Syndecans shed their reputation as inert molecules

Science Signaling

Volumn 2, Issue 64, 2009, Pages

  Bass, Mark D ^a   Morgan, Mark R ^a   Humphries, Martin J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; INTEGRIN; MATRIX METALLOPROTEINASE; PROTEIN KINASE C ALPHA; RAB PROTEIN; SYNDECAN; SYNDECAN 1;

CELL MEMBRANE; CELL SURFACE; CYTOPLASM; ENDOCYTOSIS; EXTRACELLULAR MATRIX; PRIORITY JOURNAL; SHORT SURVEY; SIGNAL TRANSDUCTION; BIOLOGICAL MODEL; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; REVIEW; WOUND HEALING;

EXTRACELLULAR MATRIX; MODELS, BIOLOGICAL; PROTEIN STRUCTURE, TERTIARY; RAB5 GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; SYNDECANS; WOUND HEALING;

EID: 66149115205     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.264pe18     Document Type: Short Survey

References (31)

1. M. R. Morgan, M. J. Humphries, M. D. Bass, Synergistic control of cell adhesion by integrins and syndecans. Nat. Rev. Mol. Cell Biol. 8, 957-969 (2007).
2. A. N. Alexopoulou, H. A. Multhaupt, J. R. Couchman, Syndecans in wound healing, inflammationand vascular biology. Int. J. Biochem. Cell Biol. 39, 505-528 (2007). (Pubitemid 46099032)
3. M. Bernfield, M. Gotte, P. W. Park, O. Reizes, M. L. Fitzgerald, J. Lincecum, M. Zako, Functions of cell surface heparan sulfate proteoglycans. Annu. Rev. Biochem. 68, 729-777 (1999). (Pubitemid 29449208)
4. M. A. Stepp, H. E. Gibson, P. H. Gala, D. D. Iglesia, A. Pajoohesh-Ganji, S. Pal-Ghosh, M. Brown, C. Aquino, A. M. Schwartz, O. Goldberger, M. T. Hinkes, M. Bernfield, Defects in keratinocyte activation during wound healing in the syndecan-1-deficient mouse. J. Cell Sci. 115, 4517-4531 (2002). (Pubitemid 36004412)
5. F. Echtermeyer, M. Streit, S. Wilcox-Adelman, S. Saoncella, F. Denhez, M. Detmar, P. Goetinck, Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4. J. Clin. Invest. 107, R9-R14 (2001). (Pubitemid 32096841)
6. M. D. Bass, K. A. Roach, M. R. Morgan, Z. Mostafavi-Pour, T. Schoen, T. Muramatsu, U. Mayer, C. Ballestrem, J. P. Spatz, M. J. Humphries, Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix. J. Cell Biol. 177, 527-538 (2007). (Pubitemid 46718280)
7. R. D. Sanderson, Y. Yang, T. Kelly, V. MacLeod, Y. Dai, A. Theus, Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: Growth regulation and the prospect of new cancer therapies. J. Cell. Biochem. 96, 897-905 (2005). (Pubitemid 41688716)
8. J. A. Buczek-Thomas, M. A. Nugent, Elastasemediated release of heparan sulfate proteoglycans from pulmonary fibroblast cultures: A mechanism for basic fibroblast growth factor (bFGF) release and attenuation of bFGF binding following elastase-induced injury. J. Biol. Chem. 274, 25167-25172 (1999). (Pubitemid 129529414)
9. S. V. Subramanian, M. L. Fitzgerald, M. Bernfield, Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation. J. Biol. Chem. 272, 14713-14720 (1997). (Pubitemid 27251736)
10. Q. Li, P. W. Park, C. L. Wilson, W. C. Parks, Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury. Cell 111, 635-646 (2002). (Pubitemid 35441246)
11. S. Brule, N. Charnaux, A. Sutton, D. Ledoux, T. Chaigneau, L. Saffar, L. Gattegno, The shedding of syndecan-4 and syndecan-1 from HeLa cells and human primary macrophages is accelerated by SDF-1/CXCL12 and mediated by the matrix metalloproteinase-9. Glycobiology 16, 488-501 (2006). (Pubitemid 43779045)
12. K. Endo, T. Takino, H. Miyamori, H. Kinsen, T. Yoshizaki, M. Furukawa, H. Sato, Cleavage of syndecan-1 by membrane type matrix metalloproteinase- 1 stimulates cell migration. J. Biol. Chem. 278, 40764-40770 (2003). (Pubitemid 37280893)
