Cross-sectional analysis of testosterone therapies in hypopituitary men on stable pituitary hormone replacement

Clinical Endocrinology

Volumn 70, Issue 6, 2009, Pages 907-913

  Ross, R J M ^a,f   Siyambalapitiya, S ^a   Jonsson, P ^b   Koltowska Haggstrom, M ^b,c   Gaillard, R ^d   Ho, K ^e  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b PFIZER INC   (United States)

^c UPPSALA UNIVERSITY   (Sweden)

^d LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^e ST VINCENT S HOSPITAL   (Australia)

^f ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN A1C; HYPOPHYSIS HORMONE; LIPID; TESTOSTERONE;

ADULT; ANDROGEN THERAPY; ARTICLE; BLOOD PRESSURE; BODY COMPOSITION; BODY FAT; BONE MINERAL; CARDIOVASCULAR RISK; CONTROLLED STUDY; DATA BASE; GLUCOSE BLOOD LEVEL; HORMONE SUBSTITUTION; HUMAN; HYPOGONADISM; HYPOPITUITARISM; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; MEN'S HEALTH; PRIORITY JOURNAL; QUALITY OF LIFE; TREATMENT RESPONSE;

BODY COMPOSITION; CROSS-SECTIONAL STUDIES; HORMONE REPLACEMENT THERAPY; HUMANS; HYPOPITUITARISM; MALE; MIDDLE AGED; PITUITARY HORMONES; QUALITY OF LIFE; TESTOSTERONE;

EID: 66149140204     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2008.03435.x     Document Type: Article

References (37)

