Spironolactone ameliorates transplant vasculopathy in renal chronic transplant dysfunction in rats

American Journal of Physiology - Renal Physiology

Volumn 296, Issue 5, 2009, Pages

  Waanders, Femke ^a   Rienstra, Heleen ^a   Boer, Mark Walther ^a   Zandvoort, André ^a   Rozing, Jan ^a   Navis, Gerjan ^a   Van Goor, Harry ^a   Hillebrands, Jan Luuk ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Aldosterone; Kidney transplantation; Proteinuria

Indexed keywords

SPIRONOLACTONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHRONIC TRANSPLANT DYSFUNCTION; CONTROLLED STUDY; CREATININE CLEARANCE; DRUG EFFICACY; FOCAL GLOMERULOSCLEROSIS; GRAFT DYSFUNCTION; GRAFT SURVIVAL; KIDNEY FIBROSIS; KIDNEY TRANSPLANTATION; MACROPHAGE MIGRATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; RAT; RENAL ARTERY; RENAL PROTECTION; SYSTOLIC BLOOD PRESSURE; VASCULAR DISEASE;

EID: 66049119620     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.90643.2008     Document Type: Article

References (49)

1. Aldigier JC, Kanjanbuch T, Ma LJ, Brown NJ, Fogo AB. Regression of existing glomerulosclerosis by inhibition of aldosterone. J Am Soc Nephrol 16: 3306-3314, 2005. (Pubitemid 46187550)
2. Amuchastegui SC, Azzollini N, Mister M, Pezzotta A, Perico N, Remuzzi G. Chronic allograft nephropathy in the rat is improved by angiotensin II receptor blockade but not by calcium channel antagonism. J Am Soc Nephrol 9: 1948-1955, 1998.
3. Arend SM, Mallat MJ, Westendorp RJ, van der Woude FJ, van Es LA. Patient survival after renal transplantation; more than 25 years follow-up. Nephrol Dial Transplant 12: 1672-1679, 1997.
4. Caprio M, Newfell BG, la SA, Baur W, Fabbri A, Rosano G, Mendelsohn ME, Jaffe IZ. Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion. Circ Res 102: 1359-1367, 2008.
5. Celik T, Iyisoy A, Kursaklioglu H, Isik E. Eplerenone suppresses neointima after coronary stenting in pigs: could it be extrapolated to stent restenosis in humans? Int J Cardiol 115: 97-98, 2007.
6. Cha DR, Kang YS, Han SY, Jee YH, Han KH, Kim HK, Han JY, Kim YS. Role of aldosterone in diabetic nephropathy. Nephrology (Carlton ) 10 Suppl: S37-S39, 2005.
7. Chapman JR, O'Connell PJ, Nankivell BJ. Chronic renal allograft dysfunction. J Am Soc Nephrol 16: 3015-3026, 2005.
8. Colvin RB, Nickeleit V. Renal transplant pathology. In: Pathology of the Kidney, edited by Jennette JC, Olson JL, Schwartz MM, and Silva FG. Philadelphia, PA: Lippincott Williams & Wilkins, 2007.
9. Cosio FG, Pelletier RP, Sedmak DD, Falkenhain ME, Henry ML, Elkhammas EA, Davies EA, Bumgardner GL, Ferguson RM. Pathologic classification of chronic allograft nephropathy: pathogenic and prognostic implications. Transplantation 67: 690-696, 1999.
10. Del Vecchio L, Procaccio M, Vigano S, Cusi D. Mechanisms of disease: the role of aldosterone in kidney damage and clinical benefits of its blockade. Nat Clin Pract Nephrol 3: 42-49, 2007. (Pubitemid 46020702)
11. Farquharson CA, Struthers AD. Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I/angiotensin II conversion in patients with chronic heart failure. Circulation 101: 594-597, 2000.
12. Farquharson CA, Struthers AD. Aldosterone induces acute endothelial dysfunction in vivo in humans: evidence for an aldosterone-induced vasculopathy. Clin Sci (Lond) 103: 425-431, 2002.
13. Feria I, Pichardo I, Juarez P, Ramirez V, Gonzalez MA, Uribe N, Garcia-Torres R, Lopez-Casillas F, Gamba G, Bobadilla NA. Therapeutic benefit of spironolactone in experimental chronic cyclosporine A nephrotoxicity. Kidney Int 63: 43-52, 2003. (Pubitemid 35463905)
14. Fujisawa G, Okada K, Muto S, Fujita N, Itabashi N, Kusano E, Ishibashi S. Spironolactone prevents early renal injury in streptozotocin-induced diabetic rats. Kidney Int 66: 1493-1502, 2004. (Pubitemid 39298382)
15. Greene EL, Kren S, Hostetter TH. Role of aldosterone in the remnant kidney model in the rat. J Clin Invest 98: 1063-1068, 1996. (Pubitemid 26293326)
