Flavoprotein imaging in the cerebellar cortex in vivo: Cellular and metabolic basis and insights into cerebellar function

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 7180, Issue , 2009, Pages

  Gao, Wangcai ^a   Chen, Gang ^a   Ebner, Timothy J ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

autofluorescence, flavoprotein, imaging, cerebellum, neurometabolic coupling

Indexed keywords

ACTIVITY-DEPENDENT; AUTOFLUORESCENCE; AUTOFLUORESCENCE IMAGING; AUTOFLUORESCENCE, FLAVOPROTEIN, IMAGING, CEREBELLUM, NEUROMETABOLIC COUPLING; BIPHASIC; CELLULAR REDOX; CEREBELLAR CORTEX; CORTICAL ACTIVITY; CORTICAL FUNCTIONS; ELECTRON TRANSPORT CHAIN; FUNCTIONAL ARCHITECTURE; GABAERGIC; GLUTAMATE RECEPTOR; IN-VIVO; INTRINSIC SIGNAL; LIGHT PHASE; MOLECULAR LAYER; NEURONAL ACTIVATION; OPTICAL SIGNALS; PARALLEL FIBERS; PURKINJE CELLS; SPATIAL PATTERNS; WAVELENGTH SELECTIVITY;

BRAIN; ELECTRON TRANSITIONS; ELECTRON TRANSPORT PROPERTIES; FLUORESCENCE; LIGHT; METABOLISM; PHOTONS; PROTEINS; SELF ASSEMBLY;

NEURONS;

EID: 65949111724     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.816637     Document Type: Conference Paper

References (48)

