CNS Regeneration: Only on One Condition

Current Biology

Volumn 19, Issue 11, 2009, Pages

  Silver, Jerry ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; CENTRAL NERVOUS SYSTEM; INJURY; NERVE FIBER; NERVE REGENERATION; PATHOLOGY; PHYSIOLOGY; RAT; SENSORY RECEPTOR; SHORT SURVEY; SPINAL GANGLION; ULTRASTRUCTURE;

ANIMALS; AXONS; CENTRAL NERVOUS SYSTEM; GANGLIA, SPINAL; NERVE REGENERATION; RATS; SENSORY RECEPTOR CELLS;

MAMMALIA;

EID: 66249106385     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2009.04.026     Document Type: Short Survey

References (17)

1. Silver J., and Miller J.H. Regeneration beyond the glial scar. Nat. Rev. Neurosci. 5 (2004) 146-156
2. McQuarrie I.G., and Grafstein B. Axon outgrowth enhanced by a previous nerve injury. Arch. Neurol. 29 (1973) 53-55
3. Ylera B., Ertürk A., Hellal F., Nadrigny F., Hurtado A., Tahirovic S., Oudega M., Kirchhoff F., and Bradke F. Chronically injured adult sensory neurons acquire axon growth competence following a lesion of their peripheral axons. Curr. Biol. 19 (2009) 930-936
4. McQuarrie I.G., and Grafstein B. Effect of a conditioning lesion on optic nerve regeneration in goldfish. Brain Res. 216 (1981) 253-264
5. Oblinger M.M., and Lasek R.J. A conditioning lesion of the peripheral axons of dorsal ganglion cells accelerates regeneration of only their peripheral axons. J. Neurosci. 4 (1984) 1736-1744
6. Steinmetz M.P., Horn K.P., Tom V.J., Miller J.H., Busch S.A., Nair D., Silver D.J., and Silver J. Chronic enhancement of the intrinsic growth capacity of sensory neurons combined with the degradation of inhibitory proteoglycans allows functional regeneration of sensory axons through the dorsal root entry zone in the mammalian spinal cord. J. Neurosci. 25 (2005) 8066-8076
7. Ramon y Cajal S. Degeneration and Regeneration in the Nervous System (1928), Oxford University Press, London
8. Neumann S., and Woolf C.J. Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury. Neuron 23 (1999) 83-91
9. Tashiro T., and Komiya Y. Changes in organization and axonal transport of cytoskeletal proteins during regeneration. J. Neurochem. 56 (2006) 1557-1563
10. Hanz S., and Fainzilber M. Retrograde signaling in injured nerve - The axon reaction revisited. J. Neurochem. 99 (2006) 13-19
11. Willis D.E., and Twiss J.L. The evolving roles of axonally synthesized proteins in regeneration. Curr. Opin. Neurobiol. 16 (2006) 111-118
12. Qiu J., Cai D., Dai H., McAtee M., Hoffman P.N., Bregman B.S., and Filbin M.T. Spinal axon regeneration induced by elevation of cyclic AMP. Neuron 34 (2002) 895-903
13. Yin Y., Cui Q., Li Y., Irwin N., Fischer D., Harvey A., and Benowitz L.I. Macrophage-derived factors stimulate optic nerve regeneration. J. Neurosci. 23 (2003) 2284-2293
14. Tom V.J., Steinmetz M.P., Miller J.H., Doller C.M., and Silver J. Studies on the development and behavior of the dystrophic growth cone, the hallmark of regeneration failure, in an in vitro model of the glial scar and after spinal cord injury. J. Neurosci. 24 (2004) 6531-6539
15. Lichtman J.W., and Sanes J.R. Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 28 (2000) 41-51
16. Horn K.P., Busch S.A., Hawthorne A.L., van Rooijen N., and Silver J. Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions. J. Neurosci. 28 (2008) 9330-9341
17. Kerschensteiner M., Schwab M.E., Lichtman J.W., and Misgeld T. In vivo imaging of axonal degeneration and regeneration in the injured spinal cord. Nat. Med. 11 (2005) 572-577