Expression of Tiam1 and VEGF-C correlates with lymphangiogenesis in human colorectal carcinoma

Cancer Biology and Therapy

Volumn 8, Issue 8, 2009, Pages 689-695

  Zhong, Daping ^a   Li, Yan ^a   Peng, Qiuping ^a   Zhou, Jinming ^a   Zhou, Qi ^a   Zhang, Rong ^a   Liang, Houjie ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Colorectal carcinoma; Lymph microvessel density; Lymph node metastasis; Lymphangiogenesis; Podoplanin; Rac1; RNA interference; Tiam1; VEGF C

Indexed keywords

PLASMID VECTOR; PLASMID VECTOR PGENESIL 1; PODOPLANIN; PROTEIN; RAC1 PROTEIN; T LYMPHOMA INVASION AND METASTASIS 1 PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN C;

ADULT; ARTICLE; CELL GROWTH; CELL STRAIN HCT116; CLINICAL ARTICLE; COLORECTAL CARCINOMA; DISEASE ASSOCIATION; FEMALE; GENE EXPRESSION; HUMAN; LYMPHANGIOGENESIS; MALE; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PLASMID; RNA INTERFERENCE;

EID: 66149139220     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.8.8.7833     Document Type: Article

References (32)

1. Maula SM, Luukkaa M, Grenman R, Jackson D, Jalkanen S, Ristamäki R. Intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinomas of the head and neck region. Cancer Res 2003; 63:1920-1926 (Pubitemid 36460859)
2. Munoz Guerra MF, Marazula EG, Martin Villa E, Quintanilla M, Gamallo C. Prognostic significance of intratumoral lymphangiogenesis in squamous cell carcinoma of the oral carity. Cancer 2004; 100:553-560
3. Kuroyama S, Kobayashi N, Ohbu M, Ohtani Y, Okayasu I, Kakita A. Enzyme carcinoma occurrence of lymphangiogenesis within the tumor. Hepatogastroenterology 2005; 52:1057-1061
4. Jiang-hong Mou, Xiao-chu Yan, Zeng-peng Li, Wang D, Duan GJ, Xiang DB. Characteristic and clinicopathologic significance of lymphangiogenesis in colorectal cancer. Zhonghua Bing Li Xue Za Zhi 2005; 34:348-352
5. Karpanen T, Egeblad M, Karkkainen MJ, Kubo H, Yla-Herttuala S, Jaattela M, et al. Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth. Cancer Res 2001; 61:1786-1790 (Pubitemid 32691984)
6. Kishimoto K, Sasaki A, Yoshihama Y, Mese H, Tsukamoto G, Matsumura T. Expression of vascular endothelial growth factor-C predicts regional lymph node metastases in early oral squamous cell carcinoma. Oral Oncol 2003; 39:391-396 (Pubitemid 36379348)
7. Timoshenko AV, Chakraborty C, Wagner GF, Lala PK. COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer. Br J Cancer 2006; 94:1154-1163
8. Liu J, Yu HG, Yu JP, Wang XL, Zhou XD, Luo HS. Overexpression of cyclooxygenase-2 in gastric cancer correlates with the high abundance of vascular endothelial growth factor-C and lymphatic metastasis. Med Oncol 2005; 22:389-397 (Pubitemid 43780296)
9. Kyzas PA, Stefanou D, Agnantis NJ. COX-2 expression correlates with VEGF-C and lymph node metastases in patients with head and neck squamous cell carcinoma. Mod Pathol 2005; 18:153-160 (Pubitemid 40128108)
10. Su JL, Yang PC, Shih JY, Yang CY, Wei LH, Hsieh CY, et al. VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. Cancer Cell 2006; 9:209-223 (Pubitemid 43357947)
11. Seiji O, Yasuhiko K, Shinji T, Toshio K, Shigeru K, Kazuaki C. Expression of VEGF-C and VEGF-D at the invasive edge correlates with lymph node metastasis and prognosis of patients with colorectal carcinoma. Cancer Sci 2004; 95:32-39 (Pubitemid 38208404)
12. Masataka M, Shoji N, Hiroshi O, Hideo A, Shigehiro Y, Yasuto U, et al. Overexpression of vascular endothelial growth factor-C correlates with lymph node micrometastasis in submucosal esophageal cancer. J Gastrointest Surg 2006; 10:1016-1022
13. Kabashima A, Maehara Y, Kakeji Y, Sugimachi K. Overexpression of vascular endothelial growth factor C is related to lymphogenous metastasis in early gastric carcinoma. Oncology 2001; 60:146-150 (Pubitemid 32245333)
