Splanchnic and leg exchange of amino acids and ammonia in acute liver failure

Gastroenterology

Volumn 118, Issue 6, 2000, Pages 1131-1139

  Clemmesen, Jens Otto ^a   Kondrup, Jens ^a   Ott, Peter ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; AMMONIA; GLUTAMINE; UREA;

ADULT; AGED; AMINO ACID TRANSPORT; ARTICLE; CLINICAL ARTICLE; FEMALE; HEPATIC ENCEPHALOPATHY; HUMAN; LEG BLOOD FLOW; LIVER FAILURE; MALE; PRIORITY JOURNAL; SPLANCHNIC BLOOD FLOW;

EID: 0034044986     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(00)70366-0     Document Type: Article

References (51)

1. C Trey CS. Davidson The management of fulminant hepatic failure H Popper F Scaffner Progress in liver disease. 1970 Grune & Stratton New York 282 298
2. SJ O'Keefe R Abraham A El Zayadi W Marshall M Davis R Williams Increased plasma tyrosine concentrations in patients with cirrhosis and fulminant hepatic failure associated with increased plasma tyrosine flux and reduced hepatic oxidation capacity Gastroenterology 81 1981 1017 1024
3. HM Rosen N Yoshimura JM Hodgman JE Fischer Plasma amino acid patterns in hepatic encephalopathy of differing etiology Gastroenterology 72 1977 483 487
4. CO Record B Buxton RA Chase G Curzon IM Murray Lyon R Williams Plasma and brain amino acids in fulminant hepatic failure and their relationship to hepatic encephalopathy Eur J Clin Invest 6 1976 387 394
5. L Ranek PB Andreasen N Tygstrup Galactose elimination capacity as a prognostic index in patients with fulminant hepatic failure Gut 17 1976 959 964
6. B Schneeweiss J Pammer K Ratheiser B Schneider C Madl L Kramer A Kranz P Ferenci W Druml G Grimm K Lenz A Gangl Energy metabolism in acute hepatic failure Gastroenterology 105 1993 1515 1521
7. JO Clemmesen FS Larsen J Kondrup BA Hansen P Ott Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration Hepatology 29 1999 648 653
8. M Swain RF Butterworth AT Blei Ammonia and related amino acids in the pathogenesis of brain edema in acute ischemic liver failure in rats Hepatology 15 1992 449 453
9. AT Blei S Olafsson G Therrien RF Butterworth Ammonia-induced brain edema and intracranial hypertension in rats after portacaval anastomosis Hepatology 19 1994 1437 1444
10. FL Weber GL Veach The importance of the small intestine in gut ammonia production in the fasting dog Gastroenterology 77 1979 235 240
11. HG Windmueller AE Spaeth Uptake and metabolism of plasma glutamine by the small intestine J Biol Chem 249 1974 5070 5079
12. M Walser LJ Bodenlos Urea metabolism in man J Clin Invest 38 1959 1617 1626
13. S Kaiser W Gerok D. Häussinger Ammonia and glutamine metabolism in human liver slices: new aspects on the pathogenesis of hyperammonemia in chronic liver disease Eur J Clin Invest 18 1988 535 542
14. D Rudman TJ DiFulco JT Galambos RB Smith AA Salam WD Warren Maximal rates of excretion and synthesis of urea in normal and cirrhotic subjects J Clin Invest 52 1973 2241 2249
15. H Vilstrup Synthesis of urea after stimulation with amino acids: relation to liver function Gut 21 1980 990 995
16. AJ Meijer WH Lamars RAFM Chamuleau Nitrogen metabolism and ornithine cycle function Physiol Rev 70 1990 701 749
17. SP Bessman AN Bessman The cerebral and peripheral uptake of ammonia in liver disease with an hypothesis for the mechanism of hepatic coma J Clin Invest 34 1955 622 628
18. OP Ganda NB Ruderman Muscle nitrogen metabolism in chronic hepatic insufficiency Metabolism 25 1976 427 435
19. MP Tyor EE Owen JN Berr y JF Flanagan The relative role of extremity, liver, and kidney as ammonia receivers and donors in patients with liver disease Gastroenterology 39 1960 420 424
20. M Hayashi H Ohnishi Y Kawade Y Muto Y Takahashi Augmented utilization of branched-chain amino acids by skeletal muscle in decompensated liver cirrhosis in special relation to ammonia detoxification Gastroenterol Jpn 16 1981 64 70
21. H Leweling R Breitkreutz F Behne U Staedt JP Striebel E Holm Hyperammonemia-induced depletion of glutamate and branched-chain amino acids in muscle and plasma J Hepatol 25 1996 756 762
22. AH Lockwood JM McDonald RE Reiman AS Gelbard JS Laughlin TE Duffy F Plum The dynamics of ammonia metabolism in man. Effects of liver disease and hyperammonemia J Clin Invest 63 1979 449 460
23. CH Dejong MT Kampman NE Deutz PB Soeters Altered gluta-mine metabolism in rat portal drained viscera and hindquarter during hyperammonemia Gastroenterology 102 1992 936 948
24. MJ Perko HB Nielsen C Skak JO Clemmesen TV Schroeder NH Secher Mesenteric, coeliac and splanchnic blood flow in humans during exercise J Physiol 513 1998 907 913
