Mutations in hepatitis C virus E2 located outside the CD81 binding sites lead to escape from broadly neutralizing antibodies but compromise virus infectivity

Journal of Virology

Volumn 83, Issue 12, 2009, Pages 6149-6160

  Keck, Zhen Yong ^a   Li, Sophia H ^a   Xia, Jinming ^a   Von Hahn, Thomas ^b   Balfe, Peter ^c   McKeating, Jane A ^c   Witteveldt, Jeroen ^d   Patel, Arvind H ^d   Alter, Harvey ^e   Rice, Charles M ^b   Foung, Steven K H ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD81 ANTIGEN; MONOCLONAL ANTIBODY; PROTEIN E2; UNCLASSIFIED DRUG; VIRUS PROTEIN; EPITOPE; GLYCOPROTEIN E2, HEPATITIS C VIRUS; HEPATITIS C ANTIBODY; LEUKOCYTE ANTIGEN; VIRUS ENVELOPE PROTEIN;

ARTICLE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; AMINO ACID SUBSTITUTION; ANTIBODY AFFINITY; BINDING SITE; CELL LINE; GENETICS; IMMUNOLOGY; METABOLISM; MUTATION; PATHOGENICITY; SEQUENCE ANALYSIS; SERODIAGNOSIS; SITE DIRECTED MUTAGENESIS; VIROLOGY;

HEPATITIS C VIRUS; MURINAE;

AMINO ACID SUBSTITUTION; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIGENS, CD; BINDING SITES; CELL LINE; EPITOPES; HEPACIVIRUS; HEPATITIS C; HEPATITIS C ANTIBODIES; HUMANS; MUTAGENESIS, SITE-DIRECTED; MUTATION; NEUTRALIZATION TESTS; SEQUENCE ANALYSIS, PROTEIN; VIRAL ENVELOPE PROTEINS;

EID: 66149117798     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00248-09     Document Type: Article

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