopharm Drug Disp , vol.6 , pp. 325-334
    • Moreau, J.P.1    Moreau, S.2    Skinner, S.3
  • 13
    • 0022471735 scopus 로고
    • Dual effect of orally administered sennasides on large intestine transit and fluid absorption in the rat
    • Leng-Peschlow E. Dual effect of orally administered sennasides on large intestine transit and fluid absorption in the rat. J Pharm Pharmacol 1986; 38: 606-10.
    • (1986) J Pharm Pharmacol , vol.38 , pp. 606-610
    • Leng-Peschlow, E.1
  • 14
    • 0018896018 scopus 로고
    • Effect of rhein on the transport of electrolytes, water and carbohydrates in the human jejunum and colon
    • Ewe K. Effect of rhein on the transport of electrolytes, water and carbohydrates in the human jejunum and colon. Pharmacol 1980; 20(Suppl. 1): 27-35.
    • (1980) Pharmacol , vol.20 , Issue.SUPPL. 1 , pp. 27-35
    • Ewe, K.1
  • 15
    • 0018822626 scopus 로고
    • Influence of rhein on electrolyte and water transfer in the isolated rat colonic mucosa
    • Wanitschke R. Influence of rhein on electrolyte and water transfer in the isolated rat colonic mucosa. Pharmacol 1980; 20(Suppl. 1): 21-6.
    • (1980) Pharmacol , vol.20 , Issue.SUPPL. 1 , pp. 21-26
    • Wanitschke, R.1
  • 16
    • 0025009755 scopus 로고
    • A comparison in vitro of human and rabbit distal colonic muscle responses to inflammatory mediators
    • Percy WH, Burton MB, Fallick F, Burakoff R. A comparison in vitro of human and rabbit distal colonic muscle responses to inflammatory mediators. Gastroenterology 1990; 99: 1324-32.
    • (1990) Gastroenterology , vol.99 , pp. 1324-1332
    • Percy, W.H.1    Burton, M.B.2    Fallick, F.3    Burakoff, R.4
  • 17
    • 0027485241 scopus 로고
    • Motor dysfunction of the small bowel and colon in patients with the carcinoid syndrome and diarrhea
    • Van der Ohe MR, Camilleri M, Kvols LK, Thomforde GM. Motor dysfunction of the small bowel and colon in patients with the carcinoid syndrome and diarrhea. N Engl J Med 1993; 329: 1073-8.
    • (1993) N Engl J Med , vol.329 , pp. 1073-1078
    • Van der Ohe, M.R.1    Camilleri, M.2    Kvols, L.K.3    Thomforde, G.M.4
  • 18
    • 0026753235 scopus 로고
    • Influence of rhein anthrone and rhein on small intestine transit in rats; evidence of prostaglandin mediation
    • Nijs G, De Witte P, Geboes K, Lemli J. Influence of rhein anthrone and rhein on small intestine transit in rats; evidence of prostaglandin mediation. Eur J Pharmacol 1992; 218: 199-203.
    • (1992) Eur J Pharmacol , vol.218 , pp. 199-203
    • Nijs, G.1    De Witte, P.2    Geboes, K.3    Lemli, J.4
  • 19
    • 0023872873 scopus 로고
    • Involvement of prostaglandin E-like material in the propulsive action of rhein anthrone, the intraluminal active metabolite of sennosides A and B in mice
    • Yagi T, Miyawaki Y, Nishikawa T, Yamauchi K, Kuwano S. Involvement of prostaglandin E-like material in the propulsive action of rhein anthrone, the intraluminal active metabolite of sennosides A and B in mice. J Pharm Pharmacol 1988; 40: 27-30.
    • (1988) J Pharm Pharmacol , vol.40 , pp. 27-30
    • Yagi, T.1    Miyawaki, Y.2    Nishikawa, T.3    Yamauchi, K.4    Kuwano, S.5
  • 20
    • 0022592651 scopus 로고
    • Acceleration of large intestine transit time in rats by sennosides and related compounds
    • Leng-Peschlow E. Acceleration of large intestine transit time in rats by sennosides and related compounds. J Pharm Pharmacol 1986; 38: 369-73.
    • (1986) J Pharm Pharmacol , vol.38 , pp. 369-373
    • Leng-Peschlow, E.1
  • 22
    • 0026063076 scopus 로고
    • Direct and indirect evidence for the involvement of prostaglandins in the secretagogue action of rhein anthrone in the small intestine
    • Nijs G, De Witte P, Van Hoestenberghe A, Geboes K, Lemli J. Direct and indirect evidence for the involvement of prostaglandins in the secretagogue action of rhein anthrone in the small intestine. Acta Gastroenterol Belg 1991; 54: 184-90.