25. JO Clemmesen N Tygstrup P Ott Hepatic plasma flow estimated according to Fick's principle in patients with hepatic encephalopathy: evaluation of indocyanine green and D-sorbitol as test substances Hepatology 27 1998 666 673
26. S Keiding E Engsted P Ott Sorbitol as a test substance for measurements of liver plasma flow in humans Hepatology 28 1998 50 56
27. J Zeeh H Lange J Bosch S Pohl H Loesgen R Eggers M Navasa J Chesta J Bircher Steady-state extrarenal sorbitol clearance as a measure of hepatic plasma flow Gastroenterology 95 1988 749 759
28. JO Clemmesen S Galatius C Skak P Dalgaard FS Larsen P Ott The effect of raising blood pressure with dopamine on systemic, splanchnic, and lower extremity hemodynamics in patients with acute liver failure Scand J Gastroenterol 34 1999 921 927
29. JO Clemmesen AL Gerbes V Gülberg BA Hansen FS Larsen C Skak N Tygstrup P. Ott Hepatic blood flow and splanchnic oxygen consumption in patients with liver failure. Effect of high-volume plasmapheresis Hepatology 29 1999 347 355
30. JK Fawcett JE Scott A rapid and precise method for the determination of urea J Clin Pathol 13 1960 156 159
31. HO Conn Studies on the origin and significance of blood ammonia. II. The distribution of ammonia in whole blood plasma and erythrocytes of man Yale J Biol Med 39 1966 38 53
32. J Wahren P Felig L Hagenfeldt Effect of protein ingestion on splanchnic and leg metabolism in normal man and in patients with diabetes mellitus J Clin Invest 57 1976 987 999
33. P Felig J Wahren Influence of endogenous insulin secretion on splanchnic glucose and amino acid metabolism in man J Clin Invest 50 1971 1702 1711
34. L Hagenfeldt A Arvidsson The distribution of amino acids between plasma and erythrocytes Clin Chim Acta 100 1980 133 141
35. P Felig J Wahren L Raf Evidence of inter-organ amino-acid transport by blood cells in humans Proc Natl Acad Sci U S A 70 1973 1775 1779
36. M Elia G Neale G Livesey Alanine and glutamine release from human forearm: effects of glucose administration Clin Sci 69 1985 123 133
37. YT Kruszynska N. McIntyre Amino acid metabolism 2nd ed J Bircher J Benhamou N McIntyre M Rizzetto J Rodés Oxford textbook of clinical hepatology. 1999 Oxford University Oxford, England 303 324
38. J Wahren L Hagenfeldt P Felig Splanchnic and leg exchange of glucose, amino acids, and free fatty acids during exercise in diabetes mellitus J Clin Invest 55 1975 1303 1314
39. MY Morgan AW Marshall JP Milsom S Sherlock Plasma amino-acid patterns in liver disease Gut 23 1982 362 370
40. DW Wilmore CW Goodwin LH Aulick MC Powanda AD Mason BA Pruitt Effect of injury and infection on visceral metabolism and circulation Ann Surg 192 1980 491 504
41. BM Wolfe SP Ahuja EB Marliss Effects of intravenously administered fructose and glucose on splanchnic amino acid and carbohydrate metabolism in hypertriglyceridemic men J Clin Invest 56 1975 970 977
42. D. Haussinger Ammonia, urea production, and pH regulation 2nd ed J Bircher J Benhamou N McIntyre M Rizzetto J Rodés Oxford textbook of clinical hepatology. 1999 Oxford University Oxford, England 324 335
43. H Vilstrup D Bucher B Krog SE Damgard Elimination of infused amino acids from plasma of control subjects and of patients with cirrhosis of the liver Eur J Clin Invest 12 1982 197 202
44. RL Jungas ML Halperin JT Brosnan Quantitative analysis of amino acic oxidation and related gluconeogenesis in humans Physiol Rev 72 1992 419 448
45. N Deutz CHC Dejong PB Soeters Ammonia and glutamine metabolism during liver insufficiency: the muscle-gut-liver axis Ital J Gastroenterol 25 1993 79 86
46. 3− , pH and the activity of carbonic anhydrase Eur J Biochem 152 1985 381 386
47. D. Häussinger Nitrogen metabolism in liver: structural and functional organization and physiological relevance Biochem J 267 1990 281 290
48. H Vilstrup J Iversen N Tygstrup Glucoregulation in acute liver failure Eur J Clin Invest 16 1986 193 197
49. G Kircheis R Nilius C Held H Berndt M Buchner R Gortelmeyer R Hendricks B Kruger B Kuklinski H Meister HJ Otto C Rink W Rosch S Stauch Therapeutic efficacy of L-ornithine-L-aspartate infusions in patients with cirrhosis and hepatic encephalopathy: results of a placebo-controlled, double-blind study Hepatology 25 1997 1351 1360
50. P Desjardins C Rose V Rao A Michalak G Quack G Kircheis RF Butterworth L-Ornithine-L-aspartate lowers hyperammonemia and prevents encephalopathy and brain edema in acute liver failure via a post-translational increase of muscle glutamine synthetase (abstr) Hepatology 30 1999 414A
51. K Maezono K Mawatari K Kajiwara A Shinkai T Maki Effect of alanine on D-galactosamine-induced acute liver failure in rats Hepatology 24 1996 1211 1216