메뉴 건너뛰기




Volumn 69, Issue 7, 2009, Pages 919-942

Sugammadex: A review of its use in anaesthetic practice

Author keywords

Pharmacodynamics; Pharmacokinetics; Selective relaxant binding agent; Sugammadex; Therapeutic use; Tolerability

Indexed keywords

ATROPINE; CISATRACURIUM; EDROPHONIUM; FLUCLOXACILLIN; FUSIDIC ACID; GLYCOPYRRONIUM BROMIDE; NEOSTIGMINE; ORAL CONTRACEPTIVE AGENT; PLACEBO; PROPOFOL; ROCURONIUM; SALBUTAMOL; SEVOFLURANE; SUGAMMADEX; SUXAMETHONIUM; TERBUTALINE SULFATE; TOREMIFENE; VECURONIUM;

EID: 66149146606     PISSN: 00126667     EISSN: 00126667     Source Type: Journal    
DOI: 10.2165/00003495-200969070-00008     Document Type: Article
Times cited : (99)

References (89)
  • 1
    • 30444438333 scopus 로고    scopus 로고
    • Neuromuscular block
    • Jan;
    • Bowman WC. Neuromuscular block. Br J Pharmacol 2006 Jan; 147 Suppl. 1: S277-86
    • (2006) Br J Pharmacol , vol.147 , Issue.SUPPL. 1
    • Bowman, W.C.1
  • 2
    • 0026564946 scopus 로고
    • The era of relaxant anaesthesia
    • Dec;
    • Utting JE. The era of relaxant anaesthesia. Br J Anaesth 1992 Dec; 69 (6): 551-3
    • (1992) Br J Anaesth , vol.69 , Issue.6 , pp. 551-553
    • Utting, J.E.1
  • 3
    • 36049006165 scopus 로고    scopus 로고
    • Update on the management of neuromuscular block: Focus on su- gammadex
    • de Boer HD, van Egmond J, Driessen JJ, et al. Update on the management of neuromuscular block: focus on su- gammadex. Neuropsych Dis Treat 2007; 3 (5): 539-44
    • (2007) Neuropsych Dis Treat , vol.3 , Issue.5 , pp. 539-544
    • de Boer, H.D.1    van Egmond, J.2    Driessen, J.J.3
  • 4
    • 34547477926 scopus 로고    scopus 로고
    • Sugammadex: A novel agent for the reversal of neuromuscular blockade
    • Aug;
    • Nicholson WT, Sprung J, Jankowski CJ. Sugammadex: a novel agent for the reversal of neuromuscular blockade. Pharmacotherapy 2007 Aug; 27 (8): 1181-8
    • (2007) Pharmacotherapy , vol.27 , Issue.8 , pp. 1181-1188
    • Nicholson, W.T.1    Sprung, J.2    Jankowski, C.J.3
  • 5
    • 0030810819 scopus 로고    scopus 로고
    • Anesthesiology: First of two parts
    • Oct 16;
    • Wiklund RA, Rosenbaum SH. Anesthesiology: first of two parts. N Engl J Med 1997 Oct 16; 337 (16): 1132-41
    • (1997) N Engl J Med , vol.337 , Issue.16 , pp. 1132-1141
    • Wiklund, R.A.1    Rosenbaum, S.H.2
  • 6
    • 0017336108 scopus 로고
    • Suxamethonium-neostigmine interaction in pa- tients with normal of atypical cholinesterase
    • May;
    • Baraka A. Suxamethonium-neostigmine interaction in pa- tients with normal of atypical cholinesterase. Br J Anaesth 1977 May; 49 (5): 479-84
    • (1977) Br J Anaesth , vol.49 , Issue.5 , pp. 479-484
    • Baraka, A.1
  • 8
    • 0027444833 scopus 로고
    • Comparison of ro- curonium, succinylcholine, and vecuronium for rapid- sequence induction of anesthesia in adult patients
    • Nov;
    • Magorian T, Flannery KB, Miller RD. Comparison of ro- curonium, succinylcholine, and vecuronium for rapid- sequence induction of anesthesia in adult patients. An- esthesiology 1993 Nov; 79 (5): 913-8
    • (1993) An- esthesiology , vol.79 , Issue.5 , pp. 913-918
    • Magorian, T.1    Flannery, K.B.2    Miller, R.D.3
  • 9
    • 0036064033 scopus 로고    scopus 로고
    • Neuromuscular blocking drugs: Discovery and development
    • Jul;
    • Raghavendra T. Neuromuscular blocking drugs: discovery and development. J R Soc Med 2002 Jul; 95 (7): 363-7
    • (2002) J R Soc Med , vol.95 , Issue.7 , pp. 363-367
    • Raghavendra, T.1
  • 10
    • 33750984759 scopus 로고    scopus 로고
    • Succinylcholine or rocuronium? A meta-analysis of the effects on intuba- tion conditions
    • Dec;
    • Karcioglu O, Arnold J, Topacoglu H, et al. Succinylcholine or rocuronium? A meta-analysis of the effects on intuba- tion conditions. Int J Clin Pract 2006 Dec; 60 (12): 1638-46
    • (2006) Int J Clin Pract , vol.60 , Issue.12 , pp. 1638-1646
    • Karcioglu, O.1    Arnold, J.2    Topacoglu, H.3
  • 13
    • 61449106490 scopus 로고    scopus 로고
    • Clinical limitations of acetylcholinesterase antagonists
    • Mar;
    • Caldwell JE. Clinical limitations of acetylcholinesterase antagonists. J Crit Care 2009 Mar; 24 (1): 21-8
    • (2009) J Crit Care , vol.24 , Issue.1 , pp. 21-28
    • Caldwell, J.E.1
  • 14
    • 34848866531 scopus 로고    scopus 로고
    • Sugammadex: An opportunity for more thinking or more cookbook medicine?
