Close encounters of the monoamine kind: Immune cells betray their nervous disposition

Immunology

Volumn 115, Issue 3, 2005, Pages 289-295

  Meredith, Elizabeth J ^a   Chamba, Anita ^a   Holder, Michelle J ^a   Barnes, Nicholas M ^b   Gordon, John ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b Medical School   (United Kingdom)

Author keywords

Central nervous system; Dopamine; Lymphocytes; Serotonin; Transporters

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 2,3 DIHYDRO 3 ISOPROPYL 2 OXO 1 BENZIMIDAZOLECARBOXYLIC ACID 3ALPHA TROPANYLAMIDE; 3 [4 (3 CHLOROPHENYL) 1 PIPERAZINYL] 1,1 DIPHENYL 2 PROPANOL; 5 (4 FLUOROBENZAMIDO) 3 (1 METHYL 4 PIPERIDINYL) 1H INDOLE FUMARATE; 5 CHLORO N [4 METHOXY 3 (1 PIPERAZINYL)PHENYL] 3 METHYL 2 BENZOTHIOPHENESULFONAMIDE; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; 8 AMINO 7 CHLORO 1,4 BENZODIOXAN 5 CARBOXYLIC ACID 1 BUTYL 4 PIPERIDINYLMETHYL ESTER; ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; DOPAMINE; DOPAMINE RECEPTOR; DOPAMINE TRANSPORTER; MONOAMINE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ONDANSETRON; PAROXETINE; SB 236057; SB 656104; SEROTONIN; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

B LYMPHOCYTE; CELL FUNCTION; CENTRAL NERVOUS SYSTEM; DOPAMINERGIC SYSTEM; HUMAN; IMMUNE SYSTEM; IMMUNOMODULATION; IMMUNOSTIMULATION; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW; SEROTONINERGIC SYSTEM; T LYMPHOCYTE; TAXONOMY;

CENTRAL NERVOUS SYSTEM; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; ENTEROCHROMAFFIN CELLS; HUMANS; LYMPHOCYTES; LYMPHOID TISSUE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MODELS, IMMUNOLOGICAL; NERVE TISSUE PROTEINS; RECEPTORS, DOPAMINE; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 21244460815     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2005.02166.x     Document Type: Review

References (48)

