Divergent frequencies of IGF-I receptor-expressing blood lymphocytes in monozygotic twin pairs discordant for Graves' disease: Evidence for a phenotypic signature ascribable to nongenetic factors

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 5, 2009, Pages 1797-1802

  Douglas, Raymond S ^a,b,c,d   Brix, Thomas H ^e,f   Hwang, Catherine J ^a,b   Hegedüs, Laszlo ^e,f   Smith, Terry J ^a,b,d  

^a HARBOR UCLA MEDICAL CENTER   (United States)

^b JULES STEIN EYE INSTITUTE   (United States)

^c Greater Los Angeles Veterans Hospital   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e ODENSE UNIVERSITY HOSPITAL   (Denmark)

^f UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; SOMATOMEDIN C RECEPTOR;

ADULT; ARTICLE; B LYMPHOCYTE; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GRAVES DISEASE; HEREDITY; HUMAN; LYMPHOCYTE; MALE; MONOZYGOTIC TWINS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; TWIN DISCORDANCE; BIOSYNTHESIS; CASE CONTROL STUDY; CD4+ T LYMPHOCYTE; DENMARK; FLOW CYTOMETRY; GENETICS; LYMPHOCYTE SUBPOPULATION; METABOLISM; MIDDLE AGED; REGISTER; TWINS;

ADULT; ANTIGENS, CD3; B-LYMPHOCYTES; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DENMARK; FEMALE; FLOW CYTOMETRY; GENE FREQUENCY; GRAVES DISEASE; HUMANS; LYMPHOCYTE SUBSETS; MALE; MIDDLE AGED; PHENOTYPE; RECEPTOR, IGF TYPE 1; REGISTRIES; T-LYMPHOCYTES; TWINS, MONOZYGOTIC;

EID: 66149143218     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2008-2810     Document Type: Article

References (46)