    • (1991) Acta Gastroenterol Belg , vol.54 , pp. 184-190
    • Nijs, G.1    De Witte, P.2    Van Hoestenberghe, A.3    Geboes, K.4    Lemli, J.5
  • 23
    • 0023849763 scopus 로고
    • Prostaglandin-mediated action of sennosides
    • Beubler E, Kollar G. Prostaglandin-mediated action of sennosides. Pharmacol 1988; 36(Suppl. 1): 85-91.
    • (1988) Pharmacol , vol.36 , Issue.SUPPL. 1 , pp. 85-91
    • Beubler, E.1    Kollar, G.2
  • 25
    • 0026547314 scopus 로고
    • The effect of rhein and rhein anthrone on intestinal fluid transport and on large intestine transit in germ-free rats
    • Van Hoestenberghe A, De Witte P, Geboes K, Eyssen H, Nijs G, Lemli J. The effect of rhein and rhein anthrone on intestinal fluid transport and on large intestine transit in germ-free rats. Eur J Pharmacol 1992; 212: 121-3.
    • (1992) Eur J Pharmacol , vol.212 , pp. 121-123
    • Van Hoestenberghe, A.1    De Witte, P.2    Geboes, K.3    Eyssen, H.4    Nijs, G.5    Lemli, J.6
  • 26
    • 0018817820 scopus 로고
    • Mitochondrial uncoupling activity as a possible base for a laxative and antipsoriatic effect
    • Verhaeren EHC. Mitochondrial uncoupling activity as a possible base for a laxative and antipsoriatic effect. Pharmacol 1980; 20(Suppl. 1): 43-9.
    • (1980) Pharmacol , vol.20 , Issue.SUPPL. 1 , pp. 43-49
    • Verhaeren, E.H.C.1
  • 27
    • 0000991248 scopus 로고
    • The uncoupling activity of substituted anthracene derivatives on isolated mitochondria from Phaseolus aureus
    • Verhaeren EHC. The uncoupling activity of substituted anthracene derivatives on isolated mitochondria from Phaseolus aureus. Phytochem 1980; 19: 501-3.
    • (1980) Phytochem , vol.19 , pp. 501-503
    • Verhaeren, E.H.C.1
  • 28
    • 0023858741 scopus 로고
    • +-ATPase and permeability in vitro
    • +-ATPase and permeability in vitro. Pharmacol 1988; 36(Suppl. 1): 98-103.
    • (1988) Pharmacol , vol.36 , Issue.SUPPL. 1 , pp. 98-103
    • Wanitschke, R.1    Karbach, U.2
  • 30
    • 0014314403 scopus 로고
    • +) adenosine triphosphatase
    • +) adenosine triphosphatase. Biochem Pharmacol 1968; 17: 1207-12.
    • (1968) Biochem Pharmacol , vol.17 , pp. 1207-1212
    • Chignell, C.F.1
  • 31
    • 0001435377 scopus 로고
    • + across the cell membrane
    • + across the cell membrane. Physiol Rev 1965; 45: 596-617.
    • (1965) Physiol Rev , vol.45 , pp. 596-617
    • Skou, J.C.1
  • 32
    • 0023840999 scopus 로고
    • Effect of rhein on electrogenic chloride secretion in rabbit distal colon
    • Clauss W, Domokos G, Leng-Peschlow E. Effect of rhein on electrogenic chloride secretion in rabbit distal colon. Pharmacol 1988; 36(Suppl. 1): 104-10.
    • (1988) Pharmacol , vol.36 , Issue.SUPPL. 1 , pp. 104-110
    • Clauss, W.1    Domokos, G.2    Leng-Peschlow, E.3
  • 33
    • 0023868871 scopus 로고
    • Rhein stimulates active chloride secretion in the short-circuited rat colonic mucosa
    • Goerg KJ, Wanitschke R, Schwarz M, Meyer zum Büschenfelde KH. Rhein stimulates active chloride secretion in the short-circuited rat colonic mucosa. Pharmacol 1988; 36(Suppl. 1): 111-19.
