Vascular dysfunction in type 2 diabetes: Emerging targets for therapy

Expert Review of Cardiovascular Therapy

Volumn 7, Issue 3, 2009, Pages 209-213

  Park, Yoonjung ^a   Wu, Junxi ^a   Zhang, Hanrui ^a   Wang, Yong ^a   Zhang, Cuihua ^a  

^a University of Missouri   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; GHRELIN; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; PROTEIN KINASE C INHIBITOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RUBOXISTAURIN; TUMOR NECROSIS FACTOR ALPHA; ADIPOCYTOKINE;

ATHEROSCLEROSIS; BEHAVIOR MODIFICATION; CARDIOVASCULAR DISEASE; CYTOKINE PRODUCTION; DIABETIC ANGIOPATHY; DYSLIPIDEMIA; EDITORIAL; ENDOTHELIAL DYSFUNCTION; EXERCISE; HUMAN; HYPERGLYCEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; MORBID OBESITY; NON INSULIN DEPENDENT DIABETES MELLITUS; WEIGHT REDUCTION; BODY WEIGHT; DRUG DELIVERY SYSTEM; METABOLISM; PATHOPHYSIOLOGY; RISK FACTOR; VASCULAR DISEASE;

ADIPOKINES; BODY WEIGHT; DIABETES MELLITUS, TYPE 2; DRUG DELIVERY SYSTEMS; DYSLIPIDEMIAS; HUMANS; REACTIVE OXYGEN SPECIES; RISK FACTORS; VASCULAR DISEASES;

EID: 66149163356     PISSN: 14779072     EISSN: 17448344     Source Type: Journal    
DOI: 10.1586/14779072.7.3.209     Document Type: Editorial

References (38)