    • Sep;
    • Donati F. Sugammadex: an opportunity for more thinking or more cookbook medicine? Can J Anesth 2007 Sep; 54 (9): 689-95
    • (2007) Can J Anesth , vol.54 , Issue.9 , pp. 689-695
    • Donati, F.1
  • 15
    • 0037171790 scopus 로고    scopus 로고
    • Adam JM, Bennett DJ, Bom A, et al. Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: synthesis and structure-activ- ity relationships. J Med Chem 2002 Apr 25; 45 (9): 1806-16
    • Adam JM, Bennett DJ, Bom A, et al. Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: synthesis and structure-activ- ity relationships. J Med Chem 2002 Apr 25; 45 (9): 1806-16
  • 16
    • 0037127108 scopus 로고    scopus 로고
    • A novel concept of reversing neuromuscular block: Chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host
    • Jan 18;
    • Bom A, Bradley M, Cameron K, et al. A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host. Angew Chem Int Ed Engl 2002 Jan 18; 41 (2): 266-70
    • (2002) Angew Chem Int Ed Engl , vol.41 , Issue.2 , pp. 266-270
    • Bom, A.1    Bradley, M.2    Cameron, K.3
  • 17
    • 33845573098 scopus 로고    scopus 로고
    • Cyclodextrins and their pharmaceu- tical applications
    • Feb 1;
    • Loftsson T, Duchêne D. Cyclodextrins and their pharmaceu- tical applications. Int J Pharm 2007 Feb 1; 329 (1-2): 1-11
    • (2007) Int J Pharm , vol.329 , Issue.1-2 , pp. 1-11
    • Loftsson, T.1    Duchêne, D.2
  • 18
    • 41949086127 scopus 로고    scopus 로고
    • Cyclodextrins
    • Stella VJ, He Q. Cyclodextrins. Toxicol Pathol 2008; 36 (1): 30-42
    • (2008) Toxicol Pathol , vol.36 , Issue.1 , pp. 30-42
    • Stella, V.J.1    He, Q.2
  • 19
    • 27744575591 scopus 로고    scopus 로고
    • Cyclodextrins in drug de- livery: An updated review
    • Oct 14;
    • Challa R, Ahuja A, Ali J, et al. Cyclodextrins in drug de- livery: an updated review. AAPS PharmSciTech 2005 Oct 14; 6 (2): E329-57
    • (2005) AAPS PharmSciTech , vol.6 , Issue.2
    • Challa, R.1    Ahuja, A.2    Ali, J.3
  • 21
    • 0038234979 scopus 로고    scopus 로고
    • Drug-specific cyclodextrins: The future of rapid neuromuscular block reversal?
    • Apr;
    • ZhangM-Q. Drug-specific cyclodextrins: the future of rapid neuromuscular block reversal? Drugs Future 2003 Apr; 28 (4): 347-54
    • (2003) Drugs Future , vol.28 , Issue.4 , pp. 347-354
    • ZhangM-Q1
  • 22
    • 0041324616 scopus 로고    scopus 로고
    • Reversal of neuromuscular blockade and simultaneous increase in plasma rocuronium concentration after the intravenous infusion of the novel re- versal agent Org 25969
    • Sep;
    • Epemolu O, Bom A, Hope F, et al. Reversal of neuromuscular blockade and simultaneous increase in plasma rocuronium concentration after the intravenous infusion of the novel re- versal agent Org 25969. Anesthesiology 2003 Sep; 99 (3): 632-7
    • (2003) Anesthesiology , vol.99 , Issue.3 , pp. 632-637
    • Epemolu, O.1    Bom, A.2    Hope, F.3
  • 23
    • 34247584581 scopus 로고    scopus 로고
    • Early reversal of profound rocuronium-induced neuromuscular blockade by sugammadex in a randomized multicenter study: Effi- cacy, safety, and pharmacokinetics
    • May;
    • Sparr HJ, Vermeyen KM, Beaufort AM, et al. Early reversal of profound rocuronium-induced neuromuscular blockade by sugammadex in a randomized multicenter study: effi- cacy, safety, and pharmacokinetics. Anesthesiology 2007 May; 106 (5): 935-43
    • (2007) Anesthesiology , vol.106 , Issue.5 , pp. 935-943
    • Sparr, H.J.1    Vermeyen, K.M.2    Beaufort, A.M.3
  • 24
    • 0036388228 scopus 로고    scopus 로고
    • Liquid chrom- atography/mass spectrometric bioanalysis of a modified g-cyclodextrin (Org 25969) and rocuronium bromide (Org 9426) in guinea pig plasma and urine: Its application to determine the plasma pharmacokinetics of Org 25969
    • Epemolu O, Mayer I, Hope F, et al. Liquid chrom- atography/mass spectrometric bioanalysis of a modified g-cyclodextrin (Org 25969) and rocuronium bromide (Org 9426) in guinea pig plasma and urine: its application to determine the plasma pharmacokinetics of Org 25969. Rapid Commun Mass Spectrom 2002; 16 (20): 1946-52
    • (2002) Rapid Commun Mass Spectrom , vol.16 , Issue.20 , pp. 1946-1952
    • Epemolu, O.1    Mayer, I.2    Hope, F.3
  • 25
    • 33645289950 scopus 로고    scopus 로고
    • Sugamma- dex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkey
    • Apr;
    • de Boer HD, van Egmond J, van de Pol F, et al. Sugamma- dex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkey. Br J Anaesth 2006 Apr; 96 (4): 473-9
    • (2006) Br J Anaesth , vol.96 , Issue.4 , pp. 473-479
    • de Boer, H.D.1    van Egmond, J.2    van de Pol, F.3
  • 26
    • 33847208500 scopus 로고    scopus 로고
    • A randomized, dose- finding, phase II study of the selective relaxant binding drug, sugammadex, capable of safely reversing profound rocuronium-induced neuromuscular block
