Expression levels of immune markers in Actinobacillus pleuropneumoniae infected pigs and their relation to breed and clinical symptoms

BMC Veterinary Research

Volumn 5, Issue , 2009, Pages

  Benga, Laurentiu ^a,b   Hoeltig, Doris ^b   Rehm, Thomas ^b   Rothkoetter, Hermann Josef ^c   Pabst, Reinhard ^a   Valentin Weigand, Peter ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^c OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTINOBACILLUS; ACTINOBACILLUS PLEUROPNEUMONIAE; BACTERIA (MICROORGANISMS); STREPTOCOCCUS SUIS; SUIDAE; SUS;

BIOLOGICAL MARKER;

ACTINOBACILLUS INFECTION; ACTINOBACILLUS PLEUROPNEUMONIAE; ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; BREEDING; GENE EXPRESSION REGULATION; IMMUNOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; STATISTICAL MODEL; SWINE; SWINE DISEASE; TIME;

ACTINOBACILLUS INFECTIONS; ACTINOBACILLUS PLEUROPNEUMONIAE; ANIMALS; BIOLOGICAL MARKERS; BREEDING; GENE EXPRESSION REGULATION; LINEAR MODELS; SWINE; SWINE DISEASES; TIME FACTORS;

EID: 66149136919     PISSN: None     EISSN: 17466148     Source Type: Journal    
DOI: 10.1186/1746-6148-5-13     Document Type: Article

References (42)

