Mutational analysis of mycobacterium UvrD1 identifies functional groups required for ATP hydrolysis, DNA unwinding, and chemomechanical coupling

Biochemistry

Volumn 48, Issue 19, 2009, Pages 4019-4030

  Sinha, Krishna Murari ^a   Glickman, Michael S ^a   Shuman, Stewart ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATP HYDROLYSIS; BINDING RESIDUES; C-TERMINAL DOMAINS; CHEMO-MECHANICAL COUPLINGS; DIVALENT CATION; DNA HELICASE; DNA UNWINDING; GAIN-OF FUNCTION; HELICASE; HELICASES; MOTOR ACTIVITY; MOTOR DOMAIN; MUTATIONAL ANALYSIS; MYCOBACTERIAL; SUBSTRATE SPECIFICITY; TRANSITION STATE; TRANSITION STATE STABILIZATION;

AMINATION; AMINES; AMINO ACIDS; CRYSTAL STRUCTURE; DNA; ESCHERICHIA COLI; FUNCTIONAL GROUPS; GENES; HYDROLYSIS; MOTORS; ORGANIC ACIDS; PLANTS (BOTANY); SUBSTRATES; SUGAR (SUCROSE); SUGARS;

NUCLEIC ACIDS;

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; ALANINE; BACTERIAL PROTEIN; DIVALENT CATION; FUNCTIONAL GROUP; GLUTAMINE; HELICASE; NUCLEOPHILE; PHOSPHATASE; PROTEIN UVRD1; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; DNA BINDING MOTIF; DNA DENATURATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CHEMISTRY; ENZYME SPECIFICITY; GENE DELETION; MUTATIONAL ANALYSIS; MYCOBACTERIUM SMEGMATIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; PROTEIN PROTEIN INTERACTION;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ALANINE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; BINDING SITES; CONSERVED SEQUENCE; DNA HELICASES; DNA MUTATIONAL ANALYSIS; DNA REPAIR; DNA, SINGLE-STRANDED; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROLYSIS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM SMEGMATIS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID;

ESCHERICHIA COLI; MYCOBACTERIUM;

EID: 66049148193     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900103d     Document Type: Article

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