    • Mar;
    • Groudine SB, Soto R, Lien C, et al. A randomized, dose- finding, phase II study of the selective relaxant binding drug, sugammadex, capable of safely reversing profound rocuronium-induced neuromuscular block. Anesth Analg 2007 Mar; 104 (3): 555-62
    • (2007) Anesth Analg , vol.104 , Issue.3 , pp. 555-562
    • Groudine, S.B.1    Soto, R.2    Lien, C.3
  • 27
    • 31144448393 scopus 로고    scopus 로고
    • Org 25969 (sugammadex), a selective relaxant binding agent for an- tagonism of prolonged rocuronium-induced neuromus- cular block
    • Jan;
    • Shields M, Giovannelli M, Mirakhur RK, et al. Org 25969 (sugammadex), a selective relaxant binding agent for an- tagonism of prolonged rocuronium-induced neuromus- cular block. Br J Anaesth 2006 Jan; 96 (1): 36-43
    • (2006) Br J Anaesth , vol.96 , Issue.1 , pp. 36-43
    • Shields, M.1    Giovannelli, M.2    Mirakhur, R.K.3
  • 28
    • 33645646481 scopus 로고    scopus 로고
    • Reversal of rocuronium-induced neuromuscular block by the selective relaxant binding agent sugammadex: A dose-finding and safety study
    • Apr;
    • Sorgenfrei IF, Norrild K, Larsen PB, et al. Reversal of rocuronium-induced neuromuscular block by the selective relaxant binding agent sugammadex: a dose-finding and safety study. Anesthesiology 2006 Apr; 104 (4): 667-74
    • (2006) Anesthesiology , vol.104 , Issue.4 , pp. 667-674
    • Sorgenfrei, I.F.1    Norrild, K.2    Larsen, P.B.3
  • 29
    • 33846586403 scopus 로고    scopus 로고
    • Effective reversal of moderate rocuronium- or vecuronium-induced neuromus- cular block with sugammadex, a selective relaxant binding agent
    • Feb;
    • Suy K, Morias K, Cammu G, et al. Effective reversal of moderate rocuronium- or vecuronium-induced neuromus- cular block with sugammadex, a selective relaxant binding agent. Anesthesiology 2007 Feb; 106 (2): 283-8
    • (2007) Anesthesiology , vol.106 , Issue.2 , pp. 283-288
    • Suy, K.1    Morias, K.2    Cammu, G.3
  • 30
    • 48849112776 scopus 로고    scopus 로고
    • Pühringer FK, Rex C, Sielenkämper AW, et al. Reversal of profound, high-dose rocuronium-induced neuromuscular blockade by sugammadex at two different time points: an international, multicenter, randomized, dose-finding, safety assessor-blinded, phase II trial. Anesthesiology 2008 Aug; 109 (2): 188-97
    • Pühringer FK, Rex C, Sielenkämper AW, et al. Reversal of profound, high-dose rocuronium-induced neuromuscular blockade by sugammadex at two different time points: an international, multicenter, randomized, dose-finding, safety assessor-blinded, phase II trial. Anesthesiology 2008 Aug; 109 (2): 188-97
  • 31
    • 34547592344 scopus 로고    scopus 로고
    • Reversal of rocuronium-induced (1.2mg/kg) profound neuromuscular block by sugammadex: A multicenter, dose-finding and safety study
    • Aug;
    • de Boer HD, Driessen JJ, Marcus MAE, et al. Reversal of rocuronium-induced (1.2mg/kg) profound neuromuscular block by sugammadex: a multicenter, dose-finding and safety study. Anesthesiology 2007 Aug; 107 (2): 239-44
    • (2007) Anesthesiology , vol.107 , Issue.2 , pp. 239-244
    • de Boer, H.D.1    Driessen, J.J.2    Marcus, M.A.E.3
  • 32
    • 26244449246 scopus 로고    scopus 로고
    • First human exposure of Org 25969, a novel agent to reverse the action of rocuronium bromide
    • Oct;
    • Gijsenbergh F, Ramael S, Houwing N, et al. First human exposure of Org 25969, a novel agent to reverse the action of rocuronium bromide. Anesthesiology 2005 Oct; 103 (4): 695-703
    • (2005) Anesthesiology , vol.103 , Issue.4 , pp. 695-703
    • Gijsenbergh, F.1    Ramael, S.2    Houwing, N.3
  • 33
    • 33847190294 scopus 로고    scopus 로고
    • Reversal of rocuronium-induced neuromuscular block with the no- vel drug sugammadex is equally effective under main- tenance anesthesia with propofol or sevoflurane
    • Mar;
    • Vanacker BF, Vermeyen KM, Struys MMR, et al. Reversal of rocuronium-induced neuromuscular block with the no- vel drug sugammadex is equally effective under main- tenance anesthesia with propofol or sevoflurane. Anesth Analg 2007 Mar; 104 (3): 563-8
    • (2007) Anesth Analg , vol.104 , Issue.3 , pp. 563-568
    • Vanacker, B.F.1    Vermeyen, K.M.2    Struys, M.M.R.3
  • 34
    • 66149153142 scopus 로고    scopus 로고
    • Sugammadex reverses neuromuscular blockade after continuous infusion of rocuronium in patients under sevoflurane or propofol maintenance anesthesia [abstract no. S218]
    • Mar;
    • Wagner S, Pühringer FK, Spies C, et al. Sugammadex reverses neuromuscular blockade after continuous infusion of rocuronium in patients under sevoflurane or propofol maintenance anesthesia [abstract no. S218]. Anesth Analg 2008 Mar; 106 Suppl. 3: S218