1. Sebunya TNK, Saunders JR. Haemophilus pleuropneumoniae infection in swine: a review. J Am Vet Med Assoc 1983, 182:1331-1337.
2. Shope RE. Porcine contagious pleuropneumonia. I. Experimental transmission, etiology and pathology. J Exp Med 1964, 119:357-368. 2137882, 14129707, 10.1084/jem.119.3.357.
3. Gobert AP, Wilson KT, Martin C. Cellular responses to attaching and effacing bacteria: activation and implication of the innate immune system. Arch Immunol Ther Exp (Warsz) 2005, 53(3):234-244.
4. Hodgson JC, Watkins CA, Bayne CW. Contribution of respiratory burst activity to innate immune function and the effects of disease status and agent on chemiluminescence responses by ruminant phagocytes in vitro. Vet Immunol Immunopathol 2006, 112:12-23. 10.1016/j.vetimm.2006.03.008, 16678912.
5. Janeway CA, Medzhitov R. Innate immune recognition. Annu Rev Immunol 2002, 20:197-216. 10.1146/annurev.immunol.20.083001.084359, 11861602.
6. Baumann H, Gauldie J. The acute phase response. Immunol Today 1994, 15:74-80. 10.1016/0167-5699(94)90137-6, 7512342.
7. Michel T, Feron O. Nitric oxide synthases: which, where, how, and why?. J Clin Invest 1997, 100:2146-2152. 508408, 9410890, 10.1172/JCI119750.
8. Hulten C, Johansson E, Fossum C, Wallgreen P. Interleukin 6, serum amyloid A and haptoglobin as markers of treatment efficacy in pigs experimentally infected with Actinobacillus pleuropneumoniae. Vet Microbiol 2003, 95:75-89. 10.1016/S0378-1135(03)00136-6, 12860078.
9. Cho WS, Chae C. Expression of nitric oxide synthase 2 and tumor necrosis factor α in swine naturally infected with Actinobacillus pleuropneumoniae. Vet Pathol 2002, 39:27-32. 10.1354/vp.39-1-27, 12102216.
10. Cho WS, Chae C. In vitro effects of Actinobacillus pleuropneumoniae on inducible nitric oxide synthase and cyclooxygenase-2 in porcine alveolar macrophages. Am J Vet Res 2003, 64:1514-1518. 10.2460/ajvr.2003.64.1514, 14672430.
11. Cho WS, Chae C. Expression of nitric oxide synthase 2 and cyclooxygenase-2 in swine experimentally infected with Actinobacillus pleuropneumoniae. Vet Pathol 2004, 41:666-672. 10.1354/vp.41-6-666, 15557075.
12. Cross ML, Qureshi T, Mackintosh CG. Oxidative responses in ferret macrophages. Vet Immunol Immunopathol 1999, 67:171-184. Hiss S, Willbrenning GS, Suntz M, Reinacher M, Sauerwein H, Immunohistochemical localization of haptoglobin in porcine lungs. Anat. Histol. Embryol. 2008, 37: 196-199., 10.1016/S0165-2427(98)00222-0, 10077423.
13. Huang H, Potter AA, Campos M, Leighton FL, Willson P, Yates WDG. Pathogenesis of porcine Actinobacillus Pleuropneumonia, Part I: Effects of surface components of Actinobacillus pleuropneumoniae in vivo and in vitro. Can J Vet Res 1998, 62:93-101. 1189454, 9553707.
14. Huang H, Potter AA, Campos M, Leighton FL, Willson P, Haines MH, Yates WDG. Pathogenesis of porcine Actinobacillus Pleuropneumonia, Part II: Roles of proinflammatory cytokines. Can J Vet Res 1999, 63:69-78. 1189518, 9918337.
15. Rehm T, Benga L, Danilowicz E, Drungowski M, Hoeltig D, Kalisch D, Oehlmann W, Probst I, Gerlach G-F. Functional genome analysis investigating resistance to respiratory tract disease in a porcine Actinobacillus pleuropneumoniae infection model. Dtsch Tierarztl Wochenschr 2008, 115:260-264.
16. Reiner G, Melchinger E, Kramarowa M, Pfaff E, Büttner M, Saalmüller A, Geldermann H. Detection of quantitative trait loci for resistance/susceptibility to pseudorabies virus in swine. J Gen Virol 2002, 83:167-172.
17. Hoeltig D, Hennig-Pauka I, Thies K, Rehm T, Beyerbach M, Gerlach G-F, Waldmann K-H, . the members of the FUGATO-consortium IRAS A novel Respiratory Health Score (RHS) supports a role of acute lung damage and pig breed in the course of an Actinobacillus pleuropneumoniae infection. BMC Vet Res 5:14. 19383120, 10.1186/1746-6148-5-14, the members of the FUGATO-consortium IRAS.
18. Pampusch MS, Bennaars AM, Harsch S, Murtaugh MP. Inducible nitric oxide synthethase expression in porcine immune cells. Vet Immunol Immunopathol 1998, 61:279-289. 10.1016/S0165-2427(97)00139-6, 9613441.
19. Diamond G, Legarda D, Ryan LK. The innate immune response of the respiratory epithelium. Immunol Rev 2000, 173:27-38. 10.1034/j.1600-065X.2000.917304.x, 10719665.
20. Van Leeuwen MA, Van Rijswijk MH. Acute phase proteins in the monitoring of inflammatory disorders. Bailliere's Clin Rheumatol 1994, 8:531-552.
21. Heegaard PMH, Klausen J, Nielsen JP, Gonzales-Ramon N, Pineiro M, Lampraeve F, Avala MA. The porcine acute phase response to infection with Actinobacillus pleuropneumoniae. Haptoglobin, C-reactive protein, major acute phase protein and serum amyloid A protein are sensitive indicators of infection. Comp Biochem Physiol B Biochem Mol Biol 1998, 119(2):365-373. 10.1016/S0305-0491(97)00362-3, 9629669.
