Influence of molecular weight of chemically sulfated citrus pectin fractions on their antithrombotic and bleeding effects

Thrombosis and Haemostasis

Volumn 101, Issue 5, 2009, Pages 860-866

  Cipriani, Thales R ^a   Gracher, Ana Helena P ^a   De Souza, Lauro M ^a   Fonseca, Roberto J C ^b   Belmiro, Celso L R ^b   Gorin, Philip A J ^a   Sassaki, Guilherme L ^a   Iacomini, Marcello ^a  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Anticoagulant; Antithrombotic; Citrus pectin; Sulfated polysaccharide

Indexed keywords

ANTITHROMBIN; BLOOD CLOTTING FACTOR 10A; HEPARIN; HEPARIN COFACTOR II; HIGH MOLECULAR WEIGHT SULFATED PECTIN; LOW MOLECULAR WEIGHT SULFATED PECTIN; PECTIN; POLYSACCHARIDE SULFATE; THROMBIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; BLEEDING; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG INHIBITION; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURAL HOMOLOGY; SUBSTITUTION REACTION; SULFATION; THROMBOCYTE AGGREGATION; THROMBOSIS PREVENTION; TREATMENT OUTCOME; VEIN THROMBOSIS;

ANIMALS; ANTICOAGULANTS; BLOOD COAGULATION; CITRUS SINENSIS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FACTOR XA; FEMALE; FIBRINOLYTIC AGENTS; HEMORRHAGE; HUMANS; MALE; MOLECULAR WEIGHT; PECTINS; PLATELET AGGREGATION; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; SULFATES; THROMBIN; VENOUS THROMBOSIS;

EID: 66149180572     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH08-08-0556     Document Type: Article

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