    • (2008) Anesth Analg , vol.106 , Issue.SUPPL. 3
    • Wagner, S.1    Pühringer, F.K.2    Spies, C.3
  • 35
    • 66149111464 scopus 로고    scopus 로고
    • European Medicines Agency. Bridion (sugammadex sodium) 100mg/mL: summary of product characteristics [online]. Available from URL: http://www.emea.europa. eu/humandocs/PDFs/EPAR/bridion/H-885-PI-en.pdf [Ac- cessed 2009 Feb 5]
    • European Medicines Agency. Bridion (sugammadex sodium) 100mg/mL: summary of product characteristics [online]. Available from URL: http://www.emea.europa. eu/humandocs/PDFs/EPAR/bridion/H-885-PI-en.pdf [Ac- cessed 2009 Feb 5]
  • 37
    • 66149156595 scopus 로고    scopus 로고
    • de Kam P, van Kuijk J, Prohn M, et al. Single IV su- gammadex doses up to 32mg/kg alone or in combination with rocuronium or vecuronium are not associated with QTc prolongation [abstract no. 9AP5-9]. Eur J Anaes- thesiol 2008 Jun; 25 Suppl. 44: 9AP5-9. Plus poster pre- sented at the 2008 AnnualMeeting of the European Societyof Anaesthesiology; 2008 May 31-Jun 3; Copenhagen
    • de Kam P, van Kuijk J, Prohn M, et al. Single IV su- gammadex doses up to 32mg/kg alone or in combination with rocuronium or vecuronium are not associated with QTc prolongation [abstract no. 9AP5-9]. Eur J Anaes- thesiol 2008 Jun; 25 Suppl. 44: 9AP5-9. Plus poster pre- sented at the 2008 AnnualMeeting of the European Societyof Anaesthesiology; 2008 May 31-Jun 3; Copenhagen
  • 39
    • 61849183509 scopus 로고    scopus 로고
    • Monitoring neuromuscular block: An update
    • Mar;
    • Fuchs-Buder T, Schreiber J-U, Meistelman C. Monitoring neuromuscular block: an update. Anaesthesia 2009 Mar; 64 Suppl. 1: 82-9
    • (2009) Anaesthesia , vol.64 , Issue.SUPPL. 1 , pp. 82-89
    • Fuchs-Buder, T.1    Schreiber, J.-U.2    Meistelman, C.3
  • 40
    • 7044281135 scopus 로고    scopus 로고
    • online, Available from URL:, Accessed 2008 Sep 26
    • American Society of Anesthesiologists. ASA physical status classification system [online]. Available from URL: http:// www.asahq.org/clinical/ physicalstatus.htm [Accessed 2008 Sep 26]
    • ASA physical status classification system
  • 41
    • 66149131146 scopus 로고    scopus 로고
    • International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Hu- man Use. The clinical evaluation of QT/QTc interval prolong- ation and proarrhythmic potential for non-antiarrhythmic drugs: E14 [online, Available from URL:, Accessed 2009 Apr 6
    • International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Hu- man Use. The clinical evaluation of QT/QTc interval prolong- ation and proarrhythmic potential for non-antiarrhythmic drugs: E14 [online]. Available from URL: http://www.ich. org/LOB/media/MEDIA1476.pdf [Accessed 2009 Apr 6]
  • 42
    • 58849105558 scopus 로고    scopus 로고
    • Reversal of rocuronium-induced neuromuscular blockade by sugamma- dex in cardiac patients
    • abstract no. A1581 plus poster, Oct 13-17; San Francisco CA
    • Dahl V, Pendeville PE, Hollman MW, et al. Reversal of rocuronium-induced neuromuscular blockade by sugamma- dex in cardiac patients [abstract no. A1581 plus poster]. 2007 Annual Meeting of the American Society of An- esthesiologists; 2007 Oct 13-17; San Francisco (CA)
    • (2007) 2007 Annual Meeting of the American Society of An- esthesiologists
    • Dahl, V.1    Pendeville, P.E.2    Hollman, M.W.3
  • 43
    • 50849154436 scopus 로고    scopus 로고
    • Neostigmine but not sugammadex impairs upper airway dilator muscle activity and breathing
    • Sep;
    • Eikermann M, Zaremba S, Malhotra A, et al. Neostigmine but not sugammadex impairs upper airway dilator muscle activity and breathing. Br J Anaesth 2008 Sep; 101 (3): 344-9
    • (2008) Br J Anaesth , vol.101 , Issue.3 , pp. 344-349
    • Eikermann, M.1    Zaremba, S.2    Malhotra, A.3
  • 44
    • 66149158286 scopus 로고    scopus 로고
    • Pharmacokinetics of rocuronium and sugammadex in patients with normal and impaired renal function
    • abstract plus poster, Cape Town
    • Staals L, Snoeck M, Hunter J, et al. Pharmacokinetics of rocuronium and sugammadex in patients with normal and impaired renal function [abstract plus poster]. 14th World Congress of Anaesthesiologists; 2008Mar 2-7; Cape Town
    • 14th World Congress of Anaesthesiologists; 2008Mar , pp. 2-7
    • Staals, L.1    Snoeck, M.2    Hunter, J.3
  • 45
    • 0029815561 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of rocuroniumbromide
    • Sep;
    • Khuenl-Brady KS, Sparr H. Clinical pharmacokinetics of rocuroniumbromide. Clin Pharmacokinet 1996 Sep; 31 (3): 174-83
    • (1996) Clin Pharmacokinet , vol.31 , Issue.3 , pp. 174-183
    • Khuenl-Brady, K.S.1    Sparr, H.2
  • 46
    • 0034979127 scopus 로고    scopus 로고
    • Newer neuromus- cular blocking agents: How do they compare with estab- lished agents?