1. Bhasin, S., Cunningham, G., Hayes, F. et al. (2006) Testosterone therapy in adult men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism, 91, 1995 2010. (Pubitemid 43854972)
2. Wang, C., Swerdloff, R., Iranmanesh, A. et al. (2000) Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men. Journal of Clinical Endocrinology and Metabolism, 85, 2839 2854.
3. Alexander, G., Swerdloff, R., Wang, C. et al. (1997) Androgen-behavior correlations in hypogonadal men and eugonadal men. I. Mood and response to auditory sexual stimuli. Hormones and Behavior, 31, 110 119. (Pubitemid 27239865)
4. Kwan, M., Greenleaf, W., Mann, J. et al. (1983) The nature of androgen action on male sexuality: a combined laboratory-self-report study on hypogonadal men. Journal of Clinical Endocrinology and Metabolism, 57, 557 562.
5. McNicholas, T., Dean, J., Mulder, H. et al. (2003) A novel testosterone gel formulation normalizes androgen levels in hypogonadal men, with improvements in body composition and sexual function. British Journal of Urology International, 91, 69 74.
6. Snyder, P., Peachey, H., Berlin, J. et al. (2000) Effects of testosterone replacement in hypogonadal men. Journal of Clinical Endocrinology and Metabolism, 85, 2670 2677. (Pubitemid 32269134)
7. Steidle, C., Schwartz, T., Jacoby, K. et al. (2003) AA2500 testosterone gel normalizes androgen levels in aging males with improvements in body composition and sexual function. Journal of Clinical Endocrinology and Metabolism, 88, 2673 2681. (Pubitemid 36724441)
8. Bhasin, S., Storer, T., Berman, N. et al. (1997) Testosterone replacement increases fat-free mass and muscle size in hypogonadal men. Journal of Clinical Endocrinology and Metabolism, 82, 407 413. (Pubitemid 27068601)
9. Brodsky, I., Balagopal, P. Nair, K. (1996) Effects of testosterone replacement on muscle mass and muscle protein synthesis in hypogonadal men - a clinical research center study. Journal of Clinical Endocrinology and Metabolism, 81, 3469 3475. (Pubitemid 26339901)
10. Katznelson, L., Finkelstein, J., Schoenfeld, D. et al. (1996) Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism. Journal of Clinical Endocrinology and Metabolism, 81, 4358 4365. (Pubitemid 26412044)
11. Behre, H., Kliesch, S., Leifke, E. et al. (1997) Long-term effect of testosterone therapy on bone mineral density in hypogonadal men. Journal of Clinical Endocrinology and Metabolism, 82, 2386 2390. (Pubitemid 27337844)
12. Malkin, C., Pugh, P., Morris, P. et al. (2004) Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life. Heart, 90, 871 876. (Pubitemid 39005930)
13. Whitsel, E., Boyko, E., Matsumoto, A. et al. (2001) Intramuscular testosterone esters and plasma lipids in hypogonadal men: a meta-analysis. American Journal of Medicine, 111, 261 269. (Pubitemid 32885620)
14. Marin, P., Krotkiewski, M. Bjorntorp, P. (1992) Androgen treatment of middle-aged, obese men: effects on metabolism, muscle and adipose tissues. European Journal of Medicine, 1, 329 336.
15. Mårin, P., Holmäng, S., Jönsson, L. et al. (1992) The effects of testosterone treatment on body composition and metabolism in middle-aged obese men. International Journal of Obesity and Related Metabolic Disorders, 16, 991 997. (Pubitemid 23010023)
16. Park, N., Yan, B., Chung, J. et al. (2003) Oral testosterone undecanoate (Andriol) supplement therapy improves the quality of life for men with testosterone deficiency. The Aging Male, 6, 86 93. (Pubitemid 36936510)
17. Rabkin, J., Rabkin, R. Wagner, G. (1995) Testosterone replacement therapy in HIV illness. General Hospital Psychiatry, 17, 37 42.
18. Hoberman, J. Yesalis, C. (1995) The history of synthetic testosterone. Scientific American, 272, 76 81.
19. Junkmann, K. (1957) Long-acting steroids in reproduction. Recent Progress in Hormone Research, 13, 389 419 discussion 419-328.
20. Nieschlag, E. (2006) Testosterone treatment comes of age: new options for hypogonadal men. Clinical Endocrinology, 65, 275 281. (Pubitemid 44244915)
21. Conway, A.J., Boylan, L.M., Howe, C. et al. (1988) Randomized clinical trial of testosterone replacement therapy in hypogonadal men. International Journal of Andrology, 11, 247 264. (Pubitemid 18192811)
22. Snyder, P. Lawrence, D. (1980) Treatment of male hypogonadism with testosterone enanthate. Journal of Clinical Endocrinology and Metabolism, 51, 1335 1339. (Pubitemid 11199624)
23. Dobs, A., Meikle, A., Arver, S. et al. (1999) Pharmacokinetics, efficacy, and safety of a permeation-enhanced testosterone transdermal system in comparison with bi-weekly injections of testosterone enanthate for the treatment of hypogonadal men. Journal of Clinical Endocrinology and Metabolism, 84, 3469 3478. (Pubitemid 30645193)
24. Wang, C., Swerdloff, R., Kipnes, M. et al. (2004) New testosterone buccal system (Striant) delivers physiological testosterone levels: pharmacokinetics study in hypogonadal men. Journal of Clinical Endocrinology and Metabolism, 89, 3821 3829. (Pubitemid 39071479)
25. Rolf, C.K.S., Lemmnitz, G., Eickenberg, U. et al. (2002) Pharmacokinetics of a new transdermal testosterone gel in gonadotrophin-suppressed normal men. European Journal of Endocrinology, 146, 673 679. (Pubitemid 34552501)
26. Meikle, A., Mazer, N., Moellmer, J. et al. (1992) Enhanced transdermal delivery of testosterone across nonscrotal skin produces physiological concentrations of testosterone and its metabolites in hypogonadal men. Journal of Clinical Endocrinology and Metabolism, 74, 623 628.
27. Gutiérrez, L., Kotowska-Häggström, M., Jönsson, P. et al. (2008) Registries as a tool in evidence-based medicine: example of KIMS (Pfizer International Metabolic Database). Pharmacoepidemiology and Drug Safety, 17, 90 102.
28. Mayo, A., Macintyre, H., Wallace, A. et al. (2004) Transdermal Testosterone Application: Pharmacokinetics and Effects on Pubertal Status, Short-Term Growth, and Bone Turnover. Journal of Clinical Endocrinology and Metabolism, 89, 681 687. (Pubitemid 38269877)
29. Kalinchenko, S., Vorslov, L., Aglamazian, N. et al. (2007) Efficacy and safety of hormonal therapy with androgens (androgel) in men with erectile dysfunction, partial androgen deficiency of aging male and cardiovascular diseases. Urologica, 57, 59 61.
30. Kenny, A., Prestwood, K. Raisz, L. (2000) Short-term effects of intramuscular and transdermal testosterone on bone turnover, prostate symptoms, cholesterol, and hematocrit in men over age 70 with low testosterone levels. Endocrine Research, 26, 153 168. (Pubitemid 30460837)
31. Salehian, B., Wang, C., Alexander, G. et al. (1995) Pharmacokinetics, bioefficacy, and safety of sublingual testosterone cyclodextrin in hypogonadal men: comparison to testosterone enanthate - a clinical research center study. American Journal of Medicine, 80, 3567 3575.
32. Münzer, T., Harman, S., Hees, P. et al. (2001) Effects of GH and/or sex steroid administration on abdominal subcutaneous and visceral fat in healthy aged women and men. Journal of Clinical Endocrinology and Metabolism, 86, 3604 3610. (Pubitemid 32755950)
33. Giannoulis, M., Sonksen, P., Umpleby, M. et al. (2006) The effects of growth hormone and/or testosterone in healthy elderly men: a randomized controlled trial. Journal of Clinical Endocrinology and Metabolism, 91, 477 484. (Pubitemid 43236912)
34. Mauras, N., Rini, A., Welch, S. et al. (2003) Synergistic effects of testosterone and growth hormone on protein metabolism and body composition in prepubertal boys. Metabolism, 52, 964 969. (Pubitemid 37098363)
35. Blackman, M., Sorkin, J., Münzer, T. et al. (2002) Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial. Journal of the American Medical Association, 288, 2282 2292. (Pubitemid 35291758)
36. Gibney, J., Wolthers, T., Johannsson, G. et al. (2005) Growth hormone and testosterone interact positively to enhance protein and energy metabolism in hypopituitary men. American Journal of Physiology Endocrinology and Metabolism, 289, E266 E271.
37. Johannsson, G., Gibney, J., Wolthers, T. et al. (2005) Independent and combined effects of testosterone and growth hormone on extracellular water in hypopituitary men. Journal of Clinical Endocrinology and Metabolism, 90, 3989 3994. (Pubitemid 41065024)