Interaction of tiagabine with valproate in the mouse pentylenetetrazole- induced seizure model: An isobolographic analysis for non-parallel dose-response relationship curves

Advances in Medical Sciences

Volumn 54, Issue 1, 2009, Pages

  Luszczki, J J ^a,b   Krzyzanowski, M ^a   Swiader, M J ^a  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

Author keywords

Dose response relationship curve; Isobolographic analysis; Pentylenetetrazole; Pharmacodynamic pharmacokinetic interaction; Tiagabine; Valproate

Indexed keywords

PENTETRAZOLE; TIAGABINE; VALPROIC ACID; ANTICONVULSIVE AGENT; CONVULSANT AGENT; NIPECOTIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; CLONIC SEIZURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BRAIN LEVEL; DRUG DOSE COMPARISON; FLUORESCENCE POLARIZATION IMMUNOASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MONOTHERAPY; MOUSE; NONHUMAN; ANIMAL; BRAIN LEVEL; CHEMICALLY INDUCED DISORDER; DRUG COMBINATION; DRUG INTERACTION; EPILEPSY; INTRAPERITONEAL DRUG ADMINISTRATION; RANDOMIZATION; SEIZURE; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; ANTICONVULSANTS; BRAIN CHEMISTRY; CONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; EPILEPSY; INJECTIONS, INTRAPERITONEAL; INJECTIONS, SUBCUTANEOUS; MALE; MICE; NIPECOTIC ACIDS; PENTYLENETETRAZOLE; RANDOM ALLOCATION; SEIZURES; VALPROIC ACID;

EID: 66149143500     PISSN: 18961126     EISSN: None     Source Type: Journal    
DOI: 10.2478/v10039-009-0006-7     Document Type: Article

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