    • Sparr HJ, Beaufort TM, Fuchs-Buder T. Newer neuromus- cular blocking agents: how do they compare with estab- lished agents? Drugs 2001; 61 (7): 919-42
    • (2001) Drugs , vol.61 , Issue.7 , pp. 919-942
    • Sparr, H.J.1    Beaufort, T.M.2    Fuchs-Buder, T.3
  • 47
    • 0033759804 scopus 로고    scopus 로고
    • Urinary, biliary and faecal excretion of rocuronium in humans
    • Nov;
    • Proost JH, Eriksson LI,Mirakhur RK, et al. Urinary, biliary and faecal excretion of rocuronium in humans. Br J An- aesth 2000 Nov; 85 (5): 717-23
    • (2000) Br J An- aesth , vol.85 , Issue.5 , pp. 717-723
    • Proost, J.H.1    Eriksson, L.I.2    Mirakhur, R.K.3
  • 48
    • 51849115179 scopus 로고    scopus 로고
    • Multicentre, par- allel-group, comparative trial evaluating the efficacy and safety of sugammadex in patients with end-stage renal failure or normal renal function
    • Oct;
    • Staals LM, Snoeck MMJ, Driessen JJ, et al. Multicentre, par- allel-group, comparative trial evaluating the efficacy and safety of sugammadex in patients with end-stage renal failure or normal renal function. Br J Anaesth 2008 Oct; 101 (4): 492-7
    • (2008) Br J Anaesth , vol.101 , Issue.4 , pp. 492-497
    • Staals, L.M.1    Snoeck, M.M.J.2    Driessen, J.J.3
  • 49
    • 61549120102 scopus 로고    scopus 로고
    • Reversal of ro- curonium-induced neuromuscular blockade with sugamma- dex in pediatric and adult surgical patients
    • Feb;
    • Plaud B, Meretoja O, Hofmockel R, et al. Reversal of ro- curonium-induced neuromuscular blockade with sugamma- dex in pediatric and adult surgical patients. Anesthesiology 2009 Feb; 110 (2): 284-94
    • (2009) Anesthesiology , vol.110 , Issue.2 , pp. 284-294
    • Plaud, B.1    Meretoja, O.2    Hofmockel, R.3
  • 50
    • 66149099360 scopus 로고    scopus 로고
    • Blobner M, Eriksson L, Scholz J, et al. Sugammadex (2.0mg/kg) significantly faster reverses shallow rocuronium- induced neuromuscular blockade compared with neostigmne (50mg/kg) [abstract no. 9AP7-10]. Eur J Anaesthesiol 2007 Jun; 24: 125. Plus poster presented at the 2007 Congress of the European Society of Anaesthesiology; 2007 Jun 9-12;Munich
    • Blobner M, Eriksson L, Scholz J, et al. Sugammadex (2.0mg/kg) significantly faster reverses shallow rocuronium- induced neuromuscular blockade compared with neostigmne (50mg/kg) [abstract no. 9AP7-10]. Eur J Anaesthesiol 2007 Jun; 24: 125. Plus poster presented at the 2007 Congress of the European Society of Anaesthesiology; 2007 Jun 9-12;Munich
  • 51
    • 43249093192 scopus 로고    scopus 로고
    • Reversal of rocuronium-induced neuromuscular block with sugamma- dex is faster than reversal of cisatracurium-induced blockwith neostigmine
    • May;
    • Flockton EA, Mastronardi P, Hunter JM, et al. Reversal of rocuronium-induced neuromuscular block with sugamma- dex is faster than reversal of cisatracurium-induced blockwith neostigmine. Br J Anaesth 2008 May; 100 (5): 622-30
    • (2008) Br J Anaesth , vol.100 , Issue.5 , pp. 622-630
    • Flockton, E.A.1    Mastronardi, P.2    Hunter, J.M.3
  • 52
    • 56149116295 scopus 로고    scopus 로고
    • Reversal of profound rocuronium-induced blockade with sugammadex: A ran- domized comparison with neostigmine
    • Nov;
    • Jones RK, Caldwell JE, Brull SJ, et al. Reversal of profound rocuronium-induced blockade with sugammadex: a ran- domized comparison with neostigmine. Anesthesiology 2008 Nov; 109 (5): 816-24
    • (2008) Anesthesiology , vol.109 , Issue.5 , pp. 816-824
    • Jones, R.K.1    Caldwell, J.E.2    Brull, S.J.3
  • 53
    • 65549091452 scopus 로고    scopus 로고
    • Reversal of profound neuro- muscular block by sugammadex administered 3 minutes after rocuronium: A comparison with spontaneous recovery from succinylcholine
    • May;
    • Lee C, Jahr JS, CandiottiKA, et al.Reversal of profound neuro- muscular block by sugammadex administered 3 minutes after rocuronium: a comparison with spontaneous recovery from succinylcholine. Anesthesiology 2009 May; 110 (5): 1020-5
    • (2009) Anesthesiology , vol.110 , Issue.5 , pp. 1020-1025
    • Lee, C.1    Jahr, J.S.2    CandiottiKA3
  • 54
    • 66149154737 scopus 로고    scopus 로고
    • Alvarez-Gomez JA, WattwillM, Vanacker B, et al. Reversal of vecuronium-induced shallow neuromuscular blockade is signi- ficantly faster with sugammadex compared with neostigmine [abstract no. 9AP7-8]. Eur J Anaesthesiol 2007 Jun; 24 Suppl. 39: 124-5. Plus poster presented at the 2007 Congress of the European Society of Anaesthesiology; 2007 Jun 9-12; Munich
    • Alvarez-Gomez JA, WattwillM, Vanacker B, et al. Reversal of vecuronium-induced shallow neuromuscular blockade is signi- ficantly faster with sugammadex compared with neostigmine [abstract no. 9AP7-8]. Eur J Anaesthesiol 2007 Jun; 24 Suppl. 39: 124-5. Plus poster presented at the 2007 Congress of the European Society of Anaesthesiology; 2007 Jun 9-12; Munich
  • 55
    • 61849164360 scopus 로고    scopus 로고
    • Sugammadex reverses profound vecuronium blockade more rapidly than neostigmine
    • abstract no. A1578 plus poster, Oct 13-17; San Francisco CA
    • Lemmens HJM, El-Orbany MI, Berry J, et al. Sugammadex reverses profound vecuronium blockade more rapidly than neostigmine [abstract no. A1578 plus poster]. 2007 Annual Meeting of the American Society of Anesthesiologists; 2007 Oct 13-17; San Francisco (CA)