    • (1988) Pharmacol , vol.36 , Issue.SUPPL. 1 , pp. 111-119
    • Goerg, K.J.1    Wanitschke, R.2    Schwarz, M.3    Meyer zum Büschenfelde, K.H.4
  • 34
    • 34250382620 scopus 로고
    • Pathway of sodium moving form blood to intestinal lumen under the influence of oxyphenisatin and deoxycholate
    • Nell G, Forth W, Rummel W, Wanitschke R. Pathway of sodium moving form blood to intestinal lumen under the influence of oxyphenisatin and deoxycholate. Arch Pharmacol 1976; 293: 31-47.
    • (1976) Arch Pharmacol , vol.293 , pp. 31-47
    • Nell, G.1    Forth, W.2    Rummel, W.3    Wanitschke, R.4
  • 35
    • 0018818642 scopus 로고
    • The physiological basis of laxative action
    • Ewe K. The physiological basis of laxative action. Pharmacol 1980; 20(Suppl. 1): 2-20.
    • (1980) Pharmacol , vol.20 , Issue.SUPPL. 1 , pp. 2-20
    • Ewe, K.1
  • 36
    • 0017357093 scopus 로고
    • Influence of hydrostatic pressure gradients on net transfer of sodium and water across isolated rat colonic mucosa
    • Wanitschke R, Nell G, Rummel W. Influence of hydrostatic pressure gradients on net transfer of sodium and water across isolated rat colonic mucosa. Arch Pharmacol 1977; 297: 191-4.
    • (1977) Arch Pharmacol , vol.297 , pp. 191-194
    • Wanitschke, R.1    Nell, G.2    Rummel, W.3
  • 39
    • 0020418375 scopus 로고
    • Missbrauch von Abführmitteln, nachweisbare Schäden an Kolon, Anus und Stoffwechsel
    • May H. Missbrauch von Abführmitteln, nachweisbare Schäden an Kolon, Anus und Stoffwechsel. Ärztezeitschr Naturheilverf 1982; 7: 365-71.
    • (1982) Ärztezeitschr Naturheilverf , vol.7 , pp. 365-371
    • May, H.1
  • 40
    • 0016268621 scopus 로고
    • Laxative abuse
    • Cummings JH. Laxative abuse. Gut 1974; 15: 758-66.
    • (1974) Gut , vol.15 , pp. 758-766
    • Cummings, J.H.1
  • 41
    • 0014024175 scopus 로고
    • Cathartic colon
    • Rawson MD. Cathartic colon. Lancet 1966; i: 1121-4.
    • (1966) Lancet , vol.1 , pp. 1121-1124
    • Rawson, M.D.1
  • 44
    • 0014274540 scopus 로고
    • Effect of irritant purgatives on the myenteric plexus in man and the mouse
    • Smith B. Effect of irritant purgatives on the myenteric plexus in man and the mouse. Gut 1968; 9: 139-43.
    • (1968) Gut , vol.9 , pp. 139-143
    • Smith, B.1
  • 45
    • 0015721853 scopus 로고
    • Pathologic changes in the colon produced by anthraquinone purgatives
    • Smith B. Pathologic changes in the colon produced by anthraquinone purgatives. Dis Colon Rectum 1973; 16: 455-8.
    • (1973) Dis Colon Rectum , vol.16 , pp. 455-458
    • Smith, B.1
  • 46
    • 0024318722 scopus 로고
    • Sennosides do not kill myenteric neurons in the colon of the rat or mouse
    • Kiernan JA, Heinicke EA. Sennosides do not kill myenteric neurons in the colon of the rat or mouse. Neuroscience 1989; 30: 837-42.
    • (1989) Neuroscience , vol.30 , pp. 837-842
    • Kiernan, J.A.1    Heinicke, E.A.2
  • 47
    • 0021674524 scopus 로고
    • Ultrastructure of mouse intestinal mucosa and changes observed after long term anthraquinone administration
    • Dufour P, Gendre P. Ultrastructure of mouse intestinal mucosa and changes observed after long term anthraquinone administration. Gut 1984; 25: 1358-63.
    • (1984) Gut , vol.25 , pp. 1358-1363
    • Dufour, P.1    Gendre, P.2
  • 48
    • 0000186437 scopus 로고
    • Melanosis coli: Experimental observations on its production and elimination in 23 cases
    • Speare GS. Melanosis coli: Experimental observations on its production and elimination in 23 cases. Am J Surg 1951; 82: 631-7.
    • (1951) Am J Surg , vol.82 , pp. 631-637
    • Speare, G.S.1
  • 49
    • 0002560522 scopus 로고
    • Melanosis coli. The ethiologic significance of the anthracene laxatives: A report of forty-one cases
    • Bockus HI, Willard JH, Banks J. Melanosis coli. The ethiologic significance of the anthracene laxatives: A report of forty-one cases. J Am Med Assoc 1933; 101: 1-6.