1. Gordon J, Barnes NM. Lymphocytes transport serotonin and dopamine: agony or ecstasy? Trends Immunol 2003; 24:438-43.
2. Yang G-B, Lackner AA. Proximity between 5-HT secreting enteroendocrine cells and lymphocytes in the gut mucosa of rhesus macaques (Macaca mulatta) is suggestive of a role for enterochromaffin cell 5-HT in mucosal immunity. J Neuroimmunol 2004; 146:46-9.
3. Felten D, Felten S, Bellinger D, Lorton D. Noradrenergic and peptidergic innervation of secondary lymphoid organs: role in experimental rheumatoid arthritis. Eur J Clin Invest 1992; 22:37-41.
4. Beresford L, Orange O, Bell EB, Miyan JA. Nerve fibres are required to evoke a contact sensitivity response in mice. Immunology 2004; 111:118-25.
5. Anthony IC, Crawford DH, Bell JE. B lymphocytes in the normal brain: contrasts with HIV-associated lymphoid infiltrates and lymphomas. Brain 2003; 126:1058-67.
6. Serafeim A, Gordon J. The immune system gets nervous. Curr Opin Pharmacol 2001; 1:398-403.
7. Abdouh M, Albert PR, Drobetsky E, Filep JG, Kouassi E. 5-HT1A-mediated promotion of mitogen-activated T and B cell survival and proliferation is associated with increased translocation of NF-κB to the nucleus. Brain Behav Immun 2004; 18:24-34.
8. Cloez-Tayarani I, Kayyali US, Fanburg BL, Cavaillon J-M. 5-HT activates ERK MAP kinase in cultured-human peripheral blood mononuclear cells via 5-HT1A receptors. Life Sci 2004; 76:429-43.
9. Freire-Garabal M, Nunez MJ, Balboa J, et al. Serotonin upregulates the activity of phagocytosis through 5-HT1A receptors. Br J Pharmacol 2003; 139:457-63.
10. Idzko M, Panther E, Stratz C, et al. The serotoninergic receptors of human dendritic cells: identification and coupling to cytokine release. J Immunol 2004; 172:6011-19.
11. Serafeim A, Grafton G, Chamba A, Gregory CD, Blakely RD, Bowery NG, Barnes NM, Gordon J. 5-Hydroxytryptamine drives apoptosis in biopsy-like Burkitt lymphoma cells: reversal by selective serotonin reuptake inhibitors. Blood 2002; 99:2545-53.
12. Serafeim A, Holder MJ, Grafton G, et al. Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells. Blood 2003; 101:3212-19.
13. Meredith EJ, Holder MJ, Chamba A, et al. The serotonin transporter (SLC6A4) is present in B-cell clones of diverse malignant origin: probing a potential anti-tumor target for psychotropics. FASEB J in press.
14. Connor TJ. Methylenedioxymethamphetamine (MDMA, 'Ecstasy'): a stressor on the immune system. Immunology 2004; 111:357-67.
15. Walther DJ, Peter JU, Winter S, et al. Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release. Cell 2003; 115:851-62.
16. Rudd ML, Nicolas AN, Brown BL, Fischer-Stenger K, Stewart JK. Peritoneal macrophages express the serotonin transporter. J Neuroimmunol 2005; 159:113-18.
17. Bencsics A, Sershen H, Baranyi M, Hashim A, Lajtha A, Vizi ES. Dopamine, as well as norepinephrine, is a link between noradrenergic nerve terminals and splenocytes. Brain Res 1997; 761:236-43.
18. McKenna F, McLaughlin PJ, Lewis BJ, Sibbring GC, Cummerson JA, Bowen-Jones D, Moots RJ. Dopamine receptor expression on human T- and B-lymphocytes, monocytes, neutrophils, eosinophils and NK cells: a flow cytometric study. J Neuroimmunol 2002; 132:34-40.
19. Kipnis J, Cardon M, Avidan H, Lewitus GM, Mordechay S, Rolls A, Shani Y, Schwartz M. Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4+CD25+ regulatory T-cell activity: implications for neurodegeneration. J Neurosci 2004; 24:6133-43.
20. Ilani T, Strous R, Fuchs S. Dopaminergic regulation of immune cells via D3 dopamine receptor: a pathway mediated by activated T cells. FASEB J 2004; 18:1600-2.
21. Mill J, Asherson P, Browes C, D'Souza U, Craig I. Expression of the dopamine transporter gene is regulated by the 3 UTR VNTR. Evidence from brain and lymphocytes using quantitative RT-PCR. Am J Med Genet 2002; 114:975-9.
22. Ilani T, Ben-Shachar D, Strous RD, Mazor M, Sheinkman A, Kotler M, Fuchs S. A peripheral marker for schizophrenia: increased levels of D3 dopamine receptor mRNA in blood lymphocytes. Proc Natl Acad Sci USA 2001; 98:625-8.
23. Barbanti P, Bronzetti E, Ricci A, Cerbo R, Fabbrini G, Buzzi M, Amenta F, Lenzi G. Increased density of dopamine D5 receptor in peripheral blood lymphocytes of migraineurs: a marker for migraine? Neuroscience Lett 1996; 207:73-6.