    • (2007) 2007 Annual Meeting of the American Society of Anesthesiologists
    • Lemmens, H.J.M.1    El-Orbany, M.I.2    Berry, J.3
  • 56
    • 33847193874 scopus 로고    scopus 로고
    • Sugammadex reversal of rocuronium-induced neuromuscular blockade: A comparison with neostigmine-glycopyrrolate and edro- phonium-atropine
    • Sacan O, White PF, Tufanogullari B, et al. Sugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and edro- phonium-atropine. Anesth Analg 2007Mar; 104 (3): 569-74
    • Anesth Analg 2007Mar , vol.104 , Issue.3 , pp. 569-574
    • Sacan, O.1    White, P.F.2    Tufanogullari, B.3
  • 57
    • 70149101963 scopus 로고    scopus 로고
    • Sugammadex given at least 15min after rocuronium is effective in reversing neuromuscular blockade
    • abstract no. A1579 plus poster, Oct 13-17; San Francisco CA
    • Pavlin EG, White PF, Viegas OJ, et al. Sugammadex given at least 15min after rocuronium is effective in reversing neuromuscular blockade [abstract no. A1579 plus poster]. 2007 Annual Meeting of the American Society of An- esthesiologists; 2007 Oct 13-17; San Francisco (CA)
    • (2007) 2007 Annual Meeting of the American Society of An- esthesiologists
    • Pavlin, E.G.1    White, P.F.2    Viegas, O.J.3
  • 59
    • 58849109959 scopus 로고    scopus 로고
    • Sugammadex safely reverses rocuronium-induced block- ade in patients with pulmonary disease [abstract no. A1582 plus poster]
    • Oct 13-17; San Francisco CA
    • Amao R, Zornow MH, McTaggart Cowan R, et al. Sugammadex safely reverses rocuronium-induced block- ade in patients with pulmonary disease [abstract no. A1582 plus poster]. 2007 AnnualMeeting of the American Societ of Anesthesiologists; 2007 Oct 13-17; San Francisco (CA)
    • (2007) 2007 AnnualMeeting of the American Societ of Anesthesiologists
    • Amao, R.1    Zornow, M.H.2    McTaggart Cowan, R.3
  • 60
    • 66249085662 scopus 로고    scopus 로고
    • Obesity has no clinically relevant impact upon recovery time following administra-ion of sugammadex
    • abstract no. A682 plus poster, Oct 18-22; Orlando FL
    • Monk TG, Rietbergen H, Woo T. Obesity has no clinically relevant impact upon recovery time following administra-ion of sugammadex [abstract no. A682 plus poster]. 2008 Annual Meeting of the American Society of Anesthesiolo- ists; 2008 Oct 18-22; Orlando (FL)
    • (2008) 2008 Annual Meeting of the American Society of Anesthesiolo- ists
    • Monk, T.G.1    Rietbergen, H.2    Woo, T.3
  • 61
    • 34447312844 scopus 로고    scopus 로고
    • Good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents II: The Stockholm revision
    • Aug;
    • Fuchs-Buder T, Claudius C, Skovgaard LT, et al. Good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents II: the Stockholm revision. Acta Anaesthesiol Scand 2007 Aug; 51 (7): 789-808
    • (2007) Acta Anaesthesiol Scand , vol.51 , Issue.7 , pp. 789-808
    • Fuchs-Buder, T.1    Claudius, C.2    Skovgaard, L.T.3
  • 62
    • 40949125983 scopus 로고    scopus 로고
    • Safety and toler- ability of single intravenous doses of sugammadex ad- ministered simultaneously with rocuronium or vecuronium in healthy volunteers
    • Cammu G, De Kam PJ, Demeyer I, et al. Safety and toler- ability of single intravenous doses of sugammadex ad- ministered simultaneously with rocuronium or vecuronium in healthy volunteers. Br J Anaesth 2008Mar; 100 (3): 373-9
    • Br J Anaesth 2008Mar , vol.100 , Issue.3 , pp. 373-379
    • Cammu, G.1    De Kam, P.J.2    Demeyer, I.3
  • 63
    • 66149152731 scopus 로고    scopus 로고
    • Peeters P, Passier P, Smeets J, et al. Single intravenous high- dose sugammadex (up to 96mg/kg) is generally safe and well tolerated in healthy volunteers [abstract no. 9AP3-6]. Eur J Anaesthesiol 2008; 25 Suppl. 4: 9AP3-6. Plus poster presented at the 2008 Congress of the European Society of Anaesthesiology; 2008 May 31-Jun 3; Copenhagen
    • Peeters P, Passier P, Smeets J, et al. Single intravenous high- dose sugammadex (up to 96mg/kg) is generally safe and well tolerated in healthy volunteers [abstract no. 9AP3-6]. Eur J Anaesthesiol 2008; 25 Suppl. 4: 9AP3-6. Plus poster presented at the 2008 Congress of the European Society of Anaesthesiology; 2008 May 31-Jun 3; Copenhagen
  • 64
    • 34250350008 scopus 로고    scopus 로고
    • Reversal of rocuronium-induced (1.2mg kg-1) profound neuromus- cular block by accidental high dose of sugammadex (40mg kg-1)
    • May;
    • Molina AL, de Boer HD, Klimek M, et al. Reversal of rocuronium-induced (1.2mg kg-1) profound neuromus- cular block by accidental high dose of sugammadex (40mg kg-1). Br J Anaesth 2007 May; 98 (5): 624-7
    • (2007) Br J Anaesth , vol.98 , Issue.5 , pp. 624-627
    • Molina, A.L.1    de Boer, H.D.2    Klimek, M.3
  • 65
    • 66149083282 scopus 로고    scopus 로고
    • discussion [online, Available from URL:, Accessed 2008 Oct 1
    • European Medicines Agency. European Public Assessment Re- port for Bridion (sugammadex): scientific discussion [online]. Available from URL: http://www.emea.europa.eu/humandocs/ PDFs/EPAR/bridion/H-885-en6.pdf [Accessed 2008 Oct 1]
    • European Public Assessment Re- port for Bridion (sugammadex): Scientific
  • 66
    • 66149149897 scopus 로고    scopus 로고
