Genome-wide impact of androgen receptor trapped clone-27 loss on androgen-regulated transcription in prostate cancer cells

Cancer Research

Volumn 69, Issue 7, 2009, Pages 3140-3147

  Nwachukwu, Jerome C ^a,b   Mita, Paolo ^a,c   Ruoff, Rachel ^a,c   Ha, Susan ^a,c   Wang, Qianben ^e   Huang, S Joseph ^f   Taneja, Samir S ^c   Brown, Myles ^e   Gerald, William L ^d   Garabedian, Michael J ^b,c   Logan, Susan K ^a,c,g  

^a Departments of Pharmacology   (United States)

^b Departments of Microbiology   (United States)

^c NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR TRAPPED CLONE 27; ANTIANDROGEN; REGULATOR PROTEIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; ANDROGEN; ANDROGEN RECEPTOR; ANILIDE; BICALUTAMIDE; MESSENGER RNA; NITRILE; TOLUENESULFONIC ACID DERIVATIVE; TUMOR PROTEIN; UXT PROTEIN, HUMAN;

ARTICLE; CANCER CELL; CANCER GROWTH; CELL CYCLE PROGRESSION; CELL NUCLEUS; CELL PROLIFERATION; CELL STRAIN LNCAP; CONTROLLED STUDY; DNA DAMAGE; DRUG RESPONSE; GENE CONTROL; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PRIMARY TUMOR; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECURRENT CANCER; STAINING; TISSUE MICROARRAY; UPREGULATION; BIOSYNTHESIS; CELL GROWTH; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEOPLASM; PATHOLOGY; PHYSIOLOGY; PROSTATE TUMOR; TUMOR CELL LINE; TUMOR RECURRENCE;

ANDROGEN ANTAGONISTS; ANDROGENS; ANILIDES; CELL GROWTH PROCESSES; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; NEOPLASM PROTEINS; NEOPLASM RECURRENCE, LOCAL; NEOPLASMS, HORMONE-DEPENDENT; NITRILES; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; RNA, MESSENGER; TOSYL COMPOUNDS;

EID: 66149085320     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-3738     Document Type: Article

References (36)