22. Knura-Deszczka S, Lipperheide C, Petersen B, Jobert JL, Berthelot-Herault F, Kobisch M, Madec F. Plasma haptoglobin concentration in swine after challenge with Streptococcus suis. J Vet Med B 2002, 49:240-244.
23. Hiss S, Willbrenning GS, Suntz M, Reinacher M, Sauerwein H. Immunohistochemical localization of haptoglobin in porcine lungs. Anat Histol Embryol 2008, 37:196-199. 10.1111/j.1439-0264.2007.00828.x, 18162095.
24. Baarsch MJ, Scamurra RW, Burger K, Foss DL, Maheswaran SK, Murtaugh MP. Inflammatory cytokine expression in swine experimentally infected with Actinobacillus pleuropneumoniae. Infect Immun 1995, 63:3587-3594. 173498, 7642295.
25. Balaji R, Wright KJ, Turner JL, Hill CM, Dritz SS, Fenwick B, Carroll JA, Zannelli ME, Beasang LA, Minton JE. Circulating cortisol, tumor necrosis factor-α, interleukin-1β, and interferon-γ in pigs infected with Actinobacillus pleuropneumoniae. J Anim Sci 2002, 80:202-207.
26. Fossum C, Wattrang E, Fuxler L, Jensen KT, Wallgren P. Evaluation of various cytokines (IL-6, IFN-α, IFN-γ, TNF-α) as markers for acute bacterial infection in swine - a possible role for serum interleukin-6. Vet Immunol Immunopathol 1998, 64:161-172. 10.1016/S0165-2427(98)00126-3, 9661265.
27. Johansson E, Fossum C, Fuxler L, Wallgren P. Effects of an experimental infection with Actinobacillus pleuropneumoniae on the interferon-α and interleukin-6 producing capacity of porcine peripheral blood mononuclear cells stimulated with bacteria, virus or plasmid DNA. Vet Microbiol 2001, 79:171-182. 10.1016/S0378-1135(00)00353-9, 11230938.
28. Myers MJ, Farrell DE, Snider RTG, Post LO. Inflammatory cytokines, pleuropneumonia infection and the effect of dexamethasone. Pathobiology 2004, 71:35-42. 10.1159/000072960, 14555843.
29. Myrianthefs P, Boutzouka E, Venetsanou K, Papalois A, Kouloukousa M, Kittas C, Baltopoulos G. Effect of different ventilatory strategies on local and systemic cytokine production in intact swine lungs in vivo. Vascul Pharmacol 2006, 44:283-289. 10.1016/j.vph.2005.12.004, 16530018.
30. Wattrang E, Wallgren P, Fossum C. Actinobacillus pleuropneumoniae serotype 2 - effects on the interferon-α production of porcine leukocytes in vivo and in vitro. Comp Immunol Microbiol Inf Dis 1998, 21:135-154.
31. Pabst R, Binns RM. The immune system of the respiratory tract in pigs. Vet Immunol Immunopathol 1994, 43:151-156. 10.1016/0165-2427(94)90131-7, 7856047.
32. Hennig-Pauka I, Jacobsen I, Blecha F, Waldmann KH, Gerlach GF. Differential proteomic analysis reveals increased cathelicidin expression in porcine bronchoalveolar lavage fluid after an Actinobacillus pleuropneumoniae infection. Vet Res 2006, 37:75-87. 10.1051/vetres:2005043, 16336926.
33. Harris DP, Haynes L, Sayles P. Reciprocal regulation of polarized cytokine production by effector B and T-cells. Nat Immunol 2000, 1:475-482. 10.1038/82717, 11101868.
34. Anderson C, Potter AA, Gerlach G-F. Isolation and molecular characterization of spontaneously occurring cytolysin-negative mutants of Actinobacillus pleuropneumoniae serotype 7. Infect Immun 1991, 59:4110-4116. 259004, 1937770.
35. Baltes N, Tonpitak W, Gerlach G-F, Hennig-Pauka I, Hoffmann-Moujahid A, Ganter M, Rothkoetter HJ. Actinobacillus pleuropneumoniae iron transport and urease activity: effects on bacterial virulence and host immune response. Infect Immun 2001, 69:472-478. 97905, 11119539, 10.1128/IAI.69.1.472-478.2001.
36. Smith HE, Damman M, Velde J, Wagennar F, Wisselink HJ, Stockhofe-Zurvieden N, Smits MA. Identification and characterisation of the cps locus of Streptococcus suis serotype 2: the capsule protects against phagocytosis and is an important virulence factor. Infect Immun 1999, 67:1750-1756. 96524, 10085014.
37. Benga L, Friedl P, Valentin-Weigand P. Adherence of Streptococcus suis to porcine endothelial cells. J Vet Med B 2005, 52:392-395.
38. Hoeltig D, Hennig-Pauka I, Beyerbach M, Thies K, Rehm T, Gerlach G-F, Waldmann KH. Comparison of the diagnostic significance of clinical, radiographic and ultrasonographic results after an experimental infection with Actinobacillus pleuropneumoniae in pigs. Berl Munch Tierarzl Wochenschr 2008, 121:422-31.
39. Hennig-Pauka I, Ganter M, Gerlach GF, Rothkoetter HJ. Enzyme activities, protein content and cellular variables in the pulmonary epithelial lining fluid in selected healthy pigs. J Vet Med A 2001, 48:631-639.
40. Pick E, Mizel D. Rapid microassays for the measurement of superoxide and hydrogen peroxide production by macrophages in a culture using an automatic enzyme immunoassay reader. J Immunol Meth 1981, 46:211-226.
41. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal Biochem 1982, 126:131-138. 10.1016/0003-2697(82)90118-X, 7181105.
42. Bertoni G, Kuhnert P, Perterhans E, Pauli U. Improved bioassay for the detection of porcine tumor necrosis factor using a homologous cell line: PK(15). J Immunol Methods 1993, 160:267-261. 10.1016/0022-1759(93)90187-C, 8459114.