16. Guo C, Martinez-Vasquez D, Mendez GP, Toniolo MF, Yao TM, Oestreicher EM, Kikuchi T, Lapointe N, Pojoga L, Williams GH, Ricchiuti V, Adler GK. Mineralocorticoid receptor antagonist reduces renal injury in rodent models of types 1 and 2 diabetes mellitus. Endocrinology 147: 5363-5373, 2006.
17. Han KH, Kang YS, Han SY, Jee YH, Lee MH, Han JY, Kim HK, Kim YS, Cha DR. Spironolactone ameliorates renal injury and connective tissue growth factor expression in type II diabetic rats. Kidney Int 70: 111-120, 2006.
18. Hariharan S, Johnson CP, Bresnahan BA, Taranto SE, McIntosh MJ, Stablein D. Improved graft survival after renal transplantation in the United States, 1988 to 1996. N Engl J Med 342: 605-612, 2000. (Pubitemid 30118412)
19. Hillebrand U, Schillers H, Riethmuller C, Stock C, Wilhelmi M, Oberleithner H, Hausberg M. Dose-dependent endothelial cell growth and stiffening by aldosterone: endothelial protection by eplerenone. J Hypertens 25: 639-647, 2007. (Pubitemid 46213803)
20. Hillebrands JL, Klatter FA, Rozing J. Origin of vascular smooth muscle cells and the role of circulating stem cells in transplant arteriosclerosis. Arterioscler Thromb Vasc Biol 23: 380-387, 2003. (Pubitemid 36337212)
21. Ikezumi Y, Atkins RC, Nikolic-Paterson DJ. Interferon-gamma augments acute macrophage-mediated renal injury via a glucocorticoid-sensitive mechanism. J Am Soc Nephrol 14: 888-898, 2003. (Pubitemid 36359271)
22. Ishizawa K, Izawa Y, Ito H, Miki C, Miyata K, Fujita Y, Kanematsu Y, Tsuchiya K, Tamaki T, Nishiyama A, Yoshizumi M. Aldosterone stimulates vascular smooth muscle cell proliferation via big mitogen-activated protein kinase 1 activation. Hypertension 46: 1046-1052, 2005.
23. Kramer AB, van der Meulen EF, Hamming I, van GH, Navis G. Effect of combining ACE inhibition with aldosterone blockade on proteinuria and renal damage in experimental nephrosis. Kidney Int 71: 417-424, 2007. (Pubitemid 46303564)
24. Krug AW, Grossmann C, Schuster C, Freudinger R, Mildenberger S, Govindan MV, Gekle M. Aldosterone stimulates epidermal growth factor receptor expression. J Biol Chem 278: 43060-43066, 2003. (Pubitemid 36920943)
25. Kunter U, Floege J, von Jurgensonn AS, Stojanovic T, Merkel S, Grone HJ, Ferran C. Expression of A20 in the vessel wall of rat-kidney allografts correlates with protection from transplant arteriosclerosis. Transplantation 75: 3-9, 2003. (Pubitemid 36139687)
26. Kwiatkowski A, Wszola M, Kosieradzki M, Danielewicz R, Ostrowski K, Domagala P, Lisik W, Nosek R, Fesolowicz S, Trzebicki J, Durlik M, Paczek L, Chmura A, Rowinski W. Machine perfusion preservation improves renal allograft survival. Am J Transplant 7: 1942-1947, 2007.
27. Macdonald JE, Kennedy N, Struthers AD. Effects of spironolactone on endothelial function, vascular angiotensin converting enzyme activity, and other prognostic markers in patients with mild heart failure already taking optimal treatment. Heart 90: 765-770, 2004. (Pubitemid 38813637)
28. Macunluoglu B, Arikan H, Atakan A, Tuglular S, Ulfer G, Cakalagaoglu F, Ozener C, Akoglu E. Effects of spironolactone in an experimental model of chronic cyclosporine nephrotoxicity. Transplant Proc 40: 273-278, 2008.
29. Mejia-Vilet JM, Ramirez V, Cruz C, Uribe N, Gamba G, Bobadilla NA. Renal ischemia-reperfusion injury is prevented by the mineralocorticoid receptor blocker spironolactone. Am J Physiol Renal Physiol 293: F78-F86, 2007. (Pubitemid 47345006)
30. Nagai Y, Miyata K, Sun GP, Rahman M, Kimura S, Miyatake A, Kiyomoto H, Kohno M, Abe Y, Yoshizumi M, Nishiyama A. Aldosterone stimulates collagen gene expression and synthesis via activation of ERK1/2 in rat renal fibroblasts. Hypertension 46: 1039-1045, 2005.
31. Nankivell BJ, Fenton-Lee CA, Kuypers DR, Cheung E, Allen RD, O'Connell PJ, Chapman JR. Effect of histological damage on long-term kidney transplant outcome. Transplantation 71: 515-523, 2001. (Pubitemid 32207202)
32. Oberleithner H. Aldosterone makes human endothelium stiff and vulnerable. Kidney Int 67: 1680-1682, 2005. (Pubitemid 40577700)
33. Perez-Rojas J, Blanco JA, Cruz C, Trujillo J, Vaidya VS, Uribe N, Bonventre JV, Gamba G, Bobadilla NA. Mineralocorticoid receptor blockade confers renoprotection in preexisting chronic cyclosporine nephrotoxicity. Am J Physiol Renal Physiol 292: F131-F139, 2007. (Pubitemid 46105252)
