Manufacture of high-purity meloxicam via its novel potassium salt monohydrate

Organic Process Research and Development

Volumn 13, Issue 3, 2009, Pages 567-572

  Mezei, Tibor ^a   Mesterházy, Norbert ^a   Bakó, Tibor ^a   Porcs Makkay, Márta ^a   Simig, Gyula ^a   Volk, Balázs ^a  

^a EGIS PHARMACEUTICALS LTD   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 66249088667     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op900031h     Document Type: Article

References (30)

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11. (a) The basic patent of meloxicam is: Trummlitz, G.; Engel, W.; Seeger, E.; Engelhardt, G. 4-Hydroxy-2H-1,2-benzothiazin-3-carboxamid- 1,1-dioxides. Ger. Pat. DE 2756113, 1979. Chem. Abstr. 1979, 91, 91656.
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13. The following paper applies the same starting materials (3, 4), but the amidation step is performed in the presence of BF3 catalyst and molecular sieves: Zia-ur-Rehman, M.; Choudary, J. A.; Ahmad, S. Bull. Korean Chem. Soc. 2005, 26, 1771-1775. Chem. Abstr 2006, 145, 83282.
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27. The PCT equivalent of this German patent application is: Trummlitz, G.; Sieger, P.; Werthmann, U.; Soyka, R.; Luger, P. PCT Pat. Appl. WO 2004/031183, 2004.
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