1. Scher HI, Sawyers CL. Biology of progressive, castra- tion-resistant prostate cancer: directed therapies target ing the androgen-receptor signaling axis. J Clin Oncol 2005;23:8253-8261
2. Long RM, Morrissey C, Fltzpatrlck JM, Watson RW. Prostate epithelial cell differentiation and its relevance to the understanding of prostate cancer therapies. Clin. Sei Lond 2005;108:1-11.
3. Chen CD, Welsble DS, Tran C, et al. Molecular determinants of resistance to antiandrogen therapy. Nat Med 2004;10:33-39
4. Arnold JT, Isaacs JT. Mechanisms Involved in the progression of androgen-independent prostate cancers: It is not only the cancer cell's fault. Endocr Relat Cancer 2002;9:61-73.
5. Abate-Shen C, Shen MM. Molecular genetics of prostate cancer. Genes Dev 2000;14:2410-2434
6. Shang Y, Myers M, Brown. M. Formation of the androgen receptor transcription complex. MoI Cell 2002;9:601-610
7. Schuurmans AL, Bolt J, Veldscholte J, Mulder E. Regulation of growth of LNCaP human prostate tumor cells by growth factors and steroid hormones. J Steroid Biochem MoI Biol 1991;40:193-197
8. Zhou HJ, Yan J, Luo W, et al. SRC-3 is required for prostate cancer cell proliferation and survival. Cancer Res 2005;65:7976-7983
9. Zheng Z, CaI C, Omwancha J, Chen SY, Baslan T, Shemshedini L. SUMO-3 enhances androgen receptor transcriptional activity through a sumoylation-indepen- dent mechanism in. prostate cancer cells. J Biol Chem 2006;281:4002-4012
10. Link KA, Burd CJ, Williams E, et al. BAF57 governs androgen receptor action and androgen-dependent proliferation through SW1./SNF. MoI Cell BIoI 2005:25: 2200-2215
11. Chen SY1 Cai C, Fisher CJ, et al. c-Jun enhancement of androgen receptor transactivation is associated with prostate cancer cell proliferation. Oncogene 2006:29: 363-373
12. Markus SM, Taneja SS1 Logan SK, et al. Identification and characterization of ART-27, a novel, coactivator for the androgen receptor N terminus. MoI. Biol Cell 2002; 13:670-682
13. Taneja SS1 Ha S1 Swenson NK, et al. ART-27, an androgen receptor coactivator regulated in prostate development and cancer. J BIoI Chem 2004:279: 13944-13952
14. Gstaiger M, Luke B, Hess D, et al. Control of nutrient- sensitive transcription programs by the unconventional prefoldin URI. Science 2003:302:1208-1212
15. Delgermaa L, Hayashi n1 Dorjsuren. D, Nomura T1 Thuy Ie TT1 Murakami S. Subcellular localization of RPB5-m.ediating protein and its putative functional partner. MoI Cell Biol 2004;24:8556-8566
16. Dorjsuren D, Lin Y1 Wei W1 et al. RMP1 a novel RNA polymerase II subunlt 5-lnteracting protein1 counteracts transacUvation by hepatitis B virus X proteia MoI Cell BIoI 1998;18:7546-7555
17. Parusel. CT, Kritikou EA, Hengartner MO, Krek W1 Gotta M. URI-I is required for DNA stability in C. elegans. Development 2006;133:621-629
18. Frank SR, Parisi T1 Taubert S1 et al. MYC recruits the TIP60 histone acetyltransferase complex to chromatin. EMBO Rep 2003;4:575-580
19. Dugan KA, Wood MA, Cole MD. TIP49, but not TRRAP, modulates c-Myc and E2.FI dependent apopto- sis. Oncogene 2002;21:5835-5843
20. Cho SG, Bhoumik A, Broday L, Ivanov V, Rosenstein B, Roñal Z. TIP49b, a regulator of activating transcrip- tion factor 2 response to stress and DNA damage. MoI Cell. Biol 2001;21:8398-8413
21. McGilvray R, Walker M, Bartholomew C. UXT interacts with the transcriptional repressor protein EVIl and suppresses cell transformation. FEBS J 2007; 274:3690-3771
22. Sun S, Tang Y, Lou X, et al. UXT is a novel and essential cofactor in the NF-{K}B transcriptional enhan- ceosome. J Cell Biol 2007;178:231-244
23. Nwachukwu. JC, Li W, Pineda-Torra I, et al. Tran- scriptional regulation of the androgen receptor cofactor androgen1 receptor trapped clone-27. MoI Endocrinol 2007;21:2864-2876
24. Oxelmark E, Roth JM, Brooks PC, Braunstein SE, Schneider RJ, Garabedian MJ. The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion. MoI. Cell Biol 2006;26:5205-5213
25. Wang Q, Carroll JS, Brown M. Spatial, and temporal, recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking MoI Cell 2005:19:631-642
26. Bookout AL.,Mangelsdorf DJ. Quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways. Nuol Recept Signal. 2003;l:e012.
27. Koklanaris n1 Nwachukwu JC, Huang SJ, et al. First- trimester trophoblast cell model gene response to hypoxia Am J Obstet Gynecol 2006;194:687-693
28. Cheng J, Sun S, Tracy A, et al. NetAffx Gene Ontology Mining Tool: a visual approach for microarray data analysis. Bioinformatlcs 2004;20:1462-1463
29. Newman JC, Weiner AM. L2L: a simple tool for discovering the hidden significance in. microarray expression data. Genome Biol 2005;6:R81.
30. Ashburner M, Ball CA, Blake JA, et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 2000;25:25-29
31. DePrimo SE, Diehn M, Nelson JB, et al. Transcrip- tional programs activated by exposure of human prostate cancer cells to androgen. Genome Biol 2002;3: RESEARCH0032.
32. Li W, Cavasotto Cn1 Cardozo T, et al. Androgen receptor mutations identified in prostate cancer and androgen insensitivity syndrome display aberrant ART-27 coactivator function. MoI Endocrinol 2005; 19:2273-2282
33. Gao M, Ossowski L, Ferrari AC. Activation of Rb and decline in androgen receptor protein precede retinóle acid-induced apoptosis in androgen-dependent LNCaP cells and their androgen-independent derivative. J Cell Physiol 1999;179:336-346
34. Yoon HG, Wong J. The corepressors silencing mediator of retinoid and thyroid hormone recep- tor and nuclear receptor corepressor are involved in agonist and antagonist-regulated transcription by androgen receptor. MoI Endocrinol 2006;20: 1048-1060
35. Hodgson MC, Astapova I, Hollen berg An1 Balk SP. Activity of Androgen Receptor Antagonist Bicaluta- mide in Prostate Cancer Cells Is Independent of NCoR and SMRT Corepressors. Cancer Res 2007;67: 8388-8395
36. Klokk TI, Kurys P1 Elbi C, et al. Ligand-speclflc dynamics of the androgen receptor at its response element in living cells. MoI. Cell Biol. 2007;27:.1823-1843