13. T. G. Popova, B. Millis, C. Bradburne, S. Nazarenko, C. Bailey, V. Chandhoke, S. G. Popov, Acceleration of epithelial cell syndecan-1 shedding by anthrax hemolytic virulence factors. BMC Microbiol. 6, 8 (2006). (Pubitemid 43324628)
14. M. L. Fitzgerald, Z. Wang, P. W. Park, G. Murphy, M. Bernfield, Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase. J. Cell Biol. 148, 811-824 (2000).
15. K. Hayashida, P. D. Stahl, P. W. Park, Syndecan-1 ectodomain shedding is regulated by the small GTPase Rab5. J. Biol. Chem. 283, 35435-35444 (2008).
16. 3 integrin activity in human mammary carcinoma cells. J. Cell Biol. 167, 171-181 (2004). (Pubitemid 39363424)
17. Z. Mostafavi-Pour, J. A. Askari, S. J. Parkinson, P. J. Parker, T. T. Ng, M. J. Humphries, Integrinspecific signaling pathways controlling focal adhesion formation and cell migration. J. Cell Biol. 161, 155-167 (2003). (Pubitemid 36459088)
18. 1-integrins. J. Cell Biol. 173, 767-780 (2006). (Pubitemid 46165584)
19. D. Valdembri, P. T. Caswell, K. I. Anderson, J. P. Schwarz, I. Konig, E. Astanina, F. Caccavari, J. C. Norman, M. J. Humphries, F. Bussolino, G. Serini, Neuropilin-1/GIPC1 signaling regulates α5β1 integrin traffic and function in endothelial cells. PLoS Biol. 7, e25 (2009).
20. P. Zimmermann, Z. Zhang, G. Degeest, E. Mortier, I. Leenaerts, C. Coomans, J. Schulz, F. N'Kuli, P. J. Courtoy, G. David, Syndecan recycling [corrected] is controlled by syntenin-PIP2 interaction and Arf6. Dev. Cell 9, 377-388 (2005). (Pubitemid 41235807)
21. J. R. Whiteford, J. R. Couchman, A conserved NXIP motif is required for cell adhesion properties of the syndecan-4 ectodomain. J. Biol. Chem. 281, 32156-32163 (2006).
22. M. D. Sternlicht, Z. Werb, How matrix metalloproteinases regulate cell behavior. Annu. Rev. Cell Dev. Biol. 17, 463-516 (2001). (Pubitemid 33096184)
23. V. W. van Hinsbergh, M. A. Engelse, P. H. Quax, Pericellular proteases in angiogenesis and vasculogenesis. Arterioscler. Thromb. Vasc. Biol. 26, 716-728 (2006).
24. R. Chirco, X. W. Liu, K. K. Jung, H. R. Kim, Novel functions of TIMPs in cell signaling. Cancer Metastasis Rev. 25, 99-113 (2006). (Pubitemid 43723986)
25. A. G. Remacle, D. V. Rozanov, P. C. Baciu, A. V. Chekanov, V. S. Golubkov, A. Y. Strongin, The transmembrane domain is essential for the microtubular trafficking of membrane type-1 matrix metalloproteinase (MT1-MMP). J. Cell Sci. 118, 4975-4984 (2005).
26. P. E. Van den Steen, I. Van Aelst, V. Hvidberg, H. Piccard, P. Fiten, C. Jacobsen, S. K. Moestrup, S. Fry, L. Royle, M. R. Wormald, R. Wallis, P. M. Rudd, R. A. Dwek, G. Opdenakker, The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors. J. Biol. Chem. 281, 18626-18637 (2006). (Pubitemid 44035522)
27. Z. Yang, D. K. Strickland, P. Bornstein, Extracellular matrix metalloproteinase 2 levels are regulated by the low density lipoprotein-related scavenger receptor and thrombospondin 2. J. Biol. Chem. 276, 8403-8408 (2001). (Pubitemid 37385652)
28. G. Su, S. A. Blaine, D. Qiao, A. Friedl, Membrane type 1 matrix metalloproteinase-mediated stromal syndecan-1 shedding stimulates breast carcinoma cell proliferation. Cancer Res. 68, 9558-9565 (2008).
29. J. J. Bravo-Cordero, R. Marrero-Diaz, D. Megias, L. Genis, A. Garcia-Grande, M. A. Garcia, A. G. Arroyo, M. C. Montoya, MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway. EMBO J. 26, 1499-1510 (2007). (Pubitemid 46480932)
30. H. K. Matthews, L. Marchant, C. Carmona-Fontaine, S. Kuriyama, J. Larrain, M. R. Holt, M. Parsons, R. Mayor, Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA. Development 135, 1771-1780 (2008).
31. R. Chakravarti, V. Sapountzi, J. C. Adams, Functional role of syndecan-1 cytoplasmic V region in lamellipodial spreading, actin bundling, and cell migration. Mol. Biol. Cell 16, 3678-3691 (2005). (Pubitemid 41077078)