Application of a newly identified and characterized 18-O-acyltransferase in chemoenzymatic synthesis of selected natural and nonnatural bioactive derivatives of phoslactomycins

Applied and Environmental Microbiology

Volumn 75, Issue 11, 2009, Pages 3469-3476

  Ghatge, Mohini S ^a   Palaniappan, Nadaraj ^a   Alhamadsheh, Ma'moun M ^a   DiBari, Jessica ^a   Reynolds, Kevin A ^a  

^a PORTLAND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL-CHAIN; ANTI-FUNGAL; AROMATIC CARBOXYLIC ACIDS; BIOLOGICAL ASSAYS; CHEMO-ENZYMATIC SYNTHESIS; CHEMOENZYMATIC ROUTE; COENZYME A; DEACYLATION; MULTI-STEP; OPEN READING FRAME; POLYHISTIDINE; STREPTOMYCES SP; SYNTHETIC PROCESS; TAGGED PROTEINS; THIOESTERS;

BIOCHEMICAL ENGINEERING; CARBOXYLIC ACIDS; ESCHERICHIA COLI; ESTERIFICATION; ESTERS;

ORGANIC ACIDS;

18 O ACETYLTRANSFERASE; 3 METHYLBUTYRYL COENZYME A; ACYLTRANSFERASE; AROMATIC CARBOXYLIC ACID; COENZYME A; CYCLOHEXYLCARBONYL COENZYME A; GENE PRODUCT; ISOBUTYRYL COENZYME A; N ACETYLCYSTEAMINE THIOESTER DERIVATIVE; PHOSLACTOMYCIN A; PHOSLACTOMYCIN C; PHOSLACTOMYCIN DERIVATIVE; PHOSLACTOMYCIN E; PHOSLACTOMYCIN F; PHOSLACTOMYCIN G; THIOESTER; UNCLASSIFIED DRUG;

BACTERIUM; BIOASSAY; CATALYSIS; ENZYME ACTIVITY; FERMENTATION; IDENTIFICATION METHOD;

ACYLATION; ARTICLE; BACTERIAL STRAIN; CATALYST; CONTROLLED STUDY; DEACYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME MECHANISM; ESTERIFICATION; GENE DELETION; GENE EXPRESSION; MOLECULAR CLONING; NONHUMAN; ONE POT SYNTHESIS; OPEN READING FRAME; REPRODUCIBILITY; STREPTOMYCES; TECHNIQUE;

ACYL COENZYME A; ACYLTRANSFERASES; BIOSYNTHETIC PATHWAYS; CARBOXYLIC ACIDS; CLONING, MOLECULAR; COENZYME A; ESCHERICHIA COLI; GENE DELETION; LACTONES; MODELS, BIOLOGICAL; ORGANOPHOSPHORUS COMPOUNDS; STREPTOMYCES;

ESCHERICHIA COLI; STREPTOMYCES SP.;

EID: 66249093141     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.02590-08     Document Type: Article

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