    • (1933) J Am Med Assoc , vol.101 , pp. 1-6
    • Bockus, H.I.1    Willard, J.H.2    Banks, J.3
  • 50
    • 0016763105 scopus 로고
    • Melanosis coli: Studies of the toxic effect of irritant purgatives
    • Steer HW, Colin-Jones DG. Melanosis coli: Studies of the toxic effect of irritant purgatives. J Pathol 1975; 115: 199-205.
    • (1975) J Pathol , vol.115 , pp. 199-205
    • Steer, H.W.1    Colin-Jones, D.G.2
  • 51
    • 0000508882 scopus 로고
    • Melanosis coli; its clinical significance
    • Zobel AJ, Susnow DA. Melanosis coli; its clinical significance. Arch Surg 1935; 30: 974-9.
    • (1935) Arch Surg , vol.30 , pp. 974-979
    • Zobel, A.J.1    Susnow, D.A.2
  • 53
    • 0021950318 scopus 로고
    • Melanosis of the rectum in patients with chronic constipation
    • Badiali D, Marcheggiano A, Pallone F, et al. Melanosis of the rectum in patients with chronic constipation. Dis Colon Rectum 1985; 28: 241-5.
    • (1985) Dis Colon Rectum , vol.28 , pp. 241-245
    • Badiali, D.1    Marcheggiano, A.2    Pallone, F.3
  • 54
    • 0026490612 scopus 로고
    • Senna and pseudomelanosis coli
    • Leng-Peschlow E. Senna and pseudomelanosis coli. Pharmacol 1992; 44(Suppl. 1): 33-5.
    • (1992) Pharmacol , vol.44 , Issue.SUPPL. 1 , pp. 33-35
    • Leng-Peschlow, E.1
  • 55
    • 0031040561 scopus 로고    scopus 로고
    • Melanosis coli is associated with an increase in colonic epithelial apoptosis and not with laxative use
    • Byers RJ, Marsh P, Parkinson D, Haboubi NY. Melanosis coli is associated with an increase in colonic epithelial apoptosis and not with laxative use. Histopathology 1997; 30: 160-4.
    • (1997) Histopathology , vol.30 , pp. 160-164
    • Byers, R.J.1    Marsh, P.2    Parkinson, D.3    Haboubi, N.Y.4
  • 56
    • 0028930592 scopus 로고
    • Chronic unexplained diarrhoea: Are biopsics necessary if colonoscopy is normal
    • Marshall JB, Singh R, Diaz-Arias AA. Chronic unexplained diarrhoea: Are biopsics necessary if colonoscopy is normal. Am J Gastroenterol 1995; 90: 372-6.
    • (1995) Am J Gastroenterol , vol.90 , pp. 372-376
    • Marshall, J.B.1    Singh, R.2    Diaz-Arias, A.A.3
  • 57
    • 0026633188 scopus 로고
    • Nebenwirkungen von Laxantien
    • Müller-Lissner S. Nebenwirkungen von Laxantien. Z Gastroenterol 1992; 30: 418-27.
    • (1992) Z Gastroenterol , vol.30 , pp. 418-427
    • Müller-Lissner, S.1
  • 58
    • 0023937746 scopus 로고
    • Melanosis coli. A consequence of anthraquinone-induced apoptosis of colonic epithelial cells
    • Walker NI, Bennett RE, Axelsen RA. Melanosis coli. A consequence of anthraquinone-induced apoptosis of colonic epithelial cells. Am J Pathol 1988; 131: 465-76.
    • (1988) Am J Pathol , vol.131 , pp. 465-476
    • Walker, N.I.1    Bennett, R.E.2    Axelsen, R.A.3
  • 59
    • 0020582107 scopus 로고
    • Melanosis coli. Changes in appearance when associated with colonic neoplasia
    • Morgenstern L, Shemen L, Allen W, Amodeo P, Michel SL. Melanosis coli. Changes in appearance when associated with colonic neoplasia. Arch Surg 1983; 118: 62-4.
    • (1983) Arch Surg , vol.118 , pp. 62-64
    • Morgenstern, L.1    Shemen, L.2    Allen, W.3    Amodeo, P.4    Michel, S.L.5
  • 60
    • 0024632362 scopus 로고
    • Melanosis coli. Prevalence, distribution and histologic features in 200 consecutive autopsies at Kuopio University Central Hospital
    • Koskela E, Kulju T, Collan Y. Melanosis coli. Prevalence, distribution and histologic features in 200 consecutive autopsies at Kuopio University Central Hospital. Dis Colon Rectum 1989; 32: 235-9.