1. Prabhakar BS, Bahn RS, Smith TJ 2003 Current perspective on the pathogenesis of Graves' disease and ophthalmopathy. Endocr Rev 24:802-835 (Pubitemid 38067700)
2. Akamizu T 2003 Monoclonal antibodies to thyroid specific autoantigens. Autoimmunity 36:361-366 (Pubitemid 37160524)
3. Chen CR, Pichurin P, Nagayama Y, Latrofa F, Rapoport B, McLachlan SM 2003 The thyrotropin receptor autoantigen in Graves' disease is the culprit as well as the victim. J Clin Invest 111:1897-1904
4. Pritchard J, Han R, Horst N, Cruikshank WW, Smith TJ 2003 Immunoglobulin activation of T cell chemoattractant expression in fibroblasts from patients with Graves' disease is mediated through the insulin-like growth factor I receptor pathway. J Immunol 170:6348-6354 (Pubitemid 36682621)
5. Pritchard J, Horst N, Cruikshank W, Smith TJ 2002 Igs from patients with Graves' disease induce the expression of T cell chemoattractants in their fibroblasts. J Immunol 168:942-950 (Pubitemid 34049599)
6. Smith TJ, Hoa N 2004 Immunoglobulins from patients with Graves' disease induce hyaluronan synthesis in their orbital fibroblasts through the self-antigen, insulin-like growth factor-I receptor. J Clin Endocrinol Metab 89:5076-5080 (Pubitemid 39391451)
7. Douglas RS, Gianoukakis AG, Kamat S, Smith TJ 2007 Aberrant expression of the insulin-like growth factor-1 receptor by T cells from patients with Graves' disease may carry functional consequences for disease pathogenesis. J Immunol 178:3281-3287 (Pubitemid 46333212)
8. Douglas RS, Naik V, Hwang CJ, Afifiyan NF, Gianoukakis AG, Sand D, Kamat S, Smith TJ 2008 B Cells from patients with Graves' disease aberrantly express the IGF-1 receptor: implications for disease pathogenesis. J Immunol 181:5768-5774
9. Brix TH, Knudsen GP, Kristiansen M, Kyvik KO, Orstavik KH, Hegedus L 2005 High frequency of skewed X-chromosome inactivation in females with autoimmune thyroid disease: a possible explanation for the female predisposition to thyroid autoimmunity. J Clin Endocrinol Metab 90:5949-5953 (Pubitemid 41606510)
10. Brix TH, Kyvik KO, Christensen K, Hegedus L 2001 Evidence for a major role of heredity in Graves' disease: a population-based study of two Danish twin cohorts. J Clin Endocrinol Metab 86:930-934 (Pubitemid 32207518)
11. Prummel MF, Strieder T, Wiersinga WM 2004 The environment and autoimmune thyroid diseases. Eur J Endocrinol 150:605-618 (Pubitemid 38786529)
12. Holm IA, Manson JE, Michels KB, Alexander EK, Willett WC, Utiger RD 2005 Smoking and other lifestyle factors and the risk of Graves' hyperthyroidism. Arch Intern Med 165:1606-1611 (Pubitemid 41124154)
13. Skytthe A, Kyvik K, Bathum L, Holm N, Vaupel JW, Christensen K 2006 The Danish Twin Registry in the new millennium. Twin Res Hum Genet 9:763-771 (Pubitemid 46093754)
14. Villanueva R, Greenberg DA, Davies TF, Tomer Y 2003 Sibling recurrence risk in autoimmune thyroid disease. Thyroid 13:761-764 (Pubitemid 37070156)
15. Taylor JC, Gough SC, Hunt PJ, Brix TH, Chatterjee K, Connell JM, Franklyn JA, Hegedus L, Robinson BG, Wiersinga WM, Wass JA, Zabaneh D, Mackay I, Weetman AP 2006 A genome-wide screen in 1119 relative pairs with autoimmune thyroid disease. J Clin Endocrinol Metab 91:646-653 (Pubitemid 43236938)
16. Tomer Y, Davies TF 2003 Searching for the autoimmune thyroid disease susceptibility genes: from gene mapping to gene function. Endocr Rev 24:694-717 (Pubitemid 37330587)
17. Jacobson EM, Tomer Y 2007 The CD40, CTLA-4, thyroglobulin, TSH receptor, and PTPN22 gene quintet and its contribution to thyroid autoimmunity: back to the future. J Autoimmun 28:85-98 (Pubitemid 46670687)
18. Kim TY, Park YJ, Hwang JK, Song JY, Park KS, Cho BY, Park DJ 2003 A C/T polymorphism in the 5′-untranslated region of the CD40 gene is associated with Graves' disease in Koreans. Thyroid 13:919-925 (Pubitemid 37351874)
19. Mochizuki M, Amemiya S, Kobayashi K, Shimura Y, Ishihara T, Nakagomi Y, Onigata K, Tamai S, Kasuga A, Nanazawa S 2003 Association of the CTLA-4 gene 49 A/G polymorphism with type 1 diabetes and autoimmune thyroid disease in Japanese children. Diabetes Care 26:843-847 (Pubitemid 36929353)
20. Lo FS, Lee YJ, Huang CY, Lin CH, Chang SC, Dang CW, Liu HF 2003 Polymorphism in the transmembrane region of the major histocompatibility complex class I chain-related gene A: association of five GCT repetitions with Graves' disease in children. Thyroid 13:839-843 (Pubitemid 37222285)
21. Chistiakov DA, Turakulov RI 2003 CTLA-4 and its role in autoimmune thyroid disease. J Mol Endocrinol 31:21-36 (Pubitemid 37063076)
22. Villanueva R, Inzerillo AM, Tomer Y, Barbesino G, Meltzer M, Concepcion ES, Greenberg DA, MacLaren N, Sun ZS, Zhang DM, Tucci S, Davies TF 2000 Limited genetic susceptibility to severe Graves' ophthalmopathy: no role for CTLA-4 but evidence for an environmental etiology. Thyroid 10:791-798
