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Volumn 136, Issue 7, 2009, Pages 2159-2168

Efficacy of L-Ornithine L-Aspartate in Acute Liver Failure: A Double-Blind, Randomized, Placebo-Controlled Study

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA; ORNITHINE ASPARTATE; PLACEBO;

EID: 66149127267     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.02.050     Document Type: Article
Times cited : (151)

References (30)
  • 1
    • 0034754145 scopus 로고    scopus 로고
    • Cerebral metabolism of ammonia and amino acids in patients with fulminant hepatic failure
    • Strauss G.I., Knudsen G.M., Kondrup J., et al. Cerebral metabolism of ammonia and amino acids in patients with fulminant hepatic failure. Gastroenterology 121 (2001) 1109-1119
    • (2001) Gastroenterology , vol.121 , pp. 1109-1119
    • Strauss, G.I.1    Knudsen, G.M.2    Kondrup, J.3
  • 2
    • 33646409052 scopus 로고    scopus 로고
    • Effects of liver failure on inter-organ trafficking of ammonia: implications for the treatment of hepatic encephalopathy
    • Chatauret N., and Butterworth R. Effects of liver failure on inter-organ trafficking of ammonia: implications for the treatment of hepatic encephalopathy. J Gastroenterol Hepatol 19 (2004) S219-S223
    • (2004) J Gastroenterol Hepatol , vol.19
    • Chatauret, N.1    Butterworth, R.2
  • 3
    • 0036988027 scopus 로고    scopus 로고
    • Ammonia, the GABA neurotransmitter system, and hepatic encephalopathy
    • Jones E.A. Ammonia, the GABA neurotransmitter system, and hepatic encephalopathy. Metab Brain Dis 17 (2002) 275-281
    • (2002) Metab Brain Dis , vol.17 , pp. 275-281
    • Jones, E.A.1
  • 4
    • 0033055873 scopus 로고    scopus 로고
    • Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration
    • Clemmesen J.O., Larsen F.S., Kondrup J., et al. Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration. Hepatology 29 (1999) 648-653
    • (1999) Hepatology , vol.29 , pp. 648-653
    • Clemmesen, J.O.1    Larsen, F.S.2    Kondrup, J.3
  • 5
    • 22544482372 scopus 로고    scopus 로고
    • Evaluation of plasma ammonia levels in patients with acute liver failure and chronic liver disease and its correlation with the severity of hepatic encephalopathy and clinical features of raised intracranial tension
    • Kundra A., Jain A., Banga A., et al. Evaluation of plasma ammonia levels in patients with acute liver failure and chronic liver disease and its correlation with the severity of hepatic encephalopathy and clinical features of raised intracranial tension. Clin Biochem 38 (2005) 696-699
    • (2005) Clin Biochem , vol.38 , pp. 696-699
    • Kundra, A.1    Jain, A.2    Banga, A.3
  • 6
    • 29244463889 scopus 로고    scopus 로고
    • Predictive value of arterial ammonia for complications and outcome in acute liver failure
    • Bhatia V., Singh R., and Acharya S.K. Predictive value of arterial ammonia for complications and outcome in acute liver failure. Gut 55 (2006) 98-104
    • (2006) Gut , vol.55 , pp. 98-104
    • Bhatia, V.1    Singh, R.2    Acharya, S.K.3
  • 7
    • 37749006615 scopus 로고    scopus 로고
    • Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure
    • Bernal W., Hall C., Karvellas C.J., et al. Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure. Hepatology 46 (2007) 1844-1852
    • (2007) Hepatology , vol.46 , pp. 1844-1852
    • Bernal, W.1    Hall, C.2    Karvellas, C.J.3
  • 8
    • 0022994268 scopus 로고
    • Ammonia toxicity: comparative protective effect of various arginine and ornithine derivatives, aspartate, benzoate and carbamyl glutamate
    • Zieve L., Lyftogt C., and Raphael D. Ammonia toxicity: comparative protective effect of various arginine and ornithine derivatives, aspartate, benzoate and carbamyl glutamate. Metab Brain Dis 1 (1986) 25-35
    • (1986) Metab Brain Dis , vol.1 , pp. 25-35
    • Zieve, L.1    Lyftogt, C.2    Raphael, D.3
  • 9
    • 0028202127 scopus 로고
    • Increase of the brain uptake index for L-ornithine in rats with hepatic encephalopathy
    • Albrecht J., Hilgier W., Januszewski S., et al. Increase of the brain uptake index for L-ornithine in rats with hepatic encephalopathy. Neuroreport 5 (1994) 671-673
    • (1994) Neuroreport , vol.5 , pp. 671-673
    • Albrecht, J.1    Hilgier, W.2    Januszewski, S.3
  • 10
    • 0031852152 scopus 로고    scopus 로고
    • L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action