    • (1989) Dis Colon Rectum , vol.32 , pp. 235-239
    • Koskela, E.1    Kulju, T.2    Collan, Y.3
  • 61
    • 0013470085 scopus 로고
    • Über das sogennante Lipofuschin
    • Lubarsch O. Über das sogennante Lipofuschin. Virchows Archiv Pathol Anat 1922; 239: 491-503.
    • (1922) Virchows Archiv Pathol Anat , vol.239 , pp. 491-503
    • Lubarsch, O.1
  • 62
    • 0013540752 scopus 로고
    • Das Pigment der melanosis coli und seine chemische Darstellung aus dem Organ
    • Pick L, Brahn B. Das Pigment der melanosis coli und seine chemische Darstellung aus dem Organ. Virchows Archiv Pathol Anat 1930; 275: 37-49.
    • (1930) Virchows Archiv Pathol Anat , vol.275 , pp. 37-49
    • Pick, L.1    Brahn, B.2
  • 63
    • 0013959420 scopus 로고
    • An electron-microscope and histochemical study of melanosis coli
    • Ghadially FN, Parry EW. An electron-microscope and histochemical study of melanosis coli. J Pathol Bacteriol 1966; 92: 313-7.
    • (1966) J Pathol Bacteriol , vol.92 , pp. 313-317
    • Ghadially, F.N.1    Parry, E.W.2
  • 64
    • 0000003481 scopus 로고
    • Melanosis coli: A study with the electron microscope
    • Schrodt GR. Melanosis coli: A study with the electron microscope. Dis Colon Rectum 1963; 6: 277-83.
    • (1963) Dis Colon Rectum , vol.6 , pp. 277-283
    • Schrodt, G.R.1
  • 65
    • 0015383455 scopus 로고
    • Apoptosis; a basic biological phenomenon with wide ranging implications in tissue kinetics
    • Kerr JFR, Wyllie AH, Currie AR. Apoptosis; a basic biological phenomenon with wide ranging implications in tissue kinetics. Br J Cancer 1972; 26: 239-57.
    • (1972) Br J Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.R.1    Wyllie, A.H.2    Currie, A.R.3
  • 67
    • 0027223967 scopus 로고
    • Ultrastructure of human melanosis coli with reference to its pathogenesis
    • Walker NI, Smith MM, Smithers BM. Ultrastructure of human melanosis coli with reference to its pathogenesis. Pathology 1993; 25: 120-3.
    • (1993) Pathology , vol.25 , pp. 120-123
    • Walker, N.I.1    Smith, M.M.2    Smithers, B.M.3
  • 69
    • 0014975699 scopus 로고
    • Studies on dithranol and dithranol-like compounds: I. Binding to nucleic acids
    • Swanbeck G, Zetterberg G. Studies on dithranol and dithranol-like compounds: I. Binding to nucleic acids. Acta Derm Venereol 1971; 51: 41-4.
    • (1971) Acta Derm Venereol , vol.51 , pp. 41-44
    • Swanbeck, G.1    Zetterberg, G.2
  • 71
    • 0022965929 scopus 로고
    • Genotoxicity in the hepatocyte/DNA repair test and toxicity to liver mitochondria of 1-hydroxyanthraquinone and several dihydroxyanthraquinones
    • Kawai K, Mori H, Sugie S, et al. Genotoxicity in the hepatocyte/DNA repair test and toxicity to liver mitochondria of 1-hydroxyanthraquinone and several dihydroxyanthraquinones. Cell Biol Toxicol 1986; 2: 457-68.
    • (1986) Cell Biol Toxicol , vol.2 , pp. 457-468
    • Kawai, K.1    Mori, H.2    Sugie, S.3
  • 72
    • 0025011002 scopus 로고
    • Hydroxyanthraquinones as tumor promoters: Enhancement of malignant transformation of C3H mouse fibroblasts and growth stimulation of primary rat hepatocytes
    • Wölfle D, Schmutte C, Westendorf J, Marquardt H. Hydroxyanthraquinones as tumor promoters: Enhancement of malignant transformation of C3H mouse fibroblasts and growth stimulation of primary rat hepatocytes. Cancer Res 1990; 50: 6540-4.