    • Plaud B, van Heumen E, Zwiers A. Sugammadex is well tol- erated for the reversal of rocuronium- or vecuronium- induced neuromuscular blockade in a pooled analysis of adverse events in 10 placebo-controlled trials [abstract no. 9AP3-3]. Eur JAnaesthesiol 2008; 25 Suppl. 44: 9AP3-3. Plus poster presented at the 2008 Congress of the European So- ciety of Anaesthesiology; 2008May 31-Jun 3; Copenhagen
    • Plaud B, van Heumen E, Zwiers A. Sugammadex is well tol- erated for the reversal of rocuronium- or vecuronium- induced neuromuscular blockade in a pooled analysis of adverse events in 10 placebo-controlled trials [abstract no. 9AP3-3]. Eur JAnaesthesiol 2008; 25 Suppl. 44: 9AP3-3. Plus poster presented at the 2008 Congress of the European So- ciety of Anaesthesiology; 2008May 31-Jun 3; Copenhagen
  • 67
    • 28344452423 scopus 로고    scopus 로고
    • Postdischarge symp- toms after ambulatory surgery: First-week incidence, intensity, and risk factors
    • Dec;
    • Mattila K, Toivonen J, Janhunen L, et al. Postdischarge symp- toms after ambulatory surgery: first-week incidence, intensity, and risk factors. Anesth Analg 2005 Dec; 101 (6): 1643-50
    • (2005) Anesth Analg , vol.101 , Issue.6 , pp. 1643-1650
    • Mattila, K.1    Toivonen, J.2    Janhunen, L.3
  • 68
    • 46749131798 scopus 로고    scopus 로고
    • An esti- mation of the global volume of surgery: A modelling strategy based on available data
    • Jul 12;
    • Weiser TG, Regenbogen SE, Thompson KD, et al. An esti- mation of the global volume of surgery: a modelling strategy based on available data. Lancet 2008 Jul 12; 372 (9633): 139-44
    • (2008) Lancet , vol.372 , Issue.9633 , pp. 139-144
    • Weiser, T.G.1    Regenbogen, S.E.2    Thompson, K.D.3
  • 69
    • 45549092389 scopus 로고    scopus 로고
    • Sugammadex: A cyclodextrin to reverse neuro- muscular blockade in anaesthesia
    • May;
    • Donati F. Sugammadex: a cyclodextrin to reverse neuro- muscular blockade in anaesthesia. Expert Opin Pharmac- other 2008 May; 9 (8): 1375-86
    • (2008) Expert Opin Pharmac- other , vol.9 , Issue.8 , pp. 1375-1386
    • Donati, F.1
  • 70
    • 0037406756 scopus 로고    scopus 로고
    • Evidence-based practice and neuromuscular monitoring: It's time for routine quantitative assessment
    • May;
    • Eriksson LI. Evidence-based practice and neuromuscular monitoring: it's time for routine quantitative assessment. Anesthesiology 2003 May; 98 (5): 1037-9
    • (2003) Anesthesiology , vol.98 , Issue.5 , pp. 1037-1039
    • Eriksson, L.I.1
  • 71
    • 0037407606 scopus 로고    scopus 로고
    • Residual paralysis in the PACU after a single intubating dose of nondepolariz- ing muscle relaxant with an intermediate duration of ac- tion
    • May;
    • Debaene B, Plaud B, Dilly M-P, et al. Residual paralysis in the PACU after a single intubating dose of nondepolariz- ing muscle relaxant with an intermediate duration of ac- tion. Anesthesiology 2003 May; 98 (5): 1042-8
    • (2003) Anesthesiology , vol.98 , Issue.5 , pp. 1042-1048
    • Debaene, B.1    Plaud, B.2    Dilly, M.-P.3
  • 72
    • 33644942363 scopus 로고    scopus 로고
    • Residual neuromuscular blockade: Incidence, assessment, and relevance in the postoperative period
    • Mar;
    • Murphy GS. Residual neuromuscular blockade: incidence, assessment, and relevance in the postoperative period. Minerva Anestesiol 2006 Mar; 72 (3): 97-109
    • (2006) Minerva Anestesiol , vol.72 , Issue.3 , pp. 97-109
    • Murphy, G.S.1
  • 73
    • 33747372242 scopus 로고    scopus 로고
    • The doughnut and the hole: A new pharmacological concept for anaesthetists
    • Aug;
    • Hunter JM, Flockton EA. The doughnut and the hole: a new pharmacological concept for anaesthetists. Br J Anaesth 2006 Aug; 97 (2): 123-6
    • (2006) Br J Anaesth , vol.97 , Issue.2 , pp. 123-126
    • Hunter, J.M.1    Flockton, E.A.2
  • 74
    • 0017225192 scopus 로고
    • Antagonism of neuromuscular blockade
    • Apr;
    • Miller RD. Antagonism of neuromuscular blockade. An- esthesiology 1976 Apr; 44 (4): 318-29
    • (1976) An- esthesiology , vol.44 , Issue.4 , pp. 318-329
    • Miller, R.D.1
  • 75
    • 34247880353 scopus 로고    scopus 로고
    • Neuromuscular mon- itoring and postoperative residual curarization: A meta- analysis
    • Mar;
    • Naguib M, Kopman AF, Ensor JE. Neuromuscular mon- itoring and postoperative residual curarization: a meta- analysis. Br J Anaesth 2007 Mar; 98 (3): 302-16
    • (2007) Br J Anaesth , vol.98 , Issue.3 , pp. 302-316
    • Naguib, M.1    Kopman, A.F.2    Ensor, J.E.3
  • 76
    • 49849100055 scopus 로고    scopus 로고
    • Residual neuro- muscular blockade and critical respiratory events in the post- anesthesia care unit
    • Jul;
    • Murphy GS, Szokol JW,Marymont JH, et al. Residual neuro- muscular blockade and critical respiratory events in the post- anesthesia care unit. Anesth Analg 2008 Jul; 107 (1): 130-7
    • (2008) Anesth Analg , vol.107 , Issue.1 , pp. 130-137
    • Murphy, G.S.1    Szokol, J.W.2    Marymont, J.H.3
  • 77
    • 13244252635 scopus 로고    scopus 로고
    • Impact of anesthesia management characteristics on severe morbidity and mortality
    • Feb;
    • Arbous MS, Meursing AEE, van Kleef JW, et al. Impact of anesthesia management characteristics on severe morbidity and mortality. Anesthesiology 2005 Feb; 102 (2): 257-68
    • (2005) Anesthesiology , vol.102 , Issue.2 , pp. 257-268
    • Arbous, M.S.1    Meursing, A.E.E.2    van Kleef, J.W.3
