P-glycoprotein is downregulated in KG1a-primitive leukemia cells by LDL cholesterol deprivation and by HMG-CoA reductase inhibitors

Experimental Hematology

Volumn 35, Issue 12, 2007, Pages 1793-1800

  Connelly Smith, Laura ^a,b   Pattinson, Joanne ^b   Grundy, Martin ^a,b   Shang, Shili ^b   Seedhouse, Claire ^b   Russell, Nigel ^b   Pallis, Monica ^a  

^a NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; DAUNORUBICIN; GLYCOPROTEIN P; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN; PRAVASTATIN;

ABCB1 GENE; ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ARTICLE; CHOLESTEROL METABOLISM; CONTROLLED STUDY; FLOW CYTOMETRY; GENE; KG1A CELL; LEUKEMIA CELL; MDR1 GENE; MEMBRANE TRANSPORT; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SCANNING ELECTRON MICROSCOPE;

ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; CHOLESTEROL, LDL; DNA PRIMERS; DOWN-REGULATION; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMUNOPHENOTYPING; LEUKEMIA, EXPERIMENTAL; P-GLYCOPROTEIN;

EID: 36148968399     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2007.07.017     Document Type: Article

References (38)

1. Gottesman M.M., and Ling V. The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research. FEBS Lett 580 (2006) 998-1009
2. Ambudkar S.V., Kimchi-Sarfaty C., Sauna Z.E., and Gottesman M.M. P-glycoprotein: from genomics to mechanism. Oncogene 22 (2003) 7468-7485
3. Szakacs G., Paterson J.K., Ludwig J.A., Booth-Genthe C., and Gottesman M.M. Targeting multidrug resistance in cancer. Nat Rev Drug Discov 5 (2006) 219-234
4. Schinkel A.H., Mol C.A., Wagenaar E., van Deemter L., Smit J.J., and Borst P. Multidrug resistance and the role of P-glycoprotein knockout mice. Eur J Cancer 31A (1995) 1295-1298
5. Ruhl R., Sczech R., Landes N., Pfluger P., Kluth D., and Schweigert F.J. Carotenoids and their metabolites are naturally occurring activators of gene expression via the pregnane X receptor. Eur J Nutr 43 (2004) 336-343
6. Park S.W., Lomri N., Simeoni L.A., Fruehauf J.P., and Mechetner E. Analysis of P-glycoprotein-mediated membrane transport in human peripheral blood lymphocytes using the UIC2 shift assay. Cytometry A 53 (2003) 67-78
7. Goldstein J.L., and Brown M.S. Regulation of the mevalonate pathway. Nature 343 (1990) 425-430
8. Vitols S., Norgren S., Juliusson G., Tatidis L., and Luthman H. Multilevel regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression in normal and leukemic cells. Blood 84 (1994) 2689-2698
9. Li H.Y., Appelbaum F.R., Willman C.L., Zager R.A., and Banker D.E. Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses. Blood 101 (2003) 3628-3634
10. Banker D.E., Mayer S.J., Li H.Y., Willman C.L., Appelbaum F.R., and Zager R.A. Cholesterol synthesis and import contribute to protective cholesterol increments in acute myeloid leukemia cells. Blood 104 (2004) 1816-1824
11. Kornblau S.M., Banker D.E., Stirewalt D., et al. Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AML by the addition of pravastatin to idarubicin + high dose Ara-C: a Phase 1 study. Blood 109 (2007) 2999-3006
12. Garrigues A., Escargueil A.E., and Orlowski S. The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane. Proc Natl Acad Sci U S A 99 (2002) 10347-10352
13. Debry P., Nash E., Neklason D., and Metherall J. Role of multidrug resistance p-glycoproteins in cholesterol esterification. J Biol Chem 272 (1997) 1026-1031
14. Luker G.D., Nilsson K.R., Covey D.F., and Piwnica-Worms D. Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol. J Biol Chem 274 (1999) 6979-6991
15. Lange Y., and Steck T.L. Cholesterol homeostasis. Modulation by amphiphiles. J Biol Chem 269 (1994) 29371-29374
16. Moore L.B., Parks D.J., Jones S.A., et al. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J Biol Chem 275 (2000) 15122-15127
17. Synold T.W., Dussault I., and Forman B.M. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med 7 (2001) 584-590
18. Bailly J.-D., Muller C., Jaffrezou J.-P., et al. Lack of correlation between expression and function of P-glycoprotein in acute myeloid leukemia cell lines. Leukemia 9 (1995) 799-807