    • (1990) Cancer Res , vol.50 , pp. 6540-6544
    • Wölfle, D.1    Schmutte, C.2    Westendorf, J.3    Marquardt, H.4
  • 73
    • 0017134531 scopus 로고
    • Mutagenesis by 9,10-anthraquinone derivatives and related compounds in Salmonella Typhimurium
    • Brown JP, Brown RJ. Mutagenesis by 9,10-anthraquinone derivatives and related compounds in Salmonella Typhimurium. Mutat Res 1976 40: 203-224.
    • (1976) Mutat Res , vol.40 , pp. 203-224
    • Brown, J.P.1    Brown, R.J.2
  • 74
    • 0021736323 scopus 로고
    • Lack of activity of the bacterial mutagen emodin in HGPRT and SCE assay with V79 Chinese hamster cells
    • Bruggeman IM, Van der Hoeven JCM. Lack of activity of the bacterial mutagen emodin in HGPRT and SCE assay with V79 Chinese hamster cells. Mutat Res 1984; 138: 219-24.
    • (1984) Mutat Res , vol.138 , pp. 219-224
    • Bruggeman, I.M.1    Van der Hoeven, J.C.M.2
  • 75
    • 0021927266 scopus 로고
    • 2-Hydroxyemodin, an active metabolite of emodin in the hepatic microsomes of rats
    • Masuda T, Haraikawa K, Morooka N, Nakano S, Ueno Y. 2-Hydroxyemodin, an active metabolite of emodin in the hepatic microsomes of rats. Mutat Res 1985; 149: 327-52.
    • (1985) Mutat Res , vol.149 , pp. 327-352
    • Masuda, T.1    Haraikawa, K.2    Morooka, N.3    Nakano, S.4    Ueno, Y.5
  • 76
    • 0020693140 scopus 로고
    • Mutagenicity of anthraquinones in the Salmonella preincubation test
    • Tikkanen L, Matsushima T, Natori S. Mutagenicity of anthraquinones in the Salmonella preincubation test. Mutat Res 1983; 116: 297-304.
    • (1983) Mutat Res , vol.116 , pp. 297-304
    • Tikkanen, L.1    Matsushima, T.2    Natori, S.3
  • 77
    • 0018330354 scopus 로고
    • Mutagenicity of anthraquinone and benzanthrone derivatives in the Salmonella/microsome test: Activation of anthraquinone glycosides by enzymic extracts of rat cecal bacteria
    • Brown JP, Dietrich PS. Mutagenicity of anthraquinone and benzanthrone derivatives in the Salmonella/microsome test: Activation of anthraquinone glycosides by enzymic extracts of rat cecal bacteria. Mutat Res 1979; 66: 9-24.
    • (1979) Mutat Res , vol.66 , pp. 9-24
    • Brown, J.P.1    Dietrich, P.S.2
  • 78
    • 0016685233 scopus 로고
    • Methods for dctecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test
    • Ames BN, McCann J, Yamasaki E. Methods for dctecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat Res 1975; 31: 347-64.
    • (1975) Mutat Res , vol.31 , pp. 347-364
    • Ames, B.N.1    McCann, J.2    Yamasaki, E.3
  • 79
    • 0023859178 scopus 로고
    • Toxic effects of sennosides in laboratory animals and in vitro
    • Mengs U. Toxic effects of sennosides in laboratory animals and in vitro. Pharmacol 1988; 36(Suppl. 1): 180-7.
    • (1988) Pharmacol , vol.36 , Issue.SUPPL. 1 , pp. 180-187
    • Mengs, U.1
  • 80
    • 0020047061 scopus 로고
    • Mutagenicity screening of crude drugs with Bacillus subtilis recassay and Salmonella/microsome reversion assay
    • Morimoto I, Watanabe F, Osawa T, Okitsu T, Kada T. Mutagenicity screening of crude drugs with Bacillus subtilis recassay and Salmonella/microsome reversion assay. Mutat Res 1982; 97: 81-102.
    • (1982) Mutat Res , vol.97 , pp. 81-102
    • Morimoto, I.1    Watanabe, F.2    Osawa, T.3    Okitsu, T.4    Kada, T.5
  • 81
    • 0026699561 scopus 로고
    • Mutagenicity of crude senna and senna glycosides in Salmonella Typhimurium
    • Sandnes D, Johansen T, Teien G, Ulsaker G. Mutagenicity of crude senna and senna glycosides in Salmonella Typhimurium. Pharmacol Toxicol 1992; 71: 165-72.
