Characterization and functional consequences of delayed rectifier current transient in ventricular repolarization

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 278, Issue 3 47-3, 2000, Pages

  Gintant, Gary A ^a,b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

Arrhythmias; Atrial myocytes; Canine myocardium; Human ether a go go related gene; Purkinje fibers

Indexed keywords

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; DOG; HEART MUSCLE CELL; HEART REPOLARIZATION; HEART VENTRICLE; NONHUMAN; PRIORITY JOURNAL; PURKINJE FIBER; VOLTAGE CLAMP;

EID: 0034103667     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2000.278.3.h806     Document Type: Article

References (32)

1. Kr potassium channels with HERG and is associated with cardiac arrhythmias. Cell 97: 165-187,1999.
2. Carmeliet, E. Electrophysiologic and voltage clamp analysis of the effects of sotalol on isolated cardiac muscle and Purkinje fibers. J. Pharmacol. Exp. Ther. 232: 817-825, 1985.
3. Clay, J. R., A. Ogbaghebriel, T. Paquette, B. I. Sasyniuk, and A. Shrier. A quantitative description of the E-4031-sensitive repolarization current in rabbit ventricular myocytes. Biophys. J. 69: 1830-1837, 1995.
4. + currents in rabbit heart Purkinje cells. J. Physiol. (Lond.) 508: 811-823, 1998.
5. Doerr, T., R. Denger, A. Doerr, and W. Trautwein. Ionic current contributing to the action potential in single ventricular myocytes of the guinea pig studied with action potential clamp. Pflügers Arch. 416: 230-237, 1990.
6. K, by flecainide and E-4031 in cat ventricular myocytes. Circulation 82: 284-293, 1990.
7. K,s in electrical heterogeneity. Am. J. Physiol. Heart Circ. Physiol. 268: H604-H613, 1995.
8. Ks play a role in the reverse rate dependence of class III agents? Circ. Res. 78: 26-37, 1996.
9. Kr in ventricular repolarization: direct measures using "action potential" clamps (Abstract). J. Mol. Cell. Cardiol. 29: A166, 1997.
10. Gwilt, M., J. E. Arrowsmith, K. J. Blackburn, R. A. Burges, P. E. Cross, H. W. Drlrymple, and A. J. Higgins. Uk-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells. J. Pharmacol. Exp. Ther. 256: 318-324, 1991.
11. Horn, R., and A. Marty. Muscarinic activation of ionic currents measured by a new whole-cell recording method. J. Gen. Physiol. 92: 145-159, 1988.
12. Isenberg, G. Cardiac Purkinje fibers: cesium as a tool to block inward rectifying potassium currents. Pflügers Arch. 365: 99-106, 1976.
13. + current by dofetilide. Circ. Res. 72: 75-83, 1993.
14. + channel in mouse and human hearts. Circ. Res. 81: 719-726, 1997.
15. + current in human ventricular myocytes. Circ. Res. 78: 689-696, 1996.
16. Ks contributes to the longer action potential of the M cell. Circ. Res. 76: 351-365, 1995.
17. Liu, D. W., G. A. Gintant, and C. Antzelevetch. Ionic basis for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle. Circ. Res. 72: 671-687, 1993.
18. + current. Circ. Res. 81: 870-878, 1997.
19. Magistretti, J., M. Mantegazza, E. Guatteo, and E. Wanke. Action potentials recorded with patch-clamp amplifiers: are they genuine? Trends Neurosci. 19: 530-534, 1996.
20. Nakajima T, T. Furukawa, T. Tanaka, Y. Katayama, R. Nagai, Y. Nakamura, and M. Hiraoka. Novel mechanism of HERG current suppression in LQT2. Shift in voltage dependence of HERG inactivation. Circ. Res. 83: 415-422, 1998.
21. + current density in arrhythmogenic subendocardial Purkinje myocytes from the infarcted heart. J. Cardiovasc. Electrophysiol. 9: 299-311, 1998.
22. Ks. Am. J. Physiol. Heart Circ. Physiol. 271: H2477-H2489, 1996.
23. Kr potassium channel. Cell 81: 299-307, 1995.
24. + current: differential sensitivity to block by class III antiarrhythmic agents. J. Gen. Physiol. 96: 195-215, 1990.
25. + currents. Pflügers Arch. 420: 180-186, 1992.
26. Shibasaki, T. Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart. J. Physiol. (Lond.) 387: 227-250, 1987.
27. Smith, P. L., T. Baukrowitz, and G. Yellen. The inward rectification mechanism of the HERG cardiac potassium channel. Nature 379: 833-836, 1996.
28. Kr channel. J. Gen. Physiol. 107: 611-619, 1996.
29. Trudeau, M. C., J. W. Warmke, B. Ganetzky, and G. A. Robertson. HERG, a human inward rectifier in the voltage-gated potassium channel family. Science 269: 92-95, 1995.
30. + current in cardiac cells. Circ. Res. 80: 782-789, 1997.
31. + current in ventricular myocytes of the guinea-pig type. Theoretical formulation and their role in repolarization. Circ. Res. 77: 140-152, 1995.
32. Zhou, Z., Q. Gong, B. Ye, Z. Fan, J. C. Makielski, G. A. Robertson, and C. T. January. Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature. Biophys. J. 74: 230-241, 1998.