    • Rose C., Michalak A., Pannunzio P., et al. L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action. Metab Brain Dis 13 (1998) 147-157
    • (1998) Metab Brain Dis , vol.13 , pp. 147-157
    • Rose, C.1    Michalak, A.2    Pannunzio, P.3
  • 11
    • 0036988608 scopus 로고    scopus 로고
    • Clinical efficacy of L-ornithine-L-aspartate in the management of hepatic encephalopathy
    • Kircheis G., Wettstein M., Dahl S., et al. Clinical efficacy of L-ornithine-L-aspartate in the management of hepatic encephalopathy. Metab Brain Dis 17 (2002) 453-462
    • (2002) Metab Brain Dis , vol.17 , pp. 453-462
    • Kircheis, G.1    Wettstein, M.2    Dahl, S.3
  • 12
    • 0032868948 scopus 로고    scopus 로고
    • L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure
    • Rose C., Michalak A., Rao K.V., et al. L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure. Hepatology 30 (1999) 636-640
    • (1999) Hepatology , vol.30 , pp. 636-640
    • Rose, C.1    Michalak, A.2    Rao, K.V.3
  • 13
    • 0033058847 scopus 로고    scopus 로고
    • Recommendations of the International Association for the Study of the Liver Subcommittee on nomenclature of acute and sub acute liver failure
    • Tandon B.N., Bernauau J., Grady J., et al. Recommendations of the International Association for the Study of the Liver Subcommittee on nomenclature of acute and sub acute liver failure. J Gastroenterol Hepatol 14 (1999) 403-404
    • (1999) J Gastroenterol Hepatol , vol.14 , pp. 403-404
    • Tandon, B.N.1    Bernauau, J.2    Grady, J.3
  • 14
    • 0035901579 scopus 로고    scopus 로고
    • The revised CONSORT statement for reporting randomized trials: explanation and elaboration
    • Altman D.G., Schulz K.F., Moher D., et al. The revised CONSORT statement for reporting randomized trials: explanation and elaboration. Ann Intern Med 134 (2001) 663-694
    • (2001) Ann Intern Med , vol.134 , pp. 663-694
    • Altman, D.G.1    Schulz, K.F.2    Moher, D.3
  • 15
    • 15844397765 scopus 로고    scopus 로고
    • Fulminant hepatitis in a tropical population: clinical course, cause and early predictors of outcome
    • Acharya S.K., Dasarathy S., Kumer T.L., et al. Fulminant hepatitis in a tropical population: clinical course, cause and early predictors of outcome. Hepatology 23 (1996) 1448-1455
    • (1996) Hepatology , vol.23 , pp. 1448-1455
    • Acharya, S.K.1    Dasarathy, S.2    Kumer, T.L.3
  • 16
    • 0026754186 scopus 로고
    • Enteric non-A, non-B hepatitis: epidemics, animal transmission, and hepatitis E virus detection by the polymerase chain reaction
    • Jameel S., Durgapal H., Habibullah C.M., et al. Enteric non-A, non-B hepatitis: epidemics, animal transmission, and hepatitis E virus detection by the polymerase chain reaction. J Med Virol 37 (1992) 263-270
    • (1992) J Med Virol , vol.37 , pp. 263-270
    • Jameel, S.1    Durgapal, H.2    Habibullah, C.M.3
  • 17
  • 18
    • 0027715183 scopus 로고
    • Effects of ornithine aspartate on plasma ammonia and plasma amino acids in patients with cirrhosis. A double-blind, randomized study using a four-fold crossover design
    • Staedt U., Leweling H., Gladisch R., et al. Effects of ornithine aspartate on plasma ammonia and plasma amino acids in patients with cirrhosis. A double-blind, randomized study using a four-fold crossover design. J Hepatol 19 (1993) 424-430
    • (1993) J Hepatol , vol.19 , pp. 424-430
    • Staedt, U.1    Leweling, H.2    Gladisch, R.3
  • 19
    • 0031003989 scopus 로고    scopus 로고
    • Therapeutic efficacy of L-ornithine-L-aspartate infusions in patients with cirrhosis and hepatic encephalopathy: results of a placebo-controlled, double-blind study
    • Kircheis G., Nilius R., Held C., et al. Therapeutic efficacy of L-ornithine-L-aspartate infusions in patients with cirrhosis and hepatic encephalopathy: results of a placebo-controlled, double-blind study. Hepatology 25 (1997) 1351-1360
    • (1997) Hepatology , vol.25 , pp. 1351-1360
    • Kircheis, G.1    Nilius, R.2    Held, C.3
  • 20
    • 0032079801 scopus 로고    scopus 로고
    • Oral L-ornithine-L-aspartate therapy of chronic hepatic encephalopathy: results of a placebo-controlled double-blind study
    • Stauch S., Kircheis G., Adler G., et al. Oral L-ornithine-L-aspartate therapy of chronic hepatic encephalopathy: results of a placebo-controlled double-blind study. J Hepatol 28 (1998) 856-864