14. Kazama S, Watanabe T, Kanazawa T, Hatano K, Nagawa H. Vascular endothelial growth factor-C (VEGF-C) is a more specific risk factor for lymph node metastasis than VEGF-D in submucosal colorectal cancer. Hepatogastroenterology 2007; 54:71-76 (Pubitemid 46511649)
15. Hu WG, Li JW, Feng B, Beveridge M, Yue F, Lu AG. Vascular endothelial growth factors C and D represent novel prognostic markers in colorectal carcinoma using quantitative image analysis. Eur Surg Res 2007; 39:229-238 (Pubitemid 47000370)
16. Fukunaga S, Maeda K, Noda E, Inoue T, Wada K, Hirakawa K. Association between expression of vascular endothelial growth factor C, chemokine receptor CXCR4 and lymph node metastasis in colorectal cancer. Oncology. 2006; 71:204-211
17. Soumaoro LT, Uetake H, Takagi Y, Iida S, Higuchi T, Yasuno M. Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis. Dis Colon Rectum 2006; 49:392-398
18. Kawakami M, Furuhata T, Kimura Y, Yamaguchi K, Hata F, Sasaki K. Quantification of vascular endothelial growth factor-C and its receptor-3 messenger RNA with real-time quantitative polymerase chain reaction as a predictor of lymph node metastasis in human colorectal cancer. Surgery 2003; 133:300-308 (Pubitemid 36390793)
19. Habets GG, Scholtes EH, Zuydgeest D, van der Kammen RA, Stam JC, Berns A. Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins. Cell 1994; 77:537-549 (Pubitemid 24153994)
20. Michiels F, Collard JG. Rho-like GTPases: their role in cell adhesion and invasion. Biochem Soc Symp.1999; 65:125-146
21. Kawauchi T, Chihama K, Nabeshima Y, Hoshino M. The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration. EMBO J 2003; 22:4190-4201
22. Buchsbaum RJ, Connolly BA, Feig LA. Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen activated protein kinase cascade. Mol Cell Biol. 2002,22:4073-4085.
23. Li Liu, Liang Zhao, Yanfei Zhang, Zhang Q, Ding Y. Proteomic analysis of Tiam1-mediated metastasis in colorectal cancer. Cell Biol Int 2007; 31:805-814 (Pubitemid 46765138)
24. Yan LI, Yong J Hou-jie L. Correlation between high mobility group protein 1, VEGF-C/D expressions and lymph node metastasis in colorectal cancer. Acta Academiae Medicinae Militaris Tertiae 2006; 28:1237-1239
25. Hahn A, Barth H, Kress M, Mertens PR, Goppelt-Struebe M. Role of Rac and Cdc42 in lysophosphatidic acid-mediated cyclo-oxygenase-2 gene expression. Biochem J 2002; 362:33-40. (Pubitemid 34174459)
26. Jen-Liang Su, Jin-Yuan Shih, Men-Luh Yen, et al. Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C upregulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma. Cancer Res 2004; 64:554-564 (Pubitemid 38120894)
27. Costa C, Soares R, Reis-Filho JS, Leitao D, Amendoeira I, Schmitt FC, et al. Cyclooxygenase-2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer. J Clin Pathol 2002; 55:429-434 (Pubitemid 34620779)
28. Yonemura Y, Fushida S, Bando E, Kinoshita K, Miwa K, Endo Y. Lymphangiogenesis and the vascular endothelial growth factor receptor-3 in gastric cancer. Eur J Cancer 2001; 37:918-923
29. Brummelkamp TR, Bernards R, Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science 2002; 296:550-553 (Pubitemid 34408678)
30. Paul CP, Good PD, Winer I, Engelke DR. Effective expression of small interfering RNA in human cells. Nat Biotechnol 2002; 20:505-508 (Pubitemid 34495939)
31. Chang HJ, Yoo BC, Kim SW, Lee BL, Kim WH. Significance of PML and p53 protein as molecular prognostic markers of gallbladder carcinomas. Pathol Oncol Res 2007; 13:326-335
32. Angeliki M, Saskia van E, Stephan H, Collard JG. The Rac exchange factor Tiam1 is required for the establishment and maintenance of cadherin-based adhesions. J Bio Chem 2004; 279:30092-30098 (Pubitemid 38937931)