Organic anion transporter protein (OATP1B1) encoded by SLCO1B1 gene polymorphism (388A>G) & susceptibility in gallstone disease

Indian Journal of Medical Research

Volumn 129, Issue 2, 2009, Pages 170-175

  Jindal, Charulata ^a   Kumar, Sandeep ^a   Choudhari, Gourdas ^b   Goel, Himanshu ^a   Mittal, Balraj ^a  

^a SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

^b KING GEORGE'S MEDICAL UNIVERSITY   (India)

Author keywords

Gallstone; LST 1; OATP C; OATP1B1; Polymorphism; SLCO1B1

Indexed keywords

ADENINE; GUANINE; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 2; POLYACRYLAMIDE GEL;

ADULT; AGED; ARTICLE; CHOLELITHIASIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; INDIAN; MAJOR CLINICAL STUDY; MALE; NUCLEIC ACID BASE SUBSTITUTION; POLYMERASE CHAIN REACTION; PREVALENCE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

CROSS-SECTIONAL STUDIES; GALLSTONES; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INDIA; ODDS RATIO; ORGANIC ANION TRANSPORTERS; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 65949103176     PISSN: 09715916     EISSN: 09715916     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Katsika D, Grjibovski A, Einarsson C, Lammert F, Lichtenstein P, Marschall HU Genetic and environmental influences on symptomatic gallstone disease: a Swedish study of 43141 twin pairs. Hepatology 2005; 41: 1138-43.
2. Paigen B, Carey MC. Gallstones. In: King RA, Rotter JF, Motulsky AG, editors. The genetic basis of common diseases. NewYork: Oxford University Press; 2001. p. 298-335.
3. Greenberger NJ, Paumgartner G. Diseases of the gallbladder and bile ducts. In: Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL, editors. Harrison's Principle of internal medicine. NewYork: McGraw-Hill; 2005. p. 1882-9.
4. Hofmann AF. The function of bile salts in fat absorption. The solvent properties of dilute micellar solutions at conjugated bile salts. Biochem J 1963; 89: 57-68.
5. Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev 2003; 83: 633-71.
6. St-Pierre MV, Kullak-Ublick GA, Hagenbuch B, Meier PJ. Transport of bile acids in hepatic and non-hepatic tissues. J Exp Biol 2001; 204: 1673-86.
7. Miiller M, Jansen PL. Molecular aspects of hepatobiliary transport. Am J Physiol 1997; 272: G1285-303.
8. Yamaguchi H, Okada M, Akitaya S, Ohara H, Mikkaichi T, Ishikawa H, et al. Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3. J Lipid Res 2006; 47: 1196-202.
9. Hagenbuch B, Meier PJ. The superfamily of organic anion transporting polypeptides. Biochim Biophys Acta 2003; 1609: 1-18.
10. König J, Cui Y, Nies AT, Keppler D. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am J Physiol Gastrointest Liver Physical 2000; 278: G156-64.
11. Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, et al. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem 1999; 274: 17159-63.
12. Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, et al. Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology 2001; 120: 525-33.
13. Nakai D, Nakagomi R, Furuta Y, Tokui T, Abe T, Ikeda T, et al. Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes. J Pharmacol Exp Ther 2001; 297: 861-7.
14. Abe T, Unno M, Onogawa T, Tokui T, Kondo T N, Nakagomi R, et al. LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology 2001; 120: 1689-99.
15. Tirona RG, Leake BF, Merino G, Kim RB. Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European and African-Americans. J Biol Chem 2001; 276: 35669-75.
16. Choi JH, Lee MG, Cho JY, Lee JE, Kim KH, Park K. Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans. Clin Pharmacol Ther 2008; 83: 251-7.
17. Lyons MA, Wittenburg H, Li R, Walsh KA, Leonard MR, Korstanie R, et al. Lith6: a new QTL for cholesterol gallstones from an intercross of CAST/Ei and DBA/2J inbred mouse strains. J Lipid Res 2003; 44: 1763-71.
18. Kivistö KT, Niemi M. Influence of drug transporter polymorphisms on pravastatin pharmacokinetics in humans. Pharm Res 2007; 24: 239-47.
19. Miller SA, Dykes DD, Polesky HF. A simple salting procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16: 1215.
20. Huang MJ, Kua KE, Teng HC, Tang KS, Weng HW, Huang CS. Risk factors for severe hyperbilirubinemia in neonates. Pediatr Res 2004; 56: 682-9.
21. Novacek G. Gender and gall stone disease. Wien Med Wochenschr 2006; 156: 527-33.
22. Michalski C, Cui Y, Nies AT, Nuessler AK, Neuhaus P, Zanger UM, et al. A Naturally Occurring Mutation in the SLC21A6 Gene Causing Impaired Membrane Localization of the Hepatocyte Uptake Transporter. J Biol Chem 2002; 277: 43058-63.
23. Nei M, Roychoudhury AK. Evolutionary Relationships of Human Populations on a Global Scale. Mol Biol Evol 1993; 10: 927-43.
24. Jada SR, Xiaochen S, Yan LY, Xiaoqiang X, Lal S, Zhou SF, et al. Pharmacogenetics of SLCO1B1: haplotypes, htSNPs and hepatic expression in three distinct Asian populations. Eur J Clin Pharmacol 2007; 63: 555-63.
25. Pasanen MK, Backman JT, Neuvonen PJ, Niemi M. Frequencies of single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide B1 SLCO1B1 gene in a Finnish population. Eur J Clin Pharmacol 2006; 62: 409-15.
26. Mwinyi J, Johne A, Bauer S, Roots I, Gerloff T. Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics. Clin Pharmacol Ther 2004; 75: 415-21.
27. Lee E, Ryan S, Birmingham B, Zalikowski J, March R, Ambrose H, et al. Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment. Clin Pharmacol Ther 2005; 78: 330-41.
28. Nozawa T, Nakajima M, Tamai I, Noda K, Nezu J, Sai Y, et al. Genetic polymorphisms of human organic anion transporters OATP-C ( SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis. J Pharmacol Exp Ther 2002; 302: 804-13.
29. Nishizato Y, Ieiri I, Suzuki H, Kimura M, Kawabata K, Hirota T, et al. Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) gene: consequences for pravastation pharmacokinetics. Clin Pharmacol Ther 2003; 73: 554-65.
30. Chung JY, Cho JY, Yu KS, Kim JR, Oh DS, Jung HR, et al. Effect of OATP1B1 (SLCO1B1) variant alleles on the pharmacokinetics of pitavastatin in healthy volunteers. Clin Pharmacol Ther 2005; 78: 342-50.