    • (1998) J Hepatol , vol.28 , pp. 856-864
    • Stauch, S.1    Kircheis, G.2    Adler, G.3
  • 21
    • 33845462426 scopus 로고    scopus 로고
    • Efficacy of oral L-ornithine-L-aspartate in cirrhotic patients with hyperammonemic hepatic encephalopathy. Results of a randomized, lactulose-controlled study
    • Poo J.L., Góngora J., Sánchez-Avila F., et al. Efficacy of oral L-ornithine-L-aspartate in cirrhotic patients with hyperammonemic hepatic encephalopathy. Results of a randomized, lactulose-controlled study. Ann Hepatol 5 (2006) 281-288
    • (2006) Ann Hepatol , vol.5 , pp. 281-288
    • Poo, J.L.1    Góngora, J.2    Sánchez-Avila, F.3
  • 22
    • 0034044986 scopus 로고    scopus 로고
    • Splanchnic and leg exchange of amino acids and ammonia in acute liver failure
    • Clemmesen J.O., Kondrup J., and Ott P. Splanchnic and leg exchange of amino acids and ammonia in acute liver failure. Gastroenterology 118 (2000) 1131-1139
    • (2000) Gastroenterology , vol.118 , pp. 1131-1139
    • Clemmesen, J.O.1    Kondrup, J.2    Ott, P.3
  • 23
    • 0017581531 scopus 로고
    • Plasma amino acid patterns in hepatic encephalopathy of differing etiology
    • Rosen H.M., Yoshimura N., Hodgman J.M., et al. Plasma amino acid patterns in hepatic encephalopathy of differing etiology. Gastroenterology 72 (1977) 483-487
    • (1977) Gastroenterology , vol.72 , pp. 483-487
    • Rosen, H.M.1    Yoshimura, N.2    Hodgman, J.M.3
  • 24
    • 0035045346 scopus 로고    scopus 로고
    • Effects of high-volume plasmapheresis on ammonia, urea, and amino acids in patients with acute liver failure
    • Clemmesen J.O., Kondrup J., Nielsen L.B., et al. Effects of high-volume plasmapheresis on ammonia, urea, and amino acids in patients with acute liver failure. Am J Gastroenterol 96 (2001) 1217-1223
    • (2001) Am J Gastroenterol , vol.96 , pp. 1217-1223
    • Clemmesen, J.O.1    Kondrup, J.2    Nielsen, L.B.3
  • 25
    • 0033795334 scopus 로고    scopus 로고
    • Effect of L-ornithine-L-aspartate on patients with and without TIPS undergoing glutamine challenge: a double blind, placebo controlled trial
    • Rees C.J., Oppong K., Al Mardini H., et al. Effect of L-ornithine-L-aspartate on patients with and without TIPS undergoing glutamine challenge: a double blind, placebo controlled trial. Gut 47 (2000) 571-574
    • (2000) Gut , vol.47 , pp. 571-574
    • Rees, C.J.1    Oppong, K.2    Al Mardini, H.3
  • 26
    • 0042990253 scopus 로고    scopus 로고
    • Lactulose therapy in acute liver failure
    • Alba L., Hay J.E., Angulo P., et al. Lactulose therapy in acute liver failure. J Hepatol 36 (2002) 33A
    • (2002) J Hepatol , vol.36
    • Alba, L.1    Hay, J.E.2    Angulo, P.3
  • 27
    • 17844365270 scopus 로고    scopus 로고
    • AASLD position paper: the management of acute liver failure
    • Polson J., and Lee W.M. AASLD position paper: the management of acute liver failure. Hepatology 41 (2005) 1179-1197
    • (2005) Hepatology , vol.41 , pp. 1179-1197
    • Polson, J.1    Lee, W.M.2
  • 28
    • 0026661330 scopus 로고
    • Sodium benzoate in the treatment of acute hepatic encephalopathy: a double-blind randomized trial
    • Sushma S., Dasarathy S., Tandon R.K., et al. Sodium benzoate in the treatment of acute hepatic encephalopathy: a double-blind randomized trial. Hepatology 16 (1992) 138-144
    • (1992) Hepatology , vol.16 , pp. 138-144
    • Sushma, S.1    Dasarathy, S.2    Tandon, R.K.3
  • 29
    • 0033638009 scopus 로고    scopus 로고
    • Effect of sodium benzoate on blood ammonia response to oral glutamine challenge in cirrhotic patients: a note of caution
    • Efrati C., Masini A., Merli M., et al. Effect of sodium benzoate on blood ammonia response to oral glutamine challenge in cirrhotic patients: a note of caution. Am J Gastroenterol 95 (2000) 3574-3578
    • (2000) Am J Gastroenterol , vol.95 , pp. 3574-3578
    • Efrati, C.1    Masini, A.2    Merli, M.3
  • 30
    • 0024560271 scopus 로고
    • Failure of sodium benzoate to alleviate plasma and liver ammonia in rats
    • Palekar A.G., Canas J.A., Kalbag S.S., et al. Failure of sodium benzoate to alleviate plasma and liver ammonia in rats. Biochem Med Metab Biol 41 (1989) 64-69
    • (1989) Biochem Med Metab Biol , vol.41 , pp. 64-69
    • Palekar, A.G.1    Canas, J.A.2    Kalbag, S.S.3


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