24. Saha B, Mondal AC, Basu S, Dasgupta PS. Circulating dopamine level, in lung carcinoma patients inhibits proliferation and cytotoxicity of CD4+ and CD8+ T cells by D1 dopamine receptors. Int Immunopharmacol 2001; 1:1363-74.
25. Bergquist J, Josefsson E, Tarkowski A, Ekman R, Ewing A. Measurements of catecholamine-mediated apoptosis of immunocompetent cells by capillary electrophoresis. Electrophoresis 1997; 18:1760-6.
26. Ghosh MC, Mondal AC, Basu S, Banerjee S, Majumder J, Bhattacharya D, Dasgupta P. Dopamine inhibits cytokine release and expression of tyrosine kinases, Lck and Fyn in activated T cells. Int Immunopharmacol 2003; 3:1019-26.
27. Liu Y, Wolfe S. Haloperidol and spiperone potentiate murine splenic B cell proliferation. Immunopharmacology 1996; 34:147-59.
28. Josefsson E, Bergquist J, Ekman R, Tarkowski A. Catecholamines are synthesized by mouse lymphocytes and regulate function of these cells by induction of apoptosis. Immunology 1996; 88:140-6.
29. Carr L, Tucker A, Fernandez-Botran R. In vivo administration of L-dopa or dopamine decreases the number of splenic IFN-gamma-producing cells. J Neuroimmunol 2003; 137:87-93.
30. Cioca DP, Watanabe N, Isobe M. Apoptosis of peripheral blood lymphocytes is induced by catecholamines. Jap Heart J 2000; 41:385-98.
31. 2), caspase-3, and nuclear factor kappa-B (NF-κB), p53, c-Jun transcription factors. Biochem Pharmacol 2002; 63:677-88.
32. Brown SW, Meyers RT, Brennan KM, et al. Catecholamines in a macrophage cell line. J Neuroimmunol 2003; 135:47-55.
33. Offen D, Ziv I, Gorodin S, Barzilai A, Malik Z, Melamed E. Dopamine-induced programmed cell death in mouse thymocytes. Biochim Biophys Acta 1995; 1268:171-7.
34. Slominski A, Goodman-Snitkoff G. Dopa inhibits induced proliferative activity of murine and human lymphocytes. Anticancer Res 1992; 12:753-6.
35. Bergquist J, Tarkowski A, Ekman R, Ewing A. Discovery of endogenous catecholamines in lymphocytes and evidence for catecholamine regulation of lymphocyte function via an autocrine loop. Proc Natl Acad Sci United States America 1994; 91:12912-16.
36. Cook-Mills J, Cohen R, Perlman R, Chambers D. Inhibition of lymphocyte activation by catecholamines: evidence for a non-classical mechanism of catecholamine action. Immunology 1995; 85:544-9.
37. Elkashef AM, Al-Barazi H, Venable D, Baker I, Hill J, Apud J, Wyatt RJ. Dopamine effect on the mitochondrial potential in B lymphocytes of schizophrenic patients and normal controls. Prog Neuro-Psychopharmacol Biol Psychiatr 2002; 26:145-8.
38. Fierová A, Starec M, Kuldová M, Ková H, Páv M, Vannucci L, Pospíil M. Effects of D2-dopamine and -adrenoceptor antagonists in stress induced changes on immune responsiveness of mice. J Neuroimmunol 2002; 130:55-65.
39. Levite M, Chowers Y, Ganor Y, Besser M, Hershkovits R, Cahalon L. Dopamine interacts directly with its D3 and D2 receptors on normal human T cells, and activates beta1 integrin function. European J Immunol 2001; 31:3504-12.
40. Tsao C, Lin Y, Cheng J. Effect of dopamine on immune cell proliferation in mice. Life Sci 1997; 61:361-71.
41. Deleplanque B, Vitiello S, Le Moal M, Neveu P. Modulation of immune reactivity by unilateral striatal and mesolimbic dopaminergic lesions. Neurosci Lett 1994; 166:216-20.
42. Idova G, Cheido M, Zhukova E, Devoino L. Stimulation of the immune response during activation of the dopaminergic system in mice with opposite types of behavior. Neurosci Behav Physiol 2004; 34:417-21.
43. Lee S, So C, Rashid A, Varghese G, Cheng R, Lança A, O'Dowd B, George SR. Dopamine D1 and D2 receptor co-activation generates a novel phospholipase C-mediated calcium signal. J Biol Chem 2004; 279:35671-8.
44. Chen J, Rusnak M, Luedtke R, Sidhu A. D1 dopamine receptor mediates dopamine-induced cytotoxicity via the ERK signal cascade. J Biol Chem 2004; 279:39317-30.
45. Bergquist. Catecholaminergic suppression of immunocompetent cells. Immunol Today 1998; 19:562-7.
46. Buu NT. Uptake of 1-methyl-4-phenylpyridinium and dopamine in the mouse brain cell nuclei. J Neurochem 1993; 61:1557-60.
47. Pifl C, Kattinger A, Reither H, Hornykiewicz O. Cellular effects of dopamine - beyond oxidative mechanisms. Parkinsonism Related Disorders 2002; 8:433-7.
48. Graham D, Tiffany S, Bell WJ, Gutknecht W. Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro. Mol Pharmacol 1978; 14:644-53.