An algal sulfated galactan has an unusual dual effect on venous thrombosis due to activation of factor XII and inhibition of the coagulation proteases

Thrombosis and Haemostasis

Volumn 99, Issue 3, 2008, Pages 531-538

  Melo, Fábio R ^a   Mourão, Paulo A S ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Anticoagulant polysaccharide; Antithrombotic polysaccharide; Hageman factor; Heparin; Sulfated polysaccharide

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 12; GALACTAN; HEPARIN; HEPARIN COFACTOR II; LOW MOLECULAR WEIGHT HEPARIN; PROTEINASE; THROMBIN;

ALGA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY THROMBOSIS; ARTICLE; BLEEDING; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; MALE; MAMMAL; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; VEIN THROMBOSIS;

ALGAE, RED; ANIMALS; ANTICOAGULANTS; ANTITHROMBINS; BLEEDING TIME; BLOOD COAGULATION; BLOOD COAGULATION TESTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FACTOR XA; FACTOR XIIA; FEMALE; FIBRINOLYTIC AGENTS; GALACTANS; HEMORRHAGE; HEPARIN; HEPARIN COFACTOR II; HUMANS; MALE; MOLECULAR WEIGHT; PROTEASE INHIBITORS; RATS; RATS, WISTAR; SULFATES; THROMBIN; THROMBOSIS; VENOUS THROMBOSIS;

EID: 42249112662     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH07-10-0649     Document Type: Article

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