23. Brix TH, Kyvik KO, Hegedus L 1998 What is the evidence of genetic factors in the etiology of Graves' disease? A brief review. Thyroid 8:727-734 (Pubitemid 28405161)
24. Lois N, Abdelkader E, Reglitz K, Garden C, Ayres JG 2008 Environmental tobacco smoke exposure and eye disease. Br J Ophthalmol 92:1304-1310
25. Bufalo NE, Santos RB, Cury AN, Andrade RA, Morari J, Morari EC, Leite JL, Monte O, Romaldini JH, Ward LS 2008 Genetic polymorphisms associated with cigarette smoking and the risk of Graves' disease. Clin Endocrinol (Oxf) 68:982-987
26. Brix TH, Hansen PS, Kyvik KO, Hegedus L 2000 Cigarette smoking and risk of clinically overt thyroid disease: a population-based twin case-control study. Arch Intern Med 160:661-666 (Pubitemid 30140415)
27. Tsai CC, Cheng CY, Liu CY, Kao SC, Kau HC, Hsu WM, Wei YH 10 October 2008 Oxidative stress in patients with Graves' ophthalmopathy: relationship between oxidative DNA damage and clinical evolution. Eye 10.1038/eye.2008.310
28. Laurberg P, Jorgensen T, Perrild H, Ovesen L, Knudsen N, Pedersen IB, Rasmussen LB, Carle A, Vejbjerg P 2006 The Danish investigation on iodine intake and thyroid disease, DanThyr: status and perspectives. Eur J Endocrinol 155:219-228 (Pubitemid 44269438)
29. Levy BS 2008 Graves' disease. N Engl J Med 359:1408; author reply, 1409
30. Kraemer MH, Donadi EA, Tambascia MA, Magna LA, Prigenzi LS 1998 Relationship between HLA antigens and infectious agents in contributing towards the development of Graves' disease. Immunol Invest 27:17-29 (Pubitemid 28193281)
31. Brix TH, Hansen PS, Hegedus L, Wenzel BE 2008 Too early to dismiss Yersinia enterocolitica infection in the aetiology of Graves' disease: evidence from a twin case-control study. Clin Endocrinol (Oxf) 69:491-496
32. Yin X, Latif R, Tomer Y, Davies TF 2007 Thyroid epigenetics:Xchromosome inactivation in patients with autoimmune thyroid disease. Ann NY Acad Sci 1110:193-200
33. Ozbalkan Z, Bagislar S, Kiraz S, Akyerli CB, Ozer HT, Yavuz S, Birlik AM, Calguneri M, Ozcelik T 2005 Skewed X chromosome inactivation in blood cells of women with scleroderma. Arthritis Rheum 52:1564-1570 (Pubitemid 40663948)
34. Uz E, Loubiere LS, Gadi VK, Ozbalkan Z, Stewart J, Nelson JL, Ozcelik T 2008 Skewed X-chromosome inactivation in scleroderma. Clin Rev Allergy Immunol 34:352-355
35. Bergerot I, Fabien N, Thivolet C 1996 Effects of insulin like growth factor-1 and insulin on effector T cells generating autoimmune diabetes. Diabetes Metab 22:235-239
36. de Mello Coelho V, Villa-Verde DM, Farias-de-Oliveira DA, de Brito JM, Dardenne M, Savino W 2002 Functional insulin-like growth factor-1/insulin-like growth factor-1 receptor-mediated circuit in human and murine thymic epithelial cells. Neuroendocrinology 75:139-150 (Pubitemid 34195774)
37. Beschorner WE, Divic J, Pulido H, Yao X, Kenworthy P, Bruce G 1991 Enhancement of thymic recovery after cyclosporine by recombinant human growth hormone and insulin-like growth factor I. Transplantation 52:879-884
38. Kooijman R, Scholtens LE, Rijkers GT, Zegers BJ 1995 Type I insulin-like growth factor receptor expression in different developmental stages of human thymocytes. J Endocrinol 147:203-209
39. Kim JH, Park HH, Lee CE 2003 IGF-1 potentiation of IL-4-induced CD23/Fc(ε)RII expression in human B cells. Mol Cells 15:307-312
40. Landreth KS, Narayanan R, Dorshkind K 1992 Insulin-like growth factor-I regulates pro-B cell differentiation. Blood 80:1207-1212
41. Stuart CA, Meehan RT, Neale LS, Cintron NM, Furlanetto RW 1991 Insulin-like growth factor-I binds selectively to human peripheral blood monocytes and B-lymphocytes. J Clin Endocrinol Metab 72:1117-1122 (Pubitemid 21921816)
42. Kimata H, Fujimoto M 1994 Growth hormone and insulin-like growth factor I induce immunoglobulin (Ig)E and IgG4 production by human B cells. J Exp Med 180:727-732 (Pubitemid 24224153)
43. Kimata H, Yoshida A 1994 Differential effect of growth hormone and insulin-like growth factor-I, insulin-like growth factor-II, and insulin on Ig production and growth in human plasma cells. Blood 83:1569-1574 (Pubitemid 24081571)
44. Robbins K, McCabe S, Scheiner T, Strasser J, Clark R, Jardieu P 1994 Immunological effects of insulin-like growth factor-I-enhancement of immunoglobulin synthesis. Clin Exp Immunol 95:337-342 (Pubitemid 24207150)
45. Jardieu P, Clark R, Mortensen D, Dorshkind K 1994 In vivo administration of insulin-like growth factor-I stimulates primary B lymphopoiesis and enhances lymphocyte recovery after bone marrow transplantation. J Immunol 152:4320-4327
46. Weightman DR, Perros P, Sherif IH, Kendall-Taylor P 1993 Autoantibodies to IGF-1 binding sites in thyroid associated ophthalmopathy. Autoimmunity 16:251-257 (Pubitemid 24111622)