34. Piecha G, Koleganova N, Gross ML, Geldyyev A, Adamczak M, Ritz E. Regression of glomerulosclerosis in subtotally nephrectomized rats: effects of monotherapy with losartan, spironolactone, and their combination. Am J Physiol Renal Physiol 295: F137-F144, 2008.
35. Racusen LC, Solez K, Colvin RB, Bonsib SM, Castro MC, Cavallo T, Croker BP, Demetris AJ, Drachenberg CB, Fogo AB, Furness P, Gaber LW, Gibson IW, Glotz D, Goldberg JC, Grande J, Halloran PF, Hansen HE, Hartley B, Hayry PJ, Hill CM, Hoffman EO, Hunsicker LG, Lindblad AS, Yamaguchi Y. The Banff 97 working classification of renal allograft pathology. Kidney Int 55: 713-723, 1999. (Pubitemid 29082898)
36. Remuzzi G, Cattaneo D, Perico N. The aggravating mechanisms of aldosterone on kidney fibrosis. J Am Soc Nephrol 19: 1459-1462, 2008.
37. Rienstra H, Boersema M, Onuta G, Walther Boer M, Zandvoort A, van Riezen M, Rozing J, van Goor H, Navis GJ, Popa ER, Hillebrands JL. Donor and recipient origin of mesenchymal and endothelial cells in chronic renal allograft remodeling. Am J Transplant 9: 463-472, 2009.
38. Rocha R, Chander PN, Khanna K, Zuckerman A, Stier CT Jr. Mineralocorticoid blockade reduces vascular injury in stroke-prone hypertensive rats. Hypertension 31: 451-458, 1998. (Pubitemid 28124757)
39. Rocha R, Chander PN, Zuckerman A, Stier CT Jr. Role of aldosterone in renal vascular injury in stroke-prone hypertensive rats. Hypertension 33: 232-237, 1999. (Pubitemid 29065665)
40. Ross R, Glomset J, Harker L. Response to injury and atherogenesis. Am J Pathol 86: 675-684, 1977. (Pubitemid 8063546)
41. Seron D, Moreso F. Protocol biopsies in renal transplantation: prognostic value of structural monitoring. Kidney Int 72: 690-697, 2007. (Pubitemid 47373786)
42. Seron D, Moreso F, Ramon JM, Hueso M, Condom E, Fulladosa X, Bover J, Gil-Vernet S, Castelao AM, Alsina J, Grinyo JM. Protocol renal allograft biopsies and the design of clinical trials aimed to prevent or treat chronic allograft nephropathy. Transplantation 69: 1849-1855, 2000.
43. Smit-van Oosten A, Navis G, Stegeman CA, Joles JA, Klok PA, Kuipers F, Tiebosch AT, van GH. Chronic blockade of angiotensin II action prevents glomerulosclerosis, but induces graft vasculopathy in experimental kidney transplantation. J Pathol 194: 122-129, 2001.
44. Solez K, Colvin RB, Racusen LC, Sis B, Halloran PF, Birk PE, Campbell PM, Cascalho M, Collins AB, Demetris AJ, Drachenberg CB, Gibson IW, Grimm PC, Haas M, Lerut E, Liapis H, Mannon RB, Marcus PB, Mengel M, Mihatsch MJ, Nankivell BJ, Nickeleit V, Papadimitriou JC, Platt JL, Randhawa P, Roberts I, Salinas-Madriga L, Salomon DR, Seron D, Sheaff M, Weening JJ. Banff'05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'). Am J Transplant 7: 518-526, 2007. (Pubitemid 46376465)
45. Taira M, Toba H, Murakami M, Iga I, Serizawa R, Murata S, Kobara M, Nakata T. Spironolactone exhibits direct renoprotective effects and inhibits renal renin-angiotensin-aldosterone system in diabetic rats. Eur J Pharmacol 589: 264-271, 2008.
46. Terada Y, Kuwana H, Kobayashi T, Okado T, Suzuki N, Yoshimoto T, Hirata Y, Sasaki S. Aldosterone-stimulated SGK1 activity mediates profibrotic signaling in the mesangium. J Am Soc Nephrol 19: 298-309, 2008.
47. Wakabayashi K, Suzuki H, Sato T, Iso Y, Katagiri T, Takeyama Y. Eplerenone suppresses neointimal formation after coronary stent implantation in swine. Int J Cardiol 107: 260-266, 2006. (Pubitemid 43075243)
48. Ward MR, Kanellakis P, Ramsey D, Funder J, Bobik A. Eplerenone suppresses constrictive remodeling and collagen accumulation after angioplasty in porcine coronary arteries. Circulation 104: 467-472, 2001. (Pubitemid 32678279)
49. Wieczorek G, Bigaud M, Menninger K, Riesen S, Quesniaux V, Schuurman HJ, Audet M, Blancher A, Mihatsch MJ, Nickeleit V. Acute and chronic vascular rejection in nonhuman primate kidney transplantation. Am J Transplant 6: 1285-1296, 2006. (Pubitemid 44030312)