Dpr acts as a molecular switch, inhibiting Wnt signaling when unphosphorylated, but promoting Wnt signaling when phosphorylated by casein kinase Iδ/ε

PLoS ONE

Volumn 4, Issue 5, 2009, Pages

  Teran, Evelyn ^a   Branscomb, Aron D ^a,b   Seeling, Joni M ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BINDING PROTEIN; CASEIN KINASE IDELTA; CASEIN KINASE IEPSILON; DAPPER1A PROTEIN; DISHEVELLED PROTEIN; PDZ PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; DISHEVELLED PROTEINS; DRP1 PROTEIN, XENOPUS; NUCLEAR PROTEIN; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; XENOPUS PROTEIN;

ANIMAL CELL; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; EMBRYO; GENE MUTATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; NONHUMAN; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; XENOPUS; ANIMAL; CELL LINE; GEL MOBILITY SHIFT ASSAY; GENETICS; IMMUNOPRECIPITATION; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PRENATAL DEVELOPMENT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BETA CATENIN; CASEIN KINASE IDELTA; CASEIN KINASE IEPSILON; CELL LINE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; IMMUNOPRECIPITATION; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; SIGNAL TRANSDUCTION; WNT PROTEINS; XENOPUS; XENOPUS PROTEINS;

EID: 65949119153     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005522     Document Type: Article

References (30)

1. Liu C, Li Y, Semenov M, Han C, Baeg GH, et al. (2002) Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108(6): 837-47.
2. He X, Semenov M, Tamai K, Zeng X (2004) LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way. Development 131(8): 1663-77.
3. Yanagawa S, van Leeuwen F, Wodarz A, Klingensmith J, Nusse R (1995) The dishevelled protein is modified by wingless signaling in Drosophila. Genes Dev 9(9): 1087-97.
4. Wong HC, Bourdelas A, Krauss A, Lee HJ, Shao Y, et al. (2003) Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol Cell 12(5): 1251-60.
5. Schwarz-Romond T, Metcalfe C, Bienz M (2007) Dynamic recruitment of axin by Dishevelled protein assemblies. J Cell Sci 120(Pt 14): 2402-12.
6. Hendriksen J, Jansen M, Brown CM, van der Velde H, van Ham M, et al. (2008) Plasma membrane recruitment of dephosphorylated beta-catenin upon activation of the Wnt pathway. J Cell Sci 121(Pt 11): 1793-802.
7. Zhang L, Jia J, Wang B, Amanai K, Wharton KA Jr, et al. (2006) Regulation of wingless signaling by the CKI family in Drosophila limb development. Dev Biol 299(1): 221-37.
8. Gao ZH, Seeling JM, Hill V, Yochum A, Virshup DM (2002) Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex. Proc Natl Acad Sci U S A 99(3): 1182-7.
9. Zeng X, Tamai K, Doble B, Li S, Huang H, et al. (2005) A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature 438(7069): 873-7.
10. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, et al. (1998) Identification of c-MYC as a target of the APC pathway. Science 281(5382): 1509-12.
11. Mann B, Gelos M, Siedow A, Hanski ML, Gratchev A, et al. (1999) Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc Natl Acad Sci U S A 96(4): 1603-8.
12. Tetsu O, McCormick F (1999) Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398(6726): 422-6.
13. Boutros M, Mlodzik M (1999) Dishevelled: at the crossroads of divergent intracellular signaling pathways. Mech Dev 83(1-2): 27-37.
14. Wharton KA Jr (2003) Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction. Dev Biol 253(1): 1-17.
15. Axelrod JD, Miller JR, Shulman JM, Moon RT, Perrimon N (1998) Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. Genes Dev 12(16): 2610-22.
16. Boutros M, Paricio N, Strutt DI, Mlodzik M (1998) Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 94(1): 109-18.
17. Moriguchi T, Kawachi K, Kamakura S, Masuyama N, Yamanaka H, et al. (1999) Distinct domains of mouse dishevelled are responsible for the c-Jun N-terminal kinase/stress-activated protein kinase activation and the axis formation in vertebrates. J Biol Chem 274(43): 30957-62.
18. Cheyette BN, Waxman JS, Miller JR, Takemaru K, Sheldahl LC, et al. (2002) Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. Dev Cell 2(4): 449-61.
19. Gloy J, Hikasa H, Sokol SY (2002) Frodo interacts with Dishevelled to transduce Wnt signals. Nat Cell Biol 4(5): 351-7.
20. Zhang L, Gao X, Wen J, Ning Y, Chen YG (2006) Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation. J Biol Chem 281(13): 8607-12.
21. Waxman JS, Hocking AM, Stoick CL, Moon RT (2004) Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes. Development 131(23): 5909-21.
22. Hikasa H, Sokol SY (2004) The involvement of Frodo in TCF-dependent signaling and neural tissue development. Development 131(19): 4725-34.
23. Gao X, Wen J, Zhang L, Li X, Ning Y, et al. (2008) Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus. J Biol Chem.
24. Price MA (2006) CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling. Genes Dev 20(4): 399-410.
25. Li X, Yost HJ, Virshup DM, Seeling JM (2001) Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus. Embo J 20(15): 4122-31.
26. Salic A, Lee E, Mayer L, Kirschner MW (2000) Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the Wnt pathway in Xenopus egg extracts. Molecular Cell 5: 523-532.
27. Yau TO, Chan CY, Chan KL, Lee MF, Wong CM, et al. (2005) HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing. Oncogene 24(9): 1607-14.
28. Jiang X, Tan J, Li J, Kivimae S, Yang X, et al. (2008) DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. Cancer Cell 13(6): 529-41.
29. Arce C, Perez-Plasencia C, Gonzalez-Fierro A, de la Cruz-Hernandez E, Revilla-Vazquez A, et al. (2006) A proof-of-principle study of epigenetic therapy added to neoadjuvant doxorubicin cyclophosphamide for locally advanced breast cancer. PLoS ONE 1: e98.
30. Cong F, Schweizer L, Varmus H (2004) Casein kinase Iepsilon modulates the signaling specificities of dishevelled. Mol Cell Biol 24(5): 2000-11.