19. Vance D.E., Weinstein D.B., and Steinberg D. Isolation and analysis of lipoproteins secreted by rat liver hepatocytes. Biochim Biophys Acta 792 (1984) 39-47
20. Gayet L., Dayan G., Barakat S., et al. Control of P-glycoprotein activity by membrane cholesterol amounts and their relation to multidrug resistance in human CEM leukemia cells. Biochemistry 44 (2005) 4499-4509
21. Pallis M., and Das-Gupta E. Flow cytometric measurement of functional and phenotypic p-glycoprotein. In: Blumenthal R.D. (Ed). Chemosensitivity (2005), Humana Press, Totowa 167-181
22. Pallisgaard N., Clausen N., Schroder H., and Hokland P. Rapid and sensitive minimal residual disease detection in acute leukemia by quantitative real-time RT-PCR exemplified by t(12;21) TEL-AML1 fusion transcript. Genes Chromosomes Cancer 26 (1999) 355-365
23. Pallis M., Turzanski T., Harrison G., et al. Use of standardised flow cytometric determinants of multidrug resistance to analyse response to remission induction chemotherapy in patients with acute myeloblastic leukaemia. Br J Haematol 104 (1999) 307-312
24. Pallis M., Syan J., and Russell N.H. Flow cytometric chemosensitivity analysis of blasts from patients with acute myeloblastic leukemia and myelodysplastic syndromes: the use of 7AAD with antibodies to CD45 or CD34. Cytometry 37 (1999) 308-313
25. Ratnasinghe D., Phang J.M., and Yeh G.C. Differential expression and activity of phosphatases and protein kinases in adriamycin sensitive and resistant human breast cancer MCF-7 cells. Int J Oncol 13 (1998) 79-84
26. Santai C.T., Fritz F., and Roepe P.D. Effects of ion gradients on H+ transport mediated by human MDR 1 protein. Biochemistry 38 (1999) 4227-4234
27. Levchenko A., Mehta B.M., Spengler B.A., et al. Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay. Anal Biochem 236 (1996) 338-343
28. Keyomarsi K., Sandoval L., Band V., and Pardee A.B. Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin. Cancer Res 51 (1991) 3602-3609
29. Leith C.P., Kopecky K.J., Godwin J., et al. Acute myeloid leukemia in the elderly: Assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy. A southwest oncology group study. Blood 89 (1997) 3323-3329
30. Leith C.P., Kopecky K.J., Chen I.M., et al. Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein, MRP1, and LRP in acute myeloid leukemia: a Southwest Oncology Group Study. Blood 94 (1999) 1086-1099
31. Metherall J., Li H., and Waugh K. Role of multidrug resistance p-glycoproteins in cholesterol biosynthesis. J Biol Chem 271 (1996) 2634-2640
32. Field F., Born E., Murthy S., and Mathur S. Transport of cholesterol from the endoplamic reticulum to the plasma membrane is constitutive in CaCo-2 cells and differs from the transport of plasma membrane cholesterol to the endoplasmic reticulum. J Lipid Res 39 (1998) 333-343
33. Le Goff W., Settle M., Greene D.J., Morton R.E., and Smith J.D. Reevaluation of the role of the multidrug-resistant P-glycoprotein in cellular cholesterol homeostasis. J Lipid Res 47 (2006) 51-58
34. Pani A., Batetta B., Putzolu M., et al. MDR1, cholesterol esterification and cell growth: a comparative study in normal and multidrug-resistant KB cell lines. Cell Mol Life Sci 57 (2000) 1094-1102
35. Rodrigues A.C., Curi R., Britto L.R., et al. Down-regulation of ABCB1 transporter by atorvastatin in a human hepatoma cell line and in human peripheral blood mononuclear cells. Biochim Biophys Acta 1760 (2006) 1866-1873
36. Dimitroulakos J., and Yeger H. HMG-CoA reductase mediates the biological effects of retinoic acid on human neuroblastoma cells: lovastatin specifically targets P-glycoprotein-expressing cells. Nat Med 2 (1996) 326-333
37. Dimitroulakos J., Nohynek D., Backway K.L., et al. Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach. Blood 93 (1999) 1308-1318
38. Maksumova L., Ohnishi K., Muratkhodjaev F., et al. Increased sensitivity of multidrug-resistant myeloid leukemia cell lines to lovastatin. Leukemia 14 (2000) 1444-1450