1. Plutzky J, Viberti G, Haffner S. Atherosclerosis in Type 2 diabetes meltitus and insulin resistance: mechanistic links and therapeutic targets. J. Diabetes Complications 16(6), 401-415 (2002).
2. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J. Clin. Endocrinol. Metab. 89(6), 2548-2556 (2004).
3. Mueller CF, Laude K, McNally JS et al. Redox mechanisms in blood vessels. Arterioscler. Thromb. Vasc. Biol. 25(2), 274-278 (2005).
4. Kashyap SR, Belfort R, Cersosimo E et al. Chronic low-dose lipid infusion in healthy patients induces markers of endothelial activation independent of its metabolic effects. J. Cardiometab. Syndr. 3(3), 141-146 (2008).
5. Gokce N, Vita JA, McDonnell M et al. Effect of medical and surgical weight loss on endothelial vasomotor function in obese patients. Am. J. Cardiol. 95(2), 266-268 (2005).
6. Hajer GR, van Haeften TW, Visseren FL. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur. Heart J. 29(24), 2959-2971 (2008).
7. Chandrasekar B, Boylston WH, Venkatachalam K et al. Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/ NF-κB/PTEN suppression. J. Biol. Chem. 283(36), 24889-24898 (2008).
8. Eringa EC, Bakker W, Smulders YM et al. Regulation of vascular function and insulin sensitivity by adipose tissue: focus on perivascular adipose tissue. Microcirculation 14(4-5), 389-402 (2007).
9. Wexler DJ, Hu FB, Manson JE et al. Mediating effects of inflammatory biomarkers on insulin resistance associated with obesity. Obes. Res. 13(10), 1772-1783 (2005).
10. Apovian CM, Bigornia S, Mott M et al. Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects. Arterioscler. Thromb. Vasc. Biol. 28(9), 1654-1659 (2008).
11. Goldstein BJ, Scalia R. Adipokines and vascular disease in diabetes. Curr. Diab. Rep. 7(1), 25-33 (2007).
12. Furukawa S, Fujita T, Shimabukuro M et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Invest. 114(12), 1752-1761 (2004).
13. Gao X, Belmadani S, Picchi A et al. Tumor necrosis factor-α induces endothelial dysfunction in Lepr(db) mice. Circulation 115(2), 245-254 (2007).
14. Bruun JM, Helge JW, Richelsen B et al. Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. Am. J. Physiol. Endocrinol. Metab. 290(5), E961-E967 (2006).
15. Chinen I, Shimabukuro M, Yamakawa K et al. Vascular lipotoxicity: endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese zucker diabetic fatty rats. Endocrinology 148(1), 160-165 (2007).
16. Picchi A, Gao X, Belmadani S et al. Tumor necrosis factor-α induces endothelial dysfunction in the prediabetic metabolic syndrome. Circ. Res. 99(1). 69-77 (2006).
17. Du X, Edelstein D, Obici S et al. Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation. J. Clin. Invest. 116(4), 1071-1080 (2006).
18. Gao X, Zhang H, Schmidt AM et al. AGE/RAGE produces endothelial dysfunction in coronary arterioles in Type 2 diabetic mice. Am. J. Physiol. Heart Circ. Physiol. 295(2), H491-H498 (2008).
19. Perassolo MS, Almeida JC, Steemburgo T et al. Endothelial dysfunction and serum fatty acid composition in patients with Type 2 diabetes mellitus. Metabolism 57(9), 1167-1172 (2008).
20. Jackson KG, Armah CK, Minihane AM. Meal fatty acids and postprandial vascular reactivity. Biochem. Soc. Trans. 35 (Pt 3), 451-453 (2007).
21. Burdge GC, Calder PC. Plasma cytokine response during the postprandial period: a potential causal process in vascular disease? Br. J. Nutr. 93(1), 3-9 (2005).
22. Chowienczyk PJ, Watts GF, Wierzbicki AS et al. Preserved endothelial function in patients with severe hypertriglyceridemia and low functional lipoprotein lipase activity. J. Am. Coll. Cardiol. 29(5), 964-968 (1997).
23. Shimabukuro M, Chinen I, Higa N et al. Effects of dietary composition on postprandial endothelial function and adiponectin concentrations in healthy humans: a crossover controlled study. Am. J. Clin. Nutr. 86(4), 923-928 (2007).
24. Itani SI, Ruderman NB, Schmieder F et al. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IκB-α. Diabetes 51(7), 2005-2011 (2002).
25. Naruse K, Rask-Madsen C, Takahara N et al. Activation of vascular protein kinase C-β inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance. Diabetes 55(3), 691-698 (2006).
26. Idris I, Donnelly R. Protein kinase C β inhibition: a novel therapeutic strategy for diabetic microangiopathy. Diab. Vasc. Dis. Res. 3(3), 172-178 (2006).
27. Edirisinghe I, McCormick Hallam K, Kappagoda CT. Effect of fatty acids on endothelium-dependent relaxation in the rabbit aorta. Clin. Sci. (Lond.) 111(2), 145-151 (2006).
28. Fontana L, Villareal DT, Weiss EP et al. Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial. Am. J. Physiol. Endocrinol. Metab. 293(1), E197-E202 (2007).
29. Klein S, Fontana L, Young VL et al. Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease. N. Engl. J. Med. 350(25), 2549-2557 (2004).
30. Rubino F. Is Type 2 diabetes an operable intestinal disease? A provocative yet reasonable hypothesis. Diabetes Care 31(Suppl. 2), S290-S296 (2008).
31. Couzin J. Medicine. Bypassing medicine to treat diabetes. Science 320(5875), 438-440 (2008).
32. Dixon JB, O'Brien PE, Playfair J et al. Adjustable gastric banding and conventional therapy for Type 2 diabetes: a randomized controlled trial. JAMA 299(3), 316-323 (2008).
33. Vazques LA, Pazos F, Berrazueta JR et al. Effects of changes in body weight and insulin resistance on inflammation and endothelial function in morbid obesity after bariatric surgery. J. Clin. Endocrinol. Metab. 90(1), 316-322 (2005).
34. Tesauro M, Schinzari F, Iantorno M et al. Ghrelin improves endothelial function in patients with metabolic syndrome. Circulation 112(19), 2986-2992 (2005).
35. Poykko SM, Kellokoski E, Horkko S et al. Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of Type 2 diabetes. Diabetes 52(10), 2546-2553 (2003).
36. Ybarra J, Bobbioni-Harsch E, Chassot G et al. Persistent correlation of ghrelin plasma levels with body mass index both in stable weight conditions and during gastric-bypass-induced weight loss. Obes. Surg. DOI: 10.1007/s11695-008-9748-8 (Epub ahead of print) (2008).
37. Garcia-Fuentes E, Garrido-Sanchez L, Garcia-Almeida JM et al. Different effect of laparoscopic Roux-en-Y gastric bypass and open biliopancreatic diversion of Scopinaro on serum PYY and ghrelin levels. Obes. Surg. 18(11), 1424-1429 (2008).
38. Xu X, Jhun BS, Ha CH et al. Molecular mechanisms of ghrelin-mediated endothelial nitric oxide synthase activation. Endocrinology 149(8), 4183-4192 (2008).