1. Grinvald, A., Lieke, E., Frostig, R. D., Gilbert, C. D. and Wiesel, T. N. "Functional architecture of cortex revealed by optical imaging of intrinsic signals," Nature 324(6095), 361-364 (1986). (Pubitemid 17180109)
2. Cohen, L. "Optical monitoring of physiological activity: a brief history," Jpn. J Physiol 43, S1-S6 (1993).
3. Ebner, T. J. and Chen, G. "Use of voltage-sensitive dyes and optical recordings in the central nervous system," Prog. Neurobiol. 46(5), 463-506 (1995).
4. Tsien, R. Y. "Fluorescent probes of cell signaling," Annu. Rev. Neurosci. 12, 227-253 (1989).
5. Tsien, R. Y. "Fluorescent indicators of ion concentrations," Methods Cell Biol. 30, 127-156 (1989).
6. Chen, G., Hanson, C. L. and Ebner, T. J. "Optical responses evoked by cerebellar surface stimulation in vivo using neutral red," Neuroscience 84, 645-668 (1998). (Pubitemid 28137885)
7. Miyawaki, A., Llopis, J., Heim, R., McCaffery, J. M., Adams, J. A., Ikura, M. and Tsien, R. Y. "Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin," Nature 388(6645), 882-887 (1997).
8. Miyawaki, A., Griesbeck, O., Heim, R. and Tsien, R. Y. "Dynamic and quantitative Ca2+ measurements using improved cameleons," Proc Natl Acad Sci USA 96(5), 2135-2140 (1999). (Pubitemid 29117880)
9. Frostig, R. D., Lieke, E. E., Ts'o, D. Y. and Grinvald, A. "Cortical functional architecture and local coupling between neuronal activity and the microcirculation revealed by in vivo high-resolution optical imaging of intrinsic signals," Proc Natl Acad Sci USA 87(16), 6082-6086 (1990). (Pubitemid 20258960)
10. Magistretti, P. J., Pellerin, L., Rothman, D. L. and Shulman, R. G. "Energy on demand," Science 283(5401), 496-497 (1999). (Pubitemid 129504607)
11. Magistretti, P. J. and Pellerin, L. "Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging," Philos. Trans. R Soc Lond B Biol Sci 354(1387), 1155-1163 (1999). (Pubitemid 29400898)
12. Chance, B., Cohen, P., Jobsis, F. F. and Schoener, B. "Intracellular oxidation-reduction states in vivo," Science 137, 499-508 (1962).
13. Chance, B. and Schoener, B. "Fluorometric studies of flavin component of the respiratory chain," Flavins and flavoproteins. Slater, E. C., Amsterdam, Elsevier Publishing Company. 510-519 (1966).
14. Shibuki, K., Hishida, R., Murakami, H., Kudoh, M., Kawaguchi, T., Watanabe, M., Watanabe, S., Kouuchi, T. and Tanaka, R. "Dynamic imaging of somatosensory cortical activity in the rat visualized by flavoprotein autofluorescence.," J Physiol 549, 919-927 (2003). (Pubitemid 36889779)
15. Husson, T. R., Mallik, A. K., Zhang, J. X. and Issa, N. P. "Functional imaging of primary visual cortex using flavoprotein autofluorescence," J. Neurosci 27(32), 8665-8675 (2007). (Pubitemid 47254267)
16. Shuttleworth, C. W., Brennan, A. M. and Connor, J. A. "NAD(P)H fluorescence imaging of postsynaptic neuronal activation in murine hippocampal slices," J Neurosci 23(8), 3196-3208 (2003). (Pubitemid 36531961)
17. Kasischke, K. A., Vishwasrao, H. D., Fisher, P. J., Zipfel, W. R. and Webb, W. W. "Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis," Science 305(5680), 99-103 (2004). (Pubitemid 38869381)
18. Reinert, K. C., Dunbar, R. L., Gao, W., Chen, G. and Ebner, T. J. "Flavoprotein autofluorescence imaging of neuronal activation in the cerebellar cortex in vivo.," J. Neurophysiol. 92(1), 199-211 (2004). (Pubitemid 38802244)
19. Gao, W., Chen, G., Reinert, K. C. and Ebner, T. J. "Cerebellar cortical molecular layer inhibition is organized in parasagittal zones," J Neurosci 26(32), 8377-8387 (2006). (Pubitemid 44309852)
20. Eccles, J. C., Ito, M. and Szentagothai, J. "The Cerebellum as a Neuronal Machine," Springer-Verlag, Berlin, 1, (1967).
21. Chance, B., Schoener, B., Oshino, R., Itshak, F. and Nakase, Y. "Oxidation-reduction ratio studies of mitochondria in freeze-trapped samples. NADH and flavoprotein fluorescence signals," J Biol Chem 254(11), 4764-4771 (1979).
22. Huang, S., Heikal, A. A. and Webb, W. W. "Two-photon fluorescence spectroscopy and microscopy of NAD(P)H and flavoprotein," Biophys. J. 82(5), 2811-2825 (2002). (Pubitemid 34441317)
23. Palmer, G. "Current issues in the chemistry of cytochrome c oxidase," J Bioenerg. Biomembr. 25(2), 145-151 (1993). (Pubitemid 23133522)
24. Majander, A., Finel, M. and Wikstrom, M. "Diphenyleneiodonium inhibits reduction of iron-sulfur clusters in the mitochondrial NADH-ubiquinone oxidoreductase (Complex I)," J. Biol. Chem. 269(33), 21037-21042 (1994). (Pubitemid 24266472)