  • 78
    • 61849146198 scopus 로고    scopus 로고
    • Antagonism of non-depolar- ising neuromuscular block: Current practice
    • Mar;
    • Kopman AF, Eikermann M. Antagonism of non-depolar- ising neuromuscular block: current practice. Anaesthesia 2009 Mar; 64 Suppl. 1: 22-30
    • (2009) Anaesthesia , vol.64 , Issue.SUPPL. 1 , pp. 22-30
    • Kopman, A.F.1    Eikermann, M.2
  • 79
    • 33847235862 scopus 로고    scopus 로고
    • Naguib M. Sugammadex: another milestone in clinical neuromuscular pharmacology. Anesth Analg 2007 Mar; 04 (3): 575-81
    • Naguib M. Sugammadex: another milestone in clinical neuromuscular pharmacology. Anesth Analg 2007 Mar; 04 (3): 575-81
  • 80
    • 66149128899 scopus 로고    scopus 로고
    • Orthopaedic surgery implications of a novel encapsulation process that improves neuromuscular blockade and reversal
    • Harris AM, Welliver M, Redfern R, et al. Orthopaedic surgery implications of a novel encapsulation process that improves neuromuscular blockade and reversal. Internet J Orthop Surg 2007; 7 (2): e1-12
    • (2007) Internet J Orthop Surg , vol.7 , Issue.2
    • Harris, A.M.1    Welliver, M.2    Redfern, R.3
  • 81
    • 0035018840 scopus 로고    scopus 로고
    • Neostigmine antagonism of rocuronium block during anesthesia with sevoflurane, isoflurane or propofol
    • Apr;
    • Reid JE, Breslin DS, Mirakhur RK, et al. Neostigmine antagonism of rocuronium block during anesthesia with sevoflurane, isoflurane or propofol. Can J Anesth 2001 Apr; 48 (4): 351-5
    • (2001) Can J Anesth , vol.48 , Issue.4 , pp. 351-355
    • Reid, J.E.1    Breslin, D.S.2    Mirakhur, R.K.3
  • 82
    • 61849148161 scopus 로고    scopus 로고
    • Mirakhur RK. Sugammadex in clinical practice. Anaes- thesia 2009 Mar; 64 Suppl. 1: 45-54
    • Mirakhur RK. Sugammadex in clinical practice. Anaes- thesia 2009 Mar; 64 Suppl. 1: 45-54
  • 83
    • 66149089644 scopus 로고    scopus 로고
    • Duvaldestin P, Kuizenga K, Kjaer CC, et al. Sugammadex achieves fast recovery from profound neuromuscular blockade induced by rocuronium or vecuronium: a dose- response study [abstract no. 9AP7-3]. Eur J Anaesthesiol 2007 Jun; 24: 123. Plus poster presented at the 2007 Congress of the European Society of Anaesthesiology; 2007 Jun 9-12; Munich
    • Duvaldestin P, Kuizenga K, Kjaer CC, et al. Sugammadex achieves fast recovery from profound neuromuscular blockade induced by rocuronium or vecuronium: a dose- response study [abstract no. 9AP7-3]. Eur J Anaesthesiol 2007 Jun; 24: 123. Plus poster presented at the 2007 Congress of the European Society of Anaesthesiology; 2007 Jun 9-12; Munich
  • 84
    • 14644412412 scopus 로고    scopus 로고
    • Genotyping the butyrylcholinesterase in patients with prolonged neuro- muscular block after succinylcholine
    • Mar;
    • Levano S, Ginz H, Siegemund M, et al. Genotyping the butyrylcholinesterase in patients with prolonged neuro- muscular block after succinylcholine. Anesthesiology 2005 Mar; 102 (3): 531-5
    • (2005) Anesthesiology , vol.102 , Issue.3 , pp. 531-535
    • Levano, S.1    Ginz, H.2    Siegemund, M.3
  • 85
    • 61949393077 scopus 로고    scopus 로고
    • Patient safety revisited: Reliability is paramount
    • Mar;
    • Brull SJ. Patient safety revisited: reliability is paramount. Anesth Analg 2009 Mar; 108 (3): 702-3
    • (2009) Anesth Analg , vol.108 , Issue.3 , pp. 702-703
    • Brull, S.J.1
  • 86
    • 61949353492 scopus 로고    scopus 로고
    • The effect of residual neuromuscular blockade on the speed of re- versal with sugammadex
    • White PF, Tufanogullari B, Sacan O, et al. The effect of residual neuromuscular blockade on the speed of re- versal with sugammadex. Anesth Analg 2009Mar; 108 (3): 846-51
    • Anesth Analg 2009Mar , vol.108 , Issue.3 , pp. 846-851
    • White, P.F.1    Tufanogullari, B.2    Sacan, O.3
  • 87
    • 44949245075 scopus 로고    scopus 로고
    • Rocuronium versus succinylcholine for rapid sequence induction intubation
    • Apr 16;, CD002788
    • Perry JJ, Lees JS, Sillberg VA, et al. Rocuronium versus succinylcholine for rapid sequence induction intubation. Cochrane Database Syst Rev 2008 Apr 16; 16 (2): CD002788
    • (2008) Cochrane Database Syst Rev , vol.16 , Issue.2
    • Perry, J.J.1    Lees, J.S.2    Sillberg, V.A.3
  • 88
    • 66149103729 scopus 로고    scopus 로고
    • The potential savings in operating room time associated with the use of sugamma- dex to reverse selected neuromuscular blocking agents: Findings from a hospital efficiency model [abstract no. PHC9]
    • May-Jun;
    • Zhang B,Menzin J, TranMH, et al. The potential savings in operating room time associated with the use of sugamma- dex to reverse selected neuromuscular blocking agents: findings from a hospital efficiency model [abstract no. PHC9]. Value Health 2008 May-Jun; 11 (3): A244
    • (2008) Value Health , vol.11 , Issue.3
    • Zhang, B.1    Menzin, J.2    Tran, M.H.3
  • 89
    • 66149093931 scopus 로고    scopus 로고
    • Schering-Plough Corp, online, Available from URL:, Accessed 2008 Aug 20
    • Schering-Plough Corp. US FDA issues action letter for sugammadex [online]. Available from URL: http:// www.schering-plough.com/schering-plough/ news/release. jsp?releaseID=1182475 [Accessed 2008 Aug 20]
    • US FDA issues action letter for sugammadex


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.