    • (1992) Pharmacol Toxicol , vol.71 , pp. 165-172
    • Sandnes, D.1    Johansen, T.2    Teien, G.3    Ulsaker, G.4
  • 82
    • 0027508059 scopus 로고
    • Two-year carcinogenicity study with sennosides in the rat: Emphasis on gastro-intestinal alterations
    • Lydén-Sokolowski A, Nilsson A, Sjöberg P. Two-year carcinogenicity study with sennosides in the rat: Emphasis on gastro-intestinal alterations. Pharmacol 1993; 47(Suppl. 1): 209-15.
    • (1993) Pharmacol , vol.47 , Issue.SUPPL. 1 , pp. 209-215
    • Lydén-Sokolowski, A.1    Nilsson, A.2    Sjöberg, P.3
  • 83
    • 0025361213 scopus 로고
    • Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: Induction of large bowel, liver and stomach neoplasms
    • Mori H, Yoshimi N, Iwata H, et al. Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: Induction of large bowel, liver and stomach neoplasms. Carcinogenesis 1990; 11: 799-802.
    • (1990) Carcinogenesis , vol.11 , pp. 799-802
    • Mori, H.1    Yoshimi, N.2    Iwata, H.3
  • 87
    • 0027082255 scopus 로고
    • Cell kinetic analysis of the mucosa epithelium and assay of ornithine decarboxylase activity during the process of 1-hydroxyanthraquinone-induced large bowel carcinogenesis in rats
    • Mori H, Mori Y, Tanaka T, et al. Cell kinetic analysis of the mucosa epithelium and assay of ornithine decarboxylase activity during the process of 1-hydroxyanthraquinone-induced large bowel carcinogenesis in rats. Carcinogenesis 1992; 13: 2217-20.
    • (1992) Carcinogenesis , vol.13 , pp. 2217-2220
    • Mori, H.1    Mori, Y.2    Tanaka, T.3
  • 88
    • 0026092411 scopus 로고
    • The synergistic effect of 1-hydroxyanthraquinone on methylazoxymethanol acetate-induced carcinogenesis in rats
    • Mori Y, Yoshimi N, Iwata H, Tanaka T, Mori H. The synergistic effect of 1-hydroxyanthraquinone on methylazoxymethanol acetate-induced carcinogenesis in rats. Carcinogenesis 1991; 12: 335-8.
    • (1991) Carcinogenesis , vol.12 , pp. 335-338
    • Mori, Y.1    Yoshimi, N.2    Iwata, H.3    Tanaka, T.4    Mori, H.5
  • 89
    • 0030026272 scopus 로고    scopus 로고
    • Evaluation of the potential carcinogenic activity of senna and cascara glycosides for the rat colon
    • Moreto E, Ghia M, Brambilla G. Evaluation of the potential carcinogenic activity of senna and cascara glycosides for the rat colon. Cancer Lett 1996; 101: 79-83.
    • (1996) Cancer Lett , vol.101 , pp. 79-83
    • Moreto, E.1    Ghia, M.2    Brambilla, G.3
  • 90
    • 0027361049 scopus 로고
    • Ability of aberrant crypt foci characteristics to predict colon tumor incidence in rats fed cholic acid
    • Magnuson BA, Carr I, Bird RP. Ability of aberrant crypt foci characteristics to predict colon tumor incidence in rats fed cholic acid. Cancer Res 1993; 53: 4499-504.
    • (1993) Cancer Res , vol.53 , pp. 4499-4504
    • Magnuson, B.A.1    Carr, I.2    Bird, R.P.3
  • 91
    • 0020513475 scopus 로고
    • Nuclear aberrations as a short-term test for genotoxicity to the colon: Evaluation of nineteen agents in mice
    • Wargovich MJ, Goldberg MT, Newmark HL, Bruce WR. Nuclear aberrations as a short-term test for genotoxicity to the colon: Evaluation of nineteen agents in mice. J Natl Cancer Inst 1983; 71: 133-7.
    • (1983) J Natl Cancer Inst , vol.71 , pp. 133-137
    • Wargovich, M.J.1    Goldberg, M.T.2    Newmark, H.L.3    Bruce, W.R.4
  • 92
    • 0021255812 scopus 로고
    • Site-specific induction of nuclear anomalies (apoptotic bodies and micronuclei) by carcinogens in mice
    • Ronen A, Heddle JA. Site-specific induction of nuclear anomalies (apoptotic bodies and micronuclei) by carcinogens in mice. Cancer Res 1984; 44: 1536-40.