25. Jobsis, F. F., Keizer, J. H., LaManna, J. C. and Rosenthal, M. "Reflectance spectrophotometry of cytochrome aa3 in vivo," J Appl. Physiol 43(5), 858-872 (1977). (Pubitemid 8238308)
26. LaManna, J. C., Sick, T. J., Pikarsky, S. M. and Rosenthal, M. "Detection of an oxidizable fraction of cytochrome oxidase in intact rat brain," Am J Physiol 253, C477-C483 (1987). (Pubitemid 17155182)
27. Malonek, D. and Grinvald, A. "Vascular regulation at sub millimeter range. Sources of intrinsic signals for high resolution optical imaging," Adv Exp Med Biol 413, 215-220 (1997). (Pubitemid 27342262)
28. Mugnaini, E. " The Comparative Anatomy and Histology of the Cerebellum: The Human Cerebellum, Cerebellar Connections and Cerebellar Cortex," University of Minnesota Press, Minneapolis, MN, USA, 201-265 (1972).
29. Gao, W. Chen, G., Wang, X., Reinert, K.and Ebner, T. J. "Cellular and metabolic sources of flavoprotein autofluorescence signal in cerebellar cortex in vivo," 1, 1, Soc. Neurosci. Abstr. (2008).
30. Pellerin, L. and Magistretti, P. J. "Glutamate uptake into astrocytes stimulates aerobic glycolysis - a mechanism coupling neuronal-activity to glucose-utilization," Proc Natl Acad Sci USA 91(22), 10625-10629 (1994). (Pubitemid 24329051)
31. Reinert, K. C., Gao, W. C., Chen, G. and Ebner, T. J. "Flavoprotein autofluorescence imaging in the cerebellar cortex in vivo," Journal of Neuroscience Research 85(15), 3221-3232 (2007). (Pubitemid 350058511)
32. Fonnum, F., Johnsen, A. and Hassel, B. "Use of fluorocitrate and fluoroacetate in the study of brain metabolism," Glia 21(1), 106-113 (1997). (Pubitemid 27389646)
33. Brodal, A. and Kawamura, K. "Olivocerebellar projection: a review," Adv. Anat. Embryol. Cell. Biol. 64, 1-140 (1980).
34. Chan-Palay, V., Palay, S. L., Brown, J. T. and van Itallie, C. "Sagittal organization of olivocerebellar and reticulocerebellar projections: autoradiographic studies with 35S-methionine," Exp Brain Res 30(4), 561-576 (1977). (Pubitemid 8234815)
35. Gao, W., Dunbar, R. L., Chen, G., Reinert, K. C., Oberdick, J. and Ebner, T. J. "Optical imaging of long-term depression in the mouse cerebellar cortex in vivo," J. Neurosci. 23(5), 1859-1866 (2003). (Pubitemid 36314741)
36. Shambes, G. M., Gibson, J. M. and Welker, W. "Fractured somatotopy in granule cell tactile areas of rat cerebellar hemispheres revealed by micromapping," Brain Behav Evol. 15(2), 94-140 (1978). (Pubitemid 8298105)
37. Attwell, D. and Iadecola, C. "The neural basis of functional brain imaging signals," Trends Neurosci. 25(12), 621-625 (2002). (Pubitemid 35356509)
38. Eccles, J. C., Llinas, R. and Sasaki, K. "Parallel fibre stimulation and the responses induced thereby in the Purkinje cells of the cerebellum," Exp. Brain Res. 1(1), 17-39 (1966).
39. Eccles, J. C., Sasaki, K. and Strata, P. "The profiles of physiological events produced by a parallel fibre volley in the cerebellar cortex," Exp. Brain Res. 2(1), 18-34 (1966).
40. Hawkes, R., Brochu, G., Dore, L., Graval, C. and Leclerc, N. "The Cerebellum Revisited," Springer-Verlag, New York, 22-55 (1992).
41. Koob, M. D., Moseley, M. L., Schut, L. J., Benzow, K. A., Bird, T. D., Day, J. W. and Ranum, L. P. W. "An untranslated CTG expansion causes a novel form of spinocerebellar ataxia (SCA8).," Nature Genetics 21(4), 379-384 (1999). (Pubitemid 29159573)
42. Moseley, M. L., Zu, T., Ikeda, Y., Gao, W., Mosemiller, A. K., Daughters, R. S., Chen, G., Weatherspoon, M. R., Clark, H. B., Ebner, T. J., Day, J. W. and Ranum, L. P. "Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8," Nat Genet 38(7), 758-769 (2006). (Pubitemid 43980596)
43. Maiti, S., Shear, J. B., Williams, R. M., Zipfel, W. R. and Webb, W. W. "Measuring serotonin distribution in live cells with three-photon excitation," Science 275(5299), 530-532 (1997). (Pubitemid 27051908)
44. Williams, R. M., Shear, J. B., Zipfel, W. R., Maiti, S. and Webb, W. W. "Mucosal mast cell secretion processes imaged using three-photon microscopy of 5-hydroxytryptamine autofluorescence," Biophys. J 76(4), 1835-1846 (1999). (Pubitemid 29266341)
45. Aubin, J. E. "Autofluorescence of viable cultured mammalian cells," J Histochem. Cytochem. 27(1), 36-43 (1979). (Pubitemid 9131769)
46. Chance, B., Mela, L. and Wong, D. "Flavins and flavoproteins," Kunio, Y. Proceedings of the 2nd conference on flavins and flavoproteins. 1 (1968).
47. Duchen, M. R. "Ca2+ -dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons.," Biochem. J. 283, 41-50 (1992).
48. Benson, R. C., Meyer, R. A., Zaruba, M. E. and McKhann, G. M. "Cellular autofluorescence--is it due to flavins?," J Histochem. Cytochem. 27(1), 44-48 (1979).