    • (1984) Cancer Res , vol.44 , pp. 1536-1540
    • Ronen, A.1    Heddle, J.A.2
  • 93
    • 0027494524 scopus 로고
    • Light and electron-microscopic changes in the colon of the guinea pig after treatment with anthranoid and non-anthranoid laxatives
    • Mengs U, Rudolph RL. Light and electron-microscopic changes in the colon of the guinea pig after treatment with anthranoid and non-anthranoid laxatives. Pharmacol 1993; 47(Suppl. 1): 172-7.
    • (1993) Pharmacol , vol.47 , Issue.SUPPL. 1 , pp. 172-177
    • Mengs, U.1    Rudolph, R.L.2
  • 94
    • 0013469877 scopus 로고
    • Gastro-intestinal cancer and use of liquid paraffin
    • Boyd JT, Doll R. Gastro-intestinal cancer and use of liquid paraffin. Br J Cancer 1954; 8: 231-7.
    • (1954) Br J Cancer , vol.8 , pp. 231-237
    • Boyd, J.T.1    Doll, R.2
  • 96
    • 0020431926 scopus 로고
    • A retrospective mortality study of substituted anthraquinone dyestuff workers
    • Gardiner JS, Walker SA, Maclean AJ. A retrospective mortality study of substituted anthraquinone dyestuff workers. Br J Indust Med 1982; 39: 355-60.
    • (1982) Br J Indust Med , vol.39 , pp. 355-360
    • Gardiner, J.S.1    Walker, S.A.2    Maclean, A.J.3
  • 97
    • 0023761461 scopus 로고
    • The role of chronic constipation, diarrhea, and laxative use in the etiology of large-bowel cancer. Data from the melbourne colorectal cancer study
    • Kune GA, Kune S, Field B, Watson LF. The role of chronic constipation, diarrhea, and laxative use in the etiology of large-bowel cancer. Data from the melbourne colorectal cancer study. Dis Colon Rectum 1988; 31: 507-12.
    • (1988) Dis Colon Rectum , vol.31 , pp. 507-512
    • Kune, G.A.1    Kune, S.2    Field, B.3    Watson, L.F.4
  • 98
    • 0015098728 scopus 로고
    • Epidemiology of cancer of the colon and rectum
    • Burkitt DP. Epidemiology of cancer of the colon and rectum. Cancer 1971; 28: 3-13.
    • (1971) Cancer , vol.28 , pp. 3-13
    • Burkitt, D.P.1
  • 99
    • 0015530176 scopus 로고
    • Effect of dietary fibre on stools and transit-times and its role in the causation of disease
    • Burkitt DP, Walker ARP, Painter NS. Effect of dietary fibre on stools and transit-times and its role in the causation of disease. Lancet 1972; ii: 1408-14.
    • (1972) Lancet , vol.2 , pp. 1408-1414
    • Burkitt, D.P.1    Walker, A.R.P.2    Painter, N.S.3
  • 101
    • 0013963674 scopus 로고
    • Etiological factors in gastrointestinal cancer in man
    • Higginson J. Etiological factors in gastrointestinal cancer in man. J Natl Cancer Inst 1966; 37: 527-45.
    • (1966) J Natl Cancer Inst , vol.37 , pp. 527-545
    • Higginson, J.1
  • 103
    • 0027454180 scopus 로고
    • Retrospective study on laxative use and melanosis coli as risk factors for colorectal neoplasia
    • Nusko G, Schneider B, Muller G, Kusche J, Hahn EG. Retrospective study on laxative use and melanosis coli as risk factors for colorectal neoplasia. Pharmacol 1993; 47(Suppl. 1): 234-41.
    • (1993) Pharmacol , vol.47 , Issue.SUPPL. 1 , pp. 234-241
    • Nusko, G.1    Schneider, B.2    Muller, G.3    Kusche, J.4    Hahn, E.G.5
  • 104
  • 106
    • 4243775722 scopus 로고    scopus 로고
    • Effects of sennosides on colonic epithelial cell proliferation and bcl-2 gene expression: Possible mechanisms for carcinogenic effects
    • Abstract
    • Van Gorkom BAP, Karrenbeld A, Koudstaal J, De Vries EGE, Kleibeuker JH. Effects of sennosides on colonic epithelial cell proliferation and bcl-2 gene expression: Possible mechanisms for carcinogenic effects. Gastroenterology 1996; 110: A608(Abstract).
    • (1996) Gastroenterology , vol.110
    • Van Gorkom, B.A.P.1    Karrenbeld, A.2    Koudstaal, J.3    De Vries, E.G.E.